H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Inv protein ID:	HIP000441459	Last modified:	27-May-2015
Definition:	Similar to Proactivator polypeptide isoform b preproprotein.

Select FormatXML fileFlat fileProtein sequence fasta

Protein information HIP ID HIP000441459 Length 380 Codon Adaptation Index (CAI). 0.808 Database links RefSeq NA UniProt NA CCDS NA Original transcript information Representative H-Inv transcript ID HIT000049061_03 H-Inv cluster ID HIX0008908 Predicted CDS 31..1173 ; 380[aa] ; Orientation:+1 ; Genomic location Chromosome 10 Location 10q22.1 CDS position 73576307-73611008 Strand - Accession number AK129790.1 CAGE tag ID NA EST ID NA Clone Number DMC06755 Experimental resources NBRC     Antibody (PSAP) ;   Catalog (PSAP) ; Length of cDNA 2317[bp] (No. of exon:15)[A:523 T:548 G:650 C:596] ; Database links RefSeq NA Ensembl NA Entrez Gene Entrez Gene ID:5660 ; KEGG GENES KEGG GENES(5660) ; GeneCard PSAP ; etc Human-Gene diversity Of Life-style related Diseases ;

MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQDQQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSIVHPAGGGQP*

Coresponding transcript member (s)

No.		1
H-Inv ID		HIT000049061_03
H-Inv cluster ID		HIX0008908
Accession number		AK129790.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding
Definition		Similar to Proactivator polypeptide isoform b preproprotein.
Similarity category		Similar to known protein(Category II).
		Similar to known protein (NP_001035930) [Identity/coverage = 99.81%/100.0%] to Homo sapiens protein.
Transcript feature		Splicing isoform;
Genomic Location	Chromosome	10
	Location	10q22.1
	CDS position	73576307-73611008
	Strand	-
Gene structure		15 exons

Protein function information

H-Inv protein ID		HIP000441459
Representative H-Inv transcript ID		HIT000049061_03
H-Inv cluster ID		HIX0008908
Definition		Similar to Proactivator polypeptide isoform b preproprotein.
Similarity category		Similar to known protein(Category II).
		Similar to known protein (NP_001035930) [Identity/coverage = 99.81%/100.0%] to Homo sapiens protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
EC number		NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	UniProt	NA
	CCDS	NA
Gene symbol/name	HGNC symbol	PSAP
	HGNC aliases	"sphingolipid activator protein-1";
	HGNC name	prosaposin;
Related H-InvDB links		G-integra ; PPI view ; TACT ;

Glycosylation GPDB (GlycoProtDB) ID NA Protein name NA Organism NA Length(aa) NA

Subcellular localization information WoLF PSORT extracellular; Target P signal peptide SOSUI membrane protein TMHMM soluble protein PTS1 Not targeted Related H-InvDB links LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel Location Variation dbSNP ID Strand CDS/UTR Translation 31..31 A/T rs121918106 + CDS Nonsynonymous[Met1Leu] 46..46 C/T rs148279196 - CDS Nonsynonymous[Leu6Phe] 66..66 C/G rs11555014 + CDS Synonymous[Gly12Gly] 78..78 C/T rs199808371 - CDS Synonymous[Ala16Ala] 90..90 T/C rs188252882 - CDS Synonymous[Leu20Leu] 97..97 A/G rs143016278 - CDS Nonsynonymous[Lys23Glu] 101^102 -/A rs34228343 - CDS 108..108 C/T rs74145688 - CDS Synonymous[Thr26Thr] 113..113 G/T rs185057837 - CDS Nonsynonymous[Gly28Val] 118..118 G/T rs144942998 - CDS Nonsynonymous[Ala30Ser] 124..124 T/G rs200008050 - CDS Nonsynonymous[Trp32Gly] 143..143 C/T rs145181011 - CDS Nonsynonymous[Thr38Met] 147..147 G/A rs200836594 - CDS Synonymous[Ala39Ala] 150..150 C/T rs141231601 - CDS Synonymous[Ser40Ser] 177..177 G/A rs112119208 - CDS Synonymous[Leu49Leu] 183..183 C/T rs11555016 + CDS Synonymous[Thr51Thr] 184..184 G/A rs147920923 - CDS Nonsynonymous[Val52Ile] 219..219 C/T rs111369573 - CDS Synonymous[Cys63Cys] 234..234 C/T rs143981174 - CDS Synonymous[Asp68Asp] 244..244 G/A rs150701404 - CDS Nonsynonymous[Ala72Thr] 247..247 G/A rs11555015 + CDS Nonsynonymous[Ala73Thr] 375..375 T/G rs11555017 + CDS Synonymous[Pro115Pro] 388..388 A/G rs142784765 - CDS Nonsynonymous[Ile120Val] 409..409 C/T rs148519599 - CDS Nonsynonymous[Arg127Cys] 518..518 A/T rs146301708 - CDS Nonsynonymous[Asp163Val] 570..570 C/T rs11555021 + CDS Synonymous[Tyr180Tyr] 579..579 C/T rs142002239 - CDS Synonymous[Asp183Asp] 586..586 C/T rs193088462 - CDS Nonsynonymous[Arg186Cys] 587..587 G/A rs138880818 - CDS Nonsynonymous[Arg186His] 595..595 C/T rs188854022 - CDS Nonsynonymous[Pro189Ser] 600..600 G/T rs142272618 - CDS Nonsynonymous[Gln190His] 607..607 G/C rs149305591 - CDS Nonsynonymous[Asp193His] 608..608 A/G rs138636858 - CDS Nonsynonymous[Asp193Gly] 612..612 T/C rs150177878 - CDS Synonymous[Asn194Asn] 619..619 G/A rs191952316 - CDS Nonsynonymous[Val197Ile] 646..646 A/G rs139503658 - CDS Nonsynonymous[Thr206Ala] 651..651 C/T rs140702696 - CDS Synonymous[Asp207Asp] 653..653 T/G rs200319381 - CDS Nonsynonymous[Ile208Ser] 667..667 C/T rs150521779 - CDS Nonsynonymous[Arg213Trp] 673..673 A/C rs121918107 + CDS Nonsynonymous[Asn215His] 680..680 C/T rs121918103 + CDS Nonsynonymous[Thr217Ile] 725..725 G/T rs147265566 - CDS Nonsynonymous[Arg232Leu] 727..727 C/T/G rs146934980 - CDS 744..744 C/G rs141199649 - CDS Synonymous[Ala238Ala] 752..752 G/C rs121918104 + CDS Nonsynonymous[Cys241Ser] 753..753 C/T rs147805036 - CDS Synonymous[Cys241Cys] 762..762 T/C rs146732171 - CDS Synonymous[Tyr244Tyr] 771..771 G/T rs202069470 - CDS Nonsynonymous[Gln247His] 810..810 G/C rs112041816 - CDS Nonsynonymous[Gln260His] 813..813 T/A rs113827790 - CDS Nonsynonymous[Asp261Glu] 837..837 G/A rs199672678 - CDS Synonymous[Ala269Ala] 861..861 G/A rs149202005 - CDS Synonymous[Val277Val] 904..904 T/C rs145404688 - CDS Nonsynonymous[Ser292Pro] 933..933 G/A rs150048951 - CDS Synonymous[Leu301Leu] 953..953 A/G rs113554687 - CDS Nonsynonymous[His308Arg] 979..979 T/C rs202041927 - CDS Nonsynonymous[Tyr317His] 1005..1005 G/A rs139413990 - CDS Synonymous[Val325Val] 1056..1056 C/T rs146778046 - CDS Synonymous[Leu342Leu] 1059..1059 C/T rs113679008 - CDS Synonymous[Asp343Asp] 1068..1068 C/A rs199650747 - CDS Nonsynonymous[Asp346Glu] 1085..1085 T/C rs121918110 + CDS Nonsynonymous[Leu352Pro] 1088..1088 C/T rs201129306 - CDS Nonsynonymous[Pro353Leu] 1095..1095 C/T rs138328594 - CDS Synonymous[Ser355Ser] 1127..1127 C/T rs140066253 - CDS Nonsynonymous[Thr366Met] 1131..1131 C/T rs200226479 - CDS Synonymous[Tyr367Tyr] 1159..1159 G/A rs146102517 - CDS Nonsynonymous[Gly377Arg] Microsatellite (Short Tandem Repeat, STR) Location Variation Strand No data available Related H-InvDB links VaryGene ;