H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000089515 Last modified: 27-May-2015
Definition: Left-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; Precursor;
[Summery][Full]
[Protein Info][Member][Motif] provide location, ID and descriptions of functional motifs (InterPro)[Function] provide human-curated functional definition, similarity category and related evidences; Gene name; HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000089515
Length 366
Codon Adaptation Index (CAI). 0.86
Database links RefSeq NA
UniProt O75610 ;
CCDS O75610;
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000252917
H-Inv cluster ID Locus view HIX0199988
Predicted CDS 68..1168 ; 366[aa] ; Orientation:+2 ;
Genomic location Chromosome 1
Location 1q42.12
CDS position 226073979-226076833
Strand -
Accession number BC027883.1
CAGE tag ID NA
EST ID NA
Clone Number DNA33461
Experimental resources NBRC: NITE Biological Resource Center NBRC   HGPD: Human Gene and Protein Database HGPD   Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (LEFTY1) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (LEFTY1) ;
Length of cDNA 1616[bp] (No. of exon:4)[A:294 T:318 G:506 C:497] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10637 ;
KEGG GENES KEGG GENES(10637) ;
GeneCard GeneCard LEFTY1 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000040334
H-Inv cluster IDLocus view HIX0199988
Accession numberBC027883.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionLeft-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (O75610) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome1
Location1q42.12
CDS position226073982-226076833
Strand-
Gene structure4 exons
No.2
H-Inv IDTranscript view HIT000066480
H-Inv cluster IDLocus view HIX0199988
Accession numberAF081512.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionLeft-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (O75610) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome1
Location1q42.12
CDS position226074080-226076836
Strand-
Gene structure4 exons
No.3
H-Inv IDTranscript view HIT000252917
H-Inv cluster IDLocus view HIX0199988
Accession numberAY358873.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionLeft-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (O75610) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help Representative H-Inv IDRepresentative transcript; Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome1
Location1q42.12
CDS position226073979-226076833
Strand-
Gene structure4 exons

Motif information in predicted CDS
ORF

length(367),orf(68:1168) MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEE LVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLV FGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWL RVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQ VSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLGDYGAQGD CDPEAPMTEGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQP PEALAFKWPFLGPRQCIASETDSLPMIVSIKEGGRTRPQVVSLPNMRVQK CSCASDGALVPRRLQP*		 a.a.
length		 InterPro Name
length(354), motif(1:354) 354IPR015615Transforming growth factor-beta-related [Family]
length(23), motif(4:26) 23IPR003942Left- Right determination factor [Family]
length(190), motif(22:211) 190IPR001111Transforming growth factor-beta, N-terminal [Domain]
length(22), motif(26:47) 22IPR003942Left- Right determination factor [Family]
length(17), motif(49:65) 17IPR003942Left- Right determination factor [Family]
length(19), motif(72:90) 19IPR003942Left- Right determination factor [Family]
length(16), motif(97:112) 16IPR003942Left- Right determination factor [Family]
length(21), motif(112:132) 21IPR003942Left- Right determination factor [Family]
length(19), motif(132:150) 19IPR003942Left- Right determination factor [Family]
length(22), motif(153:174) 22IPR003942Left- Right determination factor [Family]
length(24), motif(187:210) 24IPR003942Left- Right determination factor [Family]
length(16), motif(216:231) 16IPR003942Left- Right determination factor [Family]
length(26), motif(234:259) 26IPR003942Left- Right determination factor [Family]
length(113), motif(242:354) 113IPR001839Transforming growth factor-beta, C-terminal [Domain]
length(95), motif(259:353) 95IPR029034Cystine-knot cytokine [Domain]
length(40), motif(262:301) 40IPR001839Transforming growth factor-beta, C-terminal [Domain]
length(92), motif(263:354) 92IPR001839Transforming growth factor-beta, C-terminal [Domain]
length(22), motif(265:286) 22IPR003942Left- Right determination factor [Family]
length(16), motif(282:297) 16IPR017948Transforming growth factor beta, conserved site [Conserved_site]
length(21), motif(299:319) 21IPR003942Left- Right determination factor [Family]
length(20), motif(325:344) 20IPR003942Left- Right determination factor [Family]

Protein function information
H-Inv protein ID HIP000089515
Representative H-Inv transcript ID Transcript view HIT000252917
H-Inv cluster ID Locus view HIX0199988
Definition Left-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; Precursor;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (O75610) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt O75610 ;
CCDS O75610;
Gene symbol/name HGNC symbol LEFTY1
HGNC aliases "left-right determination, factor B";
HGNC name left-right determination factor 1;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB 		ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT extracellular;
Target P signal peptide
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
262 353 1bmpA 8e-17 25.0 88/104 g.17.1.2
Related H-InvDB links GTOP GTOP

Evolutionary information
Relationship Species Accession number MGI Links
Orthology Gallus sp. (Chicken) AB031398 G-integraG-integra
Orthology Mus sp. (Mouse) AK131943 MGI:3532224 G-integraG-integra
Orthology Oryzias sp. (Medaka) EF206722 G-integraG-integra
Orthology Macaca sp. (Macaque) ENSMMUT00000008117 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000000185 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00018477001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000154042 G-integraG-integra
Orthology Rattus sp. (Rat) XM_001061810 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_001138156 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001376637 G-integraG-integra
Orthology Bos sp. (Cow) XM_613627 G-integraG-integra
Orthology Canis sp. (Dog) XM_849632 G-integraG-integra
Phylogenetic tree [View by ATV] TNeighbor-joining (phb) 
Related H-InvDB links EvolaEvola;  dN/dS; 

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
165..165 G/A rs41310561 - CDS Nonsynonymous[Arg33Gln]
235..235 C/T rs140535323 - CDS Synonymous[His56His]
236..236 G/A rs35273824 - CDS Nonsynonymous[Val57Met]
251..251 G/A rs61995951 - CDS Nonsynonymous[Val62Met]
275..275 G/A rs149725453 - CDS Nonsynonymous[Gly70Arg]
281..281 C/T rs202024911 - CDS Nonsynonymous[Arg72Cys]
283..283 C/T rs139545692 - CDS Synonymous[Arg72Arg]
289..289 C/A rs138826949 - CDS Synonymous[Arg74Arg]
290..290 G/A rs146054726 - CDS Nonsynonymous[Gly75Arg]
305..305 C/T rs148172390 - CDS AA-STOP[Gln80*]
342..342 T/C rs145431393 - CDS Nonsynonymous[Leu92Ser]
442..442 C/T rs12753531 - CDS Synonymous[Val125Val]
492..492 G/A rs191758097 - CDS Nonsynonymous[Arg142Gln]
587..587 G/C rs201293717 - CDS Nonsynonymous[Gly174Arg]
593..593 A/G rs200306047 - CDS Nonsynonymous[Lys176Glu]
734..734 T/C rs201517157 - CDS Nonsynonymous[Ser223Pro]
745..745 G/T rs145906534 - CDS Synonymous[Ala226Ala]
755..755 C/T rs201650960 - CDS Nonsynonymous[Leu230Phe]
760..760 G/A rs41303105 - CDS Synonymous[Gly231Gly]
776..776 C/G rs200296829 - CDS Nonsynonymous[Leu237Val]
833..833 C/T rs147571576 - CDS Nonsynonymous[Pro256Ser]
842..842 G/A rs139440539 - CDS Nonsynonymous[Glu259Lys]
842..842 G/A rs75429575 - CDS Nonsynonymous[Glu259Lys]
868..868 G/C rs148675652 - CDS Nonsynonymous[Glu267Asp]
891..891 T/C rs201362049 - CDS Nonsynonymous[Met275Thr]
902..902 G/A rs146485828 - CDS Nonsynonymous[Glu279Lys]
924..924 C/T rs146082781 - CDS Nonsynonymous[Pro286Leu]
960..960 G/A rs61739581 - CDS Nonsynonymous[Arg298Gln]
969..969 C/T rs150915411 - CDS Nonsynonymous[Pro301Leu]
981..981 C/A rs202201616 - CDS Nonsynonymous[Ala305Asp]
987..987 A/C rs201076564 - CDS Nonsynonymous[Lys307Thr]
994..994 G/A rs146733248 - CDS Synonymous[Pro309Pro]
1001..1001 G/A rs143958321 - CDS Nonsynonymous[Gly312Arg]
1006..1006 T/G rs143474754 - CDS Synonymous[Pro313Pro]
1007..1007 C/G rs200607882 - CDS Nonsynonymous[Arg314Gly]
1023..1023 C/G rs117876231 - CDS Nonsynonymous[Ser319Trp]
1032..1032 A/C rs360057 - CDS Nonsynonymous[Asp322Ala]
1138..1138 T/G rs146506148 - CDS Synonymous[Gly357Gly]
1155..1155 G/A rs139254695 - CDS Nonsynonymous[Arg363Lys]
1159..1159 C/G rs35684337 - CDS Synonymous[Leu364Leu]
1166..1166 T/C rs141038694 - CDS STOP-AA[*367Gln]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;