H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000198360 Last modified: 27-May-2015
Definition: Potassium voltage-gated channel subfamily A member 4; HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4;
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000198360
Length 465
Codon Adaptation Index (CAI). 0.787
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000432528
H-Inv cluster ID Locus view HIX0036152
Predicted CDS 1085..2482 ; 465[aa] ; Orientation:+2 ;
Genomic location Chromosome 11
Location 11p14.1
CDS position 30032264-30034745
Strand -
Accession number AK313662.1
CAGE tag ID NA
EST ID NA
Clone Number BRAWH3003671
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (KCNA4) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (KCNA4) ;
Length of cDNA 2482[bp] (No. of exon:1)[A:616 T:630 G:656 C:580] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene NA
KEGG GENES NA
GeneCard GeneCard KCNA4 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000432528
H-Inv cluster IDLocus view HIX0036152
Accession numberAK313662.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionPotassium voltage-gated channel subfamily A member 4; HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (P22459) [Identity/coverage = 99.847%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11p14.1
CDS position30032264-30034745
Strand-
Gene structure1 exons

Motif information in predicted CDS
ORF

length(466),orf(1085:2482)
TQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSG
GRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENE
FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDL
VMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVV
RCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAM
SFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIG
VILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGK
IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPY
LPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSET
DKNNCSNAKAVETDV*
a.a.
length
InterPro Name
length(78), motif(1:78) 78IPR003131Potassium channel tetramerisation-type BTB domain [Domain]
length(84), motif(1:84) 84IPR011333BTB/POZ fold [Domain]
length(85), motif(1:85) 85IPR011333BTB/POZ fold [Domain]
length(458), motif(1:458) 458IPR028325Voltage-gated potassium channel [Family]
length(12), motif(17:28) 12IPR003972Potassium channel, voltage dependent, Kv1 [Family]
length(11), motif(30:40) 11IPR003968Potassium channel, voltage dependent, Kv [Family]
length(20), motif(30:49) 20IPR003091Potassium channel [Family]
length(11), motif(31:41) 11IPR003972Potassium channel, voltage dependent, Kv1 [Family]
length(12), motif(74:85) 12IPR003972Potassium channel, voltage dependent, Kv1 [Family]
length(166), motif(101:266) 166IPR027359Voltage-dependent channel, four helix bundle domain [Domain]
length(17), motif(109:125) 17IPR003972Potassium channel, voltage dependent, Kv1 [Family]
length(29), motif(112:140) 29IPR003091Potassium channel [Family]
length(12), motif(132:143) 12IPR003972Potassium channel, voltage dependent, Kv1 [Family]
length(24), motif(185:208) 24IPR003091Potassium channel [Family]
length(187), motif(185:371) 187IPR005821Ion transport domain [Domain]
length(21), motif(211:231) 21IPR003091Potassium channel [Family]
length(27), motif(260:286) 27IPR003091Potassium channel [Family]
length(9), motif(265:273) 9IPR003968Potassium channel, voltage dependent, Kv [Family]
length(15), motif(289:303) 15IPR003968Potassium channel, voltage dependent, Kv [Family]
length(24), motif(289:312) 24IPR003091Potassium channel [Family]
length(23), motif(320:342) 23IPR003091Potassium channel [Family]
length(27), motif(349:375) 27IPR003091Potassium channel [Family]
length(12), motif(360:371) 12IPR003968Potassium channel, voltage dependent, Kv [Family]

Protein function information
H-Inv protein ID HIP000198360
Representative H-Inv transcript ID Transcript view HIT000432528
H-Inv cluster ID Locus view HIX0036152
Definition Potassium voltage-gated channel subfamily A member 4; HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (P22459) [Identity/coverage = 99.847%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID HIF0000043
Gene family/group name Potassium channel, voltage dependent, Kv, tetramerisation (IPR003131).
Evidence motif (InterPro) ID 3
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol KCNA4
HGNC aliases "potassium voltage-gated channel, shaker-related subfamily, member 4-like", "potassium voltage-gated channel, shaker-related subfamily, member 4";
HGNC name potassium channel, voltage gated shaker related subfamily A, member 4;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT plasma membrane;
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
3 72 1a68A 2e-07 80.0 70/87 d.42.1.2
266 282 1p7bA2 5e-04 5.9 17/100 f.14.1.1
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
1189..1189 G/A rs201159519 - CDS Synonymous[Arg35Arg]
1252..1252 A/G rs181655275 - CDS Synonymous[Pro56Pro]
1336..1336 C/T rs45509498 - CDS Synonymous[Asp84Asp]
1555..1555 C/T rs3802914 + CDS Synonymous[Gly157Gly]
1576..1576 T/C rs151268149 - CDS Synonymous[Asn164Asn]
1589..1589 C/A rs12276475 - CDS Nonsynonymous[Pro169Thr]
1607..1607 G/A rs191521585 - CDS Nonsynonymous[Gly175Arg]
1681..1681 G/T rs202177146 - CDS Synonymous[Val199Val]
1705..1705 C/G rs199748253 - CDS Nonsynonymous[Ser207Arg]
1780..1780 C/T rs200158908 - CDS Synonymous[Gly232Gly]
1791..1791 C/T rs200479133 - CDS Nonsynonymous[Ala236Val]
1797^1798 -/A rs36059154 - CDS
1812..1812 A/G rs199975003 - CDS Nonsynonymous[Asn243Ser]
2123..2123 G/T rs201134414 - CDS Nonsynonymous[Val347Leu]
2140..2140 C/T rs201513098 - CDS Synonymous[Val352Val]
2263..2263 G/A rs199569433 - CDS Synonymous[Gln393Gln]
2272..2272 C/T rs140083893 - CDS Synonymous[Val396Val]
2344..2344 G/C rs200225575 - CDS Nonsynonymous[Lys420Asn]
2395..2395 G/C rs200767735 - CDS Nonsynonymous[Lys437Asn]
2409..2409 A/G rs200498416 - CDS Nonsynonymous[Gln442Arg]
2439..2439 A/G rs201531731 - CDS Nonsynonymous[Lys452Arg]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;