H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000008578 Accession number: AK025304 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Inositol-trisphosphate 3-kinase B; EC=2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B;
 
 

Transcript original information
Accession number AK025304.1
CAGE tag ID NA
EST ID NA
Clone Number COL08540
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ITPKB) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ITPKB);
Sequence data provider Project:FLJ; Provider:FLJ/IMSUT
Annotation project H-Invitational FLcDNA
Length of cDNA 2404[bp] (No. of exon:1)[A:514 T:561 G:645 C:684]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type colon
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 2383(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001645
Genomic location  G-integra Help Chromosome 1
Location 1q42.12
Position 226826773- 226829156
Strand -
Possible duplicated location(s) NA
Gene structure 1 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3707
KEGG GENES KEGG GENES(3707)
GeneCard GeneCardITPKB*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000083552
Predicted CDS 1521..2036;  171[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.808

Motif information
ORF

length(171),orf(1521:2036)
MPFTPPGLSYHCSLAWGCQRHPLRSPVSGHRAGSPLLCTPPPCAIRGHLG
ASTGPAPGSDGARLLCGVGWVRTVSARGSLLTPSWVGCSLSQKEDGTVNR
DFKKTKTREQVTEAFREFTKGNHNILVSLAPPERVSPASQGGTTVSTLEV
PMGRTRHPQGQHTPARVRRAL*
a.a.
length
InterPro Name
length(37), motif(92:128) 37 IPR005522 Inositol polyphosphate kinase [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000008578
H-Inv cluster ID Locus viewHIX0001645
Accession number AK025304.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Inositol-trisphosphate 3-kinase B; EC=2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P27987)  [Identity/coverage = 91.892%/3.91%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 1654894118464191548933416710414180880871866964819690332ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ITPKB
HGNC aliases "inositol 1,4,5-trisphosphate 3-kinase B"
HGNC name inositol-trisphosphate 3-kinase B
DDBJ NA
UniProt ITPKB
EC number EC 2.7.1.127inositol-trisphosphate 3-kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00562 :Inositol phosphate metabolism;  04020 :Calcium signaling pathway;  04070 :Phosphatidylinositol signaling system; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000083552
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3707
KEGG GENES KEGG GENES(3707)
GeneCard GeneCardITPKB*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function inositol trisphosphate 3-kinase activity (GO:0008440); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  nuclear;  cytosol;  peroxisome; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
92 129 1tzdA 5e-09 44.7 38/243 d.143.1.3
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB170115; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 232499_at;  232526_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 232499_at;  232526_at; 
HG-U133_Plus_2 232499_at;  232526_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2383222;  2458930;  2458931;  2458932;  2458933;  2458934;  3038352; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
95 .. 95 A/T rs148168791 - 5'UTR
260 .. 260 A/G rs143630849 - 5'UTR
356 .. 356 C/T rs148934692 - 5'UTR
559 .. 559 G/A rs187208271 - 5'UTR
642 .. 642 G/A rs111777018 - 5'UTR
820 .. 820 G/C rs79415734 - 5'UTR
866 .. 866 C/T rs184126166 - 5'UTR
1035 .. 1035 C/G rs3729551 - 5'UTR
1118 .. 1118 T/C rs1288934 + 5'UTR
1180 .. 1180 G/T rs143299645 - 5'UTR
1322 .. 1322 G/A rs143731600 - 5'UTR
1407 .. 1407 G/A rs3768368 - 5'UTR
1408 .. 1408 G/C rs191846055 - 5'UTR
1427 .. 1427 A/G rs115869337 - 5'UTR
1537 .. 1537 C/T rs4653458 - CDS Nonsynonymous[Pro6Leu]
1636 .. 1636 C/T rs1288933 + CDS Nonsynonymous[Thr39Met]
1645 .. 1645 C/T rs188989882 - CDS Nonsynonymous[Pro42Leu]
1657 .. 1657 G/A rs115803447 - CDS Nonsynonymous[Arg46His]
1664 .. 1664 C/A rs141006067 - CDS Nonsynonymous[His48Gln]
1787 .. 1787 T/C rs182672721 - CDS Synonymous[Ser89Ser]
1805 .. 1805 C/T rs112559528 - CDS Synonymous[Asp95Asp]
1830 .. 1830 A/G rs189824231 - CDS Nonsynonymous[Lys104Glu]
1841 .. 1841 G/A rs116826768 - CDS Synonymous[Thr107Thr]
1856 .. 1856 C/T rs56308606 - CDS Synonymous[Thr112Thr]
1890 .. 1890 A/G rs142841950 - CDS Nonsynonymous[Asn124Asp]
1895 .. 1895 C/T rs199794306 - CDS Synonymous[Ile125Ile]
1898 .. 1898 G/C rs140734599 - CDS Synonymous[Leu126Leu]
2016 .. 2016 C/T rs185852300 - CDS AA-STOP[Arg166*]
2017 .. 2017 G/A rs181110223 - CDS Nonsynonymous[Arg166Gln]
2074 .. 2074 C/T rs12030997 - 3'UTR
2206 .. 2206 T/C rs190730974 - 3'UTR
2325 .. 2325 A/G rs144102283 - 3'UTR
2381 ^ 2382 -/A/AA rs34013007 - 3'UTR
2382 ^ 2383 -/A/AA rs34561047 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
AluSq2 2099 2404 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer