H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000040488 Accession number: BC028210 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; AltName: CD_antigen=CD278; Precursor;
 
 

Transcript original information
Accession number BC028210.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:40066 IMAGE:5215237
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ICOS) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ICOS);
Sequence data provider Provider:MGC/NCI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 2651[bp] (No. of exon:5)[A:776 T:818 G:509 C:548]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Blood, adult leukocytes
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 2610(+) Signal: 2584-2588(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG;  CAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0002762
Genomic location  G-integra Help Chromosome 2
Location 2q33.2
Position 204801503- 204826297
Strand +
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29851; 
KEGG GENES KEGG GENES(29851); 
GeneCard GeneCardICOS;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000069778
Predicted CDS 36..635;  199[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.704
Database links RefSeq NP_036224; 
UniProt Q9Y6W8; 
CCDS CCDS2363; 

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000040488
H-Inv cluster ID Locus viewHIX0002762
Accession number BC028210.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; AltName: CD_antigen=CD278; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9Y6W8)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9930702;  10779774;  11006126;  11169414;  11735222;  12577056;  12753665;  15489334;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ICOS
HGNC aliases NA
HGNC name inducible T-cell co-stimulator
DDBJ ICOS
UniProt ICOS
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000069778
No. of interaction 1
Interaction partner(s) HIP000090185; 
BIND NA
DIP NA
MINT NA
HPRD 05757; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:29851; 
KEGG GENES KEGG GENES(29851); 
GeneCard GeneCardICOS;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT extracellular;  cytosol;  peroxisome;  plasma membrane; 
Target P signal peptide
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL endocrine_exocrine; 
Probe
information DNAProbeLocator		 AceGene AGhsB020503; 
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 210439_at; 
HG-U133A 210439_at; 
HG-U133A_2 210439_at; 
HG-U133B NA
HG-U133_Plus_2 210439_at; 
HG-U95 34607_at; 
HG-U95A 34607_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2523880;  2523881;  2523885;  2523886;  2523887;  2523889; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P108893;  A_23_P371215; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P371215; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: ICOS deficiency (607594); 
Related information in OMIM OMIM ID:  604558;  Title: INDUCIBLE T-CELL COSTIMULATOR
Co-localized orphan diseases NA
Disease related mutation MutationView:  604558; 
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(29851)
Disease Entrez Gene ID:(29851)
Substance Entrez Gene ID:(29851)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
75 .. 75 C/T rs77411896 + CDS Nonsynonymous[Arg14Cys]
128 .. 128 T/C rs147754976 + CDS Synonymous[Phe31Phe]
140 .. 140 C/T rs201031378 + CDS Synonymous[Asn35Asn]
141 .. 141 G/A rs202109644 + CDS Nonsynonymous[Gly36Arg]
185 .. 185 A/G rs55972840 + CDS Synonymous[Gln50Gln]
217 .. 217 T/A rs199880572 + CDS Nonsynonymous[Ile61Lys]
473 .. 473 A/T rs139449630 + CDS Synonymous[Gly146Gly]
486 .. 486 G/C rs76778263 + CDS Nonsynonymous[Val151Leu]
491 .. 491 A/G rs201989492 + CDS Synonymous[Val152Val]
545 .. 545 A/G rs148435889 + CDS Synonymous[Ser170Ser]
551 .. 551 T/C rs150573153 + CDS Synonymous[Ser172Ser]
610 .. 610 C/G rs144520938 + CDS Nonsynonymous[Ser192Cys]
624 .. 624 G/A rs111644920 + CDS Nonsynonymous[Val197Met]
626 .. 626 G/A rs55655222 + CDS Synonymous[Val197Val]
632 .. 632 A/G rs145698501 + CDS Synonymous[Leu199Leu]
637 .. 637 A/C rs10183087 + 3'UTR
651 .. 651 C/T rs200367053 + 3'UTR
668 .. 668 T/C rs73058105 + 3'UTR
675 .. 675 G/T rs202183147 + 3'UTR
901 .. 901 G/A rs187152949 + 3'UTR
965 .. 965 G/A rs10932035 + 3'UTR
1164 .. 1164 T/C rs56206610 + 3'UTR
1289 .. 1289 A/C rs199532572 - 3'UTR
1343 .. 1343 A/G rs192009666 + 3'UTR
1413 .. 1413 A/G rs185346329 + 3'UTR
1490 .. 1490 T/C rs73991306 + 3'UTR
1494 .. 1494 A/T rs10932036 + 3'UTR
1599 .. 1599 T/C rs4404254 + 3'UTR
1601 .. 1601 C/A rs13032826 + 3'UTR
1602 .. 1602 T/C rs13009540 + 3'UTR
1615 .. 1615 T/C rs55662879 + 3'UTR
1630 .. 1630 C/T rs190590580 + 3'UTR
1659 .. 1659 C/T rs10932037 + 3'UTR
1660 .. 1660 A/G rs77882417 + 3'UTR
1729 .. 1729 C/T rs144036725 + 3'UTR
1730 .. 1730 A/G rs73991307 + 3'UTR
1884 .. 1884 G/A rs73991308 + 3'UTR
1897 .. 1897 A/G rs10932038 + 3'UTR
1935 .. 1935 C/T rs181937379 + 3'UTR
2042 .. 2042 G/A rs1559931 + 3'UTR
2051 .. 2051 G/T rs56259923 + 3'UTR
2109 .. 2109 A/G rs55804731 + 3'UTR
2121 .. 2121 C/T rs185688044 + 3'UTR
2258 .. 2258 G/C rs113279401 + 3'UTR
2286 .. 2286 T/C rs146464273 + 3'UTR
2408 .. 2408 G/C rs4675379 + 3'UTR
2489 .. 2489 G/A rs140979765 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;