H-InvDB x AHG DB
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H-Invitational ID: HIT000051794 Accession number: BC036754 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Claudin-12;
 
 

Transcript original information
Accession number BC036754.2
CAGE tag ID NA
EST ID NA
Clone Number MGC:45162 IMAGE:5201423
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CLDN12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CLDN12);
Sequence data provider Provider:MGC/NCI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 3443[bp] (No. of exon:2)[A:996 T:1190 G:629 C:628]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Lung, Spleen, fetal, pooled
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3405(+) Signal: 3385-3389(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006831
Genomic location  G-integra Help Chromosome 7
Location 7q21.13
Position 90034832- 90045267
Strand +
Possible duplicated location(s) NA
Gene structure 2 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:9069; 
KEGG GENES KEGG GENES(9069); 
GeneCard GeneCardCLDN12;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000055160
Predicted CDS 129..863;  244[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.766
Database links RefSeq NP_001172001;  NP_001172002;  NP_036261; 
UniProt P56749;  Q5R9K1; 
CCDS CCDS5618; 

Motif information
ORF

length(244),orf(129:863) MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTV YTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGA LLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSP SIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCK SLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVVSHTT* 		a.a.
length		 InterPro Name
length(16), motif(38:53) 16 IPR013287 Claudin-12 [Family]
length(15), motif(53:67) 15 IPR017974 Claudin, conserved site [Conserved_site]
length(17), motif(65:81) 17 IPR013287 Claudin-12 [Family]
length(13), motif(123:135) 13 IPR013287 Claudin-12 [Family]
length(12), motif(150:161) 12 IPR013287 Claudin-12 [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000051794
H-Inv cluster ID Locus viewHIX0006831
Accession number BC036754.2
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Claudin-12;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P56749)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 11230166;  12690205;  12853948;  15489334;  18669648;  19690332;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CLDN12
HGNC aliases NA
HGNC name claudin 12
DDBJ CLDN12
UniProt CLDN12
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000055160
No. of interaction 4
Interaction partner(s) HIP000025790;  HIP000053638;  HIP000079334;  HIP000088109; 
BIND NA
DIP NA
MINT MINT-65603; 
HPRD 02538;  03799;  18125; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:9069; 
KEGG GENES KEGG GENES(9069); 
GeneCard GeneCardCLDN12;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function structural molecule activity (GO:0005198); 
Cellular component tight junction (GO:0005923); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT plasma membrane; 
Target P signal peptide
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA201522; 
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 223249_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 223249_at; 
HG-U133_Plus_2 223249_at; 
HG-U95 54122_at; 
HG-U95A NA
HG-U95B 54122_at; 
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3012023;  3012030;  3012031;  3012032;  3060641; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P157268;  A_23_P412515; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P157268;  A_23_P412515; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
18 .. 18 C/T rs116804658 + 5'UTR
86 .. 86 C/G rs185475099 + 5'UTR
139 .. 139 G/T rs200372770 + CDS Nonsynonymous[Arg4Leu]
140 .. 140 G/T rs201163165 + CDS Synonymous[Arg4Arg]
260 .. 260 C/T rs140108357 + CDS Synonymous[Asn44Asn]
314 .. 314 C/T rs17862175 + CDS Synonymous[Asp62Asp]
315 .. 315 G/A rs200164858 + CDS Nonsynonymous[Gly63Arg]
338 .. 338 C/T rs185427290 + CDS Synonymous[Tyr70Tyr]
359 .. 359 A/G rs200281270 + CDS Synonymous[Ser77Ser]
420 .. 420 A/G rs76988207 + CDS Nonsynonymous[Met98Val]
443 .. 443 G/T rs79632494 + CDS Synonymous[Leu105Leu]
476 .. 476 G/A rs34378679 - CDS Synonymous[Ser116Ser]
493 .. 493 T/A rs146056566 + CDS Nonsynonymous[Leu122Gln]
601 .. 601 A/G rs139669349 + CDS Nonsynonymous[Asn158Ser]
681 .. 681 C/T rs149798695 + CDS Synonymous[Leu185Leu]
707 .. 707 T/G rs144717277 + CDS Nonsynonymous[Phe193Leu]
722 .. 722 A/T rs148668482 + CDS Synonymous[Thr198Thr]
728 .. 728 A/G rs142157384 + CDS Synonymous[Lys200Lys]
795 .. 795 C/T rs189780617 + CDS Nonsynonymous[Pro223Ser]
804 .. 804 G/A rs147857522 + CDS Nonsynonymous[Ala226Thr]
807 .. 807 C/T rs141430153 + CDS Nonsynonymous[Arg227Cys]
829 .. 829 A/C rs145275926 + CDS Nonsynonymous[Glu234Ala]
895 .. 895 C/A rs182726869 + 3'UTR
903 .. 903 C/G rs147269114 + 3'UTR
945 .. 945 C/T rs140861444 + 3'UTR
995 .. 995 G/T rs3810874 - 3'UTR
1002 .. 1002 G/A rs187870115 + 3'UTR
1128 .. 1128 C/T rs191882778 + 3'UTR
1234 .. 1234 T/C rs183250663 + 3'UTR
1240 .. 1240 A/T rs17865130 + 3'UTR
1320 .. 1320 A/G rs1017104 + 3'UTR
1442 .. 1442 T/C rs1017105 + 3'UTR
1452 .. 1452 T/C rs1017106 + 3'UTR
1815 .. 1815 C/T rs193147106 + 3'UTR
2003 .. 2003 C/T rs142246998 + 3'UTR
2007 .. 2007 G/A rs11563542 + 3'UTR
2109 .. 2109 C/T rs151249770 + 3'UTR
2286 .. 2286 C/T rs17861306 + 3'UTR
2300 .. 2300 T/C rs34833025 + 3'UTR
2461 .. 2461 T/C rs17867644 + 3'UTR
2695 .. 2695 C/T rs1048881 + 3'UTR
2696 .. 2696 C/T rs1048882 + 3'UTR
2737 .. 2737 A/G rs184613376 + 3'UTR
2780 .. 2780 G/T rs1048883 + 3'UTR
2948 .. 2948 A/G rs186714887 + 3'UTR
2976 .. 2976 A/G rs191175070 + 3'UTR
3083 .. 3083 G/A rs9731 - 3'UTR
3238 .. 3238 A/G rs17863096 + 3'UTR
3365 .. 3365 C/T rs184005906 + 3'UTR
3391 .. 3391 A/G rs17866176 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;