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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000003982 Accession number: AK001508 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC=1.5.1.2;
 
 

Transcript original information
Accession number AK001508.1
CAGE tag ID NA
EST ID NA
Clone Number NT2RP2005773
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PYCR2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PYCR2);
Sequence data provider Project:FLJ; Provider:FLJ/HRI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 3149[bp] (No. of exon:5)[A:677 T:721 G:910 C:841]
Devision HUM
Molecular type mRNA
Library origin Cell type teratocarcinoma
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001639
Genomic location  G-integra Help Chromosome 1
Location 1q42.12
Position 226107578- 226111978
Strand -
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29920
KEGG GENES KEGG GENES(29920)
GeneCard GeneCardPYCR2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000437793
Predicted CDS 1928..2572;  214[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.795

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000003982
H-Inv cluster ID Locus viewHIX0001639
Accession number AK001508.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC=1.5.1.2;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q04708)  [Identity/coverage = 52.288%/56.04%] to Pisum sativum (Garden pea). protein.
Experimental evidence Protein evidence
PubMed ID 11537868ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol PYCR2
HGNC aliases NA
HGNC name pyrroline-5-carboxylate reductase family, member 2
DDBJ NA
UniProt PROC
EC number EC 1.5.1.2pyrroline-5-carboxylate reductase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00220 :Urea cycle and metabolism of amino groups;  00330 :Arginine and proline metabolism; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000437793
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29920
KEGG GENES KEGG GENES(29920)
GeneCard GeneCardPYCR2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  cytosol;  nuclear; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
2 55 1yqgA2 3e-11 16.7 54/152 c.2.1.6
55 159 1yqgA1 1e-30 26.7 105/111 a.100.1.10
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA250216; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 224855_at;  231715_s_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 224855_at;  231715_s_at; 
HG-U133_Plus_2 224855_at;  231715_s_at; 
HG-U95 49025_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 49025_at; 
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2383023;  2383025;  2383026;  2458608;  2458609;  2458610;  2458612;  2458613;  2458614;  2458615;  2458616;  2458617;  2458621;  2458622;  2458623; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P149042; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P149042;  A_24_P165259; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
9 .. 9 G/C rs112979418 - 5'UTR
34 .. 34 A/G rs77157663 + 5'UTR
42 .. 42 C/G/T rs11543045 + 5'UTR
53 .. 53 C/A rs28364597 + 5'UTR
171 .. 171 G/A rs11543043 + 5'UTR
237 .. 237 C/T rs11543044 + 5'UTR
283 .. 283 C/T/A rs146858362 - 5'UTR
303 .. 303 C/G rs144950490 - 5'UTR
396 .. 396 A/T rs114393808 - 5'UTR
478 .. 478 T/G rs148877414 - 5'UTR
604 .. 604 T/A rs192420445 - 5'UTR
617 .. 617 A/G rs187943072 - 5'UTR
683 .. 683 C/T rs184160525 - 5'UTR
693 .. 693 C/T rs71646756 - 5'UTR
694 .. 694 T/A rs146740046 - 5'UTR
695 .. 695 C/A rs2897451 - 5'UTR
746 .. 746 G/A rs75128454 - 5'UTR
768 .. 768 T/- rs35269575 - 5'UTR
845 .. 845 G/A rs192927521 - 5'UTR
855 .. 855 C/T rs187172227 - 5'UTR
959 .. 959 A/G rs183183629 - 5'UTR
1146 .. 1146 G/A rs190583285 - 5'UTR
1147 .. 1147 G/A rs188016391 - 5'UTR
1148 .. 1148 T/C rs184130808 - 5'UTR
1209 .. 1209 A/G rs144765601 - 5'UTR
1239 .. 1239 G/A rs141144947 - 5'UTR
1329 .. 1329 C/T rs116173737 - 5'UTR
1359 .. 1359 A/T rs191848863 - 5'UTR
1464 .. 1464 C/T rs10915898 - 5'UTR
1537 .. 1537 G/T rs72754998 - 5'UTR
1599 .. 1599 G/A rs113802383 - 5'UTR
1645 .. 1645 C/T rs149894811 - 5'UTR
1677 .. 1677 C/T rs149882706 - 5'UTR
1678 .. 1678 G/A rs150712428 - 5'UTR
1693 .. 1693 G/C rs138993893 - 5'UTR
1723 .. 1723 G/T rs202095611 - 5'UTR
1737 ^ 1738 -/C rs35240460 - 5'UTR
1759 .. 1759 G/A rs200064314 - 5'UTR
1773 .. 1773 G/A rs148023221 - 5'UTR
1827 .. 1827 C/T rs151170973 - 5'UTR
1828 .. 1828 C/T rs201013764 - 5'UTR
1851 .. 1851 C/T rs186126795 - 5'UTR
1853 .. 1853 C/T rs201482601 - 5'UTR
1872 .. 1872 G/A rs142139864 - 5'UTR
1903 .. 1903 C/A rs74150559 - 5'UTR
1947 .. 1947 C/G rs199719275 - CDS Nonsynonymous[Pro7Arg]
1965 .. 1965 G/T rs149587849 - CDS Nonsynonymous[Arg13Leu]
2008 .. 2008 A/G rs112885589 - CDS Synonymous[Thr27Thr]
2024 .. 2024 A/C rs200663855 - CDS Nonsynonymous[Thr33Pro]
2025 .. 2025 C/G rs191605313 - CDS Nonsynonymous[Thr33Ser]
2054 .. 2054 C/T rs139028833 - CDS Synonymous[Leu43Leu]
2064 .. 2064 T/C rs112160559 - CDS Nonsynonymous[Leu46Pro]
2075 .. 2075 G/A rs145139251 - CDS Nonsynonymous[Val50Met]
2137 .. 2137 C/G rs201440840 - CDS Nonsynonymous[Ser70Arg]
2159 .. 2159 G/A rs142577088 - CDS Nonsynonymous[Ala78Thr]
2170 .. 2170 A/T rs145493247 - CDS Synonymous[Ala81Ala]
2207 .. 2207 C/T rs199945116 - CDS Nonsynonymous[Arg94Cys]
2210 .. 2210 C/T rs56362902 - CDS Synonymous[Leu95Leu]
2216 .. 2216 A/G rs201142342 - CDS Nonsynonymous[Ile97Val]
2219 .. 2219 C/T rs113324645 - CDS AA-STOP[Gln98*]
2224 .. 2224 C/T rs55803945 - CDS Synonymous[Leu99Leu]
2248 .. 2248 T/C rs200949659 - CDS Synonymous[Ala107Ala]
2284 .. 2284 C/G rs150765933 - CDS Nonsynonymous[Cys119Trp]
2285 .. 2285 C/T rs201784173 - CDS AA-STOP[Gln120*]
2320 .. 2320 C/A rs148117976 - CDS Synonymous[Ala131Ala]
2362 .. 2362 C/T rs138792831 - CDS Synonymous[Arg145Arg]
2410 .. 2410 G/A rs200057700 - CDS Synonymous[Glu161Glu]
2443 .. 2443 C/G rs201007176 - CDS Synonymous[Ser172Ser]
2450 .. 2450 G/A rs201700928 - CDS Nonsynonymous[Ala175Thr]
2527 .. 2527 G/A rs73131849 - CDS Synonymous[Gly200Gly]
2533 .. 2533 C/G rs181648767 - CDS Synonymous[Leu202Leu]
2550 .. 2550 C/G rs117063721 - CDS Nonsynonymous[Ala208Gly]
2625 .. 2625 G/A rs111299811 - 3'UTR
2631 .. 2631 G/C rs56035614 - 3'UTR
2735 .. 2735 G/C rs184229686 - 3'UTR
2807 .. 2807 G/A rs75484905 - 3'UTR
2898 ^ 2899 -/G rs34126730 - 3'UTR
2936 .. 2936 G/C rs1065727 + 3'UTR
2940 .. 2940 A/G rs14868 - 3'UTR
3049 .. 3049 G/A rs11550734 - 3'UTR
3063 .. 3063 T/G rs182441677 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MIR 532 596 +
AluSx1 599 879 -
MIRb 894 995 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer