H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Inv protein ID:	HIP000285386	Last modified:	27-May-2015
Definition:	Similar to Abelson tyrosine-protein kinase 2 isoform h.

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000285386 Length 1079 Codon Adaptation Index (CAI). 0.763 Database links RefSeq NA UniProt NA CCDS Original transcript information Representative H-Inv transcript ID HIT000558720 H-Inv cluster ID HIX0001374 Predicted CDS 1..3240 ; 1079[aa] ; Orientation:+1 ; Genomic location Chromosome 1 Location 1q25.2 CDS position 179076853-179198532 Strand - Accession number FJ542284.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources NBRC     Antibody (ABL2) ;   Catalog (ABL2) ; Length of cDNA 3240[bp] (No. of exon:13)[A:887 T:669 G:851 C:833] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:27 ; KEGG GENES KEGG GENES(27) ; GeneCard ABL2 ; etc Human-Gene diversity Of Life-style related Diseases ;

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000558720
H-Inv cluster ID		HIX0001374
Accession number		FJ542284.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Similar to Abelson tyrosine-protein kinase 2 isoform h.
Similarity category		Similar to known protein(Category II).
		Similar to known protein (NP_001161710) [Identity/coverage = 95.841%/100.0%] to Homo sapiens protein.
Transcript feature		Representative transcript; Splicing isoform;
Genomic Location	Chromosome	1
	Location	1q25.2
	CDS position	179076853-179198532
	Strand	-
Gene structure		13 exons

Motif information in predicted CDS

	a.a. length	InterPro	Name
	61	IPR001452	SH3 domain [Domain]
	86	IPR001452	SH3 domain [Domain]
	57	IPR001452	SH3 domain [Domain]
	47	IPR001452	SH3 domain [Domain]
	120	IPR000980	SH2 domain [Domain]
	141	IPR000980	SH2 domain [Domain]
	84	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	76	IPR000980	SH2 domain [Domain]
	91	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	12	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	273	IPR011009	Protein kinase-like domain [Domain]
	251	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	252	IPR000719	Protein kinase domain [Domain]
	252	IPR020635	Tyrosine-protein kinase, catalytic domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]
	14	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	19	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	13	IPR008266	Tyrosine-protein kinase, active site [Active_site]
	11	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	23	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	23	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	122	IPR015015	F-actin binding [Domain]
	103	IPR015015	F-actin binding [Domain]

Protein function information

H-Inv protein ID		HIP000285386
Representative H-Inv transcript ID		HIT000558720
H-Inv cluster ID		HIX0001374
Definition		Similar to Abelson tyrosine-protein kinase 2 isoform h.
Similarity category		Similar to known protein(Category II).
		Similar to known protein (NP_001161710) [Identity/coverage = 95.841%/100.0%] to Homo sapiens protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		EC 2.7.10.2 non-specific protein-tyrosine kinase
KEGG metabolic pathway		04020 Calcium signaling pathway 04360 Axon guidance 04370 VEGF signaling pathway 04510 Focal adhesion 04520 Adherens junction 04530 Tight junction 04540 Gap junction 04630 Jak-STAT signaling pathway 04660 T cell receptor signaling pathway 04662 B cell receptor signaling pathway 04664 Fc epsilon RI signaling pathway 04670 Leukocyte transendothelial migration 04730 Long-term depression 04810 Regulation of actin cytoskeleton 04912 GnRH signaling pathway 04920 Adipocytokine signaling pathway 05120 Epithelial cell signaling in Helicobacter pylori infection 05130 Pathogenic Escherichia coli infection - EHEC 05131 Pathogenic Escherichia coli infection - EPEC
Protein-protein interaction (PPI)	No. of interaction	16
	Interaction partner(s)	HIP000008212; HIP000021733; HIP000022718; HIP000026075; HIP000030971; HIP000033435; HIP000041738; HIP000046292; HIP000066345; HIP000075375; HIP000083211; HIP000083789; HIP000085283; HIP000102704; HIP000106185; HIP000157576;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	00282; 00796; 01044; 01267; 01809; 02997; 05813; 12473; 16124;
	IntAct	NA
Database links	RefSeq	NA
	UniProt
	CCDS
Gene symbol/name	HGNC symbol	ABL2
	HGNC aliases	"v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase";
	HGNC name	ABL proto-oncogene 2, non-receptor tyrosine kinase;
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT nuclear; Target P Not predicted SOSUI soluble protein TMHMM soluble protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified : 27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 110 167 1aboA 2e-16 91.4 58/58 b.34.2.1 200 549 1nw1A 2e-58 8.9 349/365 d.144.1.8

Related H-InvDB links GTOP

Evolutionary information

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	DQ084361		G-integra
Orthology	Equus sp. (Horse)	ENSECAT00000006120		G-integra
Orthology	Oryzias sp. (Medaka)	ENSORLT00000009306		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000000554		G-integra
Orthology	Pan sp. (Chimpanzee)	ENSPTRT00000058473		G-integra
Orthology	Tetraodon sp. (Tetraodon)	GSTENT00028837001		G-integra
Orthology	Takifugu sp. (Fugu)	SINFRUT00000176586		G-integra
Orthology	Macaca sp. (Macaque)	XM_001115453		G-integra
Orthology	Bos sp. (Cow)	XM_001253284		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001365918		G-integra
Orthology	Danio sp. (Zebrafish)	XM_001923465		G-integra
Orthology	Gallus sp. (Chicken)	XM_422269		G-integra
Orthology	Canis sp. (Dog)	XM_537174		G-integra

Phylogenetic tree [View by ATV]	TNeighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS;

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 94..94 G/A rs61821692 - CDS Nonsynonymous[Gly32Ser] 208..208 G/A rs140292380 - CDS Nonsynonymous[Gly70Ser] 233..233 G/A rs55655202 - CDS Nonsynonymous[Arg78His] 239..239 A/G rs140935116 - CDS Nonsynonymous[Tyr80Cys] 292..292 A/G rs201376490 - CDS Nonsynonymous[Lys98Glu] 306..306 C/T rs200064313 - CDS Synonymous[Leu102Leu] 307..307 G/A rs187540054 - CDS Nonsynonymous[Gly103Arg] 336..336 C/T rs200298102 - CDS Synonymous[Phe112Phe] 337..337 G/A rs201168871 - CDS Nonsynonymous[Val113Ile] 380..380 G/A rs147306941 - CDS Nonsynonymous[Ser127Asn] 446..446 G/A rs148596386 - CDS Nonsynonymous[Arg149His] 464..464 G/T rs61821670 - CDS Nonsynonymous[Gly155Val] 509^510 -/A rs35945588 - CDS 544..544 G/A rs149352120 - CDS Nonsynonymous[Ala182Thr] 650..650 T/C rs112007604 - CDS Nonsynonymous[Val217Ala] 651..651 G/A rs28914528 + CDS Synonymous[Val217Val] 876..876 C/T rs180770623 - CDS Synonymous[His292His] 888..888 C/T rs201235188 - CDS Synonymous[Gly296Gly] 909..909 C/T rs56032037 - CDS Synonymous[Tyr303Tyr] 916..916 G/A rs200847097 - CDS Nonsynonymous[Val306Ile] 939..939 A/G rs28914532 + CDS Synonymous[Thr313Thr] 955..955 T/C rs28914533 + CDS Synonymous[Leu319Leu] 1013..1013 A/G rs192943572 - CDS Nonsynonymous[Glu338Gly] 1032..1032 G/A rs143159520 - CDS Synonymous[Leu344Leu] 1070..1070 T/G rs147552979 - CDS Nonsynonymous[Phe357Cys] 1083..1083 T/G rs150181582 - CDS Synonymous[Thr361Thr] 1086..1086 A/G rs139334603 - CDS Synonymous[Glu362Glu] 1106..1106 T/A rs141559171 - CDS AA-STOP[Leu369*] 1140..1140 G/A rs199688019 - CDS Synonymous[Glu380Glu] 1170..1170 C/T rs201521779 - CDS Synonymous[Ala390Ala] 1297..1297 T/C rs140036159 - CDS Synonymous[Leu433Leu] 1317..1317 T/C rs142746259 - CDS Synonymous[Tyr439Tyr] 1402..1402 G/A rs144729350 - CDS Nonsynonymous[Val468Ile] 1464..1464 T/C rs138565389 - CDS Synonymous[Gly488Gly] 1494..1494 A/C rs2274230 + CDS Synonymous[Leu498Leu] 1631..1631 A/G rs146942033 - CDS Nonsynonymous[His544Arg] 1677..1677 C/T rs151170340 - CDS Synonymous[Ala559Ala] 1820..1820 C/T rs185583542 - CDS Nonsynonymous[Ala607Val] 1822..1822 C/T rs148985886 - CDS Nonsynonymous[Pro608Ser] 1926..1926 A/G rs144233543 - CDS Synonymous[Thr642Thr] 1961..1961 G/C rs199575608 - CDS Nonsynonymous[Ser654Thr] 1990..1990 A/G rs141450341 - CDS Nonsynonymous[Thr664Ala] 1993..1993 C/A rs144066805 - CDS Nonsynonymous[Pro665Thr] 1998..1998 C/T rs138240636 - CDS Synonymous[Pro666Pro] 2049..2049 C/T rs146997813 - CDS Synonymous[Tyr683Tyr] 2057..2057 C/T rs200298510 - CDS Nonsynonymous[Thr686Met] 2058..2058 G/T rs28913887 + CDS Synonymous[Thr686Thr] 2198..2198 A/T rs146696301 - CDS Nonsynonymous[Lys733Ile] 2205..2205 G/A rs138005479 - CDS Synonymous[Glu735Glu] 2316..2316 C/T rs61731092 - CDS Synonymous[Asp772Asp] 2357..2357 A/- rs34839060 - CDS 2404..2404 C/A rs201832781 - CDS Nonsynonymous[Pro802Thr] 2413..2413 G/A rs145907038 - CDS Nonsynonymous[Gly805Arg] 2425..2425 G/T rs140629135 - CDS Nonsynonymous[Gly809Cys] 2467..2467 A/T rs202035355 - CDS Nonsynonymous[Thr823Ser] 2480..2480 A/G rs17277288 - CDS Nonsynonymous[Lys827Arg] 2507..2507 T/G rs201190336 - CDS Nonsynonymous[Leu836Arg] 2527..2527 G/A rs28913889 + CDS Nonsynonymous[Val843Met] 2535..2535 C/T rs35124879 - CDS Synonymous[Leu845Leu] 2540..2540 G/T rs181288208 - CDS Nonsynonymous[Gly847Val] 2575..2575 T/C rs150587634 - CDS Nonsynonymous[Ser859Pro] 2621..2621 G/A rs137859710 - CDS Nonsynonymous[Arg874Gln] 2678..2678 C/G rs28913890 + CDS Nonsynonymous[Pro893Arg] 2679..2679 G/C rs150940806 - CDS Synonymous[Pro893Pro] 2706..2706 G/A rs145868471 - CDS Synonymous[Glu902Glu] 2710..2710 A/G rs140945067 - CDS Nonsynonymous[Thr904Ala] 2756..2756 G/A rs201697670 - CDS Nonsynonymous[Gly919Glu] 2780..2780 T/C rs140016842 - CDS Nonsynonymous[Val927Ala] 2847..2847 C/A rs147901436 - CDS Synonymous[Ser949Ser] 2853..2853 G/T/A rs148651616 - CDS 2870..2870 A/G rs189362240 - CDS Nonsynonymous[Asn957Ser] 2876..2876 C/T rs202244816 - CDS Nonsynonymous[Thr959Ile] 2945..2945 G/A rs28913891 + CDS Nonsynonymous[Ser982Asn] 2974..2974 C/A rs149947908 - CDS Nonsynonymous[Leu992Ile] 2980..2980 T/A rs146190825 - CDS Nonsynonymous[Ser994Thr] 2982..2982 C/T rs184267733 - CDS Synonymous[Ser994Ser] 2984..2984 G/A rs142446654 - CDS Nonsynonymous[Ser995Asn] 2992..2992 A/G rs28913892 + CDS Nonsynonymous[Thr998Ala] 3069..3069 C/T rs201035509 - CDS Synonymous[Cys1023Cys] 3123..3123 A/G rs148342392 - CDS Synonymous[Glu1041Glu] 3149..3149 C/T rs143405311 - CDS Nonsynonymous[Ser1050Phe] 3175..3175 A/G rs138532009 - CDS Nonsynonymous[Thr1059Ala] 3181..3181 C/G rs199707055 - CDS Nonsynonymous[Pro1061Ala] 3195..3195 C/T rs141543536 - CDS Synonymous[Asn1065Asn] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;