定義:
配列相同性と機能性モチーフにより複数の遺伝子座で構成される遺伝子のグループに分類し、ヒト遺伝子ファミリー・グループをH-Invitational gene family/group(HIF)と定義し各遺伝子ファミリー・グループ単位にIDと名称を付与しました。
No. |
HIF |
Gene family/group name |
No. of HIX clusters |
Evidence InterPro ID |
1 |
HIF0000005 |
Zinc finger, C2H2-type (IPR007087). |
681 |
IPR007087 |
2 |
HIF0000006 |
7TM GPCR, rhodopsin-like (IPR000276). |
209 |
IPR000276 |
3 |
HIF0000007 |
Nucleotide-binding, alpha-beta plait (IPR012677). |
105 |
IPR012677 |
4 |
HIF0000008 |
Small GTP-binding protein (IPR005225). |
174 |
IPR005225 |
5 |
HIF0000010 |
Protein kinase, core (IPR000719). |
154 |
IPR000719 |
6 |
HIF0000011 |
Peptidase S1 and S6, chymotrypsin/Hap (IPR001254). |
124 |
IPR001254 |
7 |
HIF0000012 |
B302 (SPRY)-like (IPR001870). |
92 |
IPR001870 |
8 |
HIF0000013 |
Intermediate filament protein (IPR001664). |
62 |
IPR001664 |
9 |
HIF0000015 |
Nuclear hormone receptor, ligand-binding, core (IPR000536). |
61 |
IPR000536 |
10 |
HIF0000016 |
EF-Hand type (IPR011992). |
50 |
IPR011992 |
11 |
HIF0000017 |
Tubulin (IPR000217). |
50 |
IPR000217 |
12 |
HIF0000019 |
Collagen triple helix repeat (IPR008160). |
45 |
IPR008160 |
13 |
HIF0000020 |
Peptidase M10A and M12B, matrixin and adamalysin (IPR001818). |
44 |
IPR001818 |
14 |
HIF0000021 |
Mitochondrial substrate carrier (IPR001993). |
42 |
IPR001993 |
15 |
HIF0000022 |
BTB/Kelch-associated (IPR011705). |
37 |
IPR011705 |
16 |
HIF0000023 |
Actin/actin-like (IPR004000). |
23 |
IPR004000 |
17 |
HIF0000025 |
Ankyrin (IPR002110). |
31 |
IPR002110 |
18 |
HIF0000026 |
Protease inhibitor I4, serpin (IPR000215). |
30 |
IPR000215 |
19 |
HIF0000028 |
Tetraspanin (IPR018499). |
26 |
IPR018499 |
20 |
HIF0000029 |
Cytochrome P450 (IPR001128). |
26 |
IPR001128 |
21 |
HIF0000030 |
Transcription factor, fork head (IPR001766). |
22 |
IPR001766 |
22 |
HIF0000031 |
Homeobox (IPR001356). |
27 |
IPR001356 |
23 |
HIF0000032 |
Ubiquitin-conjugating enzyme, E2 (IPR000608). |
23 |
IPR000608 |
24 |
HIF0000033 |
Blood coagulation inhibitor, Disintegrin (IPR001762). |
25 |
IPR001762 |
25 |
HIF0000034 |
Interferon-induced transmembrane protein (IPR007593). |
22 |
IPR007593 |
26 |
HIF0000035 |
Short-chain dehydrogenase/reductase SDR (IPR002198). |
26 |
IPR002198 |
27 |
HIF0000036 |
RNA helicase, DEAD-box type, Q motif (IPR014014). |
27 |
IPR014014 |
28 |
HIF0000037 |
Tyrosine protein kinase (IPR001245). |
26 |
IPR001245 |
29 |
HIF0000038 |
Short-chain dehydrogenase/reductase SDR (IPR002198). |
24 |
IPR002198 |
30 |
HIF0000039 |
Ricin B lectin (IPR000772). |
25 |
IPR000772 |
31 |
HIF0000040 |
MAGE protein (IPR002190). |
22 |
IPR002190 |
32 |
HIF0000042 |
Mammalian taste receptor (IPR007960). |
25 |
IPR007960 |
33 |
HIF0000043 |
Potassium channel, voltage dependent, Kv, tetramerisation (IPR003131). |
24 |
IPR003131 |
34 |
HIF0000044 |
Human gene family/group candidate, HIF0000044. |
12 |
|
35 |
HIF0000045 |
Myosin head, motor region (IPR001609). |
21 |
IPR001609 |
36 |
HIF0000046 |
Helicase-associated region (IPR007502). |
23 |
IPR007502 |
37 |
HIF0000049 |
Tumour necrosis factor-like (IPR008983). |
23 |
IPR008983 |
38 |
HIF0000050 |
Neurotransmitter-gated ion-channel (IPR006201). |
22 |
IPR006201 |
39 |
HIF0000051 |
Cytosolic fatty-acid binding (IPR000463). |
17 |
IPR000463 |
40 |
HIF0000052 |
Arf GTPase activating protein (IPR001164). |
16 |
IPR001164 |
41 |
HIF0000053 |
C2 calcium-dependent membrane targeting (IPR000008). |
22 |
IPR000008 |
42 |
HIF0000054 |
Neurotransmitter-gated ion-channel (IPR006201). |
22 |
IPR006201 |
43 |
HIF0000055 |
Glutathione S-transferase/chloride channel, C-terminal (IPR017933). |
21 |
IPR017933 |
44 |
HIF0000056 |
bZIP transcription factor, bZIP-1 (IPR011616). |
15 |
IPR011616 |
45 |
HIF0000057 |
Heat shock protein 70 (IPR013126). |
17 |
IPR013126 |
46 |
HIF0000058 |
ADAM-TS Spacer 1 (IPR010294). |
20 |
IPR010294 |
47 |
HIF0000060 |
Interleukin 1/heparin-binding growth factor (IPR002348). |
17 |
IPR002348 |
48 |
HIF0000061 |
Wnt superfamily (IPR005817). |
20 |
IPR005817 |
49 |
HIF0000062 |
Immunoglobulin subtype 2 (IPR003598). |
20 |
IPR003598 |
50 |
HIF0000065 |
Sodium:neurotransmitter symporter (IPR000175). |
19 |
IPR000175 |
51 |
HIF0000066 |
Potassium channel, inwardly rectifying, Kir (IPR016449). |
20 |
IPR016449 |
52 |
HIF0000067 |
Connexins (IPR000500). |
15 |
IPR000500 |
53 |
HIF0000068 |
Carbonic anhydrase, alpha-class, catalytic domain (IPR001148). |
19 |
IPR001148 |
54 |
HIF0000069 |
Sulphate transporter (IPR011547). |
18 |
IPR011547 |
55 |
HIF0000070 |
Dynein heavy chain (IPR004273). |
20 |
IPR004273 |
56 |
HIF0000072 |
Transforming growth factor-beta-related (IPR015615). |
19 |
IPR015615 |
57 |
HIF0000073 |
UDP-glucuronosyl/UDP-glucosyltransferase (IPR002213). |
15 |
IPR002213 |
58 |
HIF0000074 |
Immunoglobulin-like fold (IPR013783). |
17 |
IPR013783 |
59 |
HIF0000075 |
EF-Hand type (IPR011992). |
16 |
IPR011992 |
60 |
HIF0000076 |
Claudin (IPR006187). |
16 |
IPR006187 |
61 |
HIF0000077 |
ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (IPR001757). |
16 |
IPR001757 |
62 |
HIF0000078 |
Annexin (IPR001464). |
13 |
IPR001464 |
63 |
HIF0000082 |
Human gene family/group candidate, HIF0000082. |
13 |
|
64 |
HIF0000083 |
G-protein, gamma subunit (IPR001770). |
14 |
IPR001770 |
65 |
HIF0000084 |
EF-Hand type (IPR011992). |
17 |
IPR011992 |
66 |
HIF0000085 |
Interferon alpha/beta/delta (IPR000471). |
17 |
IPR000471 |
67 |
HIF0000086 |
Aldo/keto reductase (IPR001395). |
13 |
IPR001395 |
68 |
HIF0000087 |
Pancreatic ribonuclease (IPR001427). |
17 |
IPR001427 |
69 |
HIF0000088 |
Guanine nucleotide binding protein (G-protein), alpha subunit (IPR001019). |
16 |
IPR001019 |
70 |
HIF0000089 |
Semaphorin/CD100 antigen (IPR001627). |
17 |
IPR001627 |
71 |
HIF0000090 |
Glycosyl transferase, family 31 (IPR002659). |
17 |
IPR002659 |
72 |
HIF0000091 |
Immunoglobulin E-set (IPR014756). |
15 |
IPR014756 |
73 |
HIF0000094 |
7TM GPCR, rhodopsin-like (IPR000276). |
16 |
IPR000276 |
74 |
HIF0000095 |
GPCR, family 2, extracellular region (IPR001879). |
16 |
IPR001879 |
75 |
HIF0000096 |
Valyl-tRNA synthetase, class Ia (IPR002303). |
15 |
IPR002303 |
76 |
HIF0000098 |
Homeobox (IPR001356). |
15 |
IPR001356 |
77 |
HIF0000099 |
ABC transporter, transmembrane region (IPR001140). |
15 |
IPR001140 |
78 |
HIF0000100 |
Chaperonin Cpn60/TCP-1 (IPR002423). |
14 |
IPR002423 |
79 |
HIF0000101 |
Tumor Necrosis Factor (IPR006052). |
16 |
IPR006052 |
80 |
HIF0000102 |
LST-1 (IPR007775). |
12 |
IPR007775 |
81 |
HIF0000103 |
ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (IPR001757). |
15 |
IPR001757 |
82 |
HIF0000104 |
Cell division/GTP binding protein (IPR000038). |
16 |
IPR000038 |
83 |
HIF0000109 |
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054). |
15 |
IPR001054 |
84 |
HIF0000113 |
Galectin, carbohydrate recognition domain (IPR001079). |
12 |
IPR001079 |
85 |
HIF0000114 |
Metallothionein, vertebrate (IPR000006). |
12 |
IPR000006 |
86 |
HIF0000116 |
General substrate transporter (IPR005828). |
12 |
IPR005828 |
87 |
HIF0000118 |
Immunoglobulin V-set (IPR013106). |
13 |
IPR013106 |
88 |
HIF0000123 |
Ran Binding Protein 1 (IPR000156). |
12 |
IPR000156 |
89 |
HIF0000124 |
Protein of unknown function DUF738 (IPR007965). |
14 |
IPR007965 |
90 |
HIF0000126 |
Fibrinogen, alpha/beta/gamma chain, C-terminal globular (IPR002181). |
14 |
IPR002181 |
91 |
HIF0000129 |
Alpha/beta hydrolase fold-1 (IPR000073). |
14 |
IPR000073 |
92 |
HIF0000130 |
Tumor Necrosis Factor (IPR006052). |
14 |
IPR006052 |
93 |
HIF0000131 |
ABC transporter, transmembrane region (IPR001140). |
14 |
IPR001140 |
94 |
HIF0000137 |
Zinc finger, LIM-type (IPR001781). |
13 |
IPR001781 |
95 |
HIF0000138 |
Armadillo-type fold (IPR016024). |
12 |
IPR016024 |
96 |
HIF0000139 |
Sterile alpha motif SAM (IPR001660). |
13 |
IPR001660 |
97 |
HIF0000141 |
Molecular chaperone, heat shock protein, Hsp40, DnaJ (IPR015609). |
13 |
IPR015609 |
98 |
HIF0000143 |
Immunoglobulin subtype (IPR003599). |
13 |
IPR003599 |
99 |
HIF0000153 |
Beta and gamma crystallin (IPR001064). |
12 |
IPR001064 |
100 |
HIF0000156 |
Ion transport 2 (IPR013099). |
12 |
IPR013099 |