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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000070223 Accession number: AF119833 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;
 
 

Transcript original information
Accession number AF119833.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CLDN12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CLDN12);
Sequence data provider NA
Annotation project NA
Length of cDNA 2043[bp] (No. of exon:15)[A:586 T:521 G:477 C:459]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006831
Genomic location  G-integra Help Chromosome 7
Location 7q21.13
Position 90225811- 90836945
Strand +
Possible duplicated location(s) NA
Gene structure 15 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000037593
Predicted CDS 139..1548;  469[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.738

Motif information
ORF

length(469),orf(139:1548)
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTR
NCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNAC
INFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVY
KGKSKVNWKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDII
HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQR
YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPP
DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLG
TPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLL
QCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES
MRAFGKNNSYGKSLSNSKH*
a.a.
length
InterPro Name
length(294), motif(131:424) 294 IPR011009 Protein kinase-like domain [Domain]
length(285), motif(135:419) 285 IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
length(285), motif(135:419) 285 IPR000719 Protein kinase domain [Domain]
length(24), motif(141:164) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(13), motif(252:264) 13 IPR008271 Serine/threonine-protein kinase, active site [Active_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000070223
H-Inv cluster ID Locus viewHIX0006831
Accession number AF119833.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O94921)  [Identity/coverage = 99.787%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 100484851131314312098780126902051285394814702039154893341646146716775625173448461751762218691976193691951952457120059949ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CLDN12
HGNC aliases NA
HGNC name claudin 12
DDBJ NA
UniProt CDK14
EC number EC 2.7.11.22cyclin-dependent kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000037593
No. of interaction 1
Interaction partner(s) HIP000043732
BIND NA
DIP NA
MINT MINT-7147585;  MINT-7147598;  MINT-7147614;  MINT-7147628;  MINT-7147647;  MINT-7147665;  MINT-7147680;  MINT-7147695;  MINT-7147713;  MINT-7147725;  MINT-7147743; 
HPRD 00215;  00298;  00886;  03184;  05457; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Twilight zone
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
56 423 1nw1A 4e-39 8.1 335/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA101023; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 211502_s_at; 
HG-U133A 211502_s_at; 
HG-U133A_2 211502_s_at; 
HG-U133B NA
HG-U133_Plus_2 211502_s_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3012069;  3012070;  3012071;  3012073;  3012097;  3012098;  3012108;  3012120;  3012122;  3012127;  3012135;  3012141;  3012153;  3012158;  3012167;  3012168;  3012169;  3012170;  3012184;  3060789;  3535448; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P145889; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P145889; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
27 .. 27 G/A rs11760706 + 5'UTR
125 .. 125 T/C rs7782773 + 5'UTR
233 .. 233 T/G rs192282583 + CDS Nonsynonymous[Leu32Trp]
251 .. 251 C/G rs17866277 + CDS Nonsynonymous[Thr38Ser]
287 .. 287 G/A rs140679817 + CDS Nonsynonymous[Arg50Gln]
321 .. 321 C/T rs144891494 + CDS Synonymous[Pro61Pro]
491 .. 491 A/G rs187133761 + CDS Nonsynonymous[His118Arg]
497 .. 497 G/A rs138436598 + CDS Nonsynonymous[Ser120Asn]
507 .. 507 G/A rs55722725 + CDS Synonymous[Ser123Ser]
581 .. 581 C/T rs148988868 + CDS Nonsynonymous[Thr148Ile]
585 .. 585 A/G rs145790847 + CDS Synonymous[Val149Val]
594 .. 594 G/A rs200795779 + CDS Synonymous[Gly152Gly]
657 .. 657 G/A rs138497570 + CDS Synonymous[Gly173Gly]
666 .. 666 C/T rs78919227 + CDS Synonymous[Phe176Phe]
715 .. 715 A/G rs146138173 + CDS Nonsynonymous[Ile193Val]
753 .. 753 G/A rs56269509 + CDS Synonymous[Thr205Thr]
819 .. 819 G/A/T rs55664580 + CDS
822 .. 822 G/A rs184702498 + CDS Synonymous[Leu228Leu]
834 .. 834 T/C rs141395840 + CDS Synonymous[Asn232Asn]
872 .. 872 C/G rs150860380 + CDS Nonsynonymous[Ser245Cys]
921 .. 921 C/T rs139294759 + CDS Synonymous[Asn261Asn]
963 .. 963 C/T rs202149959 + CDS Synonymous[Phe275Phe]
984 .. 984 C/T rs201386540 + CDS Synonymous[Ser282Ser]
1007 .. 1007 A/G rs202143669 + CDS Nonsynonymous[Asn290Ser]
1009 .. 1009 G/A rs144455762 + CDS Nonsynonymous[Glu291Lys]
1021 .. 1021 T/C rs147407359 + CDS Synonymous[Leu295Leu]
1060 .. 1060 G/C rs201692399 + CDS Nonsynonymous[Glu308Gln]
1167 .. 1167 A/G rs112955689 + CDS Synonymous[Glu343Glu]
1169 .. 1169 G/A rs139618090 + CDS Nonsynonymous[Arg344Gln]
1196 .. 1196 A/G rs145309096 + CDS Nonsynonymous[Asn353Ser]
1212 .. 1212 T/C rs199729119 + CDS Synonymous[Pro358Pro]
1273 .. 1273 C/T rs34419285 + CDS Nonsynonymous[Leu379Phe]
1274 .. 1274 T/G rs145058405 + CDS Nonsynonymous[Leu379Arg]
1301 .. 1301 A/G rs149042459 + CDS Nonsynonymous[Tyr388Cys]
1312 .. 1312 G/A rs112642464 + CDS Nonsynonymous[Ala392Thr]
1317 .. 1317 G/A rs114347546 + CDS Synonymous[Glu393Glu]
1365 .. 1365 G/A rs151182341 + CDS Synonymous[Ser409Ser]
1386 .. 1386 C/T rs56412135 + CDS Synonymous[His416His]
1411 .. 1411 C/G rs140184613 + CDS Nonsynonymous[Arg425Gly]
1414 .. 1414 C/G rs200612683 + CDS Nonsynonymous[Leu426Val]
1492 .. 1492 C/T rs145303395 + CDS Nonsynonymous[Arg452Trp]
1493 .. 1493 G/A rs74839397 + CDS Nonsynonymous[Arg452Gln]
1525 .. 1525 A/C rs35643773 + CDS Nonsynonymous[Ser463Arg]
1528 .. 1528 C/G rs199515743 + CDS Nonsynonymous[Leu464Val]
1538 .. 1538 G/A rs141334351 + CDS Nonsynonymous[Ser467Asn]
1567 .. 1567 G/T rs192554076 + 3'UTR
1740 .. 1740 C/T rs12538034 + 3'UTR
1812 .. 1812 G/A rs186946911 + 3'UTR
1817 .. 1817 T/C rs117606486 + 3'UTR
1872 .. 1872 G/A rs79425377 + 3'UTR
1913 .. 1913 A/- rs57373891 + 3'UTR
1942 .. 1942 C/A rs192257107 + 3'UTR
2014 .. 2014 C/A rs57094099 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer