H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000036281 Accession number: BC013572 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to GTPase KRas isoform b precursor.

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Transcript original information Accession number BC013572.2 CAGE tag ID NA EST ID NA Clone Number MGC:8977 IMAGE:3878884 Experimental resources   NBRC ; HGPD ; Antibody (KRAS) ; Catalog (KRAS); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 1333[bp] (No. of exon:5)[A:407 T:404 G:295 C:227] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Lung, large cell carcinoma Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1319(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCCCCCGC CATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGG GCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATG ACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGC CTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAA CAATAGAGGATTCCTACAGGAAGCAAGTAGTAATTGATGGAGAAACCTGT CTCTTGGATATTCTCGACACAGCAGGTCATGAGGAGTACAGTGCAATGAG GGACCAGTACATGAGGACTGGGGAGGGCTTTCTTTGTGTATTTGCCATAA ATAATACTAAATCATTTGAAGATATTCACCATTATAGAGAACAAATTAAA AGAGTTAAGGACTCTGAAGATGTACCTATGGTCCTAGTAGGAAATAAATG TGATTTGCCTTCTAGAACAGTAGACACAAAACAGGCTCAGGACTTAGCAA GAAGTTATGGAATTCCTTTTATTGAAACATCAGCAAAGACAAGACAGGGT GTTGATGATGCCTTCTATACATTAGTTCGAGAAATTCGAAAACATAAAGA AAAGATGAGCAAAGATGGTAAAAAGAAGAAAAAGAAGTCAAAGACAAAGT GTGTAATTATGTAAATACAATTTGTACTTTTTTCTTAAGGCATACTAGTA CAAGTGGTAATTTTTGTACATTACACTAAATTATTAGCATTTGTTTTAGC ATTACCTAATTTTTTTCCTGCTCCATGCAGACTGTTAGCTTTTACCTTAA ATGCTTATTTTAAAATGACAGTGGAAGTTTTTTTTTCCTCGAAGTGCCAG TATTCCCAGAGTTTTGGTTTTTGAACTAGCAATGCCTGTGAAAAAGAAAC TGAATACCTAAGATTTCTGTCTTGGGGTTTTTGGTGCATGCAGTTGATTA CTTCTTATTTTTCTTACCAATTGTGAATGTTGGTGTGAAACAAATTAATG AAGCTTTTGAATCATCCCTATTCTGTGTTTTATCTAGTCACATAAATGGA TTAATTACTAATTTCAGTTGAGACCTTCTAATTGGTTTTTACTGAAACAT TGAGGGAACACAAATTTATGGGCTTCCTGATGATGATTCTTCTAGGCATC ATGTCCTATAGTTTGTCATCCCTGACGAATGTAAAGTTACACTGTTCACA AAGGTTTTGTCTCCTTTCCACTGCTATTAGTCATGGTCACTCTCCCCAAA ATATTATATTTTTTCTATAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0201882
Genomic location	Chromosome	12
	Location	12p12.1
	Position	25362124- 25403820
	Strand	-
Possible duplicated location(s)		NA
Gene structure		5 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3845;
	KEGG GENES	KEGG GENES(3845);
	GeneCard	KRAS;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000106179 Predicted CDS 148..714;  188[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.695

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET CLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ GVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM*

Motif information

	a.a. length	InterPro	Name
	166	IPR020849	Small GTPase superfamily, Ras type [Family]
	188	IPR020849	Small GTPase superfamily, Ras type [Family]
	159	IPR005225	Small GTP-binding protein domain [Domain]
	179	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	163	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	22	IPR001806	Small GTPase superfamily [Family]
	160	IPR001806	Small GTPase superfamily [Family]
	17	IPR001806	Small GTPase superfamily [Family]
	23	IPR001806	Small GTPase superfamily [Family]
	14	IPR001806	Small GTPase superfamily [Family]
	23	IPR001806	Small GTPase superfamily [Family]

Gene function information

H-Inv ID		HIT000036281
H-Inv cluster ID		HIX0201882
Accession number		BC013572.2
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to GTPase KRas isoform b precursor.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_004976)  [Identity/coverage = 99.468%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	KRAS
	HGNC aliases	"v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog", "v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog"
	HGNC name	Kirsten rat sarcoma viral oncogene homolog
	DDBJ	KRAS
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000106179
	No. of interaction	2
	Interaction partner(s)	HIP000027976;  HIP000103557;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	00241;  00242;  00243;  00607;  00608;  01045;  01243;  01265;  01517;  03135;  03371;  04144;  06117;  09278;  11763;  15218;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3845;
	KEGG GENES	KEGG GENES(3845);
	GeneCard	KRAS;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	GTP binding (GO:0005525);
Biological process	small GTPase mediated signal transduction (GO:0007264);  signal transduction (GO:0007165);
Cellular component	membrane (GO:0016020);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	mitochondria;  endoplasmic;  cytosol;  nuclear;  peroxisome;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 1 164 121pA 4e-50 88.4 164/166 c.37.1.8

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsB220218;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	214352_s_at;
		HG-U133A	214352_s_at;
		HG-U133A_2	214352_s_at;
		HG-U133B	NA
		HG-U133_Plus_2	214352_s_at;
		HG-U95	32159_at;
		HG-U95A	32159_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2910949;  2910952;  3408597;  3408599;  3408615;  3447874;  3447879;  3447880;  3447884;  3447886;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P45140;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P45140;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:27-May-2015

Disease relation		Disease name: Bladder cancer (109800);  Disease name: Breast cancer, somatic (114480);  Disease name: Costello syndrome (218040);  Disease name: Lung cancer (211980);  Disease name: Noonan syndrome 3 (609942);  Disease name: Pancreatic carcinoma, somatic (260350);  Disease name: Stomach cancer (137215);
Related information in OMIM		OMIM ID:  190070;  Title: V-KI-RAS2 KIRSTEN RAT SARCOMA VIRAL ONCOGENE HOMOLOG
Co-localized orphan diseases		NA
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(3845)
	Disease	Entrez Gene ID:(3845)
	Substance	Entrez Gene ID:(3845)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 26 .. 26 C/T rs61759617 + 5'UTR 160 .. 160 A/G rs193929331 + CDS Nonsynonymous[Lys5Glu] 162 .. 162 A/T rs104894361 + CDS Nonsynonymous[Lys5Asn] 171 .. 171 A/G rs147406419 - CDS Synonymous[Val8Val] 181 .. 181 G/A/C/T rs121913530 + CDS 182 .. 182 G/A/C/T rs121913529 + CDS 184 .. 184 G/A/C/T rs121913535 + CDS 185 .. 185 G/T/C/A rs112445441 - CDS 187 .. 187 G/A rs104894365 + CDS Nonsynonymous[Val14Ile] 204 .. 204 G/T rs121913538 + CDS Nonsynonymous[Leu19Phe] 211 .. 211 C/A rs121913236 + CDS Nonsynonymous[Gln22Lys] 237 .. 237 C/T rs113623140 - CDS Synonymous[Asp30Asp] 248 .. 248 C/G rs104894366 + CDS Nonsynonymous[Pro34Arg] 320 .. 320 C/T rs104894364 + CDS Nonsynonymous[Thr58Ile] 322 .. 322 G/A rs121913528 + CDS Nonsynonymous[Ala59Thr] 323 .. 323 C/T rs104886029 + CDS Nonsynonymous[Ala59Val] 325 .. 325 G/A/C rs104894359 + CDS 328 .. 328 C/A/G rs121913238 + CDS 329 .. 329 A/C/G/T rs121913240 + CDS 330 .. 330 T/A/C rs17851045 + CDS 345 .. 345 A/G rs200229810 - CDS Synonymous[Ala66Ala] 363 .. 363 G/A rs104886028 + CDS Nonsynonymous[Met72Ile] 366 .. 366 G/A rs104886027 + CDS Synonymous[Arg73Arg] 494 .. 494 A/G rs202247812 + CDS Nonsynonymous[Asn116Ser] 570 .. 570 T/A rs138669124 - CDS Nonsynonymous[Phe141Leu] 583 .. 583 G/A rs121913527 + CDS Nonsynonymous[Ala146Thr] 602 .. 602 T/G rs104894367 + CDS Nonsynonymous[Val152Gly] 605 .. 605 A/T rs104894360 + CDS Nonsynonymous[Asp153Val] 615 .. 615 C/G rs104894362 + CDS Nonsynonymous[Phe156Leu] 666 .. 666 T/A/C rs1137282 + CDS 891 .. 891 G/T rs712 + 3'UTR 907 .. 907 C/T rs150334904 - 3'UTR 978 .. 978 T/C rs4285970 - 3'UTR 1021 .. 1021 T/G rs1141947 + 3'UTR 1118 .. 1118 T/C rs140080026 - 3'UTR 1214 .. 1214 T/C rs61763588 + 3'UTR 1226 .. 1226 C/T rs9266 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;