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H-Invitational ID: HIT000038817 Accession number: BC020553 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC=1.5.1.2;
 
 

Transcript original information
Accession number BC020553.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:21444 IMAGE:2901360
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PYCR2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PYCR2);
Sequence data provider Provider:MGC/NCI
Annotation project H-Invitational FLcDNA
Length of cDNA 1708[bp] (No. of exon:7)[A:383 T:359 G:490 C:476]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Cervix, carcinoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1693(+) Signal: 1673-1677(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG;  TAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001639
Genomic location  G-integra Help Chromosome 1
Location 1q42.12
Position 226107580- 226111965
Strand -
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29920
KEGG GENES KEGG GENES(29920)
GeneCard GeneCardPYCR2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000104386
Predicted CDS 156..1118;  320[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.8
Database links RefSeq NP_037460
UniProt Q96C36
CCDS CCDS31043

Motif information
ORF

length(320),orf(156:1118)
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV
NLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVT
ISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLE
QLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRR
LAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGF
RSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD*
a.a.
length
InterPro Name
length(162), motif(1:162) 162 IPR016040 NAD(P)-binding domain [Domain]
length(275), motif(1:275) 275 IPR000304 Pyrroline-5-carboxylate reductase [Family]
length(96), motif(3:98) 96 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal [Domain]
length(266), motif(3:268) 266 IPR000304 Pyrroline-5-carboxylate reductase [Family]
length(107), motif(162:268) 107 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain [Domain]
length(106), motif(163:268) 106 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain [Domain]
length(108), motif(163:270) 108 IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like [Domain]
length(23), motif(224:246) 23 IPR000304 Pyrroline-5-carboxylate reductase [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000038817
H-Inv cluster ID Locus viewHIX0001639
Accession number BC020553.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC=1.5.1.2;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q96C36)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 272283868941531470203915489334167104141696424318669648200682312126946021406692ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol PYCR2
HGNC aliases NA
HGNC name pyrroline-5-carboxylate reductase family, member 2
DDBJ PYCR2
UniProt PYCR2
EC number EC 1.5.1.2pyrroline-5-carboxylate reductase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00220 :Urea cycle and metabolism of amino groups;  00330 :Arginine and proline metabolism; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000104386
No. of interaction 7
Interaction partner(s) HIP000023536HIP000031195HIP000040878HIP000087414HIP000091500HIP000190859HIP000251463
BIND 150060; 
DIP 111625E;  113321E; 
MINT MINT-48946;  MINT-61687;  MINT-8079030; 
HPRD 01241;  01319;  10831; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29920
KEGG GENES KEGG GENES(29920)
GeneCard GeneCardPYCR2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function pyrroline-5-carboxylate reductase activity (GO:0004735); 
Biological process proline biosynthetic process (GO:0006561); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT extracellular;  cytosol;  nuclear;  Other; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
2 163 1yqgA2 5e-29 26.0 150/152 c.2.1.6
163 267 1yqgA1 2e-30 26.7 105/111 a.100.1.10
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA250216; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 224855_at;  231715_s_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 224855_at;  231715_s_at; 
HG-U133_Plus_2 224855_at;  231715_s_at; 
HG-U95 49025_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 49025_at; 
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2383025;  2383026;  2458608;  2458609;  2458610;  2458612;  2458613;  2458615;  2458617;  2458621;  2458622;  2458623; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P149042; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P149042;  A_24_P165259; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Macaca sp. (Macaque) AB169063 G-integraG-integra
Orthology Mus sp. (Mouse) AK150756 G-integraG-integra
Orthology Rattus sp. (Rat) BC079222 G-integraG-integra
Orthology Bos sp. (Cow) BC118324 G-integraG-integra
Orthology Gallus sp. (Chicken) CR406983 G-integraG-integra
Orthology Pongo sp. (Orangutan) CR858959 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000011399 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000015269 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00026250001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000180643 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001376617 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001918502 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_514237 G-integraG-integra
Orthology Canis sp. (Dog) XM_537234 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
21 .. 21 A/G rs77157663 + 5'UTR
29 .. 29 C/G/T rs11543045 + 5'UTR
40 .. 40 C/A rs28364597 + 5'UTR
158 .. 158 G/A rs11543043 + CDS Nonsynonymous[Met1Ile]
224 .. 224 C/T rs11543044 + CDS Synonymous[Gly23Gly]
270 .. 270 C/T/A rs146858362 - CDS
290 .. 290 C/G rs144950490 - CDS Synonymous[Leu45Leu]
315 .. 315 C/T rs149894811 - CDS Nonsynonymous[Arg54Cys]
347 .. 347 C/T rs149882706 - CDS Synonymous[Asp64Asp]
348 .. 348 G/A rs150712428 - CDS Nonsynonymous[Val65Ile]
363 .. 363 G/C rs138993893 - CDS Nonsynonymous[Val70Leu]
393 .. 393 G/T rs202095611 - CDS Nonsynonymous[Asp80Tyr]
407 ^ 408 -/C rs35240460 - CDS
429 .. 429 G/A rs200064314 - CDS Nonsynonymous[Val92Met]
443 .. 443 G/A rs148023221 - CDS Synonymous[Ala96Ala]
493 .. 493 C/G rs199719275 - CDS Nonsynonymous[Pro113Arg]
511 .. 511 G/T rs149587849 - CDS Nonsynonymous[Arg119Leu]
554 .. 554 A/G rs112885589 - CDS Synonymous[Thr133Thr]
570 .. 570 A/C rs200663855 - CDS Nonsynonymous[Thr139Pro]
571 .. 571 C/G rs191605313 - CDS Nonsynonymous[Thr139Ser]
600 .. 600 C/T rs139028833 - CDS Synonymous[Leu149Leu]
610 .. 610 T/C rs112160559 - CDS Nonsynonymous[Leu152Pro]
621 .. 621 G/A rs145139251 - CDS Nonsynonymous[Val156Met]
683 .. 683 C/G rs201440840 - CDS Nonsynonymous[Ser176Arg]
705 .. 705 G/A rs142577088 - CDS Nonsynonymous[Ala184Thr]
716 .. 716 A/T rs145493247 - CDS Synonymous[Ala187Ala]
753 .. 753 C/T rs199945116 - CDS Nonsynonymous[Arg200Cys]
756 .. 756 C/T rs56362902 - CDS Synonymous[Leu201Leu]
762 .. 762 A/G rs201142342 - CDS Nonsynonymous[Ile203Val]
765 .. 765 C/T rs113324645 - CDS AA-STOP[Gln204*]
770 .. 770 C/T rs55803945 - CDS Synonymous[Leu205Leu]
794 .. 794 T/C rs200949659 - CDS Synonymous[Ala213Ala]
830 .. 830 C/G rs150765933 - CDS Nonsynonymous[Cys225Trp]
831 .. 831 C/T rs201784173 - CDS AA-STOP[Gln226*]
866 .. 866 C/A rs148117976 - CDS Synonymous[Ala237Ala]
908 .. 908 C/T rs138792831 - CDS Synonymous[Arg251Arg]
956 .. 956 G/A rs200057700 - CDS Synonymous[Glu267Glu]
989 .. 989 C/G rs201007176 - CDS Synonymous[Ser278Ser]
996 .. 996 G/A rs201700928 - CDS Nonsynonymous[Ala281Thr]
1073 .. 1073 G/A rs73131849 - CDS Synonymous[Gly306Gly]
1079 .. 1079 C/G rs181648767 - CDS Synonymous[Leu308Leu]
1096 .. 1096 C/G rs117063721 - CDS Nonsynonymous[Ala314Gly]
1171 .. 1171 G/A rs111299811 - 3'UTR
1177 .. 1177 G/C rs56035614 - 3'UTR
1281 .. 1281 G/C rs184229686 - 3'UTR
1353 .. 1353 G/A rs75484905 - 3'UTR
1444 ^ 1445 -/G rs34126730 - 3'UTR
1482 .. 1482 G/C rs1065727 + 3'UTR
1486 .. 1486 A/G rs14868 - 3'UTR
1595 .. 1595 G/A rs11550734 - 3'UTR
1609 .. 1609 T/G rs182441677 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer