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H-Invitational ID: HIT000000551 Accession number: AB020641 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Cyclin-dependent kinase 14.
 
 

Transcript original information
Accession number AB020641.1
CAGE tag ID NA
EST ID NA
Clone Number hj05353
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CLDN12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CLDN12);
Sequence data provider Provider:KDRI
Annotation project H-Invitational FLcDNA
Length of cDNA 4957[bp] (No. of exon:14)[A:1471 T:1493 G:1014 C:979]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type brain
Develpmental stage adult
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006831
Genomic location  G-integra Help Chromosome 7
Location 7q21.13
Position 90338712- 90839904
Strand +
Possible duplicated location(s) NA
Gene structure 14 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000062429
Predicted CDS 145..1500;  451[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.74
Database links RefSeq NP_036527
UniProt NA
CCDS CCDS5619

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000000551
H-Inv cluster ID Locus viewHIX0006831
Accession number AB020641.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Cyclin-dependent kinase 14.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_036527)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CLDN12
HGNC aliases NA
HGNC name claudin 12
DDBJ KIAA0834
UniProt NA
EC number EC 2.7.11.22cyclin-dependent kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000062429
No. of interaction 1
Interaction partner(s) HIP000022816
BIND NA
DIP NA
MINT NA
HPRD 00021;  00298;  00452;  00886;  01574;  01822;  03184;  04457;  05457;  06902;  10700; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
27 405 1nw1A 5e-42 7.8 345/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA101023; 
Affymetrix
GeneChip
HG-Focus 204604_at; 
HG-U133 204604_at;  211502_s_at; 
HG-U133A 204604_at;  211502_s_at; 
HG-U133A_2 204604_at;  211502_s_at; 
HG-U133B NA
HG-U133_Plus_2 204604_at;  211502_s_at; 
HG-U95 36502_at; 
HG-U95A 36502_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3012089;  3012090;  3012097;  3012098;  3012108;  3012120;  3012122;  3012127;  3012135;  3012141;  3012153;  3012158;  3012167;  3012168;  3012169;  3012170;  3012184;  3012185;  3060698;  3060789;  3060790; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P145889; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P145889;  A_24_P29733; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
110 .. 110 A/- rs67214827 + 5'UTR
134 .. 134 C/T rs200545348 + 5'UTR
136 .. 136 T/G rs201900265 + 5'UTR
139 .. 139 C/T rs11767691 + 5'UTR
151 .. 151 G/A rs200626528 + CDS Nonsynonymous[Gly3Ser]
164 .. 164 G/T rs16867927 + CDS Nonsynonymous[Cys7Phe]
181 .. 181 C/T rs200101624 + CDS Nonsynonymous[Pro13Ser]
183 .. 183 C/T rs201256227 + CDS Synonymous[Pro13Pro]
199 .. 199 G/C rs202007582 + CDS Nonsynonymous[Val19Leu]
199 ^ 200 -/G rs35395786 + CDS
239 .. 239 G/A rs140679817 + CDS Nonsynonymous[Arg32Gln]
273 .. 273 C/T rs144891494 + CDS Synonymous[Pro43Pro]
443 .. 443 A/G rs187133761 + CDS Nonsynonymous[His100Arg]
449 .. 449 G/A rs138436598 + CDS Nonsynonymous[Ser102Asn]
459 .. 459 G/A rs55722725 + CDS Synonymous[Ser105Ser]
533 .. 533 C/T rs148988868 + CDS Nonsynonymous[Thr130Ile]
537 .. 537 A/G rs145790847 + CDS Synonymous[Val131Val]
546 .. 546 G/A rs200795779 + CDS Synonymous[Gly134Gly]
609 .. 609 G/A rs138497570 + CDS Synonymous[Gly155Gly]
618 .. 618 C/T rs78919227 + CDS Synonymous[Phe158Phe]
667 .. 667 A/G rs146138173 + CDS Nonsynonymous[Ile175Val]
705 .. 705 G/A rs56269509 + CDS Synonymous[Thr187Thr]
771 .. 771 G/A/T rs55664580 + CDS
774 .. 774 G/A rs184702498 + CDS Synonymous[Leu210Leu]
786 .. 786 T/C rs141395840 + CDS Synonymous[Asn214Asn]
824 .. 824 C/G rs150860380 + CDS Nonsynonymous[Ser227Cys]
873 .. 873 C/T rs139294759 + CDS Synonymous[Asn243Asn]
915 .. 915 C/T rs202149959 + CDS Synonymous[Phe257Phe]
936 .. 936 C/T rs201386540 + CDS Synonymous[Ser264Ser]
959 .. 959 A/G rs202143669 + CDS Nonsynonymous[Asn272Ser]
961 .. 961 G/A rs144455762 + CDS Nonsynonymous[Glu273Lys]
973 .. 973 T/C rs147407359 + CDS Synonymous[Leu277Leu]
1012 .. 1012 G/C rs201692399 + CDS Nonsynonymous[Glu290Gln]
1119 .. 1119 A/G rs112955689 + CDS Synonymous[Glu325Glu]
1121 .. 1121 G/A rs139618090 + CDS Nonsynonymous[Arg326Gln]
1148 .. 1148 A/G rs145309096 + CDS Nonsynonymous[Asn335Ser]
1164 .. 1164 T/C rs199729119 + CDS Synonymous[Pro340Pro]
1225 .. 1225 C/T rs34419285 + CDS Nonsynonymous[Leu361Phe]
1226 .. 1226 T/G rs145058405 + CDS Nonsynonymous[Leu361Arg]
1253 .. 1253 A/G rs149042459 + CDS Nonsynonymous[Tyr370Cys]
1264 .. 1264 G/A rs112642464 + CDS Nonsynonymous[Ala374Thr]
1269 .. 1269 G/A rs114347546 + CDS Synonymous[Glu375Glu]
1317 .. 1317 G/A rs151182341 + CDS Synonymous[Ser391Ser]
1338 .. 1338 C/T rs56412135 + CDS Synonymous[His398His]
1363 .. 1363 C/G rs140184613 + CDS Nonsynonymous[Arg407Gly]
1366 .. 1366 C/G rs200612683 + CDS Nonsynonymous[Leu408Val]
1444 .. 1444 C/T rs145303395 + CDS Nonsynonymous[Arg434Trp]
1445 .. 1445 G/A rs74839397 + CDS Nonsynonymous[Arg434Gln]
1477 .. 1477 A/C rs35643773 + CDS Nonsynonymous[Ser445Arg]
1480 .. 1480 C/G rs199515743 + CDS Nonsynonymous[Leu446Val]
1490 .. 1490 G/A rs141334351 + CDS Nonsynonymous[Ser449Asn]
1519 .. 1519 G/T rs192554076 + 3'UTR
1692 .. 1692 C/T rs12538034 + 3'UTR
1764 .. 1764 G/A rs186946911 + 3'UTR
1769 .. 1769 T/C rs117606486 + 3'UTR
1824 .. 1824 G/A rs79425377 + 3'UTR
1864 .. 1864 A/- rs57373891 + 3'UTR
1893 .. 1893 C/A rs192257107 + 3'UTR
1965 .. 1965 C/A rs57094099 + 3'UTR
2018 .. 2018 T/C rs144273645 + 3'UTR
2034 .. 2034 A/C rs182871876 + 3'UTR
2044 .. 2044 C/T rs187761972 + 3'UTR
2142 .. 2142 G/A rs199596982 + 3'UTR
2164 .. 2164 G/A rs148336753 + 3'UTR
2213 .. 2213 T/C rs193211295 + 3'UTR
2265 .. 2265 A/G rs11771034 + 3'UTR
2398 .. 2398 C/G rs141408927 + 3'UTR
2575 .. 2575 C/T rs57055510 + 3'UTR
2655 .. 2655 C/T rs150812728 + 3'UTR
2790 .. 2790 G/T rs184400898 + 3'UTR
2883 .. 2883 C/A rs139897081 + 3'UTR
2886 .. 2886 A/T rs115756355 + 3'UTR
2904 .. 2904 C/A rs75278656 + 3'UTR
3059 .. 3059 T/G rs189356575 + 3'UTR
3155 .. 3155 C/G rs10274344 + 3'UTR
3227 .. 3227 A/C rs145279951 + 3'UTR
3351 .. 3351 G/T rs117668282 + 3'UTR
3411 .. 3411 G/C rs10274847 + 3'UTR
3425 .. 3425 A/C rs192242688 + 3'UTR
3501 .. 3501 G/C rs112230613 + 3'UTR
3503 .. 3503 G/A rs147228643 + 3'UTR
3582 .. 3582 A/G rs140485073 + 3'UTR
3595 .. 3595 G/C rs184302851 + 3'UTR
3614 .. 3614 T/C rs188648356 + 3'UTR
3660 .. 3660 G/A rs181757742 + 3'UTR
3666 .. 3666 G/A rs12534311 + 3'UTR
3757 .. 3757 G/C rs74331397 + 3'UTR
3760 ^ 3761 -/TC rs71733271 + 3'UTR
3761 ^ 3762 -/CT rs72454560 + 3'UTR
3772 ^ 3773 -/CT rs3841400 + 3'UTR
3773 .. 3773 G/C rs78047617 + 3'UTR
3775 .. 3775 C/G rs79441121 + 3'UTR
3797 .. 3797 C/G rs185913193 + 3'UTR
3917 .. 3917 G/A rs3814097 + 3'UTR
3920 .. 3920 C/G rs3814098 + 3'UTR
3933 .. 3933 A/G rs190426743 + 3'UTR
4176 .. 4176 G/A rs112279213 + 3'UTR
4200 .. 4200 A/G rs115148946 + 3'UTR
4335 .. 4335 T/C rs60682673 + 3'UTR
4357 .. 4357 G/A rs55696729 + 3'UTR
4461 .. 4461 T/C rs149731535 + 3'UTR
4497 .. 4497 C/T rs182252809 + 3'UTR
4552 .. 4552 T/- rs34622440 + 3'UTR
4650 .. 4650 C/A rs114813205 + 3'UTR
4702 ^ 4703 -/T rs11406790 + 3'UTR
4709 ^ 4710 -/T rs34658897 + 3'UTR
4717 ^ 4718 -/T/TT/TTT rs35145764 + 3'UTR
4718 .. 4718 G/T rs200323989 - 3'UTR
4718 ^ 4719 -/T/TTT rs67505260 + 3'UTR
4770 .. 4770 C/T rs17648 + 3'UTR
4789 .. 4789 A/G rs78870345 + 3'UTR
4802 .. 4802 T/G rs145508457 + 3'UTR
4858 .. 4858 G/T rs15322 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer