H-InvDB x AHG DB
H-InvDB x AHG DB
H-InvDB_9.0 released on May 27, 2015.
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Protein complex view - Annotation for protein complex 95
Complex type: 

Protein complex (stable interactions)
Functional category(ries): 

RNA metabolism
Subcellular localization(s): 

Nucleus
Complex name: 

Ribonuclease P (RNaseP)/Ribonuclease MRP (RNaseMRP) complex
Description and evidences: 

The eukaryotic ribonuclease for mitochondrial RNA processing (RNase MRP) is mainly located in the nucleoli and belongs to the small nucleolar ribonucleoprotein (snoRNP) particles. RNase MRP is involved in the processing of pre-rRNA and the generation of RNA primers for mitochondrial DNA replication. A closely related snoRNP, which shares protein subunits with RNase MRP and contains a structurally related RNA subunit, is the pre-tRNA processing factor RNase P. Up to now, 10 protein subunits of these complexes have been described, designated hPop1, hPop4, hPop5, Rpp14, Rpp20, Rpp21, Rpp25, Rpp30, Rpp38 and Rpp40 [PubMed ID: 15096576].
CQI:  10.0.0/10  (Complex Annotation Quality Check Index: ../Total proteins)
*CQI is come from  
the defined categories of  
complex member proteins: 
: A protein of Catg.I has structural or document based evidences (scientific literatures or textbooks) to be the complex.
: A protein of Catg.II has a related function to other member proteins of the complex.
: A protein of Catg.III is just predicted as a complex member by our network analysis.
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PubMed reference ID relations

PPI data are based on H-InvDB Rel. 5.0
[Complex list] - [PCDq TOP]
for

Protein Summary for Complex 95
10
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19
Complex 95

HIX IDs &
(Gene locus)
H-ANGEL Exp-profiles
PDB IDs InterPro domains Gene Ontology (GO)
  BP: Biological Process
  CC: Cellular Component
  MF: Molecular Function
Subcellular
localizations
1

HIP000021627(2) PPI view Transcript viewRep, Catg. I(5), III(1)/6 HIT IDs
UniProt: P78345, RefSeq: NP_892117, GI: 33859837, CCDS: CCDS7108
Gene symbol: RPP38
EC No.: EC 3.1.26.5
Definition:
1. Ribonuclease P protein subunit p38 (EC 3.1.26.5) (RNaseP protein p38).
2. Ribonuclease P/MRP 38kDa subunit.
3. Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein.
HIX0018345
  Link to LOCUS view
  Link to H-ANGEL
IPR004038
Ribosomal protein L7Ae/L30e/S12e/Gadd45 [Family]
WoLF PSORT

Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
2

HIP000026056(5) PPI view Transcript viewRep, Catg. I(1), III(4)/5 HIT IDs
UniProt: O75817, RefSeq: , GI: , CCDS: CCDS5704
Gene symbol: POP7
EC No.: EC 3.1.26.5
Definition:
1. Alba, DNA/RNA-binding protein family protein.
2. Ribonuclease P protein subunit p20 (EC 3.1.26.5) (RNaseP protein p20) (hPOP7).
HIX0006932
  Link to LOCUS view
  Link to H-ANGEL
IPR002775
Alba, DNA/RNA-binding protein [Family]
MF:0003676
nucleic acid binding
WoLF PSORT
cytosol, extracellular, nuclear, Other
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
3

HIP000027777(0) PPI view Transcript viewRep, Catg. I(3), II(1), III(4)/8 HIT IDs
UniProt: Q5JPM1, RefSeq: , GI: , CCDS:
Gene symbol: RPP21
EC No.: EC 3.1.26.5
Definition:
1. RNAse P, Rpr2/Rpp21 subunit family protein.
2. Ribonuclease P protein subunit p21 (EC 3.1.26.5) (RNaseP protein p21) (Ribonucleoprotein V).
3. Similar to Ribonuclease P protein subunit p21 (EC 3.1.26.5) (RNaseP protein p21) (Ribonucleoprotein V).
HIX0005691
  Link to LOCUS view
  Link to H-ANGEL
HIX0057911
  Link to LOCUS view
  Link to H-ANGEL
HIX0058123
  Link to LOCUS view
  Link to H-ANGEL
IPR007175
RNAse P, Rpr2/Rpp21 subunit [Family]
WoLF PSORT
extracellular, cytosol, nuclear, Other
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
4

HIP000035660(0) PPI view Transcript viewRep, Catg. I(1)/1 HIT IDs
UniProt: , RefSeq: , GI: , CCDS:
Gene symbol: RPP40
Definition:
1. Ribonuclease P 40kDa subunit.
2. Ribonuclease P, Rpp40 family protein.
HIX0005551
  Link to LOCUS view
  Link to H-ANGEL
IPR013893
Ribonuclease P, Rpp40 [Family]
WoLF PSORT
cytosol, nuclear
Target P
mitochondria
SOSUI
soluble protein
TMHMM
soluble protein
5

HIP000036394(2) PPI view Transcript viewRep, Catg. I(1), III(4)/5 HIT IDs
UniProt: P78346, RefSeq: NP_006404, GI: 5454024, CCDS: CCDS7411
Gene symbol: RPP30
EC No.: EC 3.1.26.5
Definition:
1. RNase P subunit p30 family protein.
2. Ribonuclease P protein subunit p30 (EC 3.1.26.5) (RNaseP protein p30) (RNase P subunit 2).
HIX0009029
  Link to LOCUS view
  Link to H-ANGEL
IPR002738
RNase P subunit p30 [Family]
BP:0008033
tRNA processing
MF:0004540
ribonuclease activity
WoLF PSORT
cytosol, nuclear
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
6

HIP000048467(5) PPI view Transcript viewRep, Catg. I(1), III(10)/11 HIT IDs
UniProt: Q9BUL9, RefSeq: NP_060263, GI: 93277074, CCDS: CCDS10274
Gene symbol: RPP25
EC No.: EC 3.1.26.5
Definition:
1. Alba, DNA/RNA-binding protein family protein.
2. Ribonuclease P protein subunit p25 (EC 3.1.26.5) (RNase P protein subunit p25).
HIX0012434
  Link to LOCUS view
  Link to H-ANGEL
IPR002775
Alba, DNA/RNA-binding protein [Family]
MF:0003676
nucleic acid binding
WoLF PSORT

Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
7

HIP000070011(6) PPI view Transcript viewRep, Catg. I(6), II(1), III(1)/8 HIT IDs
UniProt: O95707, Q6FHW9, RefSeq: NP_006618, GI: 5729986, CCDS: CCDS12416
Gene symbol: POP4
EC No.: EC 3.1.26.5
Definition:
1. Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4).
2. Ribonuclease P, Rpp29 family protein.
3. Similar to Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4).
HIX0014977
  Link to LOCUS view
  Link to H-ANGEL
IPR002730
Ribonuclease P, Rpp29 [Family]
BP:0008033
tRNA processing
CC:0030677
ribonuclease P complex
MF:0004540
ribonuclease activity
WoLF PSORT

Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
8

HIP000082660(8) PPI view Transcript viewRep, Catg. I(4), III(1)/5 HIT IDs
UniProt: O95059, Q53X97, Q5RB79, RefSeq: NP_008973, GI: 5902066, CCDS: CCDS2888
Gene symbol: RPP14
EC No.: EC 3.1.26.5
Definition:
1. Ribonuclease P protein subunit p14 (EC 3.1.26.5).
2. Ribonuclease P-related family protein.
HIX0003400
  Link to LOCUS view
  Link to H-ANGEL
IPR002759
Ribonuclease P-related [Family]
BP:0008033
tRNA processing
MF:0004540
ribonuclease activity
WoLF PSORT

Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
9

HIP000100736(6) PPI view Transcript viewRep, Catg. I(1)/1 HIT IDs
UniProt: Q96F88, RefSeq: NP_055844, GI: 23097292, CCDS:
Gene symbol: POP1
Definition:
1. Processing of precursor 1, ribonuclease P/MRP subunit.
2. Ribonuclease P/MRP, POP1 domain containing protein.
HIX0007674
  Link to LOCUS view
  Link to H-ANGEL
IPR009723
Ribonuclease P/MRP, POP1 [Domain]
IPR012590
POPLD [Domain]
BP:0001682
tRNA 5'-leader removal
BP:0006396
RNA processing
MF:0004526
ribonuclease P activity
WoLF PSORT
nuclear, cytosol
Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
10

HIP000113018(4) PPI view Transcript viewRep, Catg. I(1), III(5)/6 HIT IDs
UniProt: Q969H6, RefSeq: NP_057002, GI: 20270249, CCDS: CCDS9202
Gene symbol: POP5
EC No.: EC 3.1.26.5
Definition:
1. Ribonuclease P-related family protein.
2. Ribonuclease P/MRP protein subunit POP5 (EC 3.1.26.5) (hPop5).
HIX0011067
  Link to LOCUS view
  Link to H-ANGEL
IPR002759
Ribonuclease P-related [Family]
BP:0008033
tRNA processing
MF:0004540
ribonuclease activity
WoLF PSORT

Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
11 HIP000006180(42) PPI view Transcript viewCatg. II(1), III(1)/2 HIT IDs
UniProt: , RefSeq: , GI: , CCDS:
Definition:
1. Autophagy protein Apg12 family protein.
2. Similar to Autophagy-related protein 12 (APG12-like).
HIX0005105
  Link to LOCUS view
  Link to H-ANGEL
IPR007242
Autophagy protein Apg12 [Family]
BP:0000045
autophagic vacuole formation
CC:0005737
cytoplasm
WoLF PSORT

Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
12 HIP000022243(21) PPI view Transcript viewRep, Catg. I(2), II(3)/5 HIT IDs
UniProt: Q96B26, RefSeq: NP_852480, GI: 31415882, CCDS: CCDS31958
Shared with Complex 35.
Gene symbol: EXOSC8
EC No.: EC 3.1.13.-
Definition:
1. Exoribonuclease, phosphorolytic domain 1 containing protein.
2. Exosome complex exonuclease RRP43 (EC 3.1.13.-) (Ribosomal RNA- processing protein 43) (Exosome component 8) (p9) (Opa-interacting protein 2).
3. Similar to Exosome complex exonuclease RRP43 (EC 3.1.13.-) (Ribosomal RNA- processing protein 43) (Exosome component 8) (p9) (Opa-interacting protein 2).
HIX0017428
  Link to LOCUS view
  Link to H-ANGEL
2nn6_C
IPR001247
Exoribonuclease, phosphorolytic domain 1 [Domain]
IPR015847
Exoribonuclease, phosphorolytic domain 2 [Domain]
BP:0006396
RNA processing
MF:0000175
3'-5'-exoribonuclease activity
MF:0003723
RNA binding
WoLF PSORT
cytosol, nuclear, extracellular, mitochondria, Other
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
13 HIP000030542(32) PPI view Transcript viewRep, Catg. I(7), II(1)/8 HIT IDs
UniProt: Q16637, Q549U5, RefSeq: NP_059107, GI: 4507091, CCDS: CCDS34181, CCDS4007
Shared with Complex 33.
Gene symbol: SMN1, SMN2
Definition:
1. Similar to Survival motor neuron protein (Component of gems 1) (Gemin-1).
2. Survival motor neuron family protein.
3. Survival motor neuron protein (Component of gems 1) (Gemin-1).
HIX0017390
  Link to LOCUS view
  Link to H-ANGEL
HIX0032074
  Link to LOCUS view
  Link to H-ANGEL
HIX0057672
  Link to LOCUS view
  Link to H-ANGEL
IPR002999
Tudor [Domain]
IPR010304
Survival motor neuron [Family]
BP:0000245
spliceosome assembly
BP:0006397
mRNA processing
CC:0005634
nucleus
CC:0005737
cytoplasm
MF:0003676
nucleic acid binding
MF:0003723
RNA binding
WoLF PSORT
nuclear, cytosol, plasma membrane
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
14 HIP000040985(2) PPI view Transcript viewRep, Catg. I(1), III(2)/3 HIT IDs
UniProt: Q9UGP4, RefSeq: NP_055055, GI: 7657307, CCDS: CCDS2729
Gene symbol: LIMD1
Definition:
1. LIM domain-containing protein 1.
2. LIM, zinc-binding domain containing protein.
HIX0030751
  Link to LOCUS view
  Link to H-ANGEL
IPR001781
LIM, zinc-binding [Domain]
MF:0008270
zinc ion binding
WoLF PSORT

Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein
15 HIP000094691(32) PPI view Transcript viewRep, Catg. I(2), II(1)/3 HIT IDs
UniProt: Q96ID5, RefSeq: , GI: , CCDS: CCDS184
Shared with Complex 298.
Gene symbol: IGSF21
Definition:
1. Immunoglobin superfamily, member 21.
2. Immunoglobulin domain containing protein.
3. Similar to Immunoglobin superfamily, member 21.
HIX0000185
  Link to LOCUS view
  Link to H-ANGEL
IPR003599
Immunoglobulin subtype [Domain]
IPR007110
Immunoglobulin-like [Domain]
IPR013151
Immunoglobulin [Domain]
IPR013783
Immunoglobulin-like fold [Domain]
WoLF PSORT
extracellular, lysosome, golgi apparatus, Other
Target P
signal peptide
SOSUI
soluble protein
TMHMM
soluble protein
16 HIP000100636(93) PPI view Transcript viewRep, Catg. I(8)/8 HIT IDs
UniProt: Q96BK5, RefSeq: , GI: , CCDS:
Shared with Complex 141, Complex 1088.
Definition:
1. D111/G-patch domain containing protein.
2. PIN2-interacting protein 1.
HIX0023045
  Link to LOCUS view
  Link to H-ANGEL
IPR000467
D111/G-patch [Domain]
CC:0005622
intracellular
MF:0003676
nucleic acid binding
WoLF PSORT

Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
17 HIP000106127(30) PPI view Transcript viewRep, Catg. I(9), III(6)/15 HIT IDs
UniProt: P04792, RefSeq: NP_001531, GI: 4504517, CCDS: CCDS5583
Shared with Complex 86, Complex 524, Complex 629.
Gene symbol: HSPB1
Definition:
1. Alpha crystallin/Heat shock protein family protein.
2. Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein).
HIX0006788
  Link to LOCUS view
  Link to H-ANGEL
IPR001436
Alpha crystallin/Heat shock protein [Family]
IPR002068
Heat shock protein Hsp20 [Domain]
IPR008978
HSP20-like chaperone [Domain]
WoLF PSORT

Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
18 HIP000109494(20) PPI view Transcript viewRep, Catg. I(12), II(5), III(11)/28 HIT IDs
UniProt: P63162, P63163, P63164, Q3UN87, Q5R6I0, Q60HD3, RefSeq: NP_073719, GI: 4507135, CCDS:
Shared with Complex 499.
Gene symbol: SNRPN, SNURF
Definition:
1. Like-Sm ribonucleoprotein, core family protein.
2. Similar to SmB /B' autoimmune antigene (Fragment).
3. Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).
HIX0012047
  Link to LOCUS view
  Link to H-ANGEL
IPR001163
Like-Sm ribonucleoprotein, core [Family]
IPR006649
Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core [Family]
IPR010920
Like-Sm ribonucleoprotein-related, core [Domain]
BP:0016071
mRNA metabolic process
CC:0030529
ribonucleoprotein complex
WoLF PSORT

Target P
Not predicted
SOSUI
soluble protein
TMHMM
soluble protein
19 HIP000163930(333) PPI view Transcript viewRep, Catg. I(1), III(6)/7 HIT IDs
UniProt: , RefSeq: NP_002458, GI: 71774083, CCDS:
Shared with Complex 4, Complex 37, Complex 60, Complex 105, Complex 140, Complex 205, Complex 220, Complex 289, Complex 493, Complex 496, Complex 501, Complex 959, Complex 1188, Complex 1195.
Gene symbol: MYC
Definition:
1. Myc proto-oncogene protein (c-Myc) (Transcription factor p64).
2. Transcription regulator Myc family protein.
HIX0007784
  Link to LOCUS view
  Link to H-ANGEL
IPR001092
Basic helix-loop-helix dimerisation region bHLH [Domain]
IPR002418
Transcription regulator Myc [Family]
IPR003327
Leucine zipper, Myc [Domain]
IPR011598
Helix-loop-helix DNA-binding [Domain]
IPR012682
Transcription regulator Myc, N-terminal [Domain]
BP:0006355
regulation of transcription, DNA-dependent
BP:0045449
regulation of transcription
CC:0005634
nucleus
MF:0003700
transcription factor activity
MF:0030528
transcription regulator activity
WoLF PSORT
nuclear
Target P
Other
SOSUI
soluble protein
TMHMM
soluble protein