H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Inv cluster ID: HIX0001647 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
 
 

Gene structure  G-integra H-DBAS
H-Inv cluster ID HIX0001647
Genomic location  G-integra Help Chromosome 1
Location 1q42.13
Position 227057885- 227083806
Strand +
Antisense cluster ID(s) NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5664; 
KEGG GENES KEGG GENES(5664); 
GeneCard GeneCardPSEN2;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Cluster member H-Inv ID(s) HIT000425096;  HIT000032787;  HIT000193897;  HIT000099904;  HIT000495767;  HIT000193896;  HIT000219377;  HIT000079309; 
Additional cluster member candidate(s) NA
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA multiple alignmentcDNA-genome multiple alignment;  ORF multiple alignmentORF multiple alignment; 
Mini-G Locus map Locus map

 
TOP 1-8 LAST 
Cluster member (s)  G-integra H-DBAS
Locus member number 1
H-Inv ID Transcript viewHIT000425096
Accession number AK292299.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 99.777%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227058321- 227083417
Strand +
Gene structure 13 exons
 
TOP 1-8 LAST 
Locus member number 2
H-Inv ID Transcript viewHIT000032787
Accession number BC006365.2
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227058969- 227083798
Strand +
Gene structure 13 exons
 
TOP 1-8 LAST 
Locus member number 3
H-Inv ID Transcript viewHIT000193897
Accession number L44577.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227058962- 227083797
Strand +
Gene structure 12 exons
 
TOP 1-8 LAST 
Locus member number 4
H-Inv ID Transcript viewHIT000099904
Accession number BT006984.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227069609- 227083278
Strand +
Gene structure 10 exons
 
TOP 1-8 LAST 
Locus member number 5
H-Inv ID Transcript viewHIT000495767
Accession number AK301143.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P49810)  [Identity/coverage = 100.0%/89.06%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227058321- 227083298
Strand +
Gene structure 12 exons
 
TOP 1-8 LAST 
Locus member number 6
H-Inv ID Transcript viewHIT000193896
Accession number L43964.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 99.777%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227058960- 227083799
Strand +
Gene structure 12 exons
 
TOP 1-8 LAST 
Locus member number 7
H-Inv ID Transcript viewHIT000219377
Accession number U34349.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P49810)  [Identity/coverage = 99.767%/96.21%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227063198- 227083798
Strand +
Gene structure 12 exons
 
TOP 1-8 LAST 
Locus member number 8
H-Inv ID Transcript viewHIT000079309
Accession number AF416718.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P49810)  [Identity/coverage = 99.487%/87.05%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Transcript feature NA
Genomic location  G-integra Chromosome 1
Location 1q42.13
Position 227063204- 227081807
Strand +
Gene structure 10 exons

Alternative splicing (AS) information  G-integra H-DBAS
Pattern of alternative splicing isoforms 5' terminal AS;  Internal AS; 
Position of alternative splicing isoforms Cassette;  Internal donor site; 
Alternative splicing isoform H-Inv ID(s) Splicing isoformHIT000425096;  Splicing isoformHIT000495767; 
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA multiple alignmentcDNA-genome multiple alignment;  ORF multiple alignmentORF multiple alignment; 

Gene function information  G-integra PPI viewer H-DBAS Gene family Similarity Search Tool TACT
H-Inv cluster ID HIX0001647
Representative H-Inv ID Representative H-Inv IDHIT000425096
Accession number AK292299.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Presenilin-2; PS-2; EC=3.4.23.-; AD3LP; AD5; E5-1; STM-2; Contains: Presenilin-2 NTF subunit; Contains: Presenilin-2 CTF subunit;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P49810)  [Identity/coverage = 99.777%/100.0%] to Homo sapiens (Human). protein.
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol PSEN2 
HGNC aliases "Alzheimer disease 4" 
HGNC name presenilin 2 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000186295
No. of interaction 2
Interaction partner(s) HIP000028058;  HIP000059101; 
BIND 177583;  177584;  177585;  177765;  177778;  177779; 
DIP NA
MINT MINT-13994;  MINT-13995;  MINT-14379;  MINT-14380;  MINT-14945;  MINT-14946;  MINT-14947;  MINT-15560;  MINT-15561;  MINT-15562;  MINT-16270;  MINT-16271;  MINT-16272;  MINT-17115;  MINT-17116;  MINT-17615;  MINT-17616;  MINT-17617; 
HPRD 00100;  00253;  00277;  00286;  00977;  01290;  01680;  01827;  02060;  02497;  02524;  02606;  02607;  02739;  02799;  02920;  03188;  03321;  03457;  03459;  03509;  03800;  04543;  04671;  05198;  05232;  05440;  05584;  05715;  06360;  06361;  06362;  06907;  09063;  09181;  09705;  10216;  10341;  10549;  11517;  12184;  12363;  17469; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5664; 
KEGG GENES KEGG GENES(5664); 
GeneCard GeneCardPSEN2;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Related H-InvDB links G-integraG-integra;  PPI viewerPPI view;  H-DBASH-DBAS;  Gene familyGene family;  Similarity Search ToolSimilarity search tool;  TACTTACT; 
Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: Alzheimer disease-4 (606889); 
Related information in OMIM OMIM ID:  600759;  Title: PRESENILIN 2
Co-localized orphan diseases NA
Disease related mutation MutationView:  600759; 
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Co-occurred words and phrases with this gene name in PubMed (LEGENDA) LEGENDA Gene name Entrez Gene ID:(5664); 
Disease Entrez Gene ID:(5664); 
Gene function Entrez Gene ID:(5664); 
Substance Entrez Gene ID:(5664); 
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA;