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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000042932 Accession number: AK123059 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor;
 
 

Transcript original information
Accession number AK123059.1
CAGE tag ID NA
EST ID NA
Clone Number TRACH2001021
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (LPAR6) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (LPAR6);
Sequence data provider Project:FLJ; Provider:FLJ/HRI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 2065[bp] (No. of exon:1)[A:663 T:690 G:357 C:355]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type trachea
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0026540
Genomic location  G-integra Help Chromosome 13
Location 13q14.2
Position 48985184- 48987249
Strand -
Possible duplicated location(s) NA
Gene structure 1 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10161
KEGG GENES KEGG GENES(10161)
GeneCard GeneCardLPAR6*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000113591
Predicted CDS 691..1725;  344[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.705

Motif information
ORF

length(344),orf(691:1725)
MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRN
ETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNM
YGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAP
AVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILN
VTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYSINLI
LYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQN
SIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA*
a.a.
length
InterPro Name
length(294), motif(10:303) 294 IPR017452 GPCR, rhodopsin-like, 7TM [Domain]
length(25), motif(19:43) 25 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(258), motif(34:291) 258 IPR017452 GPCR, rhodopsin-like, 7TM [Domain]
length(257), motif(35:291) 257 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(22), motif(52:73) 22 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(23), motif(96:118) 23 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(17), motif(102:118) 17 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(22), motif(132:153) 22 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(24), motif(185:208) 24 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(25), motif(227:251) 25 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]
length(27), motif(273:299) 27 IPR000276 G protein-coupled receptor, rhodopsin-like [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000042932
H-Inv cluster ID Locus viewHIX0026540
Accession number AK123059.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P43657)  [Identity/coverage = 99.709%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence NA
PubMed ID 7902321888955211004484147020391505782315489334179740051829707018297072ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol LPAR6
HGNC aliases "purinergic receptor P2Y, G-protein coupled, 5"
HGNC name lysophosphatidic acid receptor 6
DDBJ NA
UniProt LPAR6
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000113591
No. of interaction 10
Interaction partner(s) HIP000024854HIP000025121HIP000027981HIP000039653HIP000040680HIP000041686HIP000076344HIP000104360HIP000130925HIP000193750
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10161
KEGG GENES KEGG GENES(10161)
GeneCard GeneCardLPAR6*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function G-protein coupled receptor activity (GO:0004930); 
Biological process G-protein coupled receptor protein signaling pathway (GO:0007186); 
Cellular component integral to membrane (GO:0016021); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT plasma membrane; 
Target P signal peptide
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA170202; 
Affymetrix
GeneChip
HG-Focus 218589_at; 
HG-U133 218589_at; 
HG-U133A 218589_at; 
HG-U133A_2 218589_at; 
HG-U133B NA
HG-U133_Plus_2 218589_at; 
HG-U95 75361_r_at; 
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D 75361_r_at; 
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3489070;  3489071;  3489072;  3513525;  3513526;  3513527;  3513528;  3513529;  3513530;  3513531;  3513532;  3513533;  3513534;  3513535; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P2705; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P2705; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: Hypotrichosis, localized, autosomal recessive, 3 (611452);  Disease name: Woolly hair, autosomal recessive (278150); 
Related information in OMIM OMIM ID:  609239;  Title: PURINERGIC RECEPTOR P2Y, G PROTEIN-COUPLED, 5
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(10161)
Disease Entrez Gene ID:(10161)
Substance Entrez Gene ID:(10161)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
218 .. 218 T/C rs2227311 + 5'UTR
421 .. 421 G/A rs4151554 - 5'UTR
499 .. 499 C/T rs2233571 + 5'UTR
500 .. 500 G/A rs146822744 - 5'UTR
583 .. 583 A/C rs10220031 - 5'UTR
584 .. 584 G/C rs10220269 - 5'UTR
611 .. 611 T/C rs2233572 + 5'UTR
700 .. 700 G/A rs200140945 - CDS Nonsynonymous[Val4Ile]
732 .. 732 C/T rs148227482 - CDS Synonymous[Ser14Ser]
787 .. 787 A/G rs1060585 + CDS Nonsynonymous[Ile33Val]
792 .. 792 C/A rs143022858 - CDS Synonymous[Ser34Ser]
800 .. 800 T/C rs187575622 - CDS Nonsynonymous[Val37Ala]
815 .. 815 T/G rs200529724 - CDS Nonsynonymous[Phe42Cys]
821 .. 821 G/A rs201386780 - CDS Nonsynonymous[Cys44Tyr]
823 .. 823 G/A rs201988975 - CDS Nonsynonymous[Val45Ile]
836 .. 836 G/A rs149045565 - CDS Nonsynonymous[Arg49Gln]
839 .. 839 A/G rs199946508 - CDS Nonsynonymous[Asn50Ser]
842 .. 842 A/G rs145842102 - CDS Nonsynonymous[Glu51Gly]
858 .. 858 G/A rs146907520 - CDS Nonsynonymous[Met56Ile]
888 .. 888 T/C rs199707535 - CDS Synonymous[Phe66Phe]
946 .. 946 G/A rs200247168 - CDS Nonsynonymous[Asp86Asn]
957 .. 957 T/C rs202132018 - CDS Synonymous[Cys89Cys]
973 .. 973 C/A rs142504579 - CDS Nonsynonymous[Leu95Met]
995 .. 995 G/A rs201217722 - CDS Nonsynonymous[Gly102Glu]
1022 .. 1022 G/C rs201395083 - CDS Nonsynonymous[Ser111Thr]
1030 .. 1030 C/T rs184642826 - CDS AA-STOP[Arg114*]
1101 .. 1101 C/G rs4151553 - CDS Nonsynonymous[Cys137Trp]
1126 .. 1126 G/A rs121434308 + CDS Nonsynonymous[Gly146Arg]
1132 .. 1132 A/G rs113697253 - CDS Nonsynonymous[Ser148Gly]
1137 .. 1137 A/C rs199857507 - CDS Synonymous[Ala149Ala]
1153 .. 1153 C/T rs121434306 + CDS AA-STOP[Gln155*]
1241 .. 1241 T/C rs147725894 - CDS Nonsynonymous[Ile184Thr]
1243 .. 1243 G/T rs201663895 - CDS Nonsynonymous[Val185Leu]
1252 .. 1252 A/T rs121434307 + CDS Nonsynonymous[Ile188Phe]
1255 .. 1255 G/A rs121434309 + CDS Nonsynonymous[Glu189Lys]
1261 .. 1261 G/C rs200893624 - CDS Nonsynonymous[Val191Leu]
1275 .. 1275 T/C/G rs2233573 + CDS
1277 .. 1277 C/T rs115596308 - CDS Nonsynonymous[Pro196Leu]
1317 ^ 1318 -/A rs67908709 - CDS
1325 .. 1325 C/G rs61741709 - CDS Nonsynonymous[Thr212Ser]
1328 .. 1328 A/C rs112592020 - CDS Nonsynonymous[Lys213Thr]
1332 .. 1332 T/A rs1060587 + CDS Synonymous[Pro214Pro]
1448 .. 1448 C/G rs151284148 - CDS Nonsynonymous[Ser253Cys]
1491 .. 1491 A/C rs4151552 - CDS Synonymous[Ala267Ala]
1505 .. 1505 T/C rs114372872 - CDS Nonsynonymous[Met272Thr]
1544 .. 1544 G/T rs148717423 - CDS Nonsynonymous[Cys285Phe]
1575 .. 1575 G/T rs146017569 - CDS Synonymous[Ser295Ser]
1611 .. 1611 G/T rs17071686 - CDS Nonsynonymous[Trp307Cys]
1678 .. 1678 C/A rs200554714 - CDS Nonsynonymous[Leu330Ile]
1698 .. 1698 G/A rs151047164 - CDS Synonymous[Lys336Lys]
1729 .. 1729 A/G rs187023731 - 3'UTR
1747 .. 1747 T/C rs199942001 - 3'UTR
1811 .. 1811 A/C rs4151551 - 3'UTR
1850 ^ 1851 -/T rs34111133 - 3'UTR
1945 .. 1945 G/C rs4151550 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer