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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000053697 Accession number: BC051828 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: cAMP-regulated phosphoprotein 21; ARPP-21; Thymocyte cAMP-regulated phosphoprotein;
 
 

Transcript original information
Accession number BC051828.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:60100 IMAGE:6012704
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider Provider:MGC/NCI
Annotation project H-Invitational FLcDNA
Length of cDNA 2847[bp] (No. of exon:20)[A:856 T:583 G:692 C:716]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Testis, embryonal carcinoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 2833(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGTAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0215750
Genomic location  G-integra Help Chromosome 3
Location 3p22.3
Position 35683849- 35835580
Strand +
Possible duplicated location(s) NA
Gene structure 20 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10777
KEGG GENES KEGG GENES(10777)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000097313
Predicted CDS 265..2703;  812[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.763
Database links RefSeq NP_057384
UniProt Q9UBL0
CCDS CCDS2661

Motif information
ORF

length(812),orf(265:2703)
MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQN
QERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSL
QEEDKSRKDDSEREKEKDKNKDKTSEKPKIRMLSKDCSQEYTDSTGIDLH
EFLINTLKNNSRDRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVH
RVAAYFGLDHNVDQTGKSVIINKTSSTRIPEQRFCEHLKDEKGEESQKRF
ILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS
VCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSSSE
NELKWSDHQRAWSSTDSDSSNRNLKPAMTKTASFGGITVLTRGDSTSSTR
STGKLSKAGSESSSSAGSSGSLSRTHPPLQSTPLVSGVAAGSPGCVPYPE
NGIGGQVAPSSTSYILLPLEAATGIPPGSILLNPHTGQPFVNPDGTPAIY
NPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPLVTQRD
DVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQQ
LPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTST
TQQYRPMAPVQYNAQRSQQMPQAAQQAGYQPVLSGQQGFQGLIGVQQPPQ
SQNVINNQQGTPVQSVMVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPN
QAGQGSLPATGMPVYCNVTPPTPQNNLRLIGPHCPSSTVPVMSASCRTNC
ASMSNAGWQVKF*
a.a.
length
InterPro Name
length(121), motif(137:257) 121 IPR001374 Single-stranded nucleic acid binding R3H [Domain]
length(78), motif(147:224) 78 IPR001374 Single-stranded nucleic acid binding R3H [Domain]
length(64), motif(164:227) 64 IPR001374 Single-stranded nucleic acid binding R3H [Domain]
length(61), motif(164:224) 61 IPR001374 Single-stranded nucleic acid binding R3H [Domain]
length(64), motif(167:230) 64 IPR001374 Single-stranded nucleic acid binding R3H [Domain]
length(73), motif(228:300) 73 IPR024771 SUZ domain [Domain]
length(55), motif(245:299) 55 IPR024771 SUZ domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000053697
H-Inv cluster ID Locus viewHIX0215750
Accession number BC051828.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition cAMP-regulated phosphoprotein 21; ARPP-21; Thymocyte cAMP-regulated phosphoprotein;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9UBL0)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 812063810931946147020391509652015144186154893341797400519690332ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ ARPP-21
UniProt ARPP21
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000097313
No. of interaction 3
Interaction partner(s) HIP000020277HIP000030974HIP000104377
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10777
KEGG GENES KEGG GENES(10777)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function nucleic acid binding (GO:0003676); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
142 257 1whrA 4e-34 77.6 116/124 d.68.7.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA230507;  AGhsB141206; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 231935_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 231935_at; 
HG-U133_Plus_2 231935_at; 
HG-U95 60792_at;  68055_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 60792_at; 
HG-U95D NA
HG-U95E 68055_at; 
HG-U95Av2 NA
HuEx-1_0 2616616;  2616631;  2616632;  2616633;  2616637;  2616638;  2616639;  2616641;  2616647;  2616648;  2616649;  2616650;  2616655;  2616660;  2616661;  2616666;  2616668;  2616669;  2616672;  2616673;  2616675;  2616676;  2616680;  2616681;  2616683;  2616704;  2616706;  2616707;  2668870;  2668871; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_23_P143838; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) BC098368 G-integraG-integra
Orthology Bos sp. (Cow) ENSBTAT00000010171 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000014546 G-integraG-integra
Orthology Pan sp. (Chimpanzee) ENSPTRT00000027561 G-integraG-integra
Orthology Rattus sp. (Rat) ENSRNOT00000042854 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000179397 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001101221 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001375322 G-integraG-integra
Orthology Equus sp. (Horse) XM_001489743 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_687493 G-integraG-integra
Orthology Canis sp. (Dog) XM_853490 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
65 .. 65 T/C rs146238511 + 5'UTR
258 .. 258 T/C rs80148739 + 5'UTR
326 .. 326 C/T rs139626582 + CDS Nonsynonymous[Thr21Met]
398 .. 398 G/A rs77957430 + CDS Nonsynonymous[Arg45Gln]
446 .. 446 G/A rs149733002 + CDS Nonsynonymous[Gly61Glu]
468 .. 468 T/C/A rs969818 - CDS
507 .. 507 T/C rs201097001 + CDS Synonymous[Gly81Gly]
563 .. 563 T/G rs139587015 + CDS Nonsynonymous[Leu100Arg]
574 .. 574 G/A rs199716707 + CDS Nonsynonymous[Asp104Asn]
703 .. 703 A/G rs151024767 + CDS Nonsynonymous[Ile147Val]
843 .. 843 G/A rs150267871 + CDS Synonymous[Ser193Ser]
856 .. 856 C/T rs200003097 + CDS Nonsynonymous[Leu198Phe]
981 .. 981 A/C rs201370016 + CDS Nonsynonymous[Lys239Asn]
1038 .. 1038 T/C rs147080497 + CDS Synonymous[Ser258Ser]
1122 .. 1122 G/A rs143478890 + CDS Synonymous[Glu286Glu]
1137 .. 1137 G/A rs145771362 + CDS Synonymous[Val291Val]
1183 .. 1183 C/G rs74492876 + CDS Nonsynonymous[Leu307Val]
1254 .. 1254 C/G rs139185498 + CDS Synonymous[Leu330Leu]
1298 .. 1298 G/A rs145988544 + CDS Nonsynonymous[Arg345Gln]
1320 .. 1320 A/G rs144292807 + CDS Synonymous[Glu352Glu]
1409 .. 1409 C/T rs199754646 + CDS Nonsynonymous[Ala382Val]
1436 .. 1436 C/G rs200973242 + CDS Nonsynonymous[Thr391Ser]
1457 .. 1457 G/A rs142471124 + CDS Nonsynonymous[Ser398Asn]
1467 .. 1467 T/C rs138618895 + CDS Synonymous[Ser401Ser]
1486 .. 1486 G/A rs76948084 + CDS Nonsynonymous[Ala408Thr]
1512 .. 1512 A/G rs141819985 + CDS Synonymous[Ala416Ala]
1514 .. 1514 G/A rs202100345 + CDS Nonsynonymous[Gly417Asp]
1535 .. 1535 G/A rs147707279 + CDS Nonsynonymous[Arg424His]
1539 .. 1539 C/T rs200415538 + CDS Synonymous[Thr425Thr]
1542 .. 1542 T/C rs146391873 + CDS Synonymous[His426His]
1561 .. 1561 C/A rs150110250 + CDS Nonsynonymous[Pro433Thr]
1591 .. 1591 C/G rs138398652 + CDS Nonsynonymous[Pro443Ala]
1617 .. 1617 T/A rs188592147 + CDS Nonsynonymous[Asn451Lys]
1619 .. 1619 G/T rs193920911 + CDS Nonsynonymous[Gly452Val]
1658 .. 1658 T/C rs202203517 + CDS Nonsynonymous[Ile465Thr]
1691 .. 1691 C/T rs200486245 + CDS Nonsynonymous[Pro476Leu]
1704 .. 1704 C/T rs148441952 + CDS Synonymous[Ile480Ile]
1751 .. 1751 C/G rs141564286 + CDS Nonsynonymous[Thr496Ser]
1792 .. 1792 C/A rs192238724 + CDS Synonymous[Arg510Arg]
1827 .. 1827 A/G/T rs2278757 + CDS
1834 .. 1834 C/G rs199541246 + CDS Nonsynonymous[Gln524Glu]
1847 .. 1847 C/T rs142886822 + CDS Nonsynonymous[Pro528Leu]
1875 .. 1875 G/A rs200209237 + CDS Synonymous[Pro537Pro]
1887 .. 1887 G/A rs149775645 + CDS Nonsynonymous[Met541Ile]
1952 .. 1952 G/A rs144656036 + CDS Nonsynonymous[Arg563Gln]
1968 .. 1968 G/C rs200929703 + CDS Nonsynonymous[Glu568Asp]
1981 .. 1981 C/T rs145657305 + CDS Nonsynonymous[Pro573Ser]
2001 .. 2001 A/G rs199942974 + CDS Synonymous[Pro579Pro]
2021 .. 2021 C/A/T rs140813903 + CDS
2047 .. 2047 G/A rs151173813 + CDS Nonsynonymous[Ala595Thr]
2075 .. 2075 G/A rs150298577 + CDS Nonsynonymous[Gly604Glu]
2126 .. 2126 C/A rs141159284 + CDS Nonsynonymous[Pro621His]
2153 .. 2153 A/C rs138698634 + CDS Nonsynonymous[Gln630Pro]
2169 .. 2169 G/A rs144764224 + CDS Synonymous[Gln635Gln]
2194 .. 2194 G/T rs141444314 + CDS Nonsynonymous[Gly644Cys]
2202 .. 2202 C/A rs199538011 + CDS AA-STOP[Tyr646*]
2216 .. 2216 C/T rs139862817 + CDS Nonsynonymous[Thr651Met]
2254 .. 2254 G/A rs140987024 + CDS Nonsynonymous[Ala664Thr]
2255 .. 2255 C/T rs147476882 + CDS Nonsynonymous[Ala664Val]
2322 .. 2322 A/G rs200852825 + CDS Synonymous[Gln686Gln]
2342 .. 2342 T/C rs148862077 + CDS Nonsynonymous[Ile693Thr]
2375 .. 2375 T/C rs201683515 + CDS Nonsynonymous[Val704Ala]
2405 .. 2405 A/G rs140780259 + CDS Nonsynonymous[Gln714Arg]
2416 .. 2416 G/A rs144587268 + CDS Nonsynonymous[Val718Ile]
2428 .. 2428 A/G rs200410773 + CDS Nonsynonymous[Thr722Ala]
2518 .. 2518 G/T rs150351113 + CDS Nonsynonymous[Ala752Ser]
2555 .. 2555 T/G rs201077683 + CDS Nonsynonymous[Val764Gly]
2573 .. 2573 C/T rs149388106 + CDS Nonsynonymous[Pro770Leu]
2574 .. 2574 G/A/T rs185867328 + CDS
2620 .. 2620 T/C rs201057344 + CDS Nonsynonymous[Ser786Pro]
2645 .. 2645 C/T rs201813685 + CDS Nonsynonymous[Ala794Val]
2722 .. 2722 A/G rs149598559 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer