Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000055993 Last modified: 27-May-2015
Definition: Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3;
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000055993
Length 716
Codon Adaptation Index (CAI). 0.822
Database links RefSeq NA
UniProt NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000041549
H-Inv cluster ID Locus view HIX0003920
Predicted CDS 69..2219 ; 716[aa] ; Orientation:+3 ;
Genomic location Chromosome 3
Location 3q27.1
CDS position 183873356-183888664
Strand +
Accession number BC032459.1
Clone Number MGC:40316 IMAGE:5200610
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (DVL3) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (DVL3) ;
Length of cDNA 2415[bp] (No. of exon:15)[A:565 T:404 G:666 C:780] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:1857 ;
GeneCard GeneCard DVL3 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
H-Inv IDTranscript view HIT000041549
H-Inv cluster IDLocus view HIX0003920
Accession numberBC032459.1
Coding potential Help Protein coding
DefinitionSegment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q92997) [Identity/coverage = 99.86%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome3
CDS position183873356-183888664
Gene structure15 exons

Motif information in predicted CDS

InterPro Name
length(82), motif(1:82) 82IPR001158DIX domain [Domain]
length(716), motif(1:716) 716IPR008342Dishevelled-3 [Family]
length(716), motif(1:716) 716IPR015506Dishevelled-related protein [Family]
length(79), motif(2:80) 79IPR029071Ubiquitin-related domain [Domain]
length(80), motif(2:81) 80IPR001158DIX domain [Domain]
length(72), motif(142:213) 72IPR003351Dishevelled protein domain [Domain]
length(115), motif(227:341) 115IPR001478PDZ domain [Domain]
length(111), motif(228:338) 111IPR001478PDZ domain [Domain]
length(73), motif(249:321) 73IPR001478PDZ domain [Domain]
length(84), motif(250:333) 84IPR001478PDZ domain [Domain]
length(80), motif(258:337) 80IPR001478PDZ domain [Domain]
length(15), motif(324:338) 15IPR008339Dishevelled family [Family]
length(13), motif(358:370) 13IPR008339Dishevelled family [Family]
length(99), motif(397:495) 99IPR011991Winged helix-turn-helix DNA-binding domain [Domain]
length(75), motif(422:496) 75IPR000591DEP domain [Domain]
length(70), motif(425:494) 70IPR000591DEP domain [Domain]
length(11), motif(453:463) 11IPR008339Dishevelled family [Family]
length(12), motif(479:490) 12IPR008339Dishevelled family [Family]
length(11), motif(499:509) 11IPR008342Dishevelled-3 [Family]
length(207), motif(500:706) 207IPR024580Dishevelled C-terminal [Domain]
length(10), motif(551:560) 10IPR008342Dishevelled-3 [Family]
length(12), motif(585:596) 12IPR008342Dishevelled-3 [Family]
length(12), motif(634:645) 12IPR008342Dishevelled-3 [Family]

Protein function information
H-Inv protein ID HIP000055993
Representative H-Inv transcript ID Transcript view HIT000041549
H-Inv cluster ID Locus view HIX0003920
Definition Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (Q92997) [Identity/coverage = 99.86%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction 37
Interaction partner(s) HIP000024053; HIP000024110; HIP000024174; HIP000024846; HIP000024846; HIP000026846; HIP000027692; HIP000030159; HIP000030159; HIP000031618; HIP000031656; HIP000032348; HIP000033272; HIP000036198; HIP000048111; HIP000056415; HIP000060617; HIP000060647; HIP000060721; HIP000060867; HIP000075961; HIP000079240; HIP000093195; HIP000093195; HIP000095247; HIP000096070; HIP000103175; HIP000105951; HIP000110849; HIP000111933; HIP000112988; HIP000113911; HIP000116808; HIP000126774; HIP000161736; HIP000259815; HIP000334477;
BIND 149824; 178092; 178094; 178097; 178102;
DIP 133824E; 136195E; 136212E;
MINT MINT-60841;
HPRD 00277; 00286; 01316; 01395; 01487; 02753; 02919; 02920; 03139; 03220; 03660; 03688; 04691; 04819; 06901; 07135; 07389; 08482; 08912; 10352; 11314; 12518; 12752; 13151; 13248; 13925; 15412; 16199; 17287; 17919; 18279; 18338;
IntAct NA
Database links RefSeq NA
UniProt NA
Gene symbol/name HGNC symbol DVL3
HGNC aliases "dishevelled 3 (homologous to Drosophila dsh)", "dishevelled, dsh homolog 3 (Drosophila)";
HGNC name dishevelled segment polarity protein 3;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

GPDB (GlycoProtDB)
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT nuclear;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
3 82 1wspA1 5e-18 32.1 78/83 d.15.1.8
247 335 1i16A 7e-21 30.6 85/130 b.36.1.2
403 496 1fshA 1e-26 72.3 94/94 a.4.5.31
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
188..188 C/T rs201408685 + CDS Synonymous[Pro40Pro]
250..250 C/T rs143411607 + CDS Nonsynonymous[Ser61Leu]
353..353 C/T rs147153174 + CDS Synonymous[Asn95Asn]
359..359 G/A rs150288196 + CDS Synonymous[Ser97Ser]
374..374 T/A rs142016012 + CDS Synonymous[Pro102Pro]
386..386 G/A rs201100826 + CDS Synonymous[Thr106Thr]
395..395 C/T rs150659339 + CDS Synonymous[Ile109Ile]
406..406 G/A rs180953456 + CDS Nonsynonymous[Arg113Gln]
422..422 C/T rs139857613 + CDS Synonymous[His118His]
463..463 A/G rs143835194 + CDS Nonsynonymous[Asp132Gly]
473..473 G/A rs1687251 + CDS Synonymous[Thr135Thr]
502..502 G/A rs183681464 + CDS Nonsynonymous[Arg145Gln]
508..508 G/A rs146812695 + CDS Nonsynonymous[Arg147His]
509..509 C/A rs139649907 + CDS Synonymous[Arg147Arg]
525..525 G/C rs1687252 + CDS Nonsynonymous[Glu153Gln]
529..529 A/G rs144177739 + CDS Nonsynonymous[His154Arg]
534..534 A/G rs201932377 + CDS Nonsynonymous[Thr156Ala]
538..538 G/A rs146549809 + CDS Nonsynonymous[Arg157Gln]
555^556 -/A rs34111420 + CDS
557..557 G/A rs13068292 + CDS Synonymous[Lys163Lys]
584..584 T/C rs202225705 + CDS Synonymous[Gly172Gly]
591..591 A/G rs149103009 + CDS Nonsynonymous[Ser175Gly]
641..641 C/A rs143197489 + CDS Nonsynonymous[Asp191Glu]
661..661 C/T rs151229784 + CDS Nonsynonymous[Thr198Ile]
696..696 G/A rs200716382 + CDS Nonsynonymous[Ala210Thr]
729..729 C/G rs76594728 + CDS Nonsynonymous[Arg221Gly]
730..730 G/A rs199632718 + CDS Nonsynonymous[Arg221Gln]
749..749 T/G rs9879096 + CDS Synonymous[Ser227Ser]
751..751 G/A rs200798545 + CDS Nonsynonymous[Arg228Gln]
767..767 G/A rs114642851 + CDS Synonymous[Ser233Ser]
805..805 A/G rs201329929 + CDS Nonsynonymous[Asn246Ser]
806..806 C/T rs146995023 + CDS Synonymous[Asn246Asn]
807..807 A/G rs200772105 + CDS Nonsynonymous[Ile247Val]
814..814 C/T rs200137383 + CDS Nonsynonymous[Thr249Met]
875..875 C/T rs138011240 + CDS Synonymous[Asn269Asn]
879..879 C/T rs142071816 + CDS Nonsynonymous[Arg271Cys]
888..888 G/A rs199853617 + CDS Nonsynonymous[Gly274Ser]
920..920 T/C rs201788751 + CDS Synonymous[Gly284Gly]
926..926 C/T rs142819846 + CDS Synonymous[Ala286Ala]
945..945 A/G rs201275800 + CDS Nonsynonymous[Ile293Val]
977..977 C/T rs138393220 + CDS Synonymous[Asn303Asn]
986..986 C/- rs34078554 + CDS
1045..1045 C/T rs149251885 + CDS Nonsynonymous[Pro326Leu]
1046..1046 G/A rs186597752 + CDS Synonymous[Pro326Pro]
1061..1061 G/C rs144380814 + CDS Synonymous[Leu331Leu]
1099..1099 G/A rs148386960 + CDS Nonsynonymous[Cys344Tyr]
1118..1118 C/T rs200366490 + CDS Synonymous[Ser350Ser]
1128..1128 C/T rs201442250 + CDS Nonsynonymous[Arg354Trp]
1161..1161 A/G rs41266251 + CDS Nonsynonymous[Thr365Ala]
1169..1169 C/T rs142140216 + CDS Synonymous[Ala367Ala]
1176..1176 G/A rs146365513 + CDS Nonsynonymous[Gly370Ser]
1226..1226 C/T rs142698314 + CDS Synonymous[Ser386Ser]
1331..1331 C/T rs140653864 + CDS Synonymous[Ser421Ser]
1366..1366 T/G rs17853048 + CDS Nonsynonymous[Leu433Trp]
1420^1421 -/G rs143974514 + CDS
1438..1438 G/A rs36082642 - CDS Nonsynonymous[Gly457Asp]
1439..1439 C/G rs144312496 + CDS Synonymous[Gly457Gly]
1445..1445 G/A rs201946541 + CDS Synonymous[Thr459Thr]
1469..1469 T/C rs199713405 + CDS Synonymous[Tyr467Tyr]
1545..1545 A/G rs61758454 + CDS Nonsynonymous[Ile493Val]
1562..1562 C/T rs150607951 + CDS Synonymous[Cys498Cys]
1634..1634 C/T rs139681555 + CDS Synonymous[Ala522Ala]
1646..1646 C/T rs189465517 + CDS Synonymous[His526His]
1699..1699 C/T rs201330662 + CDS Nonsynonymous[Pro544Leu]
1713..1713 C/T rs180815441 + CDS Nonsynonymous[Pro549Ser]
1999..1999 T/C rs200811835 + CDS Nonsynonymous[Leu644Pro]
2015..2015 A/C rs149781565 + CDS Synonymous[Thr649Thr]
2143..2143 C/T rs201792550 + CDS Nonsynonymous[Pro692Leu]
2163..2163 C/A rs145617523 + CDS Nonsynonymous[Gln699Lys]
Microsatellite (Short Tandem Repeat, STR)
No data available
Related H-InvDB links
VaryGeneVaryGene ;