H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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Transcript view Locus view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Inv protein ID:	HIP000172323	Last modified:	27-May-2015
Definition:	Similar to Butyrophilin subfamily 2 member A1; Precursor;

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000172323 Length 330 Codon Adaptation Index (CAI). 0.78 Database links RefSeq NA UniProt NA CCDS Original transcript information Representative H-Inv transcript ID HIT000329712 H-Inv cluster ID HIX0200860 Predicted CDS 206..1198 ; 330[aa] ; Orientation:+2 ; Genomic location Chromosome 6 Location 6p22.2 CDS position 26458196-26476849 Strand + Accession number AB209777.1 CAGE tag ID NA EST ID NA Clone Number bm02040 Experimental resources NBRC     Antibody (BTN2A1) ;   Catalog (BTN2A1) ; Length of cDNA 1687[bp] (No. of exon:8)[A:447 T:386 G:433 C:421] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:11120 ; KEGG GENES KEGG GENES(11120) ; GeneCard BTN2A1 ; etc Human-Gene diversity Of Life-style related Diseases ;

MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKEVSMPDADGLFMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESFMPSVSPCAVALPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKERVQKEEELQVKEKLQEELRWRRTFLHAGPV*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000329712
H-Inv cluster ID		HIX0200860
Accession number		AB209777.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Similar to Butyrophilin subfamily 2 member A1; Precursor;
Similarity category		Similar to known protein(Category II).
		Similar to known protein (Q7KYR7) [Identity/coverage = 100.0%/62.05%] to Homo sapiens (Human). protein.
Transcript feature		Representative transcript; Splicing isoform;
Genomic Location	Chromosome	6
	Location	6p22.2
	CDS position	26458196-26476849
	Strand	+
Gene structure		8 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	114	IPR007110	Immunoglobulin-like domain [Domain]
	137	IPR013783	Immunoglobulin-like fold [Domain]
	96	IPR013106	Immunoglobulin V-set domain [Domain]
	108	IPR003599	Immunoglobulin subtype [Domain]
	75	IPR013162	CD80-like, immunoglobulin C2-set [Domain]
	67	IPR013783	Immunoglobulin-like fold [Domain]

Protein function information

H-Inv protein ID		HIP000172323
Representative H-Inv transcript ID		HIT000329712
H-Inv cluster ID		HIX0200860
Definition		Similar to Butyrophilin subfamily 2 member A1; Precursor;
Similarity category		Similar to known protein(Category II).
		Similar to known protein (Q7KYR7) [Identity/coverage = 100.0%/62.05%] to Homo sapiens (Human). protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	UniProt
	CCDS
Gene symbol/name	HGNC symbol	BTN2A1
	HGNC aliases	NA
	HGNC name	butyrophilin, subfamily 2, member A1;
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT endoplasmic; Target P signal peptide SOSUI membrane protein TMHMM membrane protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 38 149 12e8H1 2e-13 9.8 112/121 b.1.1.1 147 230 1dr9A2 2e-12 19.0 84/95 b.1.1.3

Related H-InvDB links GTOP

Evolutionary information

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	AY177686		G-integra
Orthology	Pongo sp. (Orangutan)	CR859991		G-integra
Orthology	Danio sp. (Zebrafish)	ENSDART00000057358		G-integra
Orthology	Macaca sp. (Macaque)	ENSMMUT00000030909		G-integra
Orthology	Pan sp. (Chimpanzee)	ENSPTRT00000032936		G-integra
Orthology	Rattus sp. (Rat)	XM_001072372		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001376604		G-integra
Orthology	Equus sp. (Horse)	XM_001917119		G-integra
Orthology	Canis sp. (Dog)	XM_545403		G-integra
Orthology	Bos sp. (Cow)	XM_870260		G-integra

Phylogenetic tree [View by ATV]	TNeighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS;

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 206..206 A/G rs199747313 + CDS Nonsynonymous[Met1Val] 208..208 G/A rs142203065 + CDS Nonsynonymous[Met1Ile] 212..212 T/C rs146399224 + CDS Nonsynonymous[Ser3Pro] 239..239 C/T rs139658946 + CDS Nonsynonymous[Pro12Ser] 246..246 C/G rs140375890 + CDS Nonsynonymous[Ser14Cys] 311..311 A/G rs146688212 + CDS Nonsynonymous[Thr36Ala] 348..348 C/T rs139118294 + CDS Nonsynonymous[Thr48Met] 354..354 G/A rs187108523 + CDS Nonsynonymous[Arg50His] 370..370 C/T rs72500817 + CDS Synonymous[Pro55Pro] 389..389 A/G rs144871432 + CDS Nonsynonymous[Met62Val] 408..408 G/A rs149038955 + CDS Nonsynonymous[Arg68Gln] 420..420 C/A rs200867396 + CDS Nonsynonymous[Ser72Tyr] 426..426 C/T rs149048780 + CDS Nonsynonymous[Ala74Val] 443..443 G/T rs146086334 + CDS Nonsynonymous[Gly80Cys] 505..505 C/T rs147859702 + CDS Synonymous[Ser100Ser] 525..525 G/T rs141312257 + CDS Nonsynonymous[Ser107Ile] 540..540 T/C rs200535507 + CDS Nonsynonymous[Ile112Thr] 575..575 C/T rs3734539 + CDS Nonsynonymous[Arg124Cys] 576..576 G/A rs143104579 + CDS Nonsynonymous[Arg124His] 626..626 G/A rs148111655 + CDS Nonsynonymous[Val141Ile] 650..650 C/T rs150220790 + CDS Nonsynonymous[Pro149Ser] 679..679 C/T rs145913124 + CDS Synonymous[Asp158Asp] 738..738 G/T rs13195401 + CDS Nonsynonymous[Trp178Leu] 739..739 G/T rs13195402 + CDS Nonsynonymous[Trp178Cys] 762..762 C/T rs139773763 + CDS Nonsynonymous[Ala186Val] 785..785 A/G rs142951857 + CDS Nonsynonymous[Met194Val] 800..800 G/A rs144358349 + CDS Nonsynonymous[Gly199Ser] 805..805 C/G rs199893249 + CDS Synonymous[Leu200Leu] 824..824 G/A rs13195509 + CDS Nonsynonymous[Val207Met] 856..856 G/A rs138727076 + CDS Nonsynonymous[Met217Ile] 895..895 A/G rs142538560 + CDS Synonymous[Lys230Lys] 931..931 C/T rs150961762 + CDS Synonymous[Pro242Pro] 990..990 T/G rs201295468 + CDS Nonsynonymous[Ile262Ser] 1049..1049 G/T rs200239130 + CDS AA-STOP[Glu282*] 1062..1062 A/G rs199697327 + CDS Nonsynonymous[Glu286Gly] 1064..1064 C/T rs148155227 + CDS Nonsynonymous[Arg287Trp] 1077..1077 A/G rs140281108 + CDS Nonsynonymous[Glu291Gly] 1085..1085 C/G rs144232372 + CDS Nonsynonymous[Leu294Val] 1097..1097 G/C rs147849789 + CDS Nonsynonymous[Glu298Gln] 1109..1109 G/A rs141482323 + CDS Nonsynonymous[Val302Met] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;