H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000247398 Last modified: 27-May-2015
Definition: Similar to Saposin-B-Val; Contains: Saposin-B; Cerebroside sulfate activator; CS-ACT; Non-specific activator; Sphingolipid activator protein 1; SAP-1;
[Summery][Full]
[Protein Info][Member][Motif] provide location, ID and descriptions of functional motifs (InterPro)[Function] provide human-curated functional definition, similarity category and related evidences; Gene name; HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000247398
Length 452
Codon Adaptation Index (CAI). 0.835
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000488296
H-Inv cluster ID Locus view HIX0008908
Predicted CDS 195..1553 ; 452[aa] ; Orientation:+3 ;
Genomic location Chromosome 10
Location 10q22.1
CDS position 73576980-73611006
Strand -
Accession number AK293672.1
CAGE tag ID NA
EST ID NA
Clone Number BRACE2039283
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PSAP) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PSAP) ;
Length of cDNA 1771[bp] (No. of exon:14)[A:416 T:397 G:487 C:471] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5660 ;
KEGG GENES KEGG GENES(5660) ;
GeneCard GeneCard PSAP ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000488296
H-Inv cluster IDLocus view HIX0008908
Accession numberAK293672.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Saposin-B-Val; Contains: Saposin-B; Cerebroside sulfate activator; CS-ACT; Non-specific activator; Sphingolipid activator protein 1; SAP-1;
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (P81405) [Identity/coverage = 88.75%/100.0%] to Sus scrofa (Pig). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome10
Location10q22.1
CDS position73576980-73611006
Strand-
Gene structure14 exons

Motif information in predicted CDS
ORF

length(453),orf(195:1553) MLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEM SRPGEACSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANI PLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEH VKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQDQQPKEICALVGFCD EVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLV KEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSIL LEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRN LEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDP SFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHV WN*		 a.a.
length		 InterPro Name
length(23), motif(1:23) 23IPR007856Saposin-like type B, 1 [Domain]
length(63), motif(1:63) 63IPR008139Saposin B [Domain]
length(64), motif(1:64) 64IPR011001Saposin-like [Domain]
length(67), motif(1:67) 67IPR008139Saposin B [Domain]
length(18), motif(2:19) 18IPR008373Saposin [Family]
length(45), motif(27:71) 45IPR011001Saposin-like [Domain]
length(34), motif(30:63) 34IPR008138Saposin-like type B, 2 [Domain]
length(19), motif(53:71) 19IPR008373Saposin [Family]
length(26), motif(81:106) 26IPR008373Saposin [Family]
length(59), motif(100:158) 59IPR011001Saposin-like [Domain]
length(82), motif(119:200) 82IPR011001Saposin-like [Domain]
length(85), motif(119:203) 85IPR008139Saposin B [Domain]
length(40), motif(120:159) 40IPR007856Saposin-like type B, 1 [Domain]
length(79), motif(121:199) 79IPR008139Saposin B [Domain]
length(22), motif(122:143) 22IPR008373Saposin [Family]
length(22), motif(158:179) 22IPR008373Saposin [Family]
length(117), motif(162:278) 117IPR011001Saposin-like [Domain]
length(37), motif(163:199) 37IPR008138Saposin-like type B, 2 [Domain]
length(80), motif(238:317) 80IPR011001Saposin-like [Domain]
length(82), motif(239:320) 82IPR008139Saposin B [Domain]
length(38), motif(241:278) 38IPR007856Saposin-like type B, 1 [Domain]
length(76), motif(241:316) 76IPR008139Saposin B [Domain]
length(21), motif(243:263) 21IPR008373Saposin [Family]
length(92), motif(281:372) 92IPR011001Saposin-like [Domain]
length(35), motif(282:316) 35IPR008138Saposin-like type B, 2 [Domain]
length(19), motif(292:310) 19IPR008373Saposin [Family]
length(80), motif(333:412) 80IPR011001Saposin-like [Domain]
length(82), motif(333:414) 82IPR008139Saposin B [Domain]
length(23), motif(334:356) 23IPR008373Saposin [Family]
length(38), motif(335:372) 38IPR007856Saposin-like type B, 1 [Domain]
length(76), motif(335:410) 76IPR008139Saposin B [Domain]
length(23), motif(366:388) 23IPR008373Saposin [Family]
length(78), motif(374:451) 78IPR011001Saposin-like [Domain]
length(35), motif(376:410) 35IPR008138Saposin-like type B, 2 [Domain]
length(24), motif(388:411) 24IPR008373Saposin [Family]
length(37), motif(416:452) 37IPR003119Saposin type A [Domain]
length(22), motif(417:438) 22IPR008373Saposin [Family]
length(34), motif(419:452) 34IPR003119Saposin type A [Domain]

Protein function information
H-Inv protein ID HIP000247398
Representative H-Inv transcript ID Transcript view HIT000488296
H-Inv cluster ID Locus view HIX0008908
Definition Similar to Saposin-B-Val; Contains: Saposin-B; Cerebroside sulfate activator; CS-ACT; Non-specific activator; Sphingolipid activator protein 1; SAP-1;
Similarity category Help Similar to known protein(Category II).
Similar to known protein (P81405) [Identity/coverage = 88.75%/100.0%] to Sus scrofa (Pig). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol PSAP
HGNC aliases "sphingolipid activator protein-1";
HGNC name prosaposin;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB 		ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT cytosol;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
1 63 2gtgA1 4e-09 44.4 61/78 a.64.1.1
120 200 1n69A 7e-13 100.0 78/78 a.64.1.3
240 317 2gtgA1 3e-15 79.5 78/78 a.64.1.1
337 410 2gtgA1 3e-14 36.5 74/78 a.64.1.1
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
314..314 T/G rs11555017 + CDS Synonymous[Pro40Pro]
327..327 A/G rs142784765 - CDS Nonsynonymous[Ile45Val]
348..348 C/T rs148519599 - CDS Nonsynonymous[Arg52Cys]
457..457 A/T rs146301708 - CDS Nonsynonymous[Asp88Val]
509..509 C/T rs11555021 + CDS Synonymous[Tyr105Tyr]
518..518 C/T rs142002239 - CDS Synonymous[Asp108Asp]
525..525 C/T rs193088462 - CDS Nonsynonymous[Arg111Cys]
526..526 G/A rs138880818 - CDS Nonsynonymous[Arg111His]
534..534 C/T rs188854022 - CDS Nonsynonymous[Pro114Ser]
539..539 G/T rs142272618 - CDS Nonsynonymous[Gln115His]
546..546 G/C rs149305591 - CDS Nonsynonymous[Asp118His]
547..547 A/G rs138636858 - CDS Nonsynonymous[Asp118Gly]
551..551 T/C rs150177878 - CDS Synonymous[Asn119Asn]
558..558 G/A rs191952316 - CDS Nonsynonymous[Val122Ile]
585..585 A/G rs139503658 - CDS Nonsynonymous[Thr131Ala]
590..590 C/T rs140702696 - CDS Synonymous[Asp132Asp]
592..592 T/G rs200319381 - CDS Nonsynonymous[Ile133Ser]
606..606 C/T rs150521779 - CDS Nonsynonymous[Arg138Trp]
612..612 A/C rs121918107 + CDS Nonsynonymous[Asn140His]
619..619 C/T rs121918103 + CDS Nonsynonymous[Thr142Ile]
664..664 G/T rs147265566 - CDS Nonsynonymous[Arg157Leu]
666..666 C/T/G rs146934980 - CDS
683..683 C/G rs141199649 - CDS Synonymous[Ala163Ala]
691..691 G/C rs121918104 + CDS Nonsynonymous[Cys166Ser]
692..692 C/T rs147805036 - CDS Synonymous[Cys166Cys]
701..701 T/C rs146732171 - CDS Synonymous[Tyr169Tyr]
710..710 G/T rs202069470 - CDS Nonsynonymous[Gln172His]
749..749 G/C rs112041816 - CDS Nonsynonymous[Gln185His]
752..752 T/A rs113827790 - CDS Nonsynonymous[Asp186Glu]
776..776 G/A rs199672678 - CDS Synonymous[Ala194Ala]
800..800 G/A rs149202005 - CDS Synonymous[Val202Val]
843..843 T/C rs145404688 - CDS Nonsynonymous[Ser217Pro]
872..872 G/A rs150048951 - CDS Synonymous[Leu226Leu]
892..892 A/G rs113554687 - CDS Nonsynonymous[His233Arg]
918..918 T/C rs202041927 - CDS Nonsynonymous[Tyr242His]
944..944 G/A rs139413990 - CDS Synonymous[Val250Val]
995..995 C/T rs146778046 - CDS Synonymous[Leu267Leu]
998..998 C/T rs113679008 - CDS Synonymous[Asp268Asp]
1007..1007 C/A rs199650747 - CDS Nonsynonymous[Asp271Glu]
1024..1024 T/C rs121918110 + CDS Nonsynonymous[Leu277Pro]
1027..1027 C/T rs201129306 - CDS Nonsynonymous[Pro278Leu]
1034..1034 C/T rs138328594 - CDS Synonymous[Ser280Ser]
1066..1066 C/T rs140066253 - CDS Nonsynonymous[Thr291Met]
1070..1070 C/T rs200226479 - CDS Synonymous[Tyr292Tyr]
1100..1100 G/A rs146102517 - CDS Synonymous[Glu302Glu]
1122..1122 T/G rs121918108 + CDS Nonsynonymous[Cys310Gly]
1123..1123 G/T rs121918105 + CDS Nonsynonymous[Cys310Phe]
1142..1142 C/T rs141254386 - CDS Synonymous[Cys316Cys]
1150..1150 C/T rs202125074 - CDS Nonsynonymous[Thr319Met]
1205..1205 C/T rs147030327 - CDS Synonymous[Cys337Cys]
1220..1220 G/T rs1803650 + CDS Nonsynonymous[Lys342Asn]
1257..1257 A/G rs148676984 - CDS Nonsynonymous[Ser355Gly]
1260..1260 A/G rs200379457 - CDS Nonsynonymous[Thr356Ala]
1266..1266 C/T rs121918109 + CDS AA-STOP[Gln358*]
1274..1274 C/T rs144042454 - CDS Synonymous[Ile360Ile]
1289..1289 G/A rs149525964 - CDS Synonymous[Glu365Glu]
1316..1316 T/C rs138217875 - CDS Synonymous[Pro374Pro]
1352..1352 C/T rs146925179 - CDS Synonymous[Tyr386Tyr]
1358..1358 C/T rs1049882 + CDS Synonymous[Pro388Pro]
1359..1359 G/A rs138716613 - CDS Nonsynonymous[Val389Met]
1430..1430 G/A rs114389264 - CDS Synonymous[Ser412Ser]
1439..1439 G/A rs140777530 - CDS Synonymous[Lys415Lys]
1454..1454 T/C rs139178900 - CDS Synonymous[Thr420Thr]
1473..1473 C/T rs143773764 - CDS Nonsynonymous[Pro427Ser]
1497..1497 G/C rs149000433 - CDS Nonsynonymous[Glu435Gln]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;