Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000441459 Last modified: 27-May-2015
Definition: Similar to Proactivator polypeptide isoform b preproprotein.
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000441459
Length 380
Codon Adaptation Index (CAI). 0.808
Database links RefSeq NA
UniProt NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000049061_03
H-Inv cluster ID Locus view HIX0008908
Predicted CDS 31..1173 ; 380[aa] ; Orientation:+1 ;
Genomic location Chromosome 10
Location 10q22.1
CDS position 73576307-73611008
Strand -
Accession number AK129790.1
Clone Number DMC06755
Experimental resources NBRC: NITE Biological Resource Center NBRC     Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PSAP) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PSAP) ;
Length of cDNA 2317[bp] (No. of exon:15)[A:523 T:548 G:650 C:596] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5660 ;
GeneCard GeneCard PSAP ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
H-Inv IDTranscript view HIT000049061_03
H-Inv cluster IDLocus view HIX0008908
Accession numberAK129790.1
Coding potential Help Protein coding
DefinitionSimilar to Proactivator polypeptide isoform b preproprotein.
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (NP_001035930) [Identity/coverage = 99.81%/100.0%] to Homo sapiens protein.
Transcript feature Help Splicing isoformSplicing isoform;
Genomic Location G-integra Help Chromosome10
CDS position73576307-73611008
Gene structure15 exons

Protein function information
H-Inv protein ID HIP000441459
Representative H-Inv transcript ID Transcript view HIT000049061_03
H-Inv cluster ID Locus view HIX0008908
Definition Similar to Proactivator polypeptide isoform b preproprotein.
Similarity category Help Similar to known protein(Category II).
Similar to known protein (NP_001035930) [Identity/coverage = 99.81%/100.0%] to Homo sapiens protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction NA
Interaction partner(s) NA
IntAct NA
Database links RefSeq NA
UniProt NA
Gene symbol/name HGNC symbol PSAP
HGNC aliases "sphingolipid activator protein-1";
HGNC name prosaposin;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

GPDB (GlycoProtDB)
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT extracellular;
Target P signal peptide
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
31..31 A/T rs121918106 + CDS Nonsynonymous[Met1Leu]
46..46 C/T rs148279196 - CDS Nonsynonymous[Leu6Phe]
66..66 C/G rs11555014 + CDS Synonymous[Gly12Gly]
78..78 C/T rs199808371 - CDS Synonymous[Ala16Ala]
90..90 T/C rs188252882 - CDS Synonymous[Leu20Leu]
97..97 A/G rs143016278 - CDS Nonsynonymous[Lys23Glu]
101^102 -/A rs34228343 - CDS
108..108 C/T rs74145688 - CDS Synonymous[Thr26Thr]
113..113 G/T rs185057837 - CDS Nonsynonymous[Gly28Val]
118..118 G/T rs144942998 - CDS Nonsynonymous[Ala30Ser]
124..124 T/G rs200008050 - CDS Nonsynonymous[Trp32Gly]
143..143 C/T rs145181011 - CDS Nonsynonymous[Thr38Met]
147..147 G/A rs200836594 - CDS Synonymous[Ala39Ala]
150..150 C/T rs141231601 - CDS Synonymous[Ser40Ser]
177..177 G/A rs112119208 - CDS Synonymous[Leu49Leu]
183..183 C/T rs11555016 + CDS Synonymous[Thr51Thr]
184..184 G/A rs147920923 - CDS Nonsynonymous[Val52Ile]
219..219 C/T rs111369573 - CDS Synonymous[Cys63Cys]
234..234 C/T rs143981174 - CDS Synonymous[Asp68Asp]
244..244 G/A rs150701404 - CDS Nonsynonymous[Ala72Thr]
247..247 G/A rs11555015 + CDS Nonsynonymous[Ala73Thr]
375..375 T/G rs11555017 + CDS Synonymous[Pro115Pro]
388..388 A/G rs142784765 - CDS Nonsynonymous[Ile120Val]
409..409 C/T rs148519599 - CDS Nonsynonymous[Arg127Cys]
518..518 A/T rs146301708 - CDS Nonsynonymous[Asp163Val]
570..570 C/T rs11555021 + CDS Synonymous[Tyr180Tyr]
579..579 C/T rs142002239 - CDS Synonymous[Asp183Asp]
586..586 C/T rs193088462 - CDS Nonsynonymous[Arg186Cys]
587..587 G/A rs138880818 - CDS Nonsynonymous[Arg186His]
595..595 C/T rs188854022 - CDS Nonsynonymous[Pro189Ser]
600..600 G/T rs142272618 - CDS Nonsynonymous[Gln190His]
607..607 G/C rs149305591 - CDS Nonsynonymous[Asp193His]
608..608 A/G rs138636858 - CDS Nonsynonymous[Asp193Gly]
612..612 T/C rs150177878 - CDS Synonymous[Asn194Asn]
619..619 G/A rs191952316 - CDS Nonsynonymous[Val197Ile]
646..646 A/G rs139503658 - CDS Nonsynonymous[Thr206Ala]
651..651 C/T rs140702696 - CDS Synonymous[Asp207Asp]
653..653 T/G rs200319381 - CDS Nonsynonymous[Ile208Ser]
667..667 C/T rs150521779 - CDS Nonsynonymous[Arg213Trp]
673..673 A/C rs121918107 + CDS Nonsynonymous[Asn215His]
680..680 C/T rs121918103 + CDS Nonsynonymous[Thr217Ile]
725..725 G/T rs147265566 - CDS Nonsynonymous[Arg232Leu]
727..727 C/T/G rs146934980 - CDS
744..744 C/G rs141199649 - CDS Synonymous[Ala238Ala]
752..752 G/C rs121918104 + CDS Nonsynonymous[Cys241Ser]
753..753 C/T rs147805036 - CDS Synonymous[Cys241Cys]
762..762 T/C rs146732171 - CDS Synonymous[Tyr244Tyr]
771..771 G/T rs202069470 - CDS Nonsynonymous[Gln247His]
810..810 G/C rs112041816 - CDS Nonsynonymous[Gln260His]
813..813 T/A rs113827790 - CDS Nonsynonymous[Asp261Glu]
837..837 G/A rs199672678 - CDS Synonymous[Ala269Ala]
861..861 G/A rs149202005 - CDS Synonymous[Val277Val]
904..904 T/C rs145404688 - CDS Nonsynonymous[Ser292Pro]
933..933 G/A rs150048951 - CDS Synonymous[Leu301Leu]
953..953 A/G rs113554687 - CDS Nonsynonymous[His308Arg]
979..979 T/C rs202041927 - CDS Nonsynonymous[Tyr317His]
1005..1005 G/A rs139413990 - CDS Synonymous[Val325Val]
1056..1056 C/T rs146778046 - CDS Synonymous[Leu342Leu]
1059..1059 C/T rs113679008 - CDS Synonymous[Asp343Asp]
1068..1068 C/A rs199650747 - CDS Nonsynonymous[Asp346Glu]
1085..1085 T/C rs121918110 + CDS Nonsynonymous[Leu352Pro]
1088..1088 C/T rs201129306 - CDS Nonsynonymous[Pro353Leu]
1095..1095 C/T rs138328594 - CDS Synonymous[Ser355Ser]
1127..1127 C/T rs140066253 - CDS Nonsynonymous[Thr366Met]
1131..1131 C/T rs200226479 - CDS Synonymous[Tyr367Tyr]
1159..1159 G/A rs146102517 - CDS Nonsynonymous[Gly377Arg]
Microsatellite (Short Tandem Repeat, STR)
No data available
Related H-InvDB links
VaryGeneVaryGene ;