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H-Inv protein ID:	HIP000097059	Last modified:	27-May-2015
Definition:	Beta-adducin; Erythrocyte adducin subunit beta;

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000097059 Length 726 Codon Adaptation Index (CAI). 0.815 Database links RefSeq NA UniProt NA CCDS NA Original transcript information Representative H-Inv transcript ID HIT000261932 H-Inv cluster ID HIX0029808 Predicted CDS 266..2446 ; 726[aa] ; Orientation:+2 ; Genomic location Chromosome 2 Location 2p13.3 CDS position 70889264-70994847 Strand - Accession number BC065525.1 CAGE tag ID NA EST ID NA Clone Number MGC:74968 IMAGE:6142886 Experimental resources NBRC   HGPD   Antibody (ADD2) ;   Catalog (ADD2) ; Length of cDNA 3777[bp] (No. of exon:16)[A:982 T:760 G:1012 C:1023] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:119 ; KEGG GENES KEGG GENES(119) ; GeneCard ADD2 ; etc Human-Gene diversity Of Life-style related Diseases ;

MSEETVPEAASPPPPQGQPYFDRFSEDDPEYMRLRNRAADLRQDFNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVFPTSSMNVSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMKWGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGVVALGDTVEEAFYKIFHLQAACEIQVSALSSAGGVENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEIPATVTAFVFEEDGAPVPALRQHAQKQQKEKTRWLNTPNAYLRVNVADEVQRSMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLEMRNKIREQNRQDVKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDEDTKDDSEETVPNPFSQLTDQELEEYKKEVERKKLELDGEKETAPEEPGSPAKSAPASPVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVVVNGREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGSPSKSPSKKKKKFRTPSFLKKSKKKEKVES*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000261932
H-Inv cluster ID		HIX0029808
Accession number		BC065525.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Beta-adducin; Erythrocyte adducin subunit beta;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P35612) [Identity/coverage = 99.862%/100.0%] to Homo sapiens (Human). protein.
Transcript feature		Splicing isoform;
Genomic Location	Chromosome	2
	Location	2p13.3
	CDS position	70889264-70994847
	Strand	-
Gene structure		16 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	726	IPR027773	Beta-adducin [Family]
	193	IPR001303	Class II aldolase/adducin N-terminal [Domain]
	206	IPR001303	Class II aldolase/adducin N-terminal [Domain]
	183	IPR001303	Class II aldolase/adducin N-terminal [Domain]
	182	IPR001303	Class II aldolase/adducin N-terminal [Domain]

Protein function information

H-Inv protein ID		HIP000097059
Representative H-Inv transcript ID		HIT000261932
H-Inv cluster ID		HIX0029808
Definition		Beta-adducin; Erythrocyte adducin subunit beta;
Similarity category		Identical to known human protein(Category I).
		Identical to known human protein (P35612) [Identity/coverage = 99.862%/100.0%] to Homo sapiens (Human). protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	11
	Interaction partner(s)	HIP000025285; HIP000026208; HIP000029340; HIP000030685; HIP000033437; HIP000033560; HIP000042542; HIP000043538; HIP000043538; HIP000060745; HIP000082857;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	UniProt	NA
	CCDS	NA
Gene symbol/name	HGNC symbol	ADD2
	HGNC aliases	NA
	HGNC name	adducin 2 (beta);
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT nuclear; Target P Other SOSUI soluble protein TMHMM soluble protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 130 340 1dzuP 4e-52 19.2 203/209 c.74.1.1

Related H-InvDB links GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 272..272 G/A rs200519011 - CDS Nonsynonymous[Glu3Lys] 312..312 A/G rs201443444 - CDS Nonsynonymous[Gln16Arg] 315..315 G/A rs34241538 + CDS Nonsynonymous[Gly17Glu] 347..347 G/A rs4986 + CDS Nonsynonymous[Asp28Asn] 382..382 G/A rs141187526 - CDS Synonymous[Ala39Ala] 390..390 G/A rs144732476 - CDS Nonsynonymous[Arg42Gln] 397..397 C/G rs138167651 - CDS Nonsynonymous[Asp44Glu] 464..464 C/T rs114456016 - CDS Synonymous[Leu67Leu] 471..471 G/T rs149147182 - CDS Nonsynonymous[Gly69Val] 517..517 C/A rs17006140 - CDS Synonymous[Ile84Ile] 526..526 G/A rs144778680 - CDS Synonymous[Leu87Leu] 535..535 C/T rs200212314 - CDS Synonymous[Ile90Ile] 536..536 G/A rs150703767 - CDS Nonsynonymous[Ala91Thr] 558..558 C/G rs4987 + CDS Nonsynonymous[Ser98Cys] 574..574 G/A rs144423262 - CDS Synonymous[Pro103Pro] 653..653 G/A rs75081591 - CDS Nonsynonymous[Glu130Lys] 662..662 A/C rs145968821 - CDS Nonsynonymous[Met133Leu] 703..703 C/G rs114904807 - CDS Synonymous[Leu146Leu] 765..765 A/G rs138007719 - CDS Nonsynonymous[His167Arg] 811..811 G/A rs150383515 - CDS Synonymous[Ala182Ala] 818..818 C/T rs200581515 - CDS Synonymous[Leu185Leu] 828..828 T/A rs7425188 - CDS Nonsynonymous[Val188Glu] 872..872 C/T rs148091443 - CDS Nonsynonymous[Pro203Ser] 889..889 C/T rs147916626 - CDS Synonymous[Gly208Gly] 904..904 G/A rs144869244 - CDS Synonymous[Ser213Ser] 916..916 A/G rs181512905 - CDS Synonymous[Ala217Ala] 929..929 G/A rs144714020 - CDS Nonsynonymous[Val222Met] 938..938 A/G rs200730724 - CDS Nonsynonymous[Ile225Val] 951..951 A/G rs201811808 - CDS Nonsynonymous[His229Arg] 1097..1097 C/G rs145329028 - CDS Nonsynonymous[Leu278Val] 1123..1123 G/A rs139387703 - CDS Synonymous[Val286Val] 1124..1124 C/T rs111700825 - CDS Synonymous[Leu287Leu] 1139..1139 G/T rs139808041 - CDS Nonsynonymous[Val292Leu] 1174..1174 T/C rs4989 + CDS Synonymous[Phe303Phe] 1219..1219 G/A rs142433540 - CDS Synonymous[Ser318Ser] 1235..1235 G/A rs201864311 - CDS Nonsynonymous[Gly324Arg] 1261..1261 G/A rs144529989 - CDS Synonymous[Leu332Leu] 1269..1269 A/T rs61030669 - CDS Nonsynonymous[Glu335Val] 1270..1270 G/T rs4982 + CDS Nonsynonymous[Glu335Asp] 1276..1276 C/A rs142392995 - CDS Nonsynonymous[His337Gln] 1278..1278 G/A rs146561886 - CDS Nonsynonymous[Arg338Gln] 1410..1410 C/T rs145886276 - CDS Nonsynonymous[Thr382Met] 1411..1411 G/A rs139827624 - CDS Synonymous[Thr382Thr] 1473..1473 C/T rs199834771 - CDS Nonsynonymous[Thr403Met] 1487..1487 G/A rs34196785 + CDS Nonsynonymous[Val408Met] 1497..1497 A/G rs150772862 - CDS Nonsynonymous[Glu411Gly] 1510..1510 G/A rs148662450 - CDS Synonymous[Pro415Pro] 1572..1572 C/T rs201022450 - CDS Nonsynonymous[Thr436Met] 1573..1573 G/T rs143711744 - CDS Synonymous[Thr436Thr] 1580..1580 G/A rs17855969 - CDS Nonsynonymous[Ala439Thr] 1641..1641 A/G rs201449367 - CDS Nonsynonymous[Lys459Arg] 1663..1663 C/T rs188058882 - CDS Synonymous[Asp466Asp] 1693..1693 G/A rs34884423 + CDS Synonymous[Pro476Pro] 1698..1698 G/A rs150426440 - CDS Nonsynonymous[Arg478His] 1702..1702 C/T rs199802003 - CDS Synonymous[Ile479Ile] 1767..1767 A/G rs112879637 - CDS Nonsynonymous[Lys501Arg] 1774..1774 A/C rs145174076 - CDS Synonymous[Arg503Arg] 1804..1804 G/C rs115841739 - CDS Synonymous[Ala513Ala] 1831..1831 C/T rs148402316 - CDS Synonymous[Ser522Ser] 1840..1840 C/G rs201133279 - CDS Synonymous[Ala525Ala] 1848..1848 G/C rs149689098 - CDS Nonsynonymous[Ser528Thr] 1851..1851 G/T rs114311724 - CDS Nonsynonymous[Arg529Leu] 1892..1892 G/A rs139586218 - CDS Nonsynonymous[Glu543Lys] 1920..1920 C/T rs114897963 - CDS Nonsynonymous[Thr552Met] 1942..1942 A/G rs115445925 - CDS Synonymous[Gln559Gln] 2082..2082 C/T rs141431061 - CDS Nonsynonymous[Ala606Val] 2090..2090 G/A rs138503054 - CDS Nonsynonymous[Ala609Thr] 2097..2097 C/A rs140129786 - CDS Nonsynonymous[Thr611Lys] 2143..2143 T/G rs199908987 - CDS Synonymous[Thr626Thr] 2168..2168 G/A rs149050833 - CDS Nonsynonymous[Ala635Thr] 2171..2171 A/G rs145267894 - CDS Nonsynonymous[Thr636Ala] 2197..2197 G/A rs115476558 - CDS Synonymous[Pro644Pro] 2254..2254 C/A rs4985 + CDS Nonsynonymous[Ser663Arg] 2265..2265 G/A rs147439886 - CDS Nonsynonymous[Ser667Asn] 2290..2290 G/A rs139265334 - CDS Synonymous[Thr675Thr] 2410..2410 G/A rs141473907 - CDS Synonymous[Leu715Leu] 2412..2412 A/T rs138841596 - CDS Nonsynonymous[Lys716Ile] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;