H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000039976 Accession number: BC025709 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Aflatoxin B1 aldehyde reductase member 3; EC=1.-.-.-; AFB1 aldehyde reductase 2; AFB1-AR 2;
 
 

Transcript original information
Accession number BC025709.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:34394 IMAGE:5224626
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (AKR7A3) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (AKR7A3);
Sequence data provider Provider:MGC/NCI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 1254[bp] (No. of exon:7)[A:284 T:236 G:359 C:375]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Pancreas, Spleen, adult pooled
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1219(+) Signal: 1205-1209(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) GAGCAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0000196
Genomic location  G-integra Help Chromosome 1
Location 1p36.13
Position 19609066- 19615266
Strand -
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:22977; 
KEGG GENES KEGG GENES(22977); 
GeneCard GeneCardAKR7A3;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000102268
Predicted CDS 64..1059;  331[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.851

Motif information
ORF

length(331),orf(64:1059) MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYS EGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLK RLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEV AEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPL AGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEK ALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA AAEEGPLEPAVVDAFNQAWHLVAHECPNYFR* 		a.a.
length		 InterPro Name
length(331), motif(1:331) 331 IPR001395 Aldo/keto reductase [Family]
length(321), motif(10:330) 321 IPR023210 NADP-dependent oxidoreductase domain [Domain]
length(320), motif(10:329) 320 IPR023210 NADP-dependent oxidoreductase domain [Domain]
length(306), motif(13:318) 306 IPR023210 NADP-dependent oxidoreductase domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000039976
H-Inv cluster ID Locus viewHIX0000196
Accession number BC025709.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Aflatoxin B1 aldehyde reductase member 3; EC=1.-.-.-; AFB1 aldehyde reductase 2; AFB1-AR 2;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O95154)  [Identity/coverage = 99.396%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 10383892;  12879023;  15489334;  16710414;  18416522;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol AKR7A3
HGNC aliases NA
HGNC name aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
DDBJ AKR7A3
UniProt AKR7A3
EC number EC 1.-.-.-Oxidoreductases; 
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000102268
No. of interaction 24
Interaction partner(s) HIP000011645;  HIP000026519;  HIP000029082;  HIP000029082;  HIP000035297;  HIP000035297;  HIP000036873;  HIP000042229;  HIP000045567;  HIP000050079;  HIP000060427;  HIP000060427;  HIP000070344;  HIP000070344;  HIP000085624;  HIP000086375;  HIP000086375;  HIP000086391;  HIP000086391;  HIP000087603;  HIP000090938;  HIP000097297;  HIP000097297;  HIP000357790; 
BIND NA
DIP NA
MINT MINT-67373; 
HPRD 04567; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:22977; 
KEGG GENES KEGG GENES(22977); 
GeneCard GeneCardAKR7A3;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  cytosol;  nuclear; 
Target P mitochondria
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
8 331 1gveA 4e-61 74.1 324/324 c.1.7.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene NA
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 216381_x_at; 
HG-U133A 216381_x_at; 
HG-U133A_2 216381_x_at; 
HG-U133B NA
HG-U133_Plus_2 216381_x_at; 
HG-U95 35925_at; 
HG-U95A 35925_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2399711;  2399712;  2399713;  2399749;  2399754;  2399755;  2399756; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P103968; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P103968; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
24 .. 24 C/T rs148972615 - 5'UTR
26 .. 26 C/T rs189446623 - 5'UTR
175 .. 175 C/T rs145667180 - CDS Nonsynonymous[Arg38Cys]
205 .. 205 G/C rs199504000 - CDS Nonsynonymous[Val48Leu]
216 .. 216 G/C rs201237444 - CDS Nonsynonymous[Glu51Asp]
225 .. 225 C/T rs118060916 - CDS Synonymous[Ser54Ser]
226 .. 226 G/A rs145878095 - CDS Nonsynonymous[Glu55Lys]
237 .. 237 T/G rs199899317 - CDS Synonymous[Leu58Leu]
240 .. 240 C/T rs139849464 - CDS Synonymous[Gly59Gly]
241 .. 241 G/T rs142091873 - CDS Nonsynonymous[Gly60Cys]
244 .. 244 C/T rs115242113 - CDS Synonymous[Leu61Leu]
253 .. 253 C/T rs140103131 - CDS Nonsynonymous[Arg64Trp]
337 .. 337 C/T rs201340875 - CDS Nonsynonymous[Arg92Trp]
370 .. 370 C/T rs138113288 - CDS AA-STOP[Gln103*]
373 .. 373 T/C rs149303529 - CDS Nonsynonymous[Cys104Arg]
409 .. 409 G/A rs35216783 - CDS Nonsynonymous[Asp116Asn]
420 .. 420 C/T rs1774079 - CDS Synonymous[Thr119Thr]
422 .. 422 C/T rs138344238 - CDS Nonsynonymous[Pro120Leu]
423 .. 423 G/A rs141897650 - CDS Synonymous[Pro120Pro]
425 .. 425 T/G rs61752488 - CDS Nonsynonymous[Val121Gly]
427 .. 427 G/A rs138337504 - CDS Nonsynonymous[Glu122Lys]
475 .. 475 G/A rs2231198 + CDS Nonsynonymous[Val138Met]
501 .. 501 A/C rs139064823 - CDS Synonymous[Ala146Ala]
517 .. 517 G/A rs141306786 - CDS Nonsynonymous[Glu152Lys]
540 .. 540 C/T rs144038063 - CDS Synonymous[Ser159Ser]
544 .. 544 G/A rs138381490 - CDS Nonsynonymous[Gly161Ser]
556 .. 556 C/T rs143014551 - CDS Nonsynonymous[Pro165Ser]
564 .. 564 C/G rs17852284 - CDS Synonymous[Val167Val]
596 .. 596 A/G rs151100364 - CDS Nonsynonymous[Gln178Arg]
606 .. 606 G/A rs140933903 - CDS Synonymous[Thr181Thr]
642 .. 642 G/T rs144024296 - CDS Nonsynonymous[Arg193Ser]
680 .. 680 C/T rs201215326 - CDS Nonsynonymous[Thr206Ile]
681 .. 681 C/T rs145436915 - CDS Synonymous[Thr206Thr]
684 .. 684 C/T rs200534957 - CDS Synonymous[Gly207Gly]
706 .. 706 G/A rs1738023 + CDS Nonsynonymous[Asp215Asn]
708 .. 708 T/C rs1738024 + CDS Synonymous[Asp215Asp]
720 .. 720 C/T rs1065658 + CDS Synonymous[Pro219Pro]
789 .. 789 T/C rs116050237 - CDS Synonymous[Phe242Phe]
825 .. 825 C/T rs149649188 - CDS Synonymous[Ala254Ala]
827 .. 827 C/T rs145872076 - CDS Nonsynonymous[Ala255Val]
828 .. 828 G/T rs146835084 - CDS Synonymous[Ala255Ala]
840 .. 840 C/T rs182478203 - CDS Synonymous[Ser259Ser]
858 .. 858 G/A rs140288397 - CDS Synonymous[Ser265Ser]
887 .. 887 C/T rs201279439 - CDS Nonsynonymous[Ser275Leu]
888 .. 888 A/G rs201763306 - CDS Synonymous[Ser275Ser]
894 .. 894 G/A rs142053998 - CDS Synonymous[Leu277Leu]
898 .. 898 G/A rs149120004 - CDS Nonsynonymous[Gly279Ser]
906 .. 906 C/T rs34949847 - CDS Synonymous[His281His]
914 .. 914 C/T rs144760570 - CDS Nonsynonymous[Ala284Val]
922 .. 922 C/T rs200264295 - CDS Synonymous[Leu287Leu]
923 .. 923 T/C rs150622134 - CDS Nonsynonymous[Leu287Pro]
965 .. 965 C/T rs148077799 - CDS Nonsynonymous[Ala301Val]
966 .. 966 G/A rs111742333 - CDS Synonymous[Ala301Ala]
989 .. 989 C/T rs145104812 - CDS Nonsynonymous[Pro309Leu]
997 .. 997 G/A rs148859866 - CDS Nonsynonymous[Val312Met]
1002 .. 1002 C/T rs17852953 - CDS Synonymous[Asp313Asp]
1022 .. 1022 A/G rs147831859 - CDS Nonsynonymous[His320Arg]
1030 .. 1030 G/A rs1738025 + CDS Nonsynonymous[Ala323Thr]
1032 .. 1032 T/C rs2995181 - CDS Synonymous[Ala323Ala]
1071 .. 1071 C/T rs1061670 + 3'UTR
1080 .. 1080 C/T rs116787495 - 3'UTR
1089 .. 1089 C/T rs1061671 + 3'UTR
1092 .. 1092 C/T rs1065660 + 3'UTR
1095 .. 1095 T/C rs191508992 - 3'UTR
1098 .. 1098 C/T rs187424258 - 3'UTR
1148 .. 1148 C/T rs1061672 + 3'UTR
1192 .. 1192 C/T rs182775256 - 3'UTR
1194 .. 1194 A/C rs1061673 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;