H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000064680 Last modified: 27-May-2015
Definition: Similar to Serine/threonine-protein kinase MRCK alpha isoform A.
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000064680
Length 1018
Codon Adaptation Index (CAI). 0.718
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000306877
H-Inv cluster ID Locus view HIX0213687
Predicted CDS 89..3145 ; 1018[aa] ; Orientation:+2 ;
Genomic location Chromosome 1
Location 1q42.13
CDS position 227181334-227288821
Strand -
Accession number BX648693.1
CAGE tag ID NA
EST ID NA
Clone Number DKFZp686L1738
Experimental resources NBRC: NITE Biological Resource Center NBRC      
Length of cDNA 3897[bp] (No. of exon:23)[A:1337 T:929 G:828 C:803] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8476 ;
KEGG GENES KEGG GENES(8476) ;
GeneCard GeneCard NA
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000057340
H-Inv cluster IDLocus view HIX0213687
Accession numberBX648693.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Serine/threonine-protein kinase MRCK alpha isoform A.
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (NP_055641) [Identity/coverage = 99.704%/61.78%] to Homo sapiens protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome1
Location1q42.13
CDS position227181334-227288821
Strand-
Gene structure23 exons
No.2
H-Inv IDTranscript view HIT000306877
H-Inv cluster IDLocus view HIX0213687
Accession numberCR933723.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Serine/threonine-protein kinase MRCK alpha isoform A.
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (NP_055641) [Identity/coverage = 99.704%/61.78%] to Homo sapiens protein.
Transcript feature Help Representative H-Inv IDRepresentative transcript; Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome1
Location1q42.13
CDS position227181334-227288821
Strand-
Gene structure23 exons

Motif information in predicted CDS
ORF

length(1019),orf(89:3145)
MILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKL
TTLYENLSIHNQQLEEEVKDLANKKESVAHWEAQITEIIQWVSDEKDARG
YLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSAL
DAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTE
ELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETDPVENTYVWNPSVKFHI
QSRSTSPSTSSEAEPVKTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQ
FFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPV
PPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLF
LYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFR
VTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVY
VPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGD
NKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGC
QTITSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQW
MAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAIC
AVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSV
YSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNK
MAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDP
EMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSI
PSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPS
PSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPVSP
RKTKSLSLESTDRGSWDP*
a.a.
length
InterPro Name
length(883), motif(1:883) 883IPR026611Serine/threonine-protein kinase MRCK alpha [Family]
length(152), motif(131:282) 152IPR014930Myotonic dystrophy protein kinase, coiled coil [Domain]
length(61), motif(145:205) 61IPR014930Myotonic dystrophy protein kinase, coiled coil [Domain]
length(51), motif(298:348) 51IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(50), motif(299:348) 50IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(51), motif(299:349) 51IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(120), motif(368:487) 120IPR001849Pleckstrin homology domain [Domain]
length(121), motif(369:489) 121IPR001849Pleckstrin homology domain [Domain]
length(115), motif(371:485) 115IPR011993Pleckstrin homology-like domain [Domain]
length(273), motif(513:785) 273IPR001180Citron-like [Domain]
length(283), motif(514:796) 283IPR001180Citron-like [Domain]
length(263), motif(519:781) 263IPR001180Citron-like [Domain]
length(14), motif(857:870) 14IPR000095CRIB domain [Domain]
length(36), motif(857:892) 36IPR000095CRIB domain [Domain]

Protein function information
H-Inv protein ID HIP000064680
Representative H-Inv transcript ID Transcript view HIT000306877
H-Inv cluster ID Locus view HIX0213687
Definition Similar to Serine/threonine-protein kinase MRCK alpha isoform A.
Similarity category Help Similar to known protein(Category II).
Similar to known protein (NP_055641) [Identity/coverage = 99.704%/61.78%] to Homo sapiens protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 2.7.11.1 non-specific serine/threonine protein kinase
KEGG metabolic pathway 04150 mTOR signaling pathway 04210 Apoptosis 04310 Wnt signaling pathway 04320 Dorso-ventral axis formation 04340 Hedgehog signaling pathway 04350 TGF-beta signaling pathway 04360 Axon guidance 04370 VEGF signaling pathway 04510 Focal adhesion 04520 Adherens junction 04530 Tight junction 04540 Gap junction 04620 Toll-like receptor signaling pathway 04630 Jak-STAT signaling pathway 04660 T cell receptor signaling pathway 04662 B cell receptor signaling pathway 04664 Fc epsilon RI signaling pathway 04720 Long-term potentiation 04730 Long-term depression 04810 Regulation of actin cytoskeleton 04910 Insulin signaling pathway 04912 GnRH signaling pathway 04920 Adipocytokine signaling pathway 05010 Alzheimer's disease 05210 Colorectal cancer
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT nuclear;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
296 356 1tbnA 4e-18 36.1 61/66 g.49.1.1
383 486 1qqgA1 2e-06 10.6 94/103 b.55.1.2
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
96..96 T/- rs67734085 - CDS
101..101 G/A rs3939280 - CDS Nonsynonymous[Asp5Asn]
111..111 A/G rs200068494 - CDS Nonsynonymous[Glu8Gly]
128..128 A/G rs145584750 - CDS Nonsynonymous[Ser14Gly]
219..219 C/T rs56119119 - CDS Nonsynonymous[Thr44Met]
243^244 -/G rs66555523 - CDS
249..249 A/G rs34943764 - CDS Nonsynonymous[Tyr54Cys]
353..353 A/C rs77122651 - CDS Nonsynonymous[Ile89Leu]
388..388 G/T rs142030346 - CDS Synonymous[Gly100Gly]
496..496 G/A rs200154961 - CDS Synonymous[Ala136Ala]
531..531 C/T rs144801895 - CDS Nonsynonymous[Ser148Leu]
532..532 G/A rs35017425 - CDS Synonymous[Ser148Ser]
568..568 C/T rs137890180 - CDS Synonymous[Ile160Ile]
578..578 T/C rs200668164 - CDS Synonymous[Leu164Leu]
614..614 T/A rs199653014 - CDS Nonsynonymous[Cys176Ser]
636..636 A/C rs200440295 - CDS Nonsynonymous[Lys183Thr]
652..652 A/G rs199733498 - CDS Synonymous[Leu188Leu]
664..664 C/T rs55845581 - CDS Synonymous[Ile192Ile]
845..845 C/T rs112760723 - CDS Nonsynonymous[Arg253Trp]
874..874 A/T rs201787239 - CDS Nonsynonymous[Glu262Asp]
880..880 G/A rs140617885 - CDS Synonymous[Glu264Glu]
897..897 A/G rs150700769 - CDS Nonsynonymous[Asp270Gly]
951..951 G/C rs199543596 - CDS Nonsynonymous[Gly288Ala]
975..975 G/A rs140416725 - CDS Nonsynonymous[Arg296His]
982..982 T/C rs113402500 - CDS Synonymous[Thr298Thr]
1008..1008 C/T rs202057695 - CDS Nonsynonymous[Thr307Ile]
1064..1064 G/A rs112933697 - CDS Nonsynonymous[Gly326Ser]
1115..1115 A/G rs142183701 - CDS Nonsynonymous[Lys343Glu]
1146^1147 -/A rs35357574 - CDS
1180..1180 G/A rs35369012 - CDS Synonymous[Gln364Gln]
1188..1188 T/C rs200344808 - CDS Nonsynonymous[Ile367Thr]
1384..1384 C/T rs201643732 - CDS Synonymous[Val432Val]
1388..1388 G/A rs56219089 - CDS Nonsynonymous[Ala434Thr]
1426..1426 C/T rs149978094 - CDS Synonymous[Pro446Pro]
1450..1450 C/T rs200331694 - CDS Synonymous[Ser454Ser]
1554..1554 T/- rs67003899 - CDS
1571..1571 A/G rs181637825 - CDS Nonsynonymous[Arg495Gly]
1578..1578 G/A rs961490 - CDS Nonsynonymous[Arg497His]
1740..1740 A/G rs201692012 - CDS Nonsynonymous[Asn551Ser]
1772..1772 A/T rs200594653 - CDS Nonsynonymous[Asn562Tyr]
1843..1843 T/C rs180784576 - CDS Synonymous[Asp585Asp]
1855..1855 C/T rs189930745 - CDS Synonymous[Thr589Thr]
1895..1895 A/C/G/T rs1929860 + CDS
1914..1914 G/A rs200056759 - CDS Nonsynonymous[Arg609His]
1955..1955 C/G rs201775243 - CDS Nonsynonymous[Gln623Glu]
1992..1992 G/A rs200051797 - CDS Nonsynonymous[Arg635His]
2008..2008 G/A rs1929861 + CDS Synonymous[Lys640Lys]
2017..2017 A/G rs200690739 - CDS Synonymous[Gln643Gln]
2021..2021 C/A rs149240330 - CDS Nonsynonymous[Pro645Thr]
2045..2045 A/G rs146203858 - CDS Nonsynonymous[Ile653Val]
2115..2115 A/- rs66656566 - CDS
2123..2123 A/G rs200486377 - CDS Nonsynonymous[Ser679Gly]
2189..2189 G/A rs183857756 - CDS Nonsynonymous[Ala701Thr]
2191..2191 A/G rs199656326 - CDS Synonymous[Ala701Ala]
2294..2294 G/T rs147617327 - CDS Nonsynonymous[Ala736Ser]
2307..2307 C/G rs142464333 - CDS Nonsynonymous[Ser740Cys]
2335..2335 G/A rs142853761 - CDS Synonymous[Ser749Ser]
2352..2352 C/T rs55687355 - CDS Nonsynonymous[Ala755Val]
2375..2375 T/C rs112426338 - CDS Nonsynonymous[Ser763Pro]
2427..2427 A/G rs146136586 - CDS Nonsynonymous[Asn780Ser]
2481..2481 A/T rs56229267 - CDS Nonsynonymous[Lys798Ile]
2484..2484 A/G rs139110633 - CDS Nonsynonymous[Asn799Ser]
2574..2574 G/A rs201852267 - CDS Nonsynonymous[Arg829His]
2627..2627 C/T rs12561938 - CDS Synonymous[Leu847Leu]
2693..2693 A/G rs200918078 - CDS Nonsynonymous[Met869Val]
2722..2722 G/C rs55848092 - CDS Synonymous[Leu878Leu]
2725..2725 A/G rs141188296 - CDS Synonymous[Lys879Lys]
2791..2791 A/G rs145724581 - CDS Synonymous[Pro901Pro]
2795..2795 A/G rs199675358 - CDS Nonsynonymous[Ile903Val]
2798..2798 A/G rs2297417 + CDS Nonsynonymous[Thr904Ala]
2807..2807 C/T rs148881297 - CDS Nonsynonymous[Arg907Cys]
2836..2836 T/C rs150430697 - CDS Synonymous[Ala916Ala]
2863..2863 C/T rs16846779 - CDS Synonymous[Ser925Ser]
2878..2878 C/T rs147810081 - CDS Synonymous[Ser930Ser]
2930..2930 A/G rs145538584 - CDS Nonsynonymous[Met948Val]
2955..2955 T/C rs200692909 - CDS Nonsynonymous[Leu956Ser]
2962..2962 C/T rs1045247 + CDS Synonymous[Ser958Ser]
2995..2995 G/A rs201963139 - CDS Synonymous[Ala969Ala]
3008..3008 G/A rs143404397 - CDS Nonsynonymous[Gly974Arg]
3025..3025 T/C rs147437313 - CDS Synonymous[Ser979Ser]
3027..3027 C/T rs148249654 - CDS Nonsynonymous[Pro980Leu]
3071^3072 -/C rs67581567 - CDS
3081..3081 T/C rs2802269 - CDS Nonsynonymous[Val998Ala]
3090..3090 G/A rs145018031 - CDS Nonsynonymous[Arg1001Gln]
3102..3102 G/T rs146538430 - CDS Nonsynonymous[Ser1005Ile]
3110..3110 C/T rs140582350 - CDS Synonymous[Leu1008Leu]
3132..3132 G/A rs142402392 - CDS Nonsynonymous[Ser1015Asn]
3142..3142 G/A rs56027641 - CDS Synonymous[Pro1018Pro]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;