H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000052674 Accession number: BC042180 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Probable phospholipid-transporting ATPase IF; EC=3.6.3.1; ATPase IR; ATPase class VI type 11B; RING finger-binding protein; Fragment;

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Transcript original information Accession number BC042180.1 CAGE tag ID NA EST ID NA Clone Number IMAGE:5395206 Experimental resources   NBRC ; HGPD ; Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 995[bp] (No. of exon:6)[A:275 T:252 G:262 C:206] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Breast, mammary adenocarcinoma. Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 962(+) Signal: 941-945(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

CAATAATGAAGGTGGCTGCGGCGCGGCGGCAGGCTCAGCTGCGCCGGGCG GGGGCGGCGCTGGGGCCGCGCCTGTAGGACTCGGGGCCGACGCCGCGGGA TGGGGACGCGGCGCGGGGAGTGAGGCAGTGGCGGCGGCGGCGGTAAGCGG AACTTCGGCCCGAGGGGCTCGCCCGCTCCCGCCTCTGTCTTGTCGGCCTC CACCTGCAGCCCCGCGGCCCCCGCGCCCCGCGGGACCCGGACGGCGACGA CGGGGGAATGTGGCGCTGGATCCGGCAGCAGCTGGGTTTTGACCCACCAC ATCAGAGTGACACAAGAACCATCTACGTAGCCAACAGGTTTCCTCAGAAT GGCCTTTACACACCTCAGAAATTTATAGATAACAGGATCATTTCATCTAA GTACACTGTGTGGAATTTTGTTCCAAAAAATTTATTTGAACAGTTCAGAA GAGTGGCAAACTTTTATTTTCTTATTATATTTTTGGTTCAGCTTATGATT GATACACCTACCAGTCCAGTTACCAGTGGACTTCCATTATTCTTTGTGAT AACAGTAACTGCCATAAAGCAGGGATATGAAGATTGGTTACGGCATAACT CAGATAATGAAGTAAATGGAGCTCCTGTTTATGTTGTTCGAAGTGGTGGC CTTGTAAAAACTAGATCAAAAAACATTCGGGTGGGTGATATTGTTCGAAT AGCCAAAGATGAAATTTTTCCTGCAGACTTGGTGCTTCTGTCCTCAGATC GACTGGATGGTTCCTGTCACGTTACAACTGCTAGTTTGGACGGAGAAACT AACCTGAAGGTTTGCTTGCATATGTTTGAGTATTGCTCTTGGTGAACAAA GTGTCTTTGGATTATAATTATACTTAACTTTGGTTAAAGTAGTAAAGTTT GACCAGATTAAGGGGAAGTTTTTAAAATTACTATTTCAAAAATAAAAAGG TTTTAAGAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0215375
Genomic location	Chromosome	3
	Location	3q26.33
	Position	182511291- 182554411
	Strand	+
Possible duplicated location(s)		NA
Gene structure		6 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:23200;
	KEGG GENES	KEGG GENES(23200);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000115480 Predicted CDS 258..845;  195[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.72

MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYT VWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITV TAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAK DEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKVCLHMFEYCSW*

Motif information

	a.a. length	InterPro	Name
	184	IPR006539	P-type ATPase, subfamily IV [Family]
	119	IPR008250	P-type ATPase, A domain [Domain]
	97	IPR001757	P-type ATPase [Family]
	88	IPR008250	P-type ATPase, A domain [Domain]

Gene function information

H-Inv ID		HIT000052674
H-Inv cluster ID		HIX0215375
Accession number		BC042180.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Probable phospholipid-transporting ATPase IF; EC=3.6.3.1; ATPase IR; ATPase class VI type 11B; RING finger-binding protein; Fragment;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q9N0Z4)  [Identity/coverage = 98.864%/15.06%] to Oryctolagus cuniculus (Rabbit). protein.
Experimental evidence		Protein evidence
PubMed ID		11058586;  11790799;  18584949;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	ATP11B
	UniProt	ATP11B
EC number		EC 3.6.3.1Mg2+-ATPase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000115480
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:23200;
	KEGG GENES	KEGG GENES(23200);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	metal ion binding (GO:0046872);  ATP binding (GO:0005524);  phospholipid-translocating ATPase activity (GO:0004012);  nucleotide binding (GO:0000166);  magnesium ion binding (GO:0000287);
Biological process	phospholipid transport (GO:0015914);
Cellular component	integral to membrane (GO:0016021);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	plasma membrane;  extracellular;  cytosol;  Other;
Target P	Not predicted
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 139 184 1f32A 1e-09 7.5 40/127 d.62.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsB040710;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	238811_at;
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	238811_at;
		HG-U133_Plus_2	238811_at;
		HG-U95	85960_at;
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	85960_at;
		HG-U95Av2	NA
		HuEx-1_0	2654816;  2654817;  2654825;  2654826;  2654827;  2654829;  2654830;  2654831;  2654832;  2707755;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	A_24_P340428;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 61 .. 61 T/C rs10222374 + 5'UTR 138 .. 138 C/G rs186930812 + 5'UTR 302 .. 302 T/G rs141226430 + CDS Nonsynonymous[His15Gln] 326 .. 326 C/T rs150296662 + CDS Synonymous[Tyr23Tyr] 328 .. 328 T/G rs137914384 + CDS Nonsynonymous[Val24Gly] 425 .. 425 A/C rs150991982 + CDS Synonymous[Pro56Pro] 492 .. 492 C/G rs146399753 + CDS Nonsynonymous[Leu79Val] 670 .. 670 A/G rs61741000 + CDS Nonsynonymous[Lys138Arg] 679 ^ 680 -/G rs35764399 + CDS 683 .. 683 G/A rs113153989 + CDS Synonymous[Val142Val] 832 .. 832 A/G rs202217070 + CDS Nonsynonymous[Tyr192Cys]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;