H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Inv protein ID:	HIP000079395	Last modified:	27-May-2015
Definition:	Protein C-ets-2;

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000079395 Length 469 Codon Adaptation Index (CAI). 0.798 Database links RefSeq NA UniProt P15036 ; CCDS P15036; Original transcript information Representative H-Inv transcript ID HIT000052766 H-Inv cluster ID HIX0016112 Predicted CDS 193..1602 ; 469[aa] ; Orientation:+1 ; Genomic location Chromosome 21 Location 21q22.2 CDS position 40177853-40195723 Strand + Accession number BC017040.1 CAGE tag ID NA EST ID NA Clone Number MGC:43964 IMAGE:5276704 Experimental resources NBRC   HGPD     Length of cDNA 2527[bp] (No. of exon:10)[A:642 T:613 G:641 C:631] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:2114 ; KEGG GENES KEGG GENES(2114) ; GeneCard NA etc Human-Gene diversity Of Life-style related Diseases ;

MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFPKSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000037802
H-Inv cluster ID		HIX0016112
Accession number		BC017040.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	21
	Location	21q22.2
	CDS position	40177883-40195723
	Strand	+
Gene structure		10 exons

No.		2
H-Inv ID		HIT000052766
H-Inv cluster ID		HIX0016112
Accession number		BC042954.2
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		Representative transcript; Splicing isoform;
Genomic Location	Chromosome	21
	Location	21q22.2
	CDS position	40177853-40195723
	Strand	+
Gene structure		10 exons

No.		3
H-Inv ID		HIT000099758
H-Inv cluster ID		HIX0016112
Accession number		BT006838.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	21
	Location	21q22.2
	CDS position	40181959-40194811
	Strand	+
Gene structure		9 exons

No.		4
H-Inv ID		HIT000191236
H-Inv cluster ID		HIX0016112
Accession number		J04102.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	21
	Location	21q22.2
	CDS position	40177755-40195380
	Strand	+
Gene structure		10 exons

No.		5
H-Inv ID		HIT000434429
H-Inv cluster ID		HIX0016112
Accession number		AK315563.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		NA
Genomic Location	Chromosome	21
	Location	21q22.2
	CDS position	40177854-40194813
	Strand	+
Gene structure		10 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	102	IPR013761	Sterile alpha motif/pointed domain [Domain]
	90	IPR013761	Sterile alpha motif/pointed domain [Domain]
	86	IPR003118	Pointed domain [Domain]
	84	IPR003118	Pointed domain [Domain]
	82	IPR003118	Pointed domain [Domain]
	121	IPR011991	Winged helix-turn-helix DNA-binding domain [Domain]
	86	IPR000418	Ets domain [Domain]
	14	IPR000418	Ets domain [Domain]
	81	IPR000418	Ets domain [Domain]
	82	IPR000418	Ets domain [Domain]
	9	IPR000418	Ets domain [Domain]
	19	IPR000418	Ets domain [Domain]
	19	IPR000418	Ets domain [Domain]
	16	IPR000418	Ets domain [Domain]
	19	IPR000418	Ets domain [Domain]

Protein function information

H-Inv protein ID		HIP000079395
Representative H-Inv transcript ID		HIT000052766
H-Inv cluster ID		HIX0016112
Definition		Protein C-ets-2;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P15036) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	37
	Interaction partner(s)	HIP000021733; HIP000022129; HIP000022526; HIP000023055; HIP000026585; HIP000027524; HIP000028809; HIP000033301; HIP000036732; HIP000041711; HIP000043673; HIP000048613; HIP000056841; HIP000068104; HIP000078885; HIP000081026; HIP000081455; HIP000087835; HIP000093084; HIP000094122; HIP000096367; HIP000100939; HIP000100939; HIP000105122; HIP000109256; HIP000110646; HIP000116713; HIP000116926; HIP000136553; HIP000144372; HIP000147100; HIP000164074; HIP000256202; HIP000258478; HIP000336432; HIP000355042; HIP000361205;
	BIND	150478; 197039; 258588; 258815; 258819;
	DIP	NA
	MINT	MINT-62043;
	HPRD	00572; 00679; 01252; 01260; 01298; 01302; 01819; 02534; 02911; 03374; 04078; 04459; 04588; 05037; 05771; 09616; 09830;
	IntAct	NA
Database links	RefSeq	NA
	UniProt	P15036 ;
	CCDS	P15036;
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT nuclear; Target P Other SOSUI soluble protein TMHMM soluble protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 77 166 1sxeA 1e-16 33.3 90/97 a.60.1.1 361 445 1bc7C 2e-30 56.5 85/93 a.4.5.21

Related H-InvDB links GTOP

Evolutionary information

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	AK152750		G-integra
Orthology	Danio sp. (Zebrafish)	BC095899		G-integra
Orthology	Bos sp. (Cow)	BC126692		G-integra
Orthology	Pongo sp. (Orangutan)	CR860643		G-integra
Orthology	Canis sp. (Dog)	ENSCAFT00000015882		G-integra
Orthology	Gallus sp. (Chicken)	ENSGALT00000025873		G-integra
Orthology	Rattus sp. (Rat)	XM_001053903		G-integra
Orthology	Macaca sp. (Macaque)	XM_001109376		G-integra
Orthology	Pan sp. (Chimpanzee)	XM_001170891		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001363017		G-integra
Orthology	Equus sp. (Horse)	XM_001916143		G-integra

Phylogenetic tree [View by ATV]	TNeighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS;

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 235..235 G/A rs115148137 + CDS Nonsynonymous[Val15Met] 242..242 A/G rs150592938 + CDS Nonsynonymous[Asn17Ser] 265..265 C/T rs139909964 + CDS Nonsynonymous[Arg25Cys] 272..272 C/T rs143407258 + CDS Nonsynonymous[Pro27Leu] 308^309 -/T rs66473060 + CDS 381..381 C/T rs184634189 + CDS Synonymous[Ser63Ser] 382..382 G/A rs34373350 - CDS Nonsynonymous[Ala64Thr] 411..411 G/A rs139241184 + CDS Synonymous[Pro73Pro] 435..435 A/G rs11700777 + CDS Synonymous[Gln81Gln] 454..454 A/C rs144867115 + CDS Nonsynonymous[Ser88Arg] 464..464 A/G rs114481523 + CDS Nonsynonymous[Lys91Arg] 476..476 G/A rs149038175 + CDS Nonsynonymous[Arg95Gln] 538..538 C/T rs78391361 + CDS Nonsynonymous[Leu116Phe] 551..551 A/G rs201321686 + CDS Nonsynonymous[Asn120Ser] 588..588 C/T rs142958770 + CDS Synonymous[Phe132Phe] 589..589 G/A rs201897945 + CDS Nonsynonymous[Gly133Ser] 626..626 A/T rs1803557 + CDS Nonsynonymous[Glu145Val] 640..640 C/T rs147754962 + CDS Synonymous[Leu150Leu] 654..654 T/A rs142517222 + CDS Nonsynonymous[Phe154Leu] 687^688 -/C rs34472454 + CDS 801..801 G/T rs200961208 + CDS Synonymous[Ala203Ala] 831..831 C/G rs200893699 + CDS Synonymous[Pro213Pro] 838..838 G/A rs115908228 + CDS Nonsynonymous[Gly216Ser] 841..841 C/A rs61735785 + CDS Nonsynonymous[Leu217Ile] 845..845 T/G rs114460001 + CDS Nonsynonymous[Leu218Arg] 857..857 G/T rs115297166 + CDS Nonsynonymous[Cys222Phe] 860..860 C/T rs114562289 + CDS Nonsynonymous[Pro223Leu] 876..876 C/T rs115786160 + CDS Synonymous[Ser228Ser] 919..919 C/T rs150430243 + CDS Nonsynonymous[Arg243Trp] 931..931 G/A rs138127643 + CDS Nonsynonymous[Val247Ile] 937..937 G/A rs116698978 + CDS Nonsynonymous[Val249Ile] 1008..1008 G/T rs457705 + CDS Synonymous[Thr272Thr] 1035..1035 C/T rs201143455 + CDS Synonymous[Asn281Asn] 1040..1040 C/T rs138783369 + CDS Nonsynonymous[Ala283Val] 1041..1041 G/A rs115426813 + CDS Synonymous[Ala283Ala] 1088..1088 A/C rs146230611 + CDS Nonsynonymous[Gln299Pro] 1125..1125 C/T rs113417859 + CDS Synonymous[Phe311Phe] 1134..1134 C/T rs201065633 + CDS Synonymous[Phe314Phe] 1156..1156 C/G rs201705823 + CDS Nonsynonymous[Leu322Val] 1214..1214 C/T rs139305338 + CDS Nonsynonymous[Pro341Leu] 1215..1215 G/A rs461155 + CDS Synonymous[Pro341Pro] 1227^1228 -/C rs34120017 + CDS 1249..1249 G/A rs116771448 + CDS Nonsynonymous[Val353Met] 1354..1354 G/A rs116387099 + CDS Nonsynonymous[Gly388Arg] 1371..1371 C/T rs116476013 + CDS Synonymous[Leu393Leu] 1374..1374 C/T rs185172042 + CDS Synonymous[Ala394Ala] 1375..1375 G/A rs115880316 + CDS Nonsynonymous[Asp395Asn] 1421..1421 C/T rs200586471 + CDS Nonsynonymous[Pro410Leu] 1491..1491 G/A rs139455779 + CDS Synonymous[Thr433Thr] 1554..1554 C/T rs149674474 + CDS Synonymous[Pro454Pro] 1558..1558 G/A rs147744979 + CDS Nonsynonymous[Glu456Lys] 1576..1576 G/A rs142665354 + CDS Nonsynonymous[Gly462Ser] 1580..1580 T/C rs144935329 + CDS Nonsynonymous[Val463Ala] 1587..1587 A/C rs17854245 + CDS Synonymous[Pro465Pro] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;