H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000049899 Accession number: AK130628 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Peptidyl-prolyl cis-trans isomerase E; PPIase E; EC=5.2.1.8; Cyclophilin E; Cyclophilin-33; Rotamase E;
 
 

Transcript original information
Accession number AK130628.1
CAGE tag ID NA
EST ID NA
Clone Number SPL06417
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PPIE) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PPIE);
Sequence data provider Project:FLJ; Provider:FLJ/IMSUT
Annotation project H-Invitational FLcDNA
Length of cDNA 1258[bp] (No. of exon:10)[A:312 T:286 G:347 C:313]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type spleen
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0000462
Genomic location  G-integra Help Chromosome 1
Location 1p34.2
Position 40204564- 40219370
Strand +
Possible duplicated location(s) NA
Gene structure 10 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10450
KEGG GENES KEGG GENES(10450)
GeneCard GeneCardPPIE*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000036097
Predicted CDS 10..915;  301[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.804
Database links RefSeq NP_006103
UniProt Q9UNP9
CCDS CCDS443

Motif information
ORF

length(301),orf(10:915)
MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFA
FVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDD
WLKKFSGKTLEENKEEEGSEPPKAETQEGEPIAKKARSNPQVYMDIKIGN
KPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQG
GDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFL
TCDKTDWLDGKHVVFGEVTEGLDVLRQIEAQGSKDGKPKQKVIIADCGEY
V*
a.a.
length
InterPro Name
length(86), motif(4:89) 86 IPR012677 Nucleotide-binding alpha-beta plait domain [Domain]
length(79), motif(6:84) 79 IPR000504 RNA recognition motif domain [Domain]
length(74), motif(7:80) 74 IPR000504 RNA recognition motif domain [Domain]
length(71), motif(8:78) 71 IPR000504 RNA recognition motif domain [Domain]
length(165), motif(135:299) 165 IPR029000 Cyclophilin-like domain [Domain]
length(166), motif(135:300) 166 IPR029000 Cyclophilin-like domain [Domain]
length(157), motif(143:299) 157 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(156), motif(143:298) 156 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(16), motif(160:175) 16 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(18), motif(184:201) 18 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [Conserved_site]
length(13), motif(189:201) 13 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(16), motif(232:247) 16 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(13), motif(247:259) 13 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]
length(16), motif(260:275) 16 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000049899
H-Inv cluster ID Locus viewHIX0000462
Accession number AK130628.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Peptidyl-prolyl cis-trans isomerase E; PPIase E; EC=5.2.1.8; Cyclophilin E; Cyclophilin-33; Rotamase E;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9UNP9)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 897710797478811199163814702039154893341671041421269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol PPIE
HGNC aliases NA
HGNC name peptidylprolyl isomerase E (cyclophilin E)
DDBJ NA
UniProt PPIE
EC number EC 5.2.1.8peptidylprolyl isomerase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04020 :Calcium signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000036097
No. of interaction 10
Interaction partner(s) HIP000014057HIP000027819HIP000027819HIP000030029HIP000030029HIP000030139HIP000036625HIP000078400HIP000100089HIP000251934
BIND NA
DIP NA
MINT NA
HPRD 01162;  04155;  04184;  04340;  06295;  11822;  11906;  11907;  11909;  11912;  13626;  16345;  18306; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10450
KEGG GENES KEGG GENES(10450)
GeneCard GeneCardPPIE*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function nucleic acid binding (GO:0003676);  peptidyl-prolyl cis-trans isomerase activity (GO:0003755);  nucleotide binding (GO:0000166); 
Biological process protein peptidyl-prolyl isomerization (GO:0000413);  protein folding (GO:0006457); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
8 83 1cvjA1 1e-21 34.2 76/80 d.58.7.1
139 301 1a33A 4e-56 50.9 163/174 b.62.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA241024; 
Affymetrix
GeneChip
HG-Focus 210502_s_at; 
HG-U133 202494_at;  210502_s_at;  221615_at; 
HG-U133A 202494_at;  210502_s_at;  221615_at; 
HG-U133A_2 202494_at;  210502_s_at;  221615_at; 
HG-U133B NA
HG-U133_Plus_2 202494_at;  210502_s_at;  221615_at; 
HG-U95 34364_at;  34366_g_at; 
HG-U95A 34364_at;  34366_g_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2331619;  2331620;  2331624;  2331625;  2331626;  2331627;  2331630;  2331633;  2331635;  2331636;  2331637; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P74518; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P74526; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
6 .. 6 C/T rs146968021 + 5'UTR
15 .. 15 C/G rs143737106 + CDS Synonymous[Ala2Ala]
21 .. 21 C/A rs200069647 + CDS Synonymous[Thr4Thr]
30 .. 30 C/T rs202000106 + CDS Synonymous[Val7Val]
48 .. 48 G/A rs201046457 + CDS Synonymous[Leu13Leu]
63 .. 63 C/T rs11809873 + CDS Synonymous[Asp18Asp]
84 .. 84 G/A rs140630770 + CDS Synonymous[Ala25Ala]
142 .. 142 A/G rs186973395 + CDS Nonsynonymous[Lys45Glu]
159 .. 159 T/C rs200299095 + CDS Synonymous[Ala50Ala]
201 .. 201 C/T rs138799550 + CDS Synonymous[Ile64Ile]
209 .. 209 T/C rs113902258 + CDS Nonsynonymous[Met67Thr]
232 .. 232 C/T rs150373599 + CDS Nonsynonymous[Arg75Cys]
318 .. 318 G/A rs12040687 + CDS Synonymous[Lys103Lys]
383 .. 383 A/C rs200484350 + CDS Nonsynonymous[Glu125Ala]
419 .. 419 G/A rs149451835 + CDS Nonsynonymous[Arg137His]
464 .. 464 C/T rs139872652 + CDS Nonsynonymous[Pro152Leu]
534 .. 534 G/A rs148125553 + CDS Synonymous[Leu175Leu]
591 .. 591 C/T rs112803459 + CDS Synonymous[Pro194Pro]
720 .. 720 C/G rs139269793 + CDS Synonymous[Ala237Ala]
817 .. 817 G/A rs72665281 + CDS Nonsynonymous[Glu270Lys]
835 .. 835 C/T rs142456461 + CDS Nonsynonymous[Arg276Trp]
891 .. 891 C/T rs146467977 + CDS Synonymous[Ile294Ile]
943 .. 943 G/A rs201342411 + 3'UTR
953 .. 953 C/G/T rs1046988 + 3'UTR
1093 .. 1093 C/G rs187239330 + 3'UTR
1151 .. 1151 G/A rs143982390 + 3'UTR
1168 .. 1168 T/C rs14528 + 3'UTR
1189 .. 1189 G/T rs191991117 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer