H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Inv protein ID:	HIP000050242	Last modified:	27-May-2015
Definition:	Similar to Butyrophilin subfamily 2 member A1; Precursor;

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000050242 Length 334 Codon Adaptation Index (CAI). 0.781 Database links RefSeq NA UniProt NA CCDS Original transcript information Representative H-Inv transcript ID HIT000037620 H-Inv cluster ID HIX0200860 Predicted CDS 213..1217 ; 334[aa] ; Orientation:+3 ; Genomic location Chromosome 6 Location 6p22.2 CDS position 26458189-26469865 Strand + Accession number BC016661.1 CAGE tag ID NA EST ID NA Clone Number MGC:17033 IMAGE:4340392 Experimental resources NBRC     Antibody (BTN2A1) ;   Catalog (BTN2A1) ; Length of cDNA 3129[bp] (No. of exon:8)[A:835 T:732 G:823 C:739] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:11120 ; KEGG GENES KEGG GENES(11120) ; GeneCard BTN2A1 ; etc Human-Gene diversity Of Life-style related Diseases ;

MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKEVSMPDADGLFMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESFMPSVSPCAVALPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKERVQKEEELQVKEKLQEELRWRRTFLHAELQFFSN*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000037620
H-Inv cluster ID		HIX0200860
Accession number		BC016661.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Similar to Butyrophilin subfamily 2 member A1; Precursor;
Similarity category		Similar to known protein(Category II).
		Similar to known protein (Q7KYR7) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		Splicing isoform;
Genomic Location	Chromosome	6
	Location	6p22.2
	CDS position	26458189-26469865
	Strand	+
Gene structure		8 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	114	IPR007110	Immunoglobulin-like domain [Domain]
	137	IPR013783	Immunoglobulin-like fold [Domain]
	96	IPR013106	Immunoglobulin V-set domain [Domain]
	108	IPR003599	Immunoglobulin subtype [Domain]
	75	IPR013162	CD80-like, immunoglobulin C2-set [Domain]
	67	IPR013783	Immunoglobulin-like fold [Domain]

Protein function information

H-Inv protein ID		HIP000050242
Representative H-Inv transcript ID		HIT000037620
H-Inv cluster ID		HIX0200860
Definition		Similar to Butyrophilin subfamily 2 member A1; Precursor;
Similarity category		Similar to known protein(Category II).
		Similar to known protein (Q7KYR7) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	UniProt
	CCDS
Gene symbol/name	HGNC symbol	BTN2A1
	HGNC aliases	NA
	HGNC name	butyrophilin, subfamily 2, member A1;
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT endoplasmic; Target P signal peptide SOSUI membrane protein TMHMM membrane protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 38 149 12e8H1 2e-13 9.8 112/121 b.1.1.1 147 230 1dr9A2 2e-12 19.0 84/95 b.1.1.3

Related H-InvDB links GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 213..213 A/G rs199747313 + CDS Nonsynonymous[Met1Val] 215..215 G/A rs142203065 + CDS Nonsynonymous[Met1Ile] 219..219 T/C rs146399224 + CDS Nonsynonymous[Ser3Pro] 246..246 C/T rs139658946 + CDS Nonsynonymous[Pro12Ser] 253..253 C/G rs140375890 + CDS Nonsynonymous[Ser14Cys] 318..318 A/G rs146688212 + CDS Nonsynonymous[Thr36Ala] 355..355 C/T rs139118294 + CDS Nonsynonymous[Thr48Met] 361..361 G/A rs187108523 + CDS Nonsynonymous[Arg50His] 377..377 C/T rs72500817 + CDS Synonymous[Pro55Pro] 396..396 A/G rs144871432 + CDS Nonsynonymous[Met62Val] 415..415 G/A rs149038955 + CDS Nonsynonymous[Arg68Gln] 427..427 C/A rs200867396 + CDS Nonsynonymous[Ser72Tyr] 433..433 C/T rs149048780 + CDS Nonsynonymous[Ala74Val] 450..450 G/T rs146086334 + CDS Nonsynonymous[Gly80Cys] 512..512 C/T rs147859702 + CDS Synonymous[Ser100Ser] 532..532 G/T rs141312257 + CDS Nonsynonymous[Ser107Ile] 547..547 T/C rs200535507 + CDS Nonsynonymous[Ile112Thr] 582..582 C/T rs3734539 + CDS Nonsynonymous[Arg124Cys] 583..583 G/A rs143104579 + CDS Nonsynonymous[Arg124His] 633..633 G/A rs148111655 + CDS Nonsynonymous[Val141Ile] 657..657 C/T rs150220790 + CDS Nonsynonymous[Pro149Ser] 686..686 C/T rs145913124 + CDS Synonymous[Asp158Asp] 745..745 G/T rs13195401 + CDS Nonsynonymous[Trp178Leu] 746..746 G/T rs13195402 + CDS Nonsynonymous[Trp178Cys] 769..769 C/T rs139773763 + CDS Nonsynonymous[Ala186Val] 792..792 A/G rs142951857 + CDS Nonsynonymous[Met194Val] 807..807 G/A rs144358349 + CDS Nonsynonymous[Gly199Ser] 812..812 C/G rs199893249 + CDS Synonymous[Leu200Leu] 831..831 G/A rs13195509 + CDS Nonsynonymous[Val207Met] 863..863 G/A rs138727076 + CDS Nonsynonymous[Met217Ile] 902..902 A/G rs142538560 + CDS Synonymous[Lys230Lys] 938..938 C/T rs150961762 + CDS Synonymous[Pro242Pro] 997..997 T/G rs201295468 + CDS Nonsynonymous[Ile262Ser] 1056..1056 G/T rs200239130 + CDS AA-STOP[Glu282*] 1069..1069 A/G rs199697327 + CDS Nonsynonymous[Glu286Gly] 1071..1071 C/T rs148155227 + CDS Nonsynonymous[Arg287Trp] 1084..1084 A/G rs140281108 + CDS Nonsynonymous[Glu291Gly] 1092..1092 C/G rs144232372 + CDS Nonsynonymous[Leu294Val] 1104..1104 G/C rs147849789 + CDS Nonsynonymous[Glu298Gln] 1116..1116 G/A rs141482323 + CDS Nonsynonymous[Val302Met] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;