H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
Search by for Advanced Search
ホーム クイックガイド 検索ナビ BLAST サイトマップ データダウンロード 問い合わせ ヘルプ
cDNA viewTranscript view Locus viewLocus view G-integraG-integra DiseaseInfo ViewerDiseaseInfo Viewer H-ANGELH-ANGEL EvolaEvola PPI viewerPPI view Gene Family/GroupGene Family/Group Hyperlink Management SystemHyperlink MS
H-Inv protein ID: HIP000022572 Last modified: 27-May-2015
Definition: Prohibitin;
[Summery][Full]
[Protein Info][Member][Motif] provide location, ID and descriptions of functional motifs (InterPro)[Function] provide human-curated functional definition, similarity category and related evidences; Gene name; HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000022572
Length 272
Codon Adaptation Index (CAI). 0.79
Database links RefSeq NA
UniProt P35232 ;
CCDS P35232;
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000423563
H-Inv cluster ID Locus view HIX0013960
Predicted CDS 74..892 ; 272[aa] ; Orientation:+2 ;
Genomic location Chromosome 17
Location 17q21.33
CDS position 47482130-47492242
Strand -
Accession number BC013401.2
CAGE tag ID NA
EST ID NA
Clone Number IMR322018133
Experimental resources NBRC: NITE Biological Resource Center NBRC   HGPD: Human Gene and Protein Database HGPD   Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PHB) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PHB) ;
Length of cDNA 1116[bp] (No. of exon:7)[A:264 T:256 G:300 C:296] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5245 ;
KEGG GENES KEGG GENES(5245) ;
GeneCard GeneCard PHB ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000036250
H-Inv cluster IDLocus view HIX0013960
Accession numberBC013401.2
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482198-47492227
Strand-
Gene structure7 exons
No.2
H-Inv IDTranscript view HIT000100331
H-Inv cluster IDLocus view HIX0013960
Accession numberBT007411.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482356-47490626
Strand-
Gene structure6 exons
No.3
H-Inv IDTranscript view HIT000217226
H-Inv cluster IDLocus view HIX0013960
Accession numberS85655.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482198-47492219
Strand-
Gene structure7 exons
No.4
H-Inv IDTranscript view HIT000335253
H-Inv cluster IDLocus view HIX0013960
Accession numberBC095460.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482198-47490655
Strand-
Gene structure6 exons
No.5
H-Inv IDTranscript view HIT000423563
H-Inv cluster IDLocus view HIX0013960
Accession numberAK290766.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help Representative H-Inv IDRepresentative transcript; Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482130-47492242
Strand-
Gene structure7 exons
No.6
H-Inv IDTranscript view HIT000431515
H-Inv cluster IDLocus view HIX0013960
Accession numberAK312649.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionProhibitin;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome17
Location17q21.33
CDS position47482354-47492242
Strand-
Gene structure7 exons

Motif information in predicted CDS
ORF

length(273),orf(74:892) MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVV GEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVA SQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQV SDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVV EKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQ LSRSRNITYLPAGQSVLLQLPQ*		 a.a.
length		 InterPro Name
length(272), motif(1:272) 272IPR000163Prohibitin [Family]
length(162), motif(26:187) 162IPR001107Band 7 protein [Family]
length(178), motif(29:206) 178IPR001107Band 7 protein [Family]
length(17), motif(70:86) 17IPR000163Prohibitin [Family]
length(20), motif(88:107) 20IPR000163Prohibitin [Family]
length(19), motif(111:129) 19IPR000163Prohibitin [Family]
length(17), motif(134:150) 17IPR000163Prohibitin [Family]
length(20), motif(157:176) 20IPR000163Prohibitin [Family]
length(24), motif(182:205) 24IPR000163Prohibitin [Family]
length(17), motif(205:221) 17IPR000163Prohibitin [Family]

Protein function information
H-Inv protein ID HIP000022572
Representative H-Inv transcript ID Transcript view HIT000423563
H-Inv cluster ID Locus view HIX0013960
Definition Prohibitin;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (P35232) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction 4
Interaction partner(s) HIP000025121; HIP000027929; HIP000027929; HIP000346184;
BIND 54912; 54913;
DIP 180174E; 40205E; 40206E; 40208E;
MINT MINT-48916; MINT-6488590; MINT-6488791; MINT-7717355; MINT-7717366; MINT-7717378; MINT-7717859; MINT-8079030;
HPRD 00017; 00032; 00312; 00494; 01061; 01241; 01248; 01265; 01574; 01576; 01778; 01803; 01806; 01859; 02091; 02483; 02533; 02911; 03143; 03723; 03975; 04285; 04459; 06659; 06763; 06942; 07038; 07601; 08201; 09006; 09690; 09803; 09918; 10355; 10584; 14358; 16246;
IntAct NA
Database links RefSeq NA
UniProt P35232 ;
CCDS P35232;
Gene symbol/name HGNC symbol PHB
HGNC aliases NA
HGNC name prohibitin;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB 		ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT cytosol;
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
62 180 1winA 2e-19 6.7 119/100 d.43.2.1
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
122..122 G/T rs11658876 - CDS Nonsynonymous[Ala17Ser]
166..166 T/G rs150024312 - CDS Nonsynonymous[Asp31Glu]
201..201 G/T rs2233665 + CDS Nonsynonymous[Arg43Leu]
202..202 T/G rs147481037 - CDS Synonymous[Arg43Arg]
225..225 G/T rs201359263 - CDS Nonsynonymous[Gly51Val]
336..336 T/C rs121918373 + CDS Nonsynonymous[Val88Ala]
370..370 C/T rs144654469 - CDS Synonymous[Val99Val]
387..387 G/A rs121918372 + CDS Nonsynonymous[Arg105His]
396..396 C/G rs199792568 - CDS Nonsynonymous[Thr108Ser]
405..405 G/A rs1049515 + CDS Nonsynonymous[Gly111Glu]
412..412 C/T rs1049517 + CDS Synonymous[Asp113Asp]
499..499 G/A rs1049525 + CDS Synonymous[Gln142Gln]
517..517 G/T rs140693016 - CDS Nonsynonymous[Arg148Ser]
547..547 C/T rs201875820 - CDS Synonymous[Ala158Ala]
597..597 T/G rs150607417 - CDS Nonsynonymous[Phe175Cys]
598..598 C/T rs191710304 - CDS Synonymous[Phe175Phe]
613..613 A/G rs141363200 - CDS Synonymous[Thr180Thr]
619..619 G/A rs148262252 - CDS Synonymous[Ala182Ala]
721..721 C/T rs144040543 - CDS Synonymous[Gly216Gly]
751..751 C/T rs149508639 - CDS Synonymous[Asn226Asn]
781..781 C/T rs142883213 - CDS Synonymous[Ile236Ile]
782..782 G/A rs137958073 - CDS Nonsynonymous[Glu237Lys]
826..826 C/T rs2233670 + CDS Synonymous[Leu251Leu]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;