H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000036626 Accession number: BC014300 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4;
 
 

Transcript original information
Accession number BC014300.1
CAGE tag ID NA
EST ID NA
Clone Number IMAGE:3938651
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CTNNBIP1) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CTNNBIP1);
Sequence data provider Provider:MGC/NCI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 1163[bp] (No. of exon:5)[A:281 T:258 G:318 C:306]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Lung, small cell carcinoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1116(+)
Vector/adapter sequence GGCACGAG(G) [1- 8]
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0000110
Genomic location  G-integra Help Chromosome 1
Location 1p36.22
Position 9910167- 9970296
Strand -
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:56998; 
KEGG GENES KEGG GENES(56998); 
GeneCard GeneCardCTNNBIP1;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000081362
Predicted CDS 262..507;  81[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.815
Database links RefSeq NP_001012329;  NP_064633; 
UniProt Q9NSA3; 
CCDS CCDS106; 

Motif information
ORF

length(81),orf(262:507) MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNS QLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ* 		a.a.
length		 InterPro Name
length(81), motif(1:81) 81 IPR009428 Beta-catenin-interacting ICAT [Domain]
length(54), motif(1:54) 54 IPR009428 Beta-catenin-interacting ICAT [Domain]
length(68), motif(6:73) 68 IPR009428 Beta-catenin-interacting ICAT [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000036626
H-Inv cluster ID Locus viewHIX0000110
Accession number BC014300.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9NSA3)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 10898789;  12408824;  12408825;  15489334;  16710414;  21269460;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CTNNBIP1
HGNC aliases "catenin, beta-interacting protein 1"
HGNC name catenin, beta interacting protein 1
DDBJ CTNNBIP1
UniProt CTNNBIP1
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000081362
No. of interaction 28
Interaction partner(s) HIP000021902;  HIP000024154;  HIP000024154;  HIP000032546;  HIP000032986;  HIP000033699;  HIP000035519;  HIP000035999;  HIP000050802;  HIP000050802;  HIP000053073;  HIP000055848;  HIP000062592;  HIP000062592;  HIP000072401;  HIP000082038;  HIP000082038;  HIP000085171;  HIP000085171;  HIP000089312;  HIP000099143;  HIP000099978;  HIP000103713;  HIP000103713;  HIP000112664;  HIP000117215;  HIP000141598;  HIP000199955; 
BIND 108640;  108663; 
DIP 112381E;  112479E;  113409E;  113904E;  114001E;  114108E;  114451E;  115811E;  116257E;  117361E;  65172E; 
MINT MINT-58679;  MINT-68465; 
HPRD 00228;  00286;  00684;  01414;  01439;  01567;  02020;  02309;  03751;  04915;  07756;  16184; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:56998; 
KEGG GENES KEGG GENES(56998); 
GeneCard GeneCardCTNNBIP1;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function beta-catenin binding (GO:0008013); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  extracellular; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
5 75 1lujB 2e-27 94.4 71/71 a.161.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsB021002; 
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 33217_at; 
HG-U95A 33217_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2319508;  2319509;  2395966;  2395967;  2395968;  2395981;  2395982;  2395987;  2396007; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
69 .. 69 G/T rs190756141 - 5'UTR
253 .. 253 G/T/A rs11555522 - 5'UTR
258 .. 258 G/A rs191807977 - 5'UTR
268 .. 268 C/T rs147067665 - CDS Nonsynonymous[Arg3Cys]
269 .. 269 G/T rs150360638 - CDS Nonsynonymous[Arg3Leu]
282 .. 282 C/G rs200381818 - CDS Synonymous[Pro7Pro]
283 .. 283 G/A rs113935062 - CDS Nonsynonymous[Gly8Arg]
294 .. 294 G/A rs139825449 - CDS Synonymous[Pro11Pro]
333 .. 333 C/T rs146431873 - CDS Synonymous[Leu24Leu]
357 .. 357 C/T rs200258284 - CDS Synonymous[Asn32Asn]
381 .. 381 C/T rs12062756 - CDS Synonymous[Phe40Phe]
386 .. 386 G/A rs201081336 - CDS Nonsynonymous[Arg42His]
387 .. 387 C/A rs139942394 - CDS Synonymous[Arg42Arg]
447 .. 447 G/T rs138271667 - CDS Nonsynonymous[Gln62His]
488 .. 488 C/T rs199900946 - CDS Nonsynonymous[Thr76Met]
510 .. 510 G/T rs113027301 - 3'UTR
537 .. 537 T/C rs189391503 - 3'UTR
608 .. 608 C/G rs1132236 + 3'UTR
624 .. 624 C/T rs71643073 - 3'UTR
685 .. 685 A/T rs111405549 - 3'UTR
750 .. 750 A/T rs1052434 + 3'UTR
819 .. 819 G/A rs141822086 - 3'UTR
861 .. 861 G/C rs180922155 - 3'UTR
872 .. 872 G/T rs112637865 - 3'UTR
924 ^ 925 -/G rs200614855 - 3'UTR
925 .. 925 G/A rs72633900 - 3'UTR
926 .. 926 A/T rs935072 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;