H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000062917 Last modified: 27-May-2015
Definition: Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A;
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000062917
Length 301
Codon Adaptation Index (CAI). 0.822
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000036244
H-Inv cluster ID Locus view HIX0022443
Predicted CDS 82..987 ; 301[aa] ; Orientation:+1 ;
Genomic location Chromosome 12
Location 12q24.31
CDS position 122064551-122079939
Strand +
Accession number BC013386.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:22830 IMAGE:3838524
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ORAI1) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ORAI1) ;
Length of cDNA 1405[bp] (No. of exon:2)[A:262 T:250 G:397 C:496] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:84876 ;
KEGG GENES KEGG GENES(84876) ;
GeneCard GeneCard ORAI1 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000036244
H-Inv cluster IDLocus view HIX0022443
Accession numberBC013386.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCalcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q96D31) [Identity/coverage = 99.668%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome12
Location12q24.31
CDS position122064551-122079939
Strand+
Gene structure2 exons

Motif information in predicted CDS
ORF

length(302),orf(82:987)
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAV
TYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFA
MVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEA
VSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFL
PLKKQPGQPRPTSKPPAGGAAANVSTSGITPGQAAAIASTTIMVPFGLIF
IVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A*
a.a.
length
InterPro Name
length(202), motif(68:269) 202IPR012446Calcium release-activated calcium channel protein [Family]

Protein function information
H-Inv protein ID HIP000062917
Representative H-Inv transcript ID Transcript view HIT000036244
H-Inv cluster ID Locus view HIX0022443
Definition Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (Q96D31) [Identity/coverage = 99.668%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction 7
Interaction partner(s) HIP000039564; HIP000066993; HIP000079240; HIP000081174; HIP000101210; HIP000102812; HIP000112664;
BIND NA
DIP 104016E; 104191E; 185610E;
MINT MINT-8186918;
HPRD 00241; 00242; 00243; 04710; 05803; 10079; 15999;
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol ORAI1
HGNC aliases "transmembrane protein 142A";
HGNC name ORAI calcium release-activated calcium modulator 1;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT plasma membrane;
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
262..262 T/C rs201617764 + CDS Nonsynonymous[Ser61Pro]
321..321 C/T rs199715755 + CDS Synonymous[Tyr80Tyr]
352..352 C/T rs118203993 + CDS Nonsynonymous[Arg91Trp]
432..432 G/- rs35949505 + CDS
586^587 -/CC rs151299882 + CDS
627..627 C/T rs3741595 + CDS Synonymous[Ile182Ile]
733..733 G/A rs3741596 + CDS Nonsynonymous[Gly218Ser]
749..749 A/G rs75603737 + CDS Nonsynonymous[Asn223Ser]
774..774 G/A rs200214435 + CDS Synonymous[Pro231Pro]
786..786 C/T rs3741597 + CDS Synonymous[Ala235Ala]
867..867 C/T rs3825174 + CDS Synonymous[Val262Val]
879..879 C/T rs3825175 + CDS Synonymous[Thr266Thr]
966..966 G/A rs187222480 + CDS Synonymous[Thr295Thr]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;