H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000087127 Accession number: BC008660 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Poly [ADP-ribose] polymerase 1; PARP-1; EC=2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1;
 
 

Transcript original information
Accession number BC008660.1
CAGE tag ID NA
EST ID NA
Clone Number IMAGE:3866228
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 833[bp] (No. of exon:5)[A:209 T:146 G:292 C:186]
Devision HTC
Molecular type mRNA
Library origin Cell type NA
Tissue type Eye, retinoblastoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature C-truncated
Kozak sequence NA
PolyA Site: 819(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0213855
Genomic location  G-integra Help Chromosome 1
Location 1q42.12
Position 226576401- 226595776
Strand -
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:142
KEGG GENES KEGG GENES(142)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000026392
Predicted CDS 147..833;  229[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.811

Motif information
ORF

length(229),orf(147:833)
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPH
WYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQD
GIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQ
LGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLP
GVKSEGKRKGDEVDGVDEVAKKKSKKKKK
a.a.
length
InterPro Name
length(99), motif(2:100) 99 IPR001510 Zinc finger, PARP-type [Domain]
length(85), motif(9:93) 85 IPR001510 Zinc finger, PARP-type [Domain]
length(78), motif(12:89) 78 IPR001510 Zinc finger, PARP-type [Domain]
length(36), motif(21:56) 36 IPR001510 Zinc finger, PARP-type [Domain]
length(107), motif(108:214) 107 IPR001510 Zinc finger, PARP-type [Domain]
length(91), motif(113:203) 91 IPR001510 Zinc finger, PARP-type [Domain]
length(84), motif(116:199) 84 IPR001510 Zinc finger, PARP-type [Domain]
length(38), motif(125:162) 38 IPR001510 Zinc finger, PARP-type [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000087127
H-Inv cluster ID Locus viewHIX0213855
Accession number BC008660.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Poly [ADP-ribose] polymerase 1; PARP-1; EC=2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P09874)  [Identity/coverage = 99.561%/22.49%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 15055172108670210932221217352123876212526925131742824474289113931134203120710312133293158519518481104674061504438315489334167104141690425716959974171779761739615017525332181725001866964819344625196088611966137919690332197794552006823120106667212694602140669221577210217999112200210622863007ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt PARP1
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000026392
No. of interaction 1
Interaction partner(s) HIP000063852
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:142
KEGG GENES KEGG GENES(142)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function zinc ion binding (GO:0008270);  DNA binding (GO:0003677); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2458829;  2458832;  2458838;  2458839;  2458840;  3501576;  3501577; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
99 .. 99 T/C rs200785577 - 5'UTR
100 .. 100 A/G rs199833781 - 5'UTR
130 .. 130 C/G rs907187 + 5'UTR
141 .. 141 G/C rs11541662 + 5'UTR
160 .. 160 C/G rs201256399 - CDS Nonsynonymous[Ser5Trp]
261 .. 261 G/C rs142025196 - CDS Nonsynonymous[Val39Leu]
274 .. 274 T/C rs202022212 - CDS Nonsynonymous[Met43Thr]
308 .. 308 C/G rs3738708 + CDS Nonsynonymous[Phe54Leu]
361 .. 361 A/C rs147105590 - CDS Nonsynonymous[Asp72Ala]
369 .. 369 T/C rs182219056 - CDS Nonsynonymous[Ser75Pro]
379 .. 379 G/A rs139202063 - CDS Nonsynonymous[Arg78Gln]
380 .. 380 G/A rs200181050 - CDS Synonymous[Arg78Arg]
389 .. 389 T/C rs1805404 + CDS Synonymous[Asp81Asp]
410 .. 410 A/G rs200812750 - CDS Synonymous[Thr88Thr]
413 .. 413 G/A rs201586576 - CDS Synonymous[Ala89Ala]
473 .. 473 T/A rs199783084 - CDS Synonymous[Thr109Thr]
485 .. 485 T/C rs61750986 - CDS Synonymous[Phe113Phe]
494 .. 494 G/A rs182943999 - CDS Synonymous[Glu116Glu]
501 .. 501 A/G rs143431455 - CDS Nonsynonymous[Lys119Glu]
508 .. 508 A/G rs200370133 - CDS Nonsynonymous[Asn121Ser]
516 .. 516 A/G rs139924814 - CDS Nonsynonymous[Thr124Ala]
518 .. 518 G/A rs199514247 - CDS Synonymous[Thr124Thr]
532 .. 532 T/C rs201841505 - CDS Nonsynonymous[Met129Thr]
558 .. 558 C/T rs193238922 - CDS Nonsynonymous[Arg138Cys]
596 .. 596 G/T rs142376976 - CDS Nonsynonymous[Gln150His]
628 .. 628 G/T rs144252227 - CDS Nonsynonymous[Gly161Val]
663 .. 663 C/T rs147537486 - CDS Nonsynonymous[Arg173Trp]
664 .. 664 G/A rs200399922 - CDS Nonsynonymous[Arg173Gln]
668 .. 668 C/G rs13306125 + CDS Synonymous[Pro174Pro]
679 .. 679 C/T rs202057244 - CDS Nonsynonymous[Ala178Val]
687 .. 687 C/T rs113258217 - CDS Nonsynonymous[Leu181Phe]
708 .. 708 G/A rs1805409 + CDS Nonsynonymous[Ala188Thr]
711 .. 711 A/G rs143482147 - CDS Nonsynonymous[Thr189Ala]
740 .. 740 G/A rs146652447 - CDS Synonymous[Gln198Gln]
793 .. 793 T/C rs144925873 - CDS Nonsynonymous[Val216Ala]
802 .. 802 T/C rs149927756 - CDS Nonsynonymous[Val219Ala]
805 .. 805 C/T rs139232092 - CDS Nonsynonymous[Ala220Val]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer