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H-Invitational ID: HIT000037620 Accession number: BC016661 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Butyrophilin subfamily 2 member A1; Precursor;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC016661.1 CAGE tag ID NA EST ID NA Clone Number MGC:17033 IMAGE:4340392 Experimental resources   NBRC ; HGPD ; Antibody (BTN2A1) ; Catalog (BTN2A1); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 3129[bp] (No. of exon:8)[A:835 T:732 G:823 C:739] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Lymph, lymphoma Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 3114(+) Signal: 3091-3095(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

CGTTTCCTGCATCTCCAAACATGGCGACCTAGGAGAAAGGGAAGAACAAT TTTTTCTCCTCTTTTGGGAAGGTTTGCGTCTAGTAGTGCCTGTGCCCCTG GGCAGATTGGAGAGAAGAGGGACGACTGGAGAATCGTCGAGAACCAGCGG AGAAAAGAAAAAGCAACGTTTAATTCTAGAAGGCCTCCTGTCCCTGCCTG CTCTGGGTGCTCATGGAATCAGCTGCTGCCCTGCACTTCTCCCGGCCAGC CTCCCTCCTCCTCCTCCTCCTCAGCCTGTGTGCACTGGTCTCAGCCCAGT TTATTGTCGTGGGGCCCACTGATCCCATCTTGGCCACGGTTGGAGAAAAC ACTACGTTACGCTGCCATCTGTCACCCGAGAAAAATGCTGAGGACATGGA GGTGCGGTGGTTCCGGTCTCAGTTCTCCCCCGCAGTGTTTGTGTATAAAG GTGGCAGAGAGAGAACAGAGGAGCAGATGGAGGAGTACCGAGGAAGAACC ACCTTTGTGAGCAAAGACATCAGCAGGGGCAGCGTGGCCCTGGTCATACA CAACATCACAGCCCAGGAAAACGGCACCTACCGCTGTTACTTCCAAGAAG GCAGGTCCTACGATGAGGCCATCCTGCACCTCGTAGTGGCAGGACTAGGC TCTAAGCCCCTCATTTCAATGAGGGGCCATGAAGACGGGGGCATCCGGCT GGAGTGCATATCTAGAGGGTGGTACCCAAAGCCCCTCACAGTGTGGAGGG ACCCCTACGGTGGGGTTGCGCCTGCCCTGAAAGAGGTCTCCATGCCTGAT GCAGACGGCCTCTTCATGGTCACCACGGCTGTGATCATCAGAGACAAGTC TGTGAGGAACATGTCCTGCTCTATCAACAACACCCTGCTCGGCCAGAAGA AAGAAAGTGTCATTTTTATTCCAGAATCCTTTATGCCCAGTGTGTCTCCC TGTGCAGTGGCCCTGCCTATCATTGTGGTTATTCTGATGATACCCATTGC CGTATGCATCTATTGGATCAACAAACTCCAAAAGGAAAAAAAGATTCTGT CAGGGGAAAAGGAGTTTGAACGGGAAACAAGAGAAATTGCTCTAAAGGAA CTGGAGAAAGAACGTGTGCAAAAAGAGGAAGAACTTCAAGTAAAAGAGAA ACTTCAAGAAGAATTGCGATGGAGAAGAACATTCTTACATGCTGAGCTCC AATTCTTCTCAAACTGAGAGAACTGCTTCTGTCTCTGGAGAGACAGAAGT GCAGCTTCAGTAATTCTCAGTGTGTGAGCTGCCTAGGATCAGAGAGCCTT CATGGAAGTGGCCACTACGTGGGGATCCCTTCAGAGATATCTGAGACCTC TCTGGGGATCAGGAACCACACAATCCCCAGGGTTCCTGAGACCCCAGGCC TAAACCTGAGACTTCCTCTGCAGTTGATGTGGTCCTGGATCCAGACACCG CTCATCCCGATCTCTTCCTGTCAGAGGACCGGAGAAGTGTGAGAAGGTGC CCCTTCAGGCACCTAGGGGAGAGCGTGCCTGACAACCCAGAGAGATTCGA CAGTCAGCCTTGTGTCCTAGGCCGGGAGAGCTTCGCTTCAGGGAAACATT ACTGGGAGGTGGAGGTGGAAAACGTGATTGAGTGGACTGTGGGGGTCTGT AGAGACAGTGTTGAGAGGAAAGGGGAGGTCCTGCTGATTCCTCAGAATGG CTTCTGGACCTTGGAGATGCATAAAGGGCAATACCGGGCCGTGTCCTCCC CTGATAGGATTCTCCCTTTGAAGGAGTCCCTTTGCCGGGTGGGCGTCTTC CTGGACTATGAAGCTGGAGATGTCTCCTTCTACAACATGAGGGACAGATC GCACATCTACACATGTCCCCGTTCAGCCTTTTCCGTGCCTGTGAGGCCCT TCTTCAGGTTGGGGTGTGAGGACAGCCCCATCTTCATCTGCCCTGCACTC ACAGGAGCCAATGGGGTCACGGTGCCTGAAGAGGGCCTGACACTTCACAG AGTGGGGACCCACCAGAGCCTATAGAATCAATTCCTTGGTCTCACAGCCA TGTAGACAAGCCCTGGTCATCTCAGCAGCCACCGCACAACACCCCTGGTG GAAGACACGCCCTCCTCCCCTCTGGTCACACAAGAGAACATCTTCCAGCT GCCTCTTTCACACCCACTACAGACCTCAGCCCCAGTTTTCTCCTCCTCAC TAGGCTGTGTTTTTAGTAGTTCCTTTGCTTGTAACTATGGGATGGGATCC AGGCATAGGGAACTAGTTGTTACACAGCTCCCAGCCAAGAAGAAAGTGTG AGAAGTTGATGGGCAGCAAACCTGCTGTTTAACATCAGGGTGACCACATT AAGCCCAGTATTCCAGTTGGCACCAGAAGATATGGACTTGGAATGAGGCC TACAGGGTTCACCAGGATGTAAGAGGAGAGAGGAATCCACAGGACCACCA GAGAGGAGAGGGAACCAGATATGCAGATCAGAGATAGAGGAAGTGGAACC AGAGAGCTGGGAGGGACCAAGGTTGTAAGGGTGGCTAAGTCCCACCATAA CAGCTAAGGGGACCTGGGAGATGATGGCTCATTTCCACCCAGCCCCAGGA TTTCCAGAGCGCACATCCACAGGCCTGGACCTGGGATGAAGATGAATGAA GAACATGGATGCACGTGGATGTAGTTTGGCTCAGGTGTCCCTGCAGTTGG CAAGGAGTCAGTACTCAGTCCCTGAGTGTGGCTGAAATTTGAGGTCCTGG CTGAGCCAAGGAGTAATGGACCAGATCTACCTCAGTATTCAAGTTCAGTG GGGACACCAGTGGCTTCAAACTTCCTGGTTTCATGATATCTTGAGACGCC TTACAAATGATGGAGGATTCCAAAGAGTTTTTGTTTATTTGGGTTAATAT TTGTTGGTATTTATGGCATTTGAGATTGAAACTAAGAAATGTTTTAATTT ATTACCTTTACAACATTTATTTACATTACATACATACATTTACAACATTT ATTAATTTATATTAAAATAGCATGAATAAGCCAATTATAGGTTAATATAA GTAGAATGTTTGTGAAAAATAAGTATGGTATCCAAAGCAAAATAAATTTT ATTGTGAAGTGTGAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0200860
Genomic location	Chromosome	6
	Location	6p22.2
	Position	26458189- 26469865
	Strand	+
Possible duplicated location(s)		NA
Gene structure		8 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:11120;
	KEGG GENES	KEGG GENES(11120);
	GeneCard	BTN2A1;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000050242 Predicted CDS 213..1217;  334[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.781 Database links RefSeq NP_510961;  UniProt NA CCDS CCDS47390;

MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLR CHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVS KDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAGLGSKPL ISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKEVSMPDADGL FMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESFMPSVSPCAVA LPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKE RVQKEEELQVKEKLQEELRWRRTFLHAELQFFSN*

Motif information

	a.a. length	InterPro	Name
	114	IPR007110	Immunoglobulin-like domain [Domain]
	137	IPR013783	Immunoglobulin-like fold [Domain]
	96	IPR013106	Immunoglobulin V-set domain [Domain]
	108	IPR003599	Immunoglobulin subtype [Domain]
	75	IPR013162	CD80-like, immunoglobulin C2-set [Domain]
	67	IPR013783	Immunoglobulin-like fold [Domain]

Gene function information

H-Inv ID		HIT000037620
H-Inv cluster ID		HIX0200860
Accession number		BC016661.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Butyrophilin subfamily 2 member A1; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q7KYR7)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		9149941;  9382921;  14574404;  14702039;  15489334;  17974005;  19349973;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	BTN2A1
	HGNC aliases	NA
	HGNC name	butyrophilin, subfamily 2, member A1
	DDBJ	BTN2A1
	UniProt	BTN2A1
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000050242
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:11120;
	KEGG GENES	KEGG GENES(11120);
	GeneCard	BTN2A1;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	protein binding (GO:0005515);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	endoplasmic;  plasma membrane;  peroxisome;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 38 149 12e8H1 2e-13 9.8 112/121 b.1.1.1 147 230 1dr9A2 2e-12 19.0 84/95 b.1.1.3

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsA210323;
	Affymetrix GeneChip	HG-Focus	203944_x_at;
		HG-U133	203944_x_at;  211256_x_at;  215493_x_at;
		HG-U133A	203944_x_at;  211256_x_at;  215493_x_at;
		HG-U133A_2	203944_x_at;  211256_x_at;  215493_x_at;
		HG-U133B	NA
		HG-U133_Plus_2	203944_x_at;  211256_x_at;  215493_x_at;
		HG-U95	32673_at;
		HG-U95A	32673_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2899359;  2899438;  2899440;  2899444;  2899445;  2899451;  2899452;  2899454;  2899455;  2899456;  2899462;  2899464;  2899465;  2899467;  2899468;  2899469;  2899470;  2946453;
		HuGeneFL	U90543_at;  U90543_s_at;
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P167993;  A_23_P501634;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P501634;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 1 .. 1 C/G rs41267927 + 5'UTR 12 .. 12 T/C rs112900025 + 5'UTR 35 .. 35 G/T rs185151668 + 5'UTR 38 .. 38 A/G rs6907302 + 5'UTR 77 .. 77 C/T rs6929846 + 5'UTR 202 .. 202 T/C rs200786224 + 5'UTR 213 .. 213 A/G rs199747313 + CDS Nonsynonymous[Met1Val] 215 .. 215 G/A rs142203065 + CDS Nonsynonymous[Met1Ile] 219 .. 219 T/C rs146399224 + CDS Nonsynonymous[Ser3Pro] 246 .. 246 C/T rs139658946 + CDS Nonsynonymous[Pro12Ser] 253 .. 253 C/G rs140375890 + CDS Nonsynonymous[Ser14Cys] 318 .. 318 A/G rs146688212 + CDS Nonsynonymous[Thr36Ala] 355 .. 355 C/T rs139118294 + CDS Nonsynonymous[Thr48Met] 361 .. 361 G/A rs187108523 + CDS Nonsynonymous[Arg50His] 377 .. 377 C/T rs72500817 + CDS Synonymous[Pro55Pro] 396 .. 396 A/G rs144871432 + CDS Nonsynonymous[Met62Val] 415 .. 415 G/A rs149038955 + CDS Nonsynonymous[Arg68Gln] 427 .. 427 C/A rs200867396 + CDS Nonsynonymous[Ser72Tyr] 433 .. 433 C/T rs149048780 + CDS Nonsynonymous[Ala74Val] 450 .. 450 G/T rs146086334 + CDS Nonsynonymous[Gly80Cys] 512 .. 512 C/T rs147859702 + CDS Synonymous[Ser100Ser] 532 .. 532 G/T rs141312257 + CDS Nonsynonymous[Ser107Ile] 547 .. 547 T/C rs200535507 + CDS Nonsynonymous[Ile112Thr] 582 .. 582 C/T rs3734539 + CDS Nonsynonymous[Arg124Cys] 583 .. 583 G/A rs143104579 + CDS Nonsynonymous[Arg124His] 633 .. 633 G/A rs148111655 + CDS Nonsynonymous[Val141Ile] 657 .. 657 C/T rs150220790 + CDS Nonsynonymous[Pro149Ser] 686 .. 686 C/T rs145913124 + CDS Synonymous[Asp158Asp] 745 .. 745 G/T rs13195401 + CDS Nonsynonymous[Trp178Leu] 746 .. 746 G/T rs13195402 + CDS Nonsynonymous[Trp178Cys] 769 .. 769 C/T rs139773763 + CDS Nonsynonymous[Ala186Val] 792 .. 792 A/G rs142951857 + CDS Nonsynonymous[Met194Val] 807 .. 807 G/A rs144358349 + CDS Nonsynonymous[Gly199Ser] 812 .. 812 C/G rs199893249 + CDS Synonymous[Leu200Leu] 831 .. 831 G/A rs13195509 + CDS Nonsynonymous[Val207Met] 863 .. 863 G/A rs138727076 + CDS Nonsynonymous[Met217Ile] 902 .. 902 A/G rs142538560 + CDS Synonymous[Lys230Lys] 938 .. 938 C/T rs150961762 + CDS Synonymous[Pro242Pro] 997 .. 997 T/G rs201295468 + CDS Nonsynonymous[Ile262Ser] 1056 .. 1056 G/T rs200239130 + CDS AA-STOP[Glu282*] 1069 .. 1069 A/G rs199697327 + CDS Nonsynonymous[Glu286Gly] 1071 .. 1071 C/T rs148155227 + CDS Nonsynonymous[Arg287Trp] 1084 .. 1084 A/G rs140281108 + CDS Nonsynonymous[Glu291Gly] 1092 .. 1092 C/G rs144232372 + CDS Nonsynonymous[Leu294Val] 1104 .. 1104 G/C rs147849789 + CDS Nonsynonymous[Glu298Gln] 1116 .. 1116 G/A rs141482323 + CDS Nonsynonymous[Val302Met] 1235 .. 1235 C/T rs114905060 + 3'UTR 1382 .. 1382 G/T rs190622395 + 3'UTR 1427 .. 1427 A/G rs144977203 + 3'UTR 1449 .. 1449 C/T rs116782726 + 3'UTR 1481 .. 1481 G/A rs143270185 + 3'UTR 1494 .. 1494 A/G rs148333227 + 3'UTR 1549 .. 1549 G/A rs199601942 + 3'UTR 1556 .. 1556 A/G rs200691973 + 3'UTR 1562 .. 1562 G/C/T rs140484480 + 3'UTR 1564 .. 1564 G/A rs145662674 + 3'UTR 1567 .. 1567 C/T rs3734541 + 3'UTR 1574 .. 1574 G/A rs3734542 + 3'UTR 1623 .. 1623 C/T rs201477758 + 3'UTR 1689 .. 1689 T/C rs201679055 + 3'UTR 1697 .. 1697 A/G rs186440261 + 3'UTR 1700 .. 1700 G/A rs201014136 + 3'UTR 1711 .. 1711 T/C rs150693671 + 3'UTR 1719 .. 1719 G/A rs138874074 + 3'UTR 1727 .. 1727 G/A rs199920614 + 3'UTR 1741 .. 1741 G/A rs149413459 + 3'UTR 1746 .. 1746 C/G rs200277863 + 3'UTR 1747 .. 1747 T/C rs202205408 + 3'UTR 1750 .. 1750 C/A rs143941468 + 3'UTR 1793 .. 1793 G/C rs3734543 + 3'UTR 1793 .. 1793 G/C rs78126484 + 3'UTR 1795 .. 1795 G/A rs201996542 + 3'UTR 1810 .. 1810 G/A rs201411917 + 3'UTR 1847 .. 1847 G/A rs144194536 + 3'UTR 1851 .. 1851 G/A rs147342363 + 3'UTR 1874 .. 1874 C/A rs201238249 + 3'UTR 1884 .. 1884 C/T rs139461431 + 3'UTR 1885 .. 1885 G/A rs142664900 + 3'UTR 1905 .. 1905 C/T rs151013448 + 3'UTR 1908 .. 1908 G/A rs3734544 + 3'UTR 1926 .. 1926 C/G rs200126468 + 3'UTR 1961 .. 1961 A/G rs149725979 + 3'UTR 1970 .. 1970 C/T rs145758816 + 3'UTR 1978 .. 1978 G/T rs80308598 + 3'UTR 1993 .. 1993 C/T rs140631628 + 3'UTR 2045 .. 2045 C/G rs199776599 + 3'UTR 2060 .. 2060 G/A rs73738456 + 3'UTR 2067 .. 2067 T/C rs187594588 + 3'UTR 2121 .. 2121 T/C rs147833036 + 3'UTR 2175 .. 2175 C/T rs200175013 + 3'UTR 2179 .. 2179 G/A rs201491803 + 3'UTR 2221 .. 2221 T/C rs190723727 + 3'UTR 2242 .. 2242 A/G rs41267929 + 3'UTR 2344 .. 2344 C/T rs114011167 + 3'UTR 2648 .. 2648 G/C rs183212595 + 3'UTR 2693 .. 2693 G/A rs9461254 + 3'UTR 2995 .. 2995 A/T rs187952157 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;