H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Inv protein ID:	HIP000035135	Last modified:	27-May-2015
Definition:	Homeobox protein MIXL1; Homeodomain protein MIX; hMix; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein;

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000035135 Length 232 Codon Adaptation Index (CAI). 0.742 Database links RefSeq NA UniProt Q9H2W2 ; CCDS Q9H2W2; Original transcript information Representative H-Inv transcript ID HIT000340103 H-Inv cluster ID HIX0028575 Predicted CDS 65..763 ; 232[aa] ; Orientation:+2 ; Genomic location Chromosome 1 Location 1q42.12 CDS position 226411319-226413566 Strand + Accession number AF211891.1 CAGE tag ID NA EST ID NA Clone Number MGC:138179 IMAGE:8327442 Experimental resources NBRC       Length of cDNA 816[bp] (No. of exon:2)[A:129 T:146 G:247 C:294] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:83881 ; KEGG GENES KEGG GENES(83881) ; GeneCard NA etc Human-Gene diversity Of Life-style related Diseases ;

MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000074030
H-Inv cluster ID		HIX0028575
Accession number		AF211891.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Homeobox protein MIXL1; Homeodomain protein MIX; hMix; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (Q9H2W2) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	1
	Location	1q42.12
	CDS position	226411383-226413513
	Strand	+
Gene structure		2 exons

No.		2
H-Inv ID		HIT000340103
H-Inv cluster ID		HIX0028575
Accession number		BC111974.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Homeobox protein MIXL1; Homeodomain protein MIX; hMix; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (Q9H2W2) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		Representative transcript; Splicing isoform;
Genomic Location	Chromosome	1
	Location	1q42.12
	CDS position	226411319-226413566
	Strand	+
Gene structure		2 exons

No.		3
H-Inv ID		HIT000386894
H-Inv cluster ID		HIX0028575
Accession number		BC113441.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Homeobox protein MIXL1; Homeodomain protein MIX; hMix; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (Q9H2W2) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	1
	Location	1q42.12
	CDS position	226411319-226413565
	Strand	+
Gene structure		2 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	65	IPR009057	Homeodomain-like [Domain]
	66	IPR009057	Homeodomain-like [Domain]
	61	IPR001356	Homeobox domain [Domain]
	63	IPR001356	Homeobox domain [Domain]
	57	IPR001356	Homeobox domain [Domain]
	24	IPR017970	Homeobox, conserved site [Conserved_site]

Protein function information

H-Inv protein ID		HIP000035135
Representative H-Inv transcript ID		HIT000340103
H-Inv cluster ID		HIX0028575
Definition		Homeobox protein MIXL1; Homeodomain protein MIX; hMix; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (Q9H2W2) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	UniProt	Q9H2W2 ;
	CCDS	Q9H2W2;
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT nuclear; Target P Other SOSUI soluble protein TMHMM soluble protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 86 155 1b72B 1e-16 22.9 70/73 a.4.1.1

Related H-InvDB links GTOP

Evolutionary information

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	AF154573		G-integra
Orthology	Bos sp. (Cow)	ENSBTAT00000002773		G-integra
Orthology	Oryzias sp. (Medaka)	ENSORLT00000021759		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000000178		G-integra
Orthology	Tetraodon sp. (Tetraodon)	GSTENT00013398001		G-integra
Orthology	Rattus sp. (Rat)	XM_001061956		G-integra
Orthology	Macaca sp. (Macaque)	XM_001091234		G-integra
Orthology	Pan sp. (Chimpanzee)	XM_001140733		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001376893		G-integra
Orthology	Equus sp. (Horse)	XM_001491266		G-integra

Phylogenetic tree [View by ATV]	TNeighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS;

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 368..368 G/C rs202005618 + CDS Nonsynonymous[Glu102Gln] 436..436 G/A rs202018885 + CDS Synonymous[Leu124Leu] 489..489 G/T rs145225693 + CDS Nonsynonymous[Arg142Leu] 558^559 -/C rs36100504 + CDS 562..562 T/C rs150124070 + CDS Synonymous[Thr166Thr] 584..584 C/T rs79599422 + CDS AA-STOP[Gln174*] 589..589 G/A rs143213308 + CDS Synonymous[Leu175Leu] 613..613 C/T rs3738796 - CDS Synonymous[Cys183Cys] 623..623 C/A rs201172577 + CDS Nonsynonymous[Pro187Thr] 655..655 T/C rs114679749 + CDS Synonymous[Ser197Ser] 664..664 A/C rs200310896 + CDS Nonsynonymous[Gln200His] 689..689 C/T rs151275498 + CDS Nonsynonymous[Pro209Ser] 713..713 A/G rs200659360 + CDS Nonsynonymous[Lys217Glu] 748..748 C/T rs143393232 + CDS Synonymous[Ala228Ala] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;