H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000031553 Accession number: BC003410 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: NTF2-related export protein 1; Protein p15;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC003410.1 CAGE tag ID NA EST ID NA Clone Number MGC:4978 IMAGE:3450767 Experimental resources   NBRC ; HGPD ; Antibody (NXT1) ; Catalog (NXT1); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 1176[bp] (No. of exon:2)[A:294 T:257 G:316 C:309] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Placenta, choriocarcinoma Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1118(+) Signal: 1096-1100(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GGCTGACTTCGCTGCCCGTCACGGGAATGCGGGAGAGGGCGGCGCCGGGG CGCTCGCGTCTGCGTGGAGACCGGCTGGCCGCGCGCGGGAAGCCGCGGAA CTGCGCCGGAAAGTCCCCCGGCTCTGGGGCCCCGGTGACCCAGAGTAAGC CTCCAAGAAGGAGGAGGAGGAGAGAAAGGCGGCTCTTCCCGTGCCCCTAC CAGAGGCTTCGGTGGGCCCACCTTGTGACCTCCGCGGCCGGCCCCTCAGT GGAACTGCGTCCCACGCGGGGGGCGTCCCGACCGTGGGGGCCGCGGCCCG CGCTGACCCTGGACGTCGCCGCGCAGCCCCTGGTTCCCCAAGGCAGAGGA AATACCCTGGTGGAGCCCTCCTTCCATAGAACCAGAGATGGCATCTGTGG ATTTCAAGACCTATGTGGATCAGGCCTGCAGAGCTGCTGAGGAGTTTGTC AATGTCTACTACACCACCATGGATAAGCGGCGGCGTTTGCTGTCCCGCCT GTACATGGGCACAGCCACCCTGGTCTGGAATGGCAATGCTGTTTCAGGAC AAGAATCCTTGAGTGAGTTTTTTGAAATGTTGCCTTCCAGCGAGTTCCAA ATCAGCGTGGTAGACTGCCAGCCTGTTCATGATGAAGCCACACCAAGCCA GACCACGGTCCTTGTTGTCATCTGTGGATCAGTGAAGTTTGAGGGGAACA AACAACGGGACTTCAACCAGAACTTCATCCTGACCGCCCAGGCCTCACCC AGCAACACAGTGTGGAAGATCGCAAGTGACTGCTTCCGCTTCCAGGACTG GGCCAGCTAGTGGGGGTGGCAGAGGTCTCTTTGCTTCATTCAGCCCTAGC TCTGTAGAGAAATGCAAACCTCGACTCTCAAGGATGTGAGGAACACAAGT TCATTTCTGTTGTTGCGGAGACACTGCAGACTCCACTGTGCCGAGGTTGA ACTCTTTTTTGTTGCTCAAGTTCTAGGAGTCCCTTTCCTGAATATATACT TGTTTGTCATAGTTTCCTTTTCAAAGTAGTAAACTTTTCTATTTTTCTAC TTGCCCAGTAGAGACTCTGATTCTGGAAATTCTGACAAATAATTTAATAA TACACATGTTGCTTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0015690
Genomic location	Chromosome	20
	Location	20p11.21
	Position	23331373- 23335408
	Strand	+
Possible duplicated location(s)		NA
Gene structure		2 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:29107;
	KEGG GENES	KEGG GENES(29107);
	GeneCard	NXT1;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000034948 Predicted CDS 388..810;  140[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.81 Database links RefSeq NP_037380;  UniProt Q9UKK6;  CCDS CCDS13150;

MASVDFKTYVDQACRAAEEFVNVYYTTMDKRRRLLSRLYMGTATLVWNGN AVSGQESLSEFFEMLPSSEFQISVVDCQPVHDEATPSQTTVLVVICGSVK FEGNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAS*

Motif information

	a.a. length	InterPro	Name
	120	IPR018222	Nuclear transport factor 2, eukaryote [Domain]
	119	IPR002075	Nuclear transport factor 2 [Domain]

Gene function information

H-Inv ID		HIT000031553
H-Inv cluster ID		HIX0015690
Accession number		BC003410.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Protein coding;
Definition		NTF2-related export protein 1; Protein p15;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (Q9UKK6)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		10567585;  10848583;  11259602;  11583626;  11780052;  15489334;  19165146;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NXT1
	HGNC aliases	"NTX2-like export factor1", "NTF2-like export factor 1"
	HGNC name	nuclear transport factor 2-like export factor 1
	DDBJ	NXT1
	UniProt	NXT1
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000034948
	No. of interaction	9
	Interaction partner(s)	HIP000031815;  HIP000033751;  HIP000039542;  HIP000039637;  HIP000063375;  HIP000087211;  HIP000101437;  HIP000115316;  HIP000361677;
	BIND	98981;  98982;
	DIP	115968E;
	MINT	MINT-25019;  MINT-67669;  MINT-68466;  MINT-7040261;
	HPRD	02260;  02261;  03109;  03975;  04035;  04116;  09168;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:29107;
	KEGG GENES	KEGG GENES(29107);
	GeneCard	NXT1;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	transport (GO:0006810);
Cellular component	intracellular (GO:0005622);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;  cytosol;  extracellular;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 2 140 1jkgA 1e-36 100.0 139/139 d.17.4.2

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsC051223;
	Affymetrix GeneChip	HG-Focus	218708_at;
		HG-U133	218708_at;
		HG-U133A	218708_at;
		HG-U133A_2	218708_at;
		HG-U133B	NA
		HG-U133_Plus_2	218708_at;
		HG-U95	48836_s_at;  64041_at;
		HG-U95A	NA
		HG-U95B	48836_s_at;
		HG-U95C	64041_at;
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3510429;  3510430;  3510431;  3510433;  3880177;  3880178;  3880179;  3880180;  3880181;  3880184;  3880185;  3880186;  3880187;  3880188;  3901167;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P251695;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P251695;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Evolutionary information

Last modified:27-May-2015

Relationship	Species	Accession number	MGI	Links
Orthology	Bos sp. (Cow)	BC112489		G-integra
Orthology	Danio sp. (Zebrafish)	BC122134		G-integra
Orthology	Tetraodon sp. (Tetraodon)	CR706647		G-integra
Orthology	Mus sp. (Mouse)	ENSMUST00000109961		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000012504		G-integra
Orthology	Takifugu sp. (Fugu)	SINFRUT00000135058		G-integra
Orthology	Rattus sp. (Rat)	XM_001057228		G-integra
Orthology	Pan sp. (Chimpanzee)	XM_001146149		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001372109		G-integra
Orthology	Canis sp. (Dog)	XM_534323		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 57 .. 57 C/A rs142868260 + 5'UTR 77 .. 77 G/C rs151073152 + 5'UTR 242 .. 242 C/G rs189848672 + 5'UTR 367 .. 367 C/T rs202108278 + 5'UTR 444 .. 444 G/A rs34105430 - CDS Synonymous[Glu19Glu] 452 .. 452 A/G rs149042553 + CDS Nonsynonymous[Asn22Ser] 462 .. 462 C/T rs142050922 + CDS Synonymous[Tyr25Tyr] 490 .. 490 C/T rs41282288 + CDS Synonymous[Leu35Leu] 492 .. 492 G/C rs201558944 + CDS Synonymous[Leu35Leu] 505 .. 505 A/G rs140297530 + CDS Nonsynonymous[Met40Val] 605 .. 605 G/A rs145307350 + CDS Nonsynonymous[Ser73Asn] 723 .. 723 C/A rs6114063 + CDS Nonsynonymous[Asn112Lys] 735 .. 735 C/G rs143714669 + CDS Synonymous[Thr116Thr] 831 .. 831 T/C rs201704168 + 3'UTR 840 .. 840 T/C rs113253216 + 3'UTR 954 .. 954 C/T rs1046125 + 3'UTR 961 .. 961 G/T rs1046128 + 3'UTR 1008 .. 1008 C/T rs2683 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;