H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000098024 Last modified: 27-May-2015
Definition: Similar to Serine/threonine-protein kinase MRCK alpha isoform B.
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000098024
Length 1638
Codon Adaptation Index (CAI). 0.702
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000248404
H-Inv cluster ID Locus view HIX0001650
Predicted CDS 1..4917 ; 1638[aa] ; Orientation:+1 ;
Genomic location Chromosome 1
Location 1q42.13
CDS position 227181969-227504883
Strand -
Accession number AJ518976.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CDC42BPA) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CDC42BPA) ;
Length of cDNA 4917[bp] (No. of exon:35)[A:1654 T:1233 G:1108 C:922] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8476 ;
KEGG GENES KEGG GENES(8476) ;
GeneCard GeneCard CDC42BPA ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000248404
H-Inv cluster IDLocus view HIX0001650
Accession numberAJ518976.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Serine/threonine-protein kinase MRCK alpha isoform B.
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (NP_003598) [Identity/coverage = 99.937%/97.15%] to Homo sapiens protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome1
Location1q42.13
CDS position227181969-227504883
Strand-
Gene structure35 exons

Motif information in predicted CDS
ORF

length(1639),orf(1:4917)
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRRE
KNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNAD
KVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNL
YLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHR
DIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQ
AMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDN
IRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFV
GFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLR
KQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKL
EVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIE
HQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLA
LNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTS
ELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDE
KDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLE
LQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQL
IKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPT
LRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCE
VCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKP
AGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVS
SVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVG
VLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALG
NEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFP
MSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELF
QSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSM
LHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQ
ELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNN
EGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRY
SFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKD
LPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGS
ALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSP
RHSTASNSSNLSSPPSPVSPRKTKSLSLESTDRGSWDP*
a.a.
length
InterPro Name
length(1503), motif(1:1503) 1503IPR026611Serine/threonine-protein kinase MRCK alpha [Family]
length(345), motif(56:400) 345IPR011009Protein kinase-like domain [Domain]
length(267), motif(77:343) 267IPR000719Protein kinase domain [Domain]
length(267), motif(77:343) 267IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
length(24), motif(83:106) 24IPR017441Protein kinase, ATP binding site [Binding_site]
length(13), motif(197:209) 13IPR008271Serine/threonine-protein kinase, active site [Active_site]
length(63), motif(344:406) 63IPR000961AGC-kinase, C-terminal [Domain]
length(71), motif(344:414) 71IPR000961AGC-kinase, C-terminal [Domain]
length(46), motif(361:406) 46IPR017892Protein kinase, C-terminal [Domain]
length(117), motif(786:902) 117IPR014930Myotonic dystrophy protein kinase, coiled coil [Domain]
length(61), motif(800:860) 61IPR014930Myotonic dystrophy protein kinase, coiled coil [Domain]
length(51), motif(918:968) 51IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(50), motif(919:968) 50IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(51), motif(919:969) 51IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [Domain]
length(120), motif(988:1107) 120IPR001849Pleckstrin homology domain [Domain]
length(121), motif(989:1109) 121IPR001849Pleckstrin homology domain [Domain]
length(273), motif(1133:1405) 273IPR001180Citron-like [Domain]
length(283), motif(1134:1416) 283IPR001180Citron-like [Domain]
length(263), motif(1139:1401) 263IPR001180Citron-like [Domain]
length(14), motif(1477:1490) 14IPR000095CRIB domain [Domain]
length(36), motif(1477:1512) 36IPR000095CRIB domain [Domain]

Protein function information
H-Inv protein ID HIP000098024
Representative H-Inv transcript ID Transcript view HIT000248404
H-Inv cluster ID Locus view HIX0001650
Definition Similar to Serine/threonine-protein kinase MRCK alpha isoform B.
Similarity category Help Similar to known protein(Category II).
Similar to known protein (NP_003598) [Identity/coverage = 99.937%/97.15%] to Homo sapiens protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 2.7.11.1 non-specific serine/threonine protein kinase
KEGG metabolic pathway 04150 mTOR signaling pathway 04210 Apoptosis 04310 Wnt signaling pathway 04320 Dorso-ventral axis formation 04340 Hedgehog signaling pathway 04350 TGF-beta signaling pathway 04360 Axon guidance 04370 VEGF signaling pathway 04510 Focal adhesion 04520 Adherens junction 04530 Tight junction 04540 Gap junction 04620 Toll-like receptor signaling pathway 04630 Jak-STAT signaling pathway 04660 T cell receptor signaling pathway 04662 B cell receptor signaling pathway 04664 Fc epsilon RI signaling pathway 04720 Long-term potentiation 04730 Long-term depression 04810 Regulation of actin cytoskeleton 04910 Insulin signaling pathway 04912 GnRH signaling pathway 04920 Adipocytokine signaling pathway 05010 Alzheimer's disease 05210 Colorectal cancer
Protein-protein interaction (PPI) PPI viewer No. of interaction 5
Interaction partner(s) HIP000037174; HIP000037399; HIP000080656; HIP000097487; HIP000104907;
BIND NA
DIP NA
MINT NA
HPRD 01181; 03585; 11452; 17619;
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol CDC42BPA
HGNC aliases "CDC42-binding protein kinase alpha (DMPK-like)";
HGNC name CDC42 binding protein kinase alpha (DMPK-like);
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT nuclear;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
6 343 1nw1A 4e-45 7.7 325/365 d.144.1.8
332 434 3d19A1 2e-19 9.7 103/134 a.29.13.1
916 976 1tbnA 6e-18 36.1 61/66 g.49.1.1
983 1111 1v5pA 8e-06 12.1 116/126 b.55.1.1
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
45..45 G/A rs200600700 - CDS Synonymous[Leu15Leu]
54..54 C/T rs185771662 - CDS Synonymous[Pro18Pro]
69..69 G/A rs139047710 - CDS Synonymous[Gly23Gly]
72..72 G/T rs146651448 - CDS Nonsynonymous[Gln24His]
90..90 A/G rs11804613 - CDS Synonymous[Thr30Thr]
128..128 A/G rs201862186 - CDS Nonsynonymous[Asn43Ser]
139..139 T/C rs144296174 - CDS Synonymous[Leu47Leu]
258..258 A/G rs11548283 + CDS Synonymous[Gly86Gly]
308^309 -/T rs66970709 - CDS
390..390 G/T rs138147922 - CDS Synonymous[Val130Val]
400..400 A/G rs147024844 - CDS Nonsynonymous[Asn134Asp]
415..415 A/G rs146827361 - CDS Nonsynonymous[Thr139Ala]
430^431 -/T rs66481220 - CDS
479..479 G/A rs201422232 - CDS Nonsynonymous[Gly160Glu]
536..536 G/A rs201287522 - CDS Nonsynonymous[Arg179Lys]
540^541 -/T rs67564598 - CDS
546..546 G/A rs151080605 - CDS Synonymous[Leu182Leu]
585..585 A/G rs201936989 - CDS Synonymous[Leu195Leu]
632..632 T/G rs148839966 - CDS Nonsynonymous[Met211Arg]
645^646 -/T rs35643738 - CDS
692..692 C/T rs34614709 - CDS Nonsynonymous[Thr231Met]
831..831 C/T rs139987030 - CDS Synonymous[Tyr277Tyr]
870..870 A/G rs56311356 - CDS Synonymous[Thr290Thr]
873..873 C/T rs141895289 - CDS Synonymous[Tyr291Tyr]
1006..1006 G/A rs200168774 - CDS Nonsynonymous[Asp336Asn]
1016^1017 -/A rs67972781 - CDS
1100..1100 A/G rs111893322 - CDS Nonsynonymous[Asp367Gly]
1138..1138 A/T rs147469048 - CDS Nonsynonymous[Asn380Tyr]
1165..1165 C/T rs201384556 - CDS Nonsynonymous[His389Tyr]
1243..1243 T/C rs201022380 - CDS Nonsynonymous[Cys415Arg]
1263..1263 T/G rs201645647 - CDS Synonymous[Gly421Gly]
1269..1269 C/T rs201820010 - CDS Synonymous[Thr423Thr]
1507..1507 G/A rs139384904 - CDS Nonsynonymous[Val503Ile]
1573..1573 G/A rs200713147 - CDS Nonsynonymous[Asp525Asn]
1581..1581 T/- rs66665503 - CDS
1587..1587 A/G rs149633059 - CDS Synonymous[Gln529Gln]
1594..1594 G/A rs201130103 - CDS Nonsynonymous[Ala532Thr]
1610..1610 T/C rs56364976 - CDS Nonsynonymous[Ile537Thr]
1741..1741 G/A rs199746122 - CDS Nonsynonymous[Glu581Lys]
1782..1782 A/G rs200326381 - CDS Synonymous[Pro594Pro]
1795..1795 A/G rs140818561 - CDS Nonsynonymous[Ile599Val]
1823..1823 T/C rs201126700 - CDS Nonsynonymous[Leu608Pro]
1845^1846 -/A rs67804260 - CDS
1849..1849 A/G rs142697103 - CDS Nonsynonymous[Ile617Val]
1856..1856 A/T rs201979872 - CDS Nonsynonymous[Tyr619Phe]
1973..1973 T/- rs67734085 - CDS
1978..1978 G/A rs3939280 - CDS Nonsynonymous[Asp660Asn]
1988..1988 A/G rs200068494 - CDS Nonsynonymous[Glu663Gly]
2005..2005 A/G rs145584750 - CDS Nonsynonymous[Ser669Gly]
2096..2096 C/T rs56119119 - CDS Nonsynonymous[Thr699Met]
2120^2121 -/G rs66555523 - CDS
2126..2126 A/G rs34943764 - CDS Nonsynonymous[Tyr709Cys]
2230..2230 A/C rs77122651 - CDS Nonsynonymous[Ile744Leu]
2265..2265 G/T rs142030346 - CDS Synonymous[Gly755Gly]
2373..2373 G/A rs200154961 - CDS Synonymous[Ala791Ala]
2408..2408 C/T rs144801895 - CDS Nonsynonymous[Ser803Leu]
2409..2409 G/A rs35017425 - CDS Synonymous[Ser803Ser]
2445..2445 C/T rs137890180 - CDS Synonymous[Ile815Ile]
2455..2455 T/C rs200668164 - CDS Synonymous[Leu819Leu]
2491..2491 T/A rs199653014 - CDS Nonsynonymous[Cys831Ser]
2513..2513 A/C rs200440295 - CDS Nonsynonymous[Lys838Thr]
2529..2529 A/G rs199733498 - CDS Synonymous[Leu843Leu]
2541..2541 C/T rs55845581 - CDS Synonymous[Ile847Ile]
2669..2669 A/G rs150700769 - CDS Nonsynonymous[Asp890Gly]
2723..2723 G/C rs199543596 - CDS Nonsynonymous[Gly908Ala]
2747..2747 G/A rs140416725 - CDS Nonsynonymous[Arg916His]
2754..2754 T/C rs113402500 - CDS Synonymous[Thr918Thr]
2780..2780 C/T rs202057695 - CDS Nonsynonymous[Thr927Ile]
2836..2836 G/A rs112933697 - CDS Nonsynonymous[Gly946Ser]
2887..2887 A/G rs142183701 - CDS Nonsynonymous[Lys963Glu]
2918^2919 -/A rs35357574 - CDS
2952..2952 G/A rs35369012 - CDS Synonymous[Gln984Gln]
2960..2960 T/C rs200344808 - CDS Nonsynonymous[Ile987Thr]
3156..3156 C/T rs201643732 - CDS Synonymous[Val1052Val]
3160..3160 G/A rs56219089 - CDS Nonsynonymous[Ala1054Thr]
3198..3198 C/T rs149978094 - CDS Synonymous[Pro1066Pro]
3222..3222 C/T rs200331694 - CDS Synonymous[Ser1074Ser]
3326..3326 T/- rs67003899 - CDS
3343..3343 A/G rs181637825 - CDS Nonsynonymous[Arg1115Gly]
3350..3350 G/A rs961490 - CDS Nonsynonymous[Arg1117His]
3512..3512 A/G rs201692012 - CDS Nonsynonymous[Asn1171Ser]
3544..3544 A/T rs200594653 - CDS Nonsynonymous[Asn1182Tyr]
3615..3615 T/C rs180784576 - CDS Synonymous[Asp1205Asp]
3627..3627 C/T rs189930745 - CDS Synonymous[Thr1209Thr]
3667..3667 G/A/C/T rs1929860 + CDS
3686..3686 G/A rs200056759 - CDS Nonsynonymous[Arg1229His]
3727..3727 C/G rs201775243 - CDS Nonsynonymous[Gln1243Glu]
3764..3764 G/A rs200051797 - CDS Nonsynonymous[Arg1255His]
3780..3780 A/G rs1929861 + CDS Synonymous[Lys1260Lys]
3789..3789 A/G rs200690739 - CDS Synonymous[Gln1263Gln]
3793..3793 C/A rs149240330 - CDS Nonsynonymous[Pro1265Thr]
3817..3817 A/G rs146203858 - CDS Nonsynonymous[Ile1273Val]
3887..3887 A/- rs66656566 - CDS
3895..3895 A/G rs200486377 - CDS Nonsynonymous[Ser1299Gly]
3961..3961 G/A rs183857756 - CDS Nonsynonymous[Ala1321Thr]
3963..3963 A/G rs199656326 - CDS Synonymous[Ala1321Ala]
4066..4066 G/T rs147617327 - CDS Nonsynonymous[Ala1356Ser]
4079..4079 C/G rs142464333 - CDS Nonsynonymous[Ser1360Cys]
4107..4107 G/A rs142853761 - CDS Synonymous[Ser1369Ser]
4124..4124 C/T rs55687355 - CDS Nonsynonymous[Ala1375Val]
4147..4147 T/C rs112426338 - CDS Nonsynonymous[Ser1383Pro]
4199..4199 A/G rs146136586 - CDS Nonsynonymous[Asn1400Ser]
4253..4253 A/T rs56229267 - CDS Nonsynonymous[Lys1418Ile]
4256..4256 A/G rs139110633 - CDS Nonsynonymous[Asn1419Ser]
4346..4346 G/A rs201852267 - CDS Nonsynonymous[Arg1449His]
4399..4399 C/T rs12561938 - CDS Synonymous[Leu1467Leu]
4465..4465 A/G rs200918078 - CDS Nonsynonymous[Met1489Val]
4494..4494 G/C rs55848092 - CDS Synonymous[Leu1498Leu]
4497..4497 A/G rs141188296 - CDS Synonymous[Lys1499Lys]
4563..4563 A/G rs145724581 - CDS Synonymous[Pro1521Pro]
4567..4567 A/G rs199675358 - CDS Nonsynonymous[Ile1523Val]
4570..4570 A/G rs2297417 + CDS Nonsynonymous[Thr1524Ala]
4579..4579 C/T rs148881297 - CDS Nonsynonymous[Arg1527Cys]
4608..4608 T/C rs150430697 - CDS Synonymous[Ala1536Ala]
4635..4635 C/T rs16846779 - CDS Synonymous[Ser1545Ser]
4650..4650 C/T rs147810081 - CDS Synonymous[Ser1550Ser]
4702..4702 A/G rs145538584 - CDS Nonsynonymous[Met1568Val]
4727..4727 T/C rs200692909 - CDS Nonsynonymous[Leu1576Ser]
4734..4734 C/T rs1045247 + CDS Synonymous[Ser1578Ser]
4767..4767 G/A rs201963139 - CDS Synonymous[Ala1589Ala]
4780..4780 G/A rs143404397 - CDS Nonsynonymous[Gly1594Arg]
4797..4797 T/C rs147437313 - CDS Synonymous[Ser1599Ser]
4799..4799 C/T rs148249654 - CDS Nonsynonymous[Pro1600Leu]
4843^4844 -/C rs67581567 - CDS
4853..4853 T/C rs2802269 - CDS Nonsynonymous[Val1618Ala]
4862..4862 G/A rs145018031 - CDS Nonsynonymous[Arg1621Gln]
4874..4874 G/T rs146538430 - CDS Nonsynonymous[Ser1625Ile]
4882..4882 C/T rs140582350 - CDS Synonymous[Leu1628Leu]
4904..4904 G/A rs142402392 - CDS Nonsynonymous[Ser1635Asn]
4914..4914 G/A rs56027641 - CDS Synonymous[Pro1638Pro]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;