H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000053961 Accession number: BC053657 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;

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Transcript original information Accession number BC053657.1 CAGE tag ID NA EST ID NA Clone Number MGC:61459 IMAGE:5752337 Experimental resources   NBRC ; HGPD ; Antibody (ST8SIA4) ; Catalog (ST8SIA4); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 3680[bp] (No. of exon:5)[A:1213 T:1088 G:728 C:651] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Brain, Lung, Testis, adult, pooled whole Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 3586(+) Signal: 3558-3562(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GCTGCAGAAGCTGCCGCCACCTCCAATGCACAAGGTGTCTCATCTGGAAA GAAACCTGAGCCCCAGGGAGGCGGCGCGGAGCGACCCTGGCAGAGCTGGC GCAAACAGGGCGAGAGGTCGCTGGGCAGCGTTCGAGGACCAGAGGGAGCT CGGCCACAGAAGACCCCAGTGATCTGATCCCGGGATCCCGGCTCCAAGCT CTCCTCGCATTTTACAGATTTCACCCCCGCGACTATCTCCCCAAAACGGA GCCTTTATATCAAGAGAAGGTGCGGGAGCTGGGGCAACCAGGACTTTCTC GGGCACCCAAGATGCGCTCCATTAGGAAGAGGTGGACGATCTGCACAATA AGTCTGCTCCTGATCTTTTATAAGACAAAAGAAATAGCAAGAACTGAGGA GCACCAGGAGACGCAACTCATCGGAGATGGTGAATTGTCTTTGAGTCGGT CACTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATC TTCCAGCACAATGTAGAAGGTTGGAAAATCAATTCCTCTTTGGTCCTAGA GATAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGTGTCAG TGGTCAAGAGCAGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGAC AGGCGCCGGACACTAAACATTTCTCATGATCTACATAGCCTCCTACCTGA AGTTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAA ATTCTGGCATTCTGTTAGACAGTGAATGTGGAAAGGAGATTGACAGTCAC AATTTTGTAATAAGGTGTAATCTAGCTCCTGTGGTGGAGTTTGCTGCAGA TGTGGGAACTAAATCAGATTTTATTACCATGAATCCATCAGTTGTACAAA GAGCATTTGGAGGCTTTCGAAATGAGAGTGACAGAGAAAAATTTGTGCAT AGACTTTCCATGCTGAATGACAGTGTCCTTTGGATTCCTGCTTTCATGGT CAAAGGAGGAGAGAAGCACGTGGAGTGGGTTAATGCATTAATCCTTAAGA ATAAACTGAAAGTGCGAACTGCCTATCCGTCATTGAGACTTATTCATGCT GTCAGAGGTTACTGGCTGACCAACAAAGTTCCTATCAAAAGACCCAGCAC AGGTCTTCTCATGTATACACTTGCCACAAGATTCTGTGATGAAATTCACC TGTATGGATTCTGGCCCTTCCCTAAGGATTTAAATGGAAAAGCGGTCAAA TATCATTATTATGATGACTTAAAATATAGGTACTTTTCCAATGCAAGCCC TCACAGAATGCCATTAGAATTCAAAACATTAAATGTGCTACATAATAGAG GAGCTCTAAAACTGACAACAGGAAAGTGTGTAAAGCAATAAAGCACATTT TGAAACAAACAATATGCACTTCTTTTCTGAAGATGCTTCCGAAGATTTGA AAATAGGATCCAAAACACGGCTGGGTTTCAGCATCCACCAATGAACTGAA AGGTGAATAAAGGACGTTCATGAGAAATCGACTACCAGCTGATGAAATAC CTGCAAAGTGCTCTAAAAATTAAATATTTTGACTTTAAGGGTCCTAGTAA GTGCCACTTCCACTAAGAATACAGTTTGAATGTATAATCAGTAGTGTTTA CAAGATCCAACAGTGCACTCATCATTAGTTAACAAAGCAAATATGTTCAT CACTGTCAGGCTGCCCACAGCAACACCAAGCATATTAGAAGAGGAACCCC AGGAACGCAACTCAGACCTTGGGAAATTAAACCATCCTTGTCAGCAGAAG CCAAGATGGAAGCAGTTTGAGCAATGAAATCCGTAAGATTAAACAACTCA AGTAAATGCTTCAGTCAGGACTCTGAGTCTGATCATGAATTTTATGTTTT AATTTATGTTTTTTTTTTTGTCTTCTGGAATCTCTTTTGGTTTGGATATT GGGATGCTTAGAAATCCTTTCTGAGATGCATATGAGTGAGGAAATAAACT TTAAGTAATTATTTTTAAAGTTCTTATACTTTTTAAAAGCTATCACACAA AGACTTTTTTTTTTTTTTTTGTCTCGCTCTGTTGCCCAGGCTGGAGTACA GTGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCAAGTTCACTCCAT TCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTGCAGGCGCCTGCCACCA CGCCTGGCTAATTTTTTGTATTTTTAGTGGAGACGGATTTTCACCGTGTT AGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTTGGCCT CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCGACATTT TTAAAAAAGTTTTATTTTGCACGGCTCTAAACCTCCATGTTATTTTCCAG TGGTGTAGAAGGTACCAGCTAAAGTGAACCACTATGTAATATTAGGCCAT TCTAAAGGAAAGATGTTCCATGTCATCAGAGATGGTAAAATAGGCAGGGA AAAAAAAATCTTTGGTACCAAAGATTACACTTGTGTTTCTACACAGCAAA CCATTTTTCTTTCATGAAAATAATATATTATTAACATGAATATATTATTT TGCTATTAATGTGAAAGTTGTCTCTAAATATTTTTTAATTTTCAAACTCA TACTTTATTTTCATTTGAAATGTTTTTCACACCTTTTGCATTACATAATA ATTTTGTGGAAGCATTTTGCCCTTTAGAATAAATATTAGATTGATATAGC TGAAATGTGACTTCCAGTTCTTTGATATTCCCCTTGTTATTCAAATAGAA ATATGGAAATGCTTTATATATTACTGTTAAATTTCTTAGTGCAGAAATAA CATTATTAATAGAGTATTGTTTTCAAAACAGATGATTAATTTCAAGAGGT TTAACAGTGAAATTGTGTCAATATTTTGCATTTAAAATGAATTTAATTGA CCGATATTTTCTGTAGTTAAATTTAGTCACAATATCACATATGTTCTTCA AGAAACACATGAAATTATTAATAAAGTAATTAAAAAATTTTTAATGTATA ACAGAATTGACCAATAGGCCAGTTTTCTGGTAACTTATGATAGTAGATTG TTTCTTTAGAAACTGGGCAGAAGCTCTGCATTCTCACTTGTACTTTGATT TCTTATTTCTTGGTCAGGCAATTTGAGGAAAGAAGAAATGGCATGGGGAA TATATATGTTTTGTTTCTTAGGGAAAACAGTCTGAGAAATGAATAAAAAG CATGAAGTACGTGTGTGTGTGTGTGTGTGTGTTACCATGGAAAAGGATAT TCACAGTAGTACAGTTCTCAATATTTTTAATTAGATGTCATATTTTTTTA ATATAGTAAAACCTTGGGATATAGAATATTACATCTTTTGAGAATGTATG TGTCTCTAAGTAAGTAAAATCTAATGCGTATAGGAGACTGATAGCTAAAA ATGAATGGAACATTAATGTACTTTTATAATTAAACCTCTTATCTATCAGA AATTGTAAGAGAATAGATACATGTTTTGAATGTAAAGTTGAAAAGTCTGG TTTACTGAATAAATTGAAAGTGATTTATAAAATCTAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0005064
Genomic location	Chromosome	5
	Location	5q21.1
	Position	100145359- 100238970
	Strand	-
Possible duplicated location(s)		NA
Gene structure		5 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:7903;
	KEGG GENES	KEGG GENES(7903);
	GeneCard	ST8SIA4;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000094442 Predicted CDS 312..1391;  359[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.707 Database links RefSeq NP_005659;  UniProt P61645;  Q92187;  CCDS CCDS4091;

MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVN SSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKS SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGI LLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFG GFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLK VRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALK LTTGKCVKQ*

Motif information

	a.a. length	InterPro	Name
	264	IPR001675	Glycosyl transferase, family 29 [Family]

Gene function information

H-Inv ID		HIT000053961
H-Inv cluster ID		HIX0005064
Accession number		BC053657.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;  Splicing isoform
Coding potential		Protein coding;
Definition		CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (Q92187)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		7624364;  11279095;  14702039;  15372022;  15489334;  16959974;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	ST8SIA4
	HGNC aliases	"sialyltransferase 8 (alpha-2, 8-polysialytransferase) D"
	HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
	DDBJ	ST8SIA4
	UniProt	ST8SIA4
EC number		EC 2.4.99.-Transferring Other Glycosyl Groups;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000094442
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:7903;
	KEGG GENES	KEGG GENES(7903);
	GeneCard	ST8SIA4;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	sialyltransferase activity (GO:0008373);
Biological process	protein amino acid glycosylation (GO:0006486);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	mitochondria;  cytosol;  nuclear;  Other;
Target P	signal peptide
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsA020716;
	Affymetrix GeneChip	HG-Focus	206925_at;
		HG-U133	206925_at;  230261_at;  242943_at;
		HG-U133A	206925_at;
		HG-U133A_2	206925_at;
		HG-U133B	230261_at;  242943_at;
		HG-U133_Plus_2	206925_at;  230261_at;  242943_at;
		HG-U95	33649_at;  46175_i_at;  46176_r_at;  80847_at;
		HG-U95A	33649_at;
		HG-U95B	46175_i_at;  46176_r_at;
		HG-U95C	NA
		HG-U95D	80847_at;
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2822022;  2868912;  2868913;  2868914;  2868915;  2868916;  2868917;  2868918;  2868938;  2868939;  2868940;  2868944;  2868946;  2868951;  2868952;  2868953;  2868954;  2868955;
		HuGeneFL	L41680_at;
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P41693;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P361984;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Evolutionary information

Last modified:27-May-2015

Relationship	Species	Accession number	MGI	Links
Orthology	Gallus sp. (Chicken)	AF008194		G-integra
Orthology	Mus sp. (Mouse)	AJ223956	MGI:106018	G-integra
Orthology	Pan sp. (Chimpanzee)	AJ697661		G-integra
Orthology	Bos sp. (Cow)	AJ699421		G-integra
Orthology	Danio sp. (Zebrafish)	DQ779599		G-integra
Orthology	Monodelphis sp. (Opossum)	ENSMODT00000024487		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000018219		G-integra
Orthology	Macaca sp. (Macaque)	XM_001097339		G-integra
Orthology	Equus sp. (Horse)	XM_001504603		G-integra
Orthology	Canis sp. (Dog)	XM_546003		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 51 .. 51 G/A rs200194686 + 5'UTR 170 .. 170 T/C rs1428439 - 5'UTR 178 .. 178 T/A rs77888994 - 5'UTR 194 .. 194 C/T rs144473066 - 5'UTR 248 .. 248 G/T rs28617677 - 5'UTR 331 .. 331 G/A rs199768560 - CDS Nonsynonymous[Arg7Lys] 481 .. 481 G/A rs148751339 - CDS Nonsynonymous[Arg57Gln] 486 .. 486 G/A rs140658602 - CDS Nonsynonymous[Ala59Thr] 506 .. 506 G/A rs144123874 - CDS Synonymous[Gln65Gln] 571 .. 571 G/A rs149573011 - CDS Nonsynonymous[Arg87His] 603 .. 603 G/A rs199572556 - CDS Nonsynonymous[Val98Ile] 657 .. 657 C/T rs138152532 - CDS Nonsynonymous[Arg116Trp] 658 .. 658 G/A rs150785295 - CDS Nonsynonymous[Arg116Gln] 662 .. 662 A/T rs111610860 - CDS Synonymous[Thr117Thr] 786 .. 786 G/A rs200594223 - CDS Nonsynonymous[Glu159Lys] 803 .. 803 T/C rs138641468 - CDS Synonymous[Asn164Asn] 878 .. 878 C/T rs201525407 - CDS Synonymous[Thr189Thr] 912 .. 912 G/A rs144812419 - CDS Nonsynonymous[Gly201Ser] 913 .. 913 G/A rs184109088 - CDS Nonsynonymous[Gly201Asp] 914 .. 914 C/T rs191662668 - CDS Synonymous[Gly201Gly] 968 .. 968 T/C rs140878740 - CDS Synonymous[Asn219Asn] 1109 .. 1109 T/C rs148019074 - CDS Synonymous[Gly266Gly] 1145 .. 1145 C/T rs143503881 - CDS Synonymous[Pro278Pro] 1190 .. 1190 T/A rs148811953 - CDS Nonsynonymous[Asp293Glu] 1200 .. 1200 C/T rs145473445 - CDS Synonymous[Leu297Leu] 1244 .. 1244 G/A rs147105549 - CDS Synonymous[Ala311Ala] 1327 .. 1327 C/T rs141895424 - CDS Nonsynonymous[Thr339Ile] 1341 .. 1341 C/A rs200429642 - CDS Nonsynonymous[His344Asn] 1362 .. 1362 C/A rs181265141 - CDS Nonsynonymous[Leu351Met] 1372 .. 1372 G/A rs147924375 - CDS Nonsynonymous[Gly354Glu] 1531 .. 1531 A/G rs113309201 - 3'UTR 1544 .. 1544 G/A rs3076 - 3'UTR 1558 .. 1558 G/A rs141593443 - 3'UTR 1639 .. 1639 C/A rs139860572 - 3'UTR 1678 .. 1678 G/A rs189920171 - 3'UTR 1733 .. 1733 T/C rs10075853 - 3'UTR 1820 .. 1820 A/G rs150522303 - 3'UTR 1917 ^ 1918 -/T rs3842024 - 3'UTR 1920 .. 1920 G/T rs77924520 - 3'UTR 1920 ^ 1921 -/T rs5869926 - 3'UTR 1922 .. 1922 C/T rs200066566 - 3'UTR 1999 .. 1999 C/T rs185904021 - 3'UTR 2020 .. 2020 G/A rs80313395 - 3'UTR 2026 .. 2026 A/G rs6864891 - 3'UTR 2070 .. 2070 T/G rs201098848 - 3'UTR 2071 .. 2071 G/T rs150564207 - 3'UTR 2177 .. 2177 T/G rs11748306 - 3'UTR 2190 .. 2190 G/C rs181783701 - 3'UTR 2211 .. 2211 A/G rs143586479 - 3'UTR 2267 .. 2267 A/G rs190562478 - 3'UTR 2496 .. 2496 A/C rs2544919 + 3'UTR 2586 .. 2586 A/C rs79061882 - 3'UTR 2637 .. 2637 A/G rs187274363 - 3'UTR 2673 .. 2673 T/G rs181006190 - 3'UTR 2734 .. 2734 T/C rs189551449 - 3'UTR 2836 .. 2836 T/A rs142817493 - 3'UTR 2924 .. 2924 T/C rs73163637 - 3'UTR 3021 .. 3021 A/G rs191824121 - 3'UTR 3038 .. 3038 T/A rs138781620 - 3'UTR 3039 .. 3039 T/G rs112066813 - 3'UTR 3087 .. 3087 A/T rs77788876 - 3'UTR 3164 .. 3164 T/G rs2725124 + 3'UTR 3180 .. 3180 A/T rs188642219 - 3'UTR 3196 .. 3196 G/T rs147065508 - 3'UTR 3221 .. 3221 G/C rs184715869 - 3'UTR 3259 .. 3259 A/G rs202195846 + 3'UTR 3260 ^ 3261 -/GTGT rs200238711 - 3'UTR 3260 ^ 3261 -/GTGT/GTGTA rs56881158 - 3'UTR 3274 ^ 3275 -/TGTG rs71964891 - 3'UTR 3275 ^ 3276 -/GTGT rs67471601 - 3'UTR 3277 ^ 3278 -/GTGT rs72115355 - 3'UTR 3340 .. 3340 A/G rs193067470 - 3'UTR 3355 .. 3355 A/C rs188919274 - 3'UTR 3427 .. 3427 C/T rs141692307 - 3'UTR 3557 .. 3557 G/T rs11584 - 3'UTR 3579 .. 3579 A/G rs145748636 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  Type Start End Strand AluY 2055 2343 - L1MEd 3554 3680 + Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;