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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000087461 Accession number: BC010237 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Beta-adducin; Erythrocyte adducin subunit beta;
 
 

Transcript original information
Accession number BC010237.1
CAGE tag ID NA
EST ID NA
Clone Number IMAGE:4153471
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ADD2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ADD2);
Sequence data provider NA
Annotation project NA
Length of cDNA 2572[bp] (No. of exon:16)[A:657 T:426 G:767 C:722]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Brain, anaplastic oligodendroglioma with 1p/19q loss
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature C-truncated
Kozak sequence NA
PolyA Site: 2558(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGAAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0029808
Genomic location  G-integra Help Chromosome 2
Location 2p13.3
Position 70890625- 70995309
Strand -
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:119
KEGG GENES KEGG GENES(119)
GeneCard GeneCardADD2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000097064
Predicted CDS 446..2572;  709[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.811

Motif information
ORF

length(709),orf(446:2572)
MSEETVPEAASPPPPQGQPYFDRFSEDDPEYMRLRNRAADLRQDFNLMEQ
KKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHA
VFPTSSMNVSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWA
QLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSS
CFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMKWGLLPVSHNA
LLVGDMAYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGVVALGDTVE
EAFYKIFHLQAACEIQVSALSSAGGVENLILLEQEKHRPHEVGSVQWAGS
TFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEI
PATVTAFVFEEDGAPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQ
RSMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLEMRN
KIREQNRQDVKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDEDTKDDSE
ETVPNPFSQLTDQELEEYKKEVERKKLELDGEKETAPEEPGSPAKSAPAS
PVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVVVN
GREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGSPSK
SPSKKKKKK
a.a.
length
InterPro Name
length(708), motif(1:708) 708 IPR027773 Beta-adducin [Family]
length(193), motif(130:322) 193 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(206), motif(130:335) 206 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(183), motif(135:317) 183 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(182), motif(136:317) 182 IPR001303 Class II aldolase/adducin N-terminal [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000087461
H-Inv cluster ID Locus viewHIX0029808
Accession number BC010237.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Beta-adducin; Erythrocyte adducin subunit beta;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P35612)  [Identity/coverage = 100.0%/97.52%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 184060385667988810272129510581470203915489334158156212140669221697133ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ADD2
HGNC aliases NA
HGNC name adducin 2 (beta)
DDBJ ADD2
UniProt ADD2
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000097064
No. of interaction 11
Interaction partner(s) HIP000025285HIP000026208HIP000029340HIP000030685HIP000033437HIP000033560HIP000042542HIP000043538HIP000043538HIP000060745HIP000082857
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:119
KEGG GENES KEGG GENES(119)
GeneCard GeneCardADD2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR181793
Accession
Description
Location
PMID
FR ID FR234658
Accession
Description
Location
PMID

Gene ontology information
Cellular component cytoskeleton (GO:0005856); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB140706;  AGhsB140806;  AGhsB140906; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 36051_s_at; 
HG-U95A 36051_s_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2558756;  2558765;  2558767;  2558768;  2558772;  2558774;  2558776;  2558780;  2558781;  2558783;  2558790;  2558791;  2558792;  2558798;  2558799;  2558800;  2558801;  2558805;  2558818; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
77 .. 77 C/T rs2287099 - 5'UTR
84 .. 84 G/T rs28365917 + 5'UTR
93 .. 93 T/A rs2287098 - 5'UTR
181 .. 181 C/T rs2287097 - 5'UTR
194 .. 194 T/C rs115262291 - 5'UTR
214 .. 214 A/G rs146289331 - 5'UTR
436 .. 436 C/T rs188664399 - 5'UTR
440 .. 440 G/A rs199889944 - 5'UTR
444 .. 444 A/G rs62642474 - 5'UTR
452 .. 452 G/A rs200519011 - CDS Nonsynonymous[Glu3Lys]
492 .. 492 A/G rs201443444 - CDS Nonsynonymous[Gln16Arg]
495 .. 495 G/A rs34241538 + CDS Nonsynonymous[Gly17Glu]
527 .. 527 G/A rs4986 + CDS Nonsynonymous[Asp28Asn]
562 .. 562 G/A rs141187526 - CDS Synonymous[Ala39Ala]
570 .. 570 G/A rs144732476 - CDS Nonsynonymous[Arg42Gln]
577 .. 577 C/G rs138167651 - CDS Nonsynonymous[Asp44Glu]
644 .. 644 C/T rs114456016 - CDS Synonymous[Leu67Leu]
651 .. 651 G/T rs149147182 - CDS Nonsynonymous[Gly69Val]
697 .. 697 C/A rs17006140 - CDS Synonymous[Ile84Ile]
706 .. 706 G/A rs144778680 - CDS Synonymous[Leu87Leu]
715 .. 715 C/T rs200212314 - CDS Synonymous[Ile90Ile]
716 .. 716 G/A rs150703767 - CDS Nonsynonymous[Ala91Thr]
738 .. 738 C/G rs4987 + CDS Nonsynonymous[Ser98Cys]
754 .. 754 G/A rs144423262 - CDS Synonymous[Pro103Pro]
833 .. 833 G/A rs75081591 - CDS Nonsynonymous[Glu130Lys]
842 .. 842 A/C rs145968821 - CDS Nonsynonymous[Met133Leu]
883 .. 883 C/G rs114904807 - CDS Synonymous[Leu146Leu]
945 .. 945 A/G rs138007719 - CDS Nonsynonymous[His167Arg]
991 .. 991 G/A rs150383515 - CDS Synonymous[Ala182Ala]
998 .. 998 C/T rs200581515 - CDS Synonymous[Leu185Leu]
1008 .. 1008 T/A rs7425188 - CDS Nonsynonymous[Val188Glu]
1052 .. 1052 C/T rs148091443 - CDS Nonsynonymous[Pro203Ser]
1069 .. 1069 C/T rs147916626 - CDS Synonymous[Gly208Gly]
1084 .. 1084 G/A rs144869244 - CDS Synonymous[Ser213Ser]
1096 .. 1096 A/G rs181512905 - CDS Synonymous[Ala217Ala]
1109 .. 1109 G/A rs144714020 - CDS Nonsynonymous[Val222Met]
1118 .. 1118 A/G rs200730724 - CDS Nonsynonymous[Ile225Val]
1131 .. 1131 A/G rs201811808 - CDS Nonsynonymous[His229Arg]
1277 .. 1277 C/G rs145329028 - CDS Nonsynonymous[Leu278Val]
1303 .. 1303 G/A rs139387703 - CDS Synonymous[Val286Val]
1304 .. 1304 C/T rs111700825 - CDS Synonymous[Leu287Leu]
1319 .. 1319 G/T rs139808041 - CDS Nonsynonymous[Val292Leu]
1354 .. 1354 T/C rs4989 + CDS Synonymous[Phe303Phe]
1399 .. 1399 G/A rs142433540 - CDS Synonymous[Ser318Ser]
1415 .. 1415 G/A rs201864311 - CDS Nonsynonymous[Gly324Arg]
1441 .. 1441 G/A rs144529989 - CDS Synonymous[Leu332Leu]
1449 .. 1449 A/T rs61030669 - CDS Nonsynonymous[Glu335Val]
1450 .. 1450 G/T rs4982 + CDS Nonsynonymous[Glu335Asp]
1456 .. 1456 C/A rs142392995 - CDS Nonsynonymous[His337Gln]
1458 .. 1458 G/A rs146561886 - CDS Nonsynonymous[Arg338Gln]
1590 .. 1590 C/T rs145886276 - CDS Nonsynonymous[Thr382Met]
1591 .. 1591 G/A rs139827624 - CDS Synonymous[Thr382Thr]
1653 .. 1653 C/T rs199834771 - CDS Nonsynonymous[Thr403Met]
1667 .. 1667 G/A rs34196785 + CDS Nonsynonymous[Val408Met]
1677 .. 1677 A/G rs150772862 - CDS Nonsynonymous[Glu411Gly]
1690 .. 1690 G/A rs148662450 - CDS Synonymous[Pro415Pro]
1752 .. 1752 C/T rs201022450 - CDS Nonsynonymous[Thr436Met]
1753 .. 1753 G/T rs143711744 - CDS Synonymous[Thr436Thr]
1760 .. 1760 A/G rs17855969 - CDS Nonsynonymous[Thr439Ala]
1821 .. 1821 A/G rs201449367 - CDS Nonsynonymous[Lys459Arg]
1843 .. 1843 C/T rs188058882 - CDS Synonymous[Asp466Asp]
1873 .. 1873 G/A rs34884423 + CDS Synonymous[Pro476Pro]
1878 .. 1878 G/A rs150426440 - CDS Nonsynonymous[Arg478His]
1882 .. 1882 C/T rs199802003 - CDS Synonymous[Ile479Ile]
1947 .. 1947 A/G rs112879637 - CDS Nonsynonymous[Lys501Arg]
1954 .. 1954 A/C rs145174076 - CDS Synonymous[Arg503Arg]
1984 .. 1984 G/C rs115841739 - CDS Synonymous[Ala513Ala]
2011 .. 2011 C/T rs148402316 - CDS Synonymous[Ser522Ser]
2020 .. 2020 C/G rs201133279 - CDS Synonymous[Ala525Ala]
2028 .. 2028 G/C rs149689098 - CDS Nonsynonymous[Ser528Thr]
2031 .. 2031 G/T rs114311724 - CDS Nonsynonymous[Arg529Leu]
2072 .. 2072 G/A rs139586218 - CDS Nonsynonymous[Glu543Lys]
2100 .. 2100 C/T rs114897963 - CDS Nonsynonymous[Thr552Met]
2122 .. 2122 A/G rs115445925 - CDS Synonymous[Gln559Gln]
2262 .. 2262 C/T rs141431061 - CDS Nonsynonymous[Ala606Val]
2270 .. 2270 G/A rs138503054 - CDS Nonsynonymous[Ala609Thr]
2277 .. 2277 C/A rs140129786 - CDS Nonsynonymous[Thr611Lys]
2323 .. 2323 T/G rs199908987 - CDS Synonymous[Thr626Thr]
2348 .. 2348 G/A rs149050833 - CDS Nonsynonymous[Ala635Thr]
2351 .. 2351 A/G rs145267894 - CDS Nonsynonymous[Thr636Ala]
2377 .. 2377 G/A rs115476558 - CDS Synonymous[Pro644Pro]
2434 .. 2434 C/A rs4985 + CDS Nonsynonymous[Ser663Arg]
2445 .. 2445 G/A rs147439886 - CDS Nonsynonymous[Ser667Asn]
2470 .. 2470 G/A rs139265334 - CDS Synonymous[Thr675Thr]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer