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H-Inv cluster ID: HIX0201882 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to GTPase KRas isoform b precursor.

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Gene structure

H-Inv cluster ID		HIX0201882
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25357723- 25403870
	Strand	-
Antisense cluster ID(s)		NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3845;
	KEGG GENES	KEGG GENES(3845);
	GeneCard	KRAS;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Cluster member H-Inv ID(s)		HIT000425307;  HIT000036281;  HIT000034971;  HIT000080765;  HIT000195757;  HIT000100073;  HIT000195638;  HIT000195639;  HIT000091841;  HIT000194513;
Additional cluster member candidate(s)		NA
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome multiple alignment;  ORF multiple alignment;

 

TOP 1-10 LAST

Cluster member (s)

Locus member number		1
H-Inv ID		HIT000425307
Accession number		AK292510.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		Representative transcript;  Splicing isoform
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25362031- 25403826
	Strand	-
Gene structure		5 exons

 

TOP 1-10 LAST

Locus member number		2
H-Inv ID		HIT000036281
Accession number		BC013572.2
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 99.468%/100.0%] to Homo sapiens protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25362124- 25403820
	Strand	-
Gene structure		5 exons

 

TOP 1-10 LAST

Locus member number		3
H-Inv ID		HIT000034971
Accession number		BC010502.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Conserved hypothetical protein.
Similarity category		Category: Conserved hypothetical protein(Category IV).
		Conserved hypothetical protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25358180- 25361930
	Strand	-
Gene structure		1 exons

 

TOP 1-10 LAST

Locus member number		4
H-Inv ID		HIT000080765
Accession number		AF493917.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25362729- 25398318
	Strand	-
Gene structure		4 exons

 

TOP 1-10 LAST

Locus member number		5
H-Inv ID		HIT000195757
Accession number		M54968.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 99.468%/100.0%] to Homo sapiens protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25357723- 25403865
	Strand	-
Gene structure		5 exons

 

TOP 1-10 LAST

Locus member number		6
H-Inv ID		HIT000100073
Accession number		BT007153.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 99.468%/100.0%] to Homo sapiens protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25362730- 25398318
	Strand	-
Gene structure		4 exons

 

TOP 1-10 LAST

Locus member number		7
H-Inv ID		HIT000195638
Accession number		M35504.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; Contains: GTPase KRas, N-terminally processed; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q07983)  [Identity/coverage = 98.0%/79.79%] to Monodelphis domestica (Gray short-tailed opossum). protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25378548- 25398318
	Strand	-
Gene structure		3 exons

 

TOP 1-10 LAST

Locus member number		8
H-Inv ID		HIT000195639
Accession number		M35505.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; Contains: GTPase KRas, N-terminally processed; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q07983)  [Identity/coverage = 98.0%/79.79%] to Monodelphis domestica (Gray short-tailed opossum). protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25378548- 25398318
	Strand	-
Gene structure		3 exons

 

TOP 1-10 LAST

Locus member number		9
H-Inv ID		HIT000091841
Accession number		BC029545.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to Ras-like protein 1; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (B4KB60)  [Identity/coverage = 96.97%/18.23%] to Drosophila mojavensis (Fruit fly). protein.
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		Splicing isoform
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25386768- 25403863
	Strand	-
Gene structure		3 exons

 

TOP 1-10 LAST

Locus member number		10
H-Inv ID		HIT000194513
Accession number		M17087.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Non-protein-coding;
Definition		Non-protein-coding transcript, uncharacterized transcript.
Similarity category		Category: Non-protein coding transcript.
		NA
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Transcript feature		NA
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25398219- 25398331
	Strand	-
Gene structure		1 exons

Alternative splicing (AS) information

Pattern of alternative splicing isoforms	5' terminal AS;  3' terminal AS;
Position of alternative splicing isoforms	Internal donor site;
Alternative splicing isoform H-Inv ID(s)	HIT000091841;  HIT000425307;
Related H-InvDB links	H-DBAS;  G-integra;  cDNA-genome multiple alignment;  ORF multiple alignment;

Gene function information

H-Inv cluster ID		HIX0201882
Representative H-Inv ID		HIT000425307
Accession number		AK292510.1
CAGE tag ID		NA
EST ID		NA
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000106181
	No. of interaction	2
	Interaction partner(s)	HIP000027976;  HIP000103557;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	00241;  00242;  00243;  00607;  00608;  01045;  01243;  01265;  01517;  03135;  03371;  04144;  06117;  09278;  11763;  15218;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3845;
	KEGG GENES	KEGG GENES(3845);
	GeneCard	KRAS;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Related H-InvDB links		G-integra;  PPI view;  H-DBAS;  Gene family;  Similarity search tool;  TACT;

Disease/pathology information

Last modified:27-May-2015

Disease relation			Disease name: Bladder cancer (109800);  Disease name: Breast cancer, somatic (114480);  Disease name: Costello syndrome (218040);  Disease name: Lung cancer (211980);  Disease name: Noonan syndrome 3 (609942);  Disease name: Pancreatic carcinoma, somatic (260350);  Disease name: Stomach cancer (137215);
Related information in OMIM			OMIM ID:  190070;  Title: V-KI-RAS2 KIRSTEN RAT SARCOMA VIRAL ONCOGENE HOMOLOG
Co-localized orphan diseases			NA
Disease related mutation			NA
Co-occurred words and phrases with this gene name in PubMed (LEGENDA)	Gene name	Entrez Gene ID:(3845);
	Disease	Entrez Gene ID:(3845);
	Gene function	Entrez Gene ID:(3845);
	Substance	Entrez Gene ID:(3845);
Related H-InvDB links			DiseaseInfo Viewer;  LEGENDA;