H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000437793 Last modified: 27-May-2015
Definition: Similar to Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC=1.5.1.2;
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000437793
Length 214
Codon Adaptation Index (CAI). 0.795
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000003982
H-Inv cluster ID Locus view HIX0001639
Predicted CDS 1928..2572 ; 214[aa] ; Orientation:+2 ;
Genomic location Chromosome 1
Location 1q42.12
CDS position 226107578-226111978
Strand -
Accession number AK001508.1
CAGE tag ID NA
EST ID NA
Clone Number NT2RP2005773
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PYCR2) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PYCR2) ;
Length of cDNA 3149[bp] (No. of exon:5)[A:677 T:721 G:910 C:841] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29920 ;
KEGG GENES KEGG GENES(29920) ;
GeneCard GeneCard PYCR2 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000003982
H-Inv cluster IDLocus view HIX0001639
Accession numberAK001508.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC=1.5.1.2;
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (Q04708) [Identity/coverage = 52.288%/56.04%] to Pisum sativum (Garden pea). protein.
Transcript feature Help Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome1
Location1q42.12
CDS position226107578-226111978
Strand-
Gene structure5 exons

Protein function information
H-Inv protein ID HIP000437793
Representative H-Inv transcript ID Transcript view HIT000003982
H-Inv cluster ID Locus view HIX0001639
Definition Similar to Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC=1.5.1.2;
Similarity category Help Similar to known protein(Category II).
Similar to known protein (Q04708) [Identity/coverage = 52.288%/56.04%] to Pisum sativum (Garden pea). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 1.5.1.2 pyrroline-5-carboxylate reductase
KEGG metabolic pathway 00220 Urea cycle and metabolism of amino groups 00330 Arginine and proline metabolism
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol PYCR2
HGNC aliases NA
HGNC name pyrroline-5-carboxylate reductase family, member 2;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT mitochondria;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
2 55 1yqgA2 3e-11 16.7 54/152 c.2.1.6
55 159 1yqgA1 1e-30 26.7 105/111 a.100.1.10
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
1947..1947 C/G rs199719275 - CDS Nonsynonymous[Pro7Arg]
1965..1965 G/T rs149587849 - CDS Nonsynonymous[Arg13Leu]
2008..2008 A/G rs112885589 - CDS Synonymous[Thr27Thr]
2024..2024 A/C rs200663855 - CDS Nonsynonymous[Thr33Pro]
2025..2025 C/G rs191605313 - CDS Nonsynonymous[Thr33Ser]
2054..2054 C/T rs139028833 - CDS Synonymous[Leu43Leu]
2064..2064 T/C rs112160559 - CDS Nonsynonymous[Leu46Pro]
2075..2075 G/A rs145139251 - CDS Nonsynonymous[Val50Met]
2137..2137 C/G rs201440840 - CDS Nonsynonymous[Ser70Arg]
2159..2159 G/A rs142577088 - CDS Nonsynonymous[Ala78Thr]
2170..2170 A/T rs145493247 - CDS Synonymous[Ala81Ala]
2207..2207 C/T rs199945116 - CDS Nonsynonymous[Arg94Cys]
2210..2210 C/T rs56362902 - CDS Synonymous[Leu95Leu]
2216..2216 A/G rs201142342 - CDS Nonsynonymous[Ile97Val]
2219..2219 C/T rs113324645 - CDS AA-STOP[Gln98*]
2224..2224 C/T rs55803945 - CDS Synonymous[Leu99Leu]
2248..2248 T/C rs200949659 - CDS Synonymous[Ala107Ala]
2284..2284 C/G rs150765933 - CDS Nonsynonymous[Cys119Trp]
2285..2285 C/T rs201784173 - CDS AA-STOP[Gln120*]
2320..2320 C/A rs148117976 - CDS Synonymous[Ala131Ala]
2362..2362 C/T rs138792831 - CDS Synonymous[Arg145Arg]
2410..2410 G/A rs200057700 - CDS Synonymous[Glu161Glu]
2443..2443 C/G rs201007176 - CDS Synonymous[Ser172Ser]
2450..2450 G/A rs201700928 - CDS Nonsynonymous[Ala175Thr]
2527..2527 G/A rs73131849 - CDS Synonymous[Gly200Gly]
2533..2533 C/G rs181648767 - CDS Synonymous[Leu202Leu]
2550..2550 C/G rs117063721 - CDS Nonsynonymous[Ala208Gly]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;