H-InvDB x AHG DB
Transcript view
H-InvDB_9.0 released on May 27, 2015.
Search by for Advanced Search
Home Quick guide Navi BLAST Site map Download Contact us Help
H-Invitational ID: HIT000000168 Accession number: AB007920 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Serine/threonine-protein kinase MRCK alpha; EC=2.7.11.1; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha;
 
 

Transcript original information
Accession number AB007920.2
CAGE tag ID NA
EST ID NA
Clone Number pf06424
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider Provider:KDRI
Annotation project H-Invitational FLcDNA
Length of cDNA 7335[bp] (No. of exon:21)[A:2088 T:2021 G:1569 C:1657]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type brain
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0213687
Genomic location  G-integra Help Chromosome 1
Location 1q42.13
Position 227177567- 227268680
Strand -
Possible duplicated location(s) NA
Gene structure 21 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8476
KEGG GENES KEGG GENES(8476)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000121463
Predicted CDS 2..2953;  983[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.724

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000000168
H-Inv cluster ID Locus viewHIX0213687
Accession number AB007920.2
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Serine/threonine-protein kinase MRCK alpha; EC=2.7.11.1; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q5VT25)  [Identity/coverage = 99.783%/53.93%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9092543941886194554841128325611340065113997751256872015723050167104141734484617974005186696481885416020188707212694602140669221457715ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ KIAA0451
UniProt CDC42BPA
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000121463
No. of interaction 1
Interaction partner(s) HIP000023385
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8476
KEGG GENES KEGG GENES(8476)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
153 213 1tbnA 6e-18 36.1 61/66 g.49.1.1
240 343 1qqgA1 1e-06 10.6 94/103 b.55.1.2
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA111209;  AGhsB080803; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 203794_at;  213595_s_at; 
HG-U133A 203794_at;  213595_s_at; 
HG-U133A_2 203794_at;  213595_s_at; 
HG-U133B NA
HG-U133_Plus_2 203794_at;  213595_s_at; 
HG-U95 32206_at; 
HG-U95A 32206_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2383427;  2383429;  2383430;  2383431;  2459045;  2459046;  2459047;  2459048;  2459049;  2459050;  2459051;  2459055;  2459059;  2459060;  2459061;  2459062;  2459063;  2459064;  2459065;  2459066;  2459067;  2459068;  2459069;  2459070;  2459071;  2459072;  2459074;  2459076;  2459077;  2459080;  2459082;  2459095;  2459097;  2459098;  2459099;  2459100;  3987200; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_23_P51394;  A_24_P205458;  A_24_P944299; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
80 .. 80 A/C rs77122651 - CDS Nonsynonymous[Ile27Leu]
115 .. 115 G/T rs142030346 - CDS Synonymous[Gly38Gly]
223 .. 223 G/A rs200154961 - CDS Synonymous[Ala74Ala]
258 .. 258 C/T rs144801895 - CDS Nonsynonymous[Ser86Leu]
259 .. 259 G/A rs35017425 - CDS Synonymous[Ser86Ser]
295 .. 295 C/T rs137890180 - CDS Synonymous[Ile98Ile]
305 .. 305 T/C rs200668164 - CDS Synonymous[Leu102Leu]
341 .. 341 T/A rs199653014 - CDS Nonsynonymous[Cys114Ser]
363 .. 363 A/C rs200440295 - CDS Nonsynonymous[Lys121Thr]
379 .. 379 A/G rs199733498 - CDS Synonymous[Leu126Leu]
391 .. 391 C/T rs55845581 - CDS Synonymous[Ile130Ile]
519 .. 519 A/G rs150700769 - CDS Nonsynonymous[Asp173Gly]
573 .. 573 G/C rs199543596 - CDS Nonsynonymous[Gly191Ala]
597 .. 597 G/A rs140416725 - CDS Nonsynonymous[Arg199His]
604 .. 604 T/C rs113402500 - CDS Synonymous[Thr201Thr]
630 .. 630 C/T rs202057695 - CDS Nonsynonymous[Thr210Ile]
686 .. 686 G/A rs112933697 - CDS Nonsynonymous[Gly229Ser]
737 .. 737 A/G rs142183701 - CDS Nonsynonymous[Lys246Glu]
768 ^ 769 -/A rs35357574 - CDS
802 .. 802 G/A rs35369012 - CDS Synonymous[Gln267Gln]
810 .. 810 T/C rs200344808 - CDS Nonsynonymous[Ile270Thr]
1006 .. 1006 C/T rs201643732 - CDS Synonymous[Val335Val]
1010 .. 1010 G/A rs56219089 - CDS Nonsynonymous[Ala337Thr]
1048 .. 1048 C/T rs149978094 - CDS Synonymous[Pro349Pro]
1072 .. 1072 C/T rs200331694 - CDS Synonymous[Ser357Ser]
1176 .. 1176 T/- rs67003899 - CDS
1193 .. 1193 A/G rs181637825 - CDS Nonsynonymous[Arg398Gly]
1200 .. 1200 G/A rs961490 - CDS Nonsynonymous[Arg400His]
1362 .. 1362 A/G rs201692012 - CDS Nonsynonymous[Asn454Ser]
1394 .. 1394 A/T rs200594653 - CDS Nonsynonymous[Asn465Tyr]
1465 .. 1465 T/C rs180784576 - CDS Synonymous[Asp488Asp]
1477 .. 1477 C/T rs189930745 - CDS Synonymous[Thr492Thr]
1517 .. 1517 G/A/C/T rs1929860 + CDS
1536 .. 1536 G/A rs200056759 - CDS Nonsynonymous[Arg512His]
1577 .. 1577 C/G rs201775243 - CDS Nonsynonymous[Gln526Glu]
1614 .. 1614 G/A rs200051797 - CDS Nonsynonymous[Arg538His]
1630 .. 1630 A/G rs1929861 + CDS Synonymous[Lys543Lys]
1639 .. 1639 A/G rs200690739 - CDS Synonymous[Gln546Gln]
1643 .. 1643 C/A rs149240330 - CDS Nonsynonymous[Pro548Thr]
1667 .. 1667 A/G rs146203858 - CDS Nonsynonymous[Ile556Val]
1737 .. 1737 A/- rs66656566 - CDS
1745 .. 1745 A/G rs200486377 - CDS Nonsynonymous[Ser582Gly]
1811 .. 1811 G/A rs183857756 - CDS Nonsynonymous[Ala604Thr]
1813 .. 1813 A/G rs199656326 - CDS Synonymous[Ala604Ala]
1916 .. 1916 G/T rs147617327 - CDS Nonsynonymous[Ala639Ser]
1929 .. 1929 C/G rs142464333 - CDS Nonsynonymous[Ser643Cys]
1957 .. 1957 G/A rs142853761 - CDS Synonymous[Ser652Ser]
1974 .. 1974 C/T rs55687355 - CDS Nonsynonymous[Ala658Val]
1997 .. 1997 T/C rs112426338 - CDS Nonsynonymous[Ser666Pro]
2049 .. 2049 A/G rs146136586 - CDS Nonsynonymous[Asn683Ser]
2103 .. 2103 A/T rs56229267 - CDS Nonsynonymous[Lys701Ile]
2106 .. 2106 A/G rs139110633 - CDS Nonsynonymous[Asn702Ser]
2196 .. 2196 G/A rs201852267 - CDS Nonsynonymous[Arg732His]
2249 .. 2249 C/T rs12561938 - CDS Synonymous[Leu750Leu]
2315 .. 2315 A/G rs200918078 - CDS Nonsynonymous[Met772Val]
2344 .. 2344 G/C rs55848092 - CDS Synonymous[Leu781Leu]
2347 .. 2347 A/G rs141188296 - CDS Synonymous[Lys782Lys]
2387 .. 2387 C/G rs116416229 - CDS Nonsynonymous[His796Asp]
2395 .. 2395 C/T rs187224217 - CDS Synonymous[Ser798Ser]
2413 .. 2413 G/A rs145540185 - CDS Synonymous[Pro804Pro]
2486 .. 2486 C/T rs149721518 - CDS Nonsynonymous[Pro829Ser]
2599 .. 2599 A/G rs145724581 - CDS Synonymous[Pro866Pro]
2603 .. 2603 A/G rs199675358 - CDS Nonsynonymous[Ile868Val]
2606 .. 2606 A/G rs2297417 + CDS Nonsynonymous[Thr869Ala]
2615 .. 2615 C/T rs148881297 - CDS Nonsynonymous[Arg872Cys]
2644 .. 2644 T/C rs150430697 - CDS Synonymous[Ala881Ala]
2671 .. 2671 C/T rs16846779 - CDS Synonymous[Ser890Ser]
2686 .. 2686 C/T rs147810081 - CDS Synonymous[Ser895Ser]
2738 .. 2738 A/G rs145538584 - CDS Nonsynonymous[Met913Val]
2763 .. 2763 T/C rs200692909 - CDS Nonsynonymous[Leu921Ser]
2770 .. 2770 T/C rs1045247 + CDS Synonymous[Ser923Ser]
2803 .. 2803 G/A rs201963139 - CDS Synonymous[Ala934Ala]
2816 .. 2816 A/G rs143404397 - CDS Nonsynonymous[Lys939Glu]
2833 .. 2833 T/C rs147437313 - CDS Synonymous[Ser944Ser]
2835 .. 2835 C/T rs148249654 - CDS Nonsynonymous[Pro945Leu]
2879 ^ 2880 -/C rs67581567 - CDS
2889 .. 2889 T/C rs2802269 - CDS Nonsynonymous[Val963Ala]
2898 .. 2898 G/A rs145018031 - CDS Nonsynonymous[Arg966Gln]
2910 .. 2910 G/T rs146538430 - CDS Nonsynonymous[Ser970Ile]
2918 .. 2918 C/T rs140582350 - CDS Synonymous[Leu973Leu]
2940 .. 2940 G/A rs142402392 - CDS Nonsynonymous[Ser980Asn]
2950 .. 2950 G/A rs56027641 - CDS Synonymous[Pro983Pro]
2976 .. 2976 T/C rs3795452 - 3'UTR
2977 .. 2977 C/T rs200292265 - 3'UTR
2984 .. 2984 C/T rs144798693 - 3'UTR
2999 .. 2999 G/A rs3795451 - 3'UTR
3062 .. 3062 T/C rs3795450 - 3'UTR
3084 .. 3084 A/C rs3795449 - 3'UTR
3105 .. 3105 G/A rs186210023 - 3'UTR
3260 .. 3260 C/T rs182064499 - 3'UTR
3319 .. 3319 A/T rs76236428 - 3'UTR
3367 .. 3367 T/C rs1045252 + 3'UTR
3368 .. 3368 G/C/CC/TG rs1062908 + 3'UTR
3368 .. 3368 G/C rs41314928 + 3'UTR
3386 .. 3386 C/A rs35189169 - 3'UTR
3435 ^ 3436 -/G rs35409537 - 3'UTR
3444 .. 3444 T/C rs15425 + 3'UTR
3461 .. 3461 C/T rs190446902 - 3'UTR
3483 .. 3483 T/A rs1801784 + 3'UTR
3536 .. 3536 C/T rs186460615 - 3'UTR
3645 .. 3645 C/T rs182042929 - 3'UTR
3875 .. 3875 T/A rs149839514 - 3'UTR
3940 .. 3940 G/A rs139998015 - 3'UTR
3941 .. 3941 A/G rs3795446 - 3'UTR
3975 .. 3975 T/G rs3795445 - 3'UTR
3981 ^ 3982 -/G rs35600383 - 3'UTR
4064 .. 4064 A/G rs1801783 + 3'UTR
4117 .. 4117 T/C rs113604509 - 3'UTR
4212 .. 4212 G/A rs141866072 - 3'UTR
4273 ^ 4274 -/C rs34133198 - 3'UTR
4424 .. 4424 A/G rs77506278 - 3'UTR
4515 .. 4515 C/G rs189444419 - 3'UTR
4632 .. 4632 C/T rs138298781 - 3'UTR
4688 .. 4688 G/A rs184630947 - 3'UTR
4848 .. 4848 T/C rs16846772 - 3'UTR
5047 .. 5047 T/G rs12741503 - 3'UTR
5061 .. 5061 C/T rs146341950 - 3'UTR
5093 .. 5093 G/C rs117021021 - 3'UTR
5095 .. 5095 C/T rs75106495 - 3'UTR
5179 .. 5179 T/C rs61833998 - 3'UTR
5264 ^ 5265 -/C rs34760775 - 3'UTR
5546 .. 5546 G/A rs2997438 + 3'UTR
5607 .. 5607 G/A rs138647710 - 3'UTR
5642 .. 5642 G/A rs143132234 - 3'UTR
5648 .. 5648 G/A rs149100908 - 3'UTR
5672 .. 5672 T/G rs111997356 - 3'UTR
5674 .. 5674 G/A rs138108319 - 3'UTR
5727 .. 5727 C/T rs150296308 - 3'UTR
5728 .. 5728 G/A rs180751392 - 3'UTR
5768 .. 5768 C/G rs115381746 - 3'UTR
5801 .. 5801 G/A rs189941160 - 3'UTR
5850 .. 5850 C/T rs1045285 + 3'UTR
5857 .. 5857 A/G rs3768431 - 3'UTR
5867 .. 5867 C/A rs1045286 + 3'UTR
5942 .. 5942 A/G rs1045287 + 3'UTR
5956 .. 5956 C/T rs2989946 + 3'UTR
6078 .. 6078 T/C rs72762309 - 3'UTR
6111 .. 6111 T/C rs59349491 - 3'UTR
6189 .. 6189 A/C rs184569762 - 3'UTR
6191 .. 6191 G/A rs1045289 + 3'UTR
6204 .. 6204 T/C rs1045290 + 3'UTR
6325 .. 6325 G/A rs192136646 - 3'UTR
6380 .. 6380 G/T rs113129804 - 3'UTR
6441 .. 6441 C/T rs147775745 - 3'UTR
6446 .. 6446 A/G rs74912293 - 3'UTR
6584 .. 6584 A/G rs115092897 - 3'UTR
6686 .. 6686 C/G rs187516567 - 3'UTR
6707 .. 6707 C/G rs184320519 - 3'UTR
6718 .. 6718 C/T rs79812796 - 3'UTR
6719 .. 6719 G/A rs144277377 - 3'UTR
6769 .. 6769 T/C rs11549694 - 3'UTR
6777 .. 6777 T/C rs3768425 - 3'UTR
6817 .. 6817 C/G rs142069826 - 3'UTR
6898 .. 6898 C/T rs151290005 - 3'UTR
6919 .. 6919 G/T rs192620915 - 3'UTR
7018 ^ 7019 -/GTT rs80259012 - 3'UTR
7019 ^ 7020 -/TGT/TG rs67424708 - 3'UTR
7020 ^ 7021 -/TGT rs3835713 - 3'UTR
7021 .. 7021 A/T rs201600801 - 3'UTR
7171 .. 7171 T/A rs1186 - 3'UTR
7202 .. 7202 T/C rs142426953 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MER5B 3697 3799 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer