H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000094442 Last modified: 27-May-2015
Definition: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000094442
Length 359
Codon Adaptation Index (CAI). 0.707
Database links RefSeq NA
UniProt P61645 ;
CCDS P61645;
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000053961
H-Inv cluster ID Locus view HIX0005064
Predicted CDS 312..1391 ; 359[aa] ; Orientation:+3 ;
Genomic location Chromosome 5
Location 5q21.1
CDS position 100145359-100238970
Strand -
Accession number BC053657.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:61459 IMAGE:5752337
Experimental resources NBRC: NITE Biological Resource Center NBRC   HGPD: Human Gene and Protein Database HGPD   Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ST8SIA4) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ST8SIA4) ;
Length of cDNA 3680[bp] (No. of exon:5)[A:1213 T:1088 G:728 C:651] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:7903 ;
KEGG GENES KEGG GENES(7903) ;
GeneCard GeneCard ST8SIA4 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000053961
H-Inv cluster IDLocus view HIX0005064
Accession numberBC053657.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q92187) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help Representative H-Inv IDRepresentative transcript; Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome5
Location5q21.1
CDS position100145359-100238970
Strand-
Gene structure5 exons
No.2
H-Inv IDTranscript view HIT000193787
H-Inv cluster IDLocus view HIX0005064
Accession numberL41680.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q92187) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome5
Location5q21.1
CDS position100146949-100238871
Strand-
Gene structure5 exons
No.3
H-Inv IDTranscript view HIT000425669
H-Inv cluster IDLocus view HIX0005064
Accession numberAK292872.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q92187) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome5
Location5q21.1
CDS position100147338-100238941
Strand-
Gene structure5 exons

Motif information in predicted CDS
ORF

length(360),orf(312:1391)
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVN
SSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKS
SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGI
LLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFG
GFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLK
VRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALK
LTTGKCVKQ*
a.a.
length
InterPro Name
length(264), motif(92:355) 264IPR001675Glycosyl transferase, family 29 [Family]

Protein function information
H-Inv protein ID HIP000094442
Representative H-Inv transcript ID Transcript view HIT000053961
H-Inv cluster ID Locus view HIX0005064
Definition CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (Q92187) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 2.4.99.- Transferring Other Glycosyl Groups
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt P61645 ;
CCDS P61645;
Gene symbol/name HGNC symbol ST8SIA4
HGNC aliases "sialyltransferase 8 (alpha-2, 8-polysialytransferase) D";
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT mitochondria;
Target P signal peptide
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Evolutionary information
Relationship Species Accession number MGI Links
Orthology Gallus sp. (Chicken) AF008194 G-integraG-integra
Orthology Mus sp. (Mouse) AJ223956 MGI:106018 G-integraG-integra
Orthology Pan sp. (Chimpanzee) AJ697661 G-integraG-integra
Orthology Bos sp. (Cow) AJ699421 G-integraG-integra
Orthology Danio sp. (Zebrafish) DQ779599 G-integraG-integra
Orthology Monodelphis sp. (Opossum) ENSMODT00000024487 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000018219 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001097339 G-integraG-integra
Orthology Equus sp. (Horse) XM_001504603 G-integraG-integra
Orthology Canis sp. (Dog) XM_546003 G-integraG-integra
Phylogenetic tree [View by ATV] TNeighbor-joining (phb) 
Related H-InvDB links EvolaEvola dN/dS

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
331..331 G/A rs199768560 - CDS Nonsynonymous[Arg7Lys]
481..481 G/A rs148751339 - CDS Nonsynonymous[Arg57Gln]
486..486 G/A rs140658602 - CDS Nonsynonymous[Ala59Thr]
506..506 G/A rs144123874 - CDS Synonymous[Gln65Gln]
571..571 G/A rs149573011 - CDS Nonsynonymous[Arg87His]
603..603 G/A rs199572556 - CDS Nonsynonymous[Val98Ile]
657..657 C/T rs138152532 - CDS Nonsynonymous[Arg116Trp]
658..658 G/A rs150785295 - CDS Nonsynonymous[Arg116Gln]
662..662 A/T rs111610860 - CDS Synonymous[Thr117Thr]
786..786 G/A rs200594223 - CDS Nonsynonymous[Glu159Lys]
803..803 T/C rs138641468 - CDS Synonymous[Asn164Asn]
878..878 C/T rs201525407 - CDS Synonymous[Thr189Thr]
912..912 G/A rs144812419 - CDS Nonsynonymous[Gly201Ser]
913..913 G/A rs184109088 - CDS Nonsynonymous[Gly201Asp]
914..914 C/T rs191662668 - CDS Synonymous[Gly201Gly]
968..968 T/C rs140878740 - CDS Synonymous[Asn219Asn]
1109..1109 T/C rs148019074 - CDS Synonymous[Gly266Gly]
1145..1145 C/T rs143503881 - CDS Synonymous[Pro278Pro]
1190..1190 T/A rs148811953 - CDS Nonsynonymous[Asp293Glu]
1200..1200 C/T rs145473445 - CDS Synonymous[Leu297Leu]
1244..1244 G/A rs147105549 - CDS Synonymous[Ala311Ala]
1327..1327 C/T rs141895424 - CDS Nonsynonymous[Thr339Ile]
1341..1341 C/A rs200429642 - CDS Nonsynonymous[His344Asn]
1362..1362 C/A rs181265141 - CDS Nonsynonymous[Leu351Met]
1372..1372 G/A rs147924375 - CDS Nonsynonymous[Gly354Glu]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;