H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000039527 Accession number: BC022415 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Signal recognition particle 9 kDa protein; SRP9;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC022415.1 CAGE tag ID NA EST ID NA Clone Number MGC:24591 IMAGE:4243562 Experimental resources   NBRC ; HGPD ; Antibody (SRP9) ; Catalog (SRP9); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 1485[bp] (No. of exon:3)[A:473 T:496 G:292 C:224] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Skin, melanotic melanoma, high MDR. Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1455(+) Signal: 1440-1444(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GAACTCGCGTCGGTTGGCGACTCCCGGACGTAGGTAGTTTGTTGGGCCGG GTTCTGAGGCCTTGCTTCTCTTTACTTTTCCACTCTAGGCCACGATGCCG CAGTACCAGACCTGGGAGGAGTTCAGCCGCGCTGCCGAGAAGCTTTACCT CGCTGACCCTATGAAGGCACGTGTGGTTCTCAAATATAGGCATTCTGATG GGAACTTGTGTGTTAAAGTAACAGATGATTTAGTTTGTTTGGTGTATAAA ACAGACCAAGCTCAAGATGTAAAGAAGATTGAGAAATTCCACAGTCAACT AATGCGACTTATGGTAGCCAAGGAAGCCCGCAATGTTACCATGGAAACTG AGTGAATGGTTTGAAATGAAGACTTTGTCGTGTACTTAGGAAGTAAATAT CTTTTGAATTAGAGAAAGTGTTGGGACAGAAAGTACTTTATGTAACTAAG TGGGCTGTTCAGAAGCTTAGAGGTCATTTTTTGTAATTTTCTTTTTAATT ACTTTAGAGAGCTAGGGATGCAAATGTTTTCAGTTAGAAAGCCTTTATTT ACTTTTGGAAATTGAACAAGAAATGCATCTGTCTTAGAAACTGGAGATTA TTTGATGTTAGGTAAAACATGTAATTGTTTCTCTGGCAAATTTGTATCAG TAATTTGAAAATGAGATATTAGGAAAAACCAATTCTTCTTAAATTTAGTT CATCTTTCTTTAAAAGAACATTAAATGTAACCATTTTGTCAGATCCATGT ATTTTGGAGCATAAAATGTATGCTGTTGTGACCAATAAATATAAAATATG GTAATTGGAATTAACTCCACACCATAGTATGCATTGTTATACATACTGTG TACCTAATTATGTATAGCAGTGTAGTCTCAATTATATCTGAAAGTAATTG TGACTAACAAGTATGCTTTGCCTTATTTCCACATTTAAACTACCTGTTAA TATAAGGGATTTGTAGTATCAGCTTGTTGAGCAATGACTTTGAATCTAGT TTTCAGTGATCAGAAGCAGCAGTTATTTGAGTGTATGAATGGAATGATGA TCACTGTGCTATAATGTACTGAAACCACCATATTACAGAAATATTTACTA CATATTTTCCATCTGTAGTTTCTCAGAAGGGCTATGGATTAGTTTGAACT GTCAAATCCTTGCATACTTCTGTGACACCCCTGCCCATTTTCTGTCTTTA ATTAACCAAGGTGTTAGGTGTGACTGTCACAACTGTTATGTTTTCCAGTA AACTAGAAGTACGATATTTGATAATTATATTTGTATTTCACCACCTAAAT GTAATGTTGATTCCTCAAGAATGAAATGAAGGCACTACATTGAAATATGT TTTGTATAAATTTGTCATGTTGAACAGCATTTTAGCATGGTAAGTTCCCT TAGCTATATGAATTTTGGCATGTTTCAGAGAGATCAGTAAATAAAATATT AGATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0001635
Genomic location	Chromosome	1
	Location	1q42.12
	Position	225965551- 225978161
	Strand	+
Possible duplicated location(s)		NA
Gene structure		3 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:6726;
	KEGG GENES	KEGG GENES(6726);
	GeneCard	SRP9;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000085983 Predicted CDS 95..355;  86[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.697 Database links RefSeq NP_003124;  UniProt P49458;  CCDS CCDS1546;

MPQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCVKVTDDLVCLV YKTDQAQDVKKIEKFHSQLMRLMVAKEARNVTMETE*

Motif information

	a.a. length	InterPro	Name
	85	IPR009018	Signal recognition particle, SRP9/SRP14 subunit [Domain]
	85	IPR008832	Signal recognition particle, SRP9 subunit [Family]
	75	IPR009018	Signal recognition particle, SRP9/SRP14 subunit [Domain]

Gene function information

H-Inv ID		HIT000039527
H-Inv cluster ID		HIX0001635
Accession number		BC022415.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Signal recognition particle 9 kDa protein; SRP9;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (P49458)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		7730321;  11089964;  14702039;  15489334;  19608861;  21269460;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	SRP9
	HGNC aliases	"signal recognition particle 9kD"
	HGNC name	signal recognition particle 9kDa
	DDBJ	SRP9
	UniProt	SRP9
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000085983
	No. of interaction	2
	Interaction partner(s)	HIP000033231;  HIP000096070;
	BIND	90144;  90145;
	DIP	11015E;  113899E;  116014E;
	MINT	NA
	HPRD	01818;  02831;  03144;  10064;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:6726;
	KEGG GENES	KEGG GENES(6726);
	GeneCard	SRP9;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	7S RNA binding (GO:0008312);
Biological process	negative regulation of translational elongation (GO:0045900);  SRP-dependent cotranslational protein targeting to membrane (GO:0006614);
Cellular component	signal recognition particle (GO:0048500);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	cytosol;  extracellular;  nuclear;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 4 81 1914A1 8e-30 92.3 78/100 d.49.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsA011014;
	Affymetrix GeneChip	HG-Focus	201273_s_at;
		HG-U133	201273_s_at;
		HG-U133A	201273_s_at;
		HG-U133A_2	201273_s_at;
		HG-U133B	NA
		HG-U133_Plus_2	201273_s_at;
		HG-U95	36981_at;
		HG-U95A	36981_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2382872;  2382873;  2382878;  2382886;  2382887;  2382888;  2382889;  2458503;  3257926;  3257927;  3300190;  3300191;  3300192;
		HuGeneFL	U20998_at;
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P45928;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P45934;  A_24_P66528;  A_32_P151594;  A_32_P165340;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 57 .. 57 A/G rs150506040 + 5'UTR 65 .. 65 C/G rs201121310 + 5'UTR 130 .. 130 C/T rs200191596 + CDS Synonymous[Arg12Arg] 151 .. 151 C/T rs148080629 + CDS Synonymous[Leu19Leu] 187 .. 187 T/C rs142361213 + CDS Synonymous[Tyr31Tyr] 201 .. 201 G/A rs61849056 + CDS Nonsynonymous[Gly36Glu] 211 .. 211 T/C rs143580849 + CDS Synonymous[Cys39Cys] 226 .. 226 T/C rs138611908 + CDS Synonymous[Asp44Asp] 233 .. 233 G/C rs201380978 + CDS Nonsynonymous[Val47Leu] 329 .. 329 C/T rs199511703 + CDS Nonsynonymous[Arg79Cys] 333 .. 333 A/G rs201568819 + CDS Nonsynonymous[Asn80Ser] 343 .. 343 G/A rs149323412 + CDS Nonsynonymous[Met83Ile] 379 .. 379 C/T rs200262058 + 3'UTR 382 .. 382 G/A rs146544886 + 3'UTR 512 .. 512 C/G rs188550487 + 3'UTR 528 .. 528 T/C rs141268331 + 3'UTR 567 .. 567 C/G rs74604368 - 3'UTR 682 .. 682 A/C rs11555109 - 3'UTR 802 .. 802 T/C rs189915800 + 3'UTR 827 .. 827 G/A rs182555497 + 3'UTR 832 .. 832 C/T rs11555121 + 3'UTR 1036 .. 1036 T/C rs11555113 - 3'UTR 1046 .. 1046 G/A rs145846119 + 3'UTR 1176 .. 1176 C/T rs186531623 + 3'UTR 1239 .. 1239 T/C rs191367978 + 3'UTR 1262 .. 1262 C/T rs1050033 + 3'UTR 1264 .. 1264 A/G rs184461856 + 3'UTR 1301 .. 1301 G/C rs14113 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;