H-InvDB x AHG DB
Transcript view
H-InvDB_9.0 released on May 27, 2015.
Search by for Advanced Search
Home Quick guide Navi BLAST Site map Download Contact us Help
H-Invitational ID: HIT000089630 Accession number: BC018583 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog;
 
 

Transcript original information
Accession number BC018583.1
CAGE tag ID NA
EST ID NA
Clone Number IMAGE:4155691
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (SUZ12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (SUZ12);
Sequence data provider NA
Annotation project NA
Length of cDNA 4024[bp] (No. of exon:15)[A:1294 T:1185 G:808 C:737]
Devision HTC
Molecular type mRNA
Library origin Cell type NA
Tissue type Brain, anaplastic oligodendroglioma with 1p/19q loss
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3961(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0013689
Genomic location  G-integra Help Chromosome 17
Location 17q11.2
Position 30264086- 30327650
Strand +
Possible duplicated location(s) NA
Gene structure 15 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23512
KEGG GENES KEGG GENES(23512)
GeneCard GeneCardSUZ12*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000031496
Predicted CDS 181..2331;  716[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.699

Motif information
ORF

length(716),orf(181:2331)
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGG
SYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFL
RTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSP
NSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTK
PGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNEN
IDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEME
ECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPI
AKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENR
QKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSR
FIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRT
PITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLP
LRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMK
HGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMS
IDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALE
TDSVSGVSKQSKKQKL*
a.a.
length
InterPro Name
length(24), motif(425:448) 24 IPR015880 Zinc finger, C2H2-like [Domain]
length(137), motif(522:658) 137 IPR019135 Polycomb protein, VEFS-Box [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000089630
H-Inv cluster ID Locus viewHIX0013689
Accession number BC018583.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q15022)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 859028011371647115648661235167612435631145321061509951815225548152317371538596215489334156840441622402116431907166188011671278917081983172006701734441418086877182203361828546418628979186696481877243919026781196903322006823121406692ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol SUZ12
HGNC aliases "suppressor of zeste 12 homolog (Drosophila)"
HGNC name SUZ12 polycomb repressive complex 2 subunit
DDBJ NA
UniProt SUZ12
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000031496
No. of interaction 12
Interaction partner(s) HIP000023351HIP000026716HIP000035533HIP000042725HIP000065282HIP000080231HIP000085996HIP000094069HIP000104226HIP000146054HIP000236471HIP000253875
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23512
KEGG GENES KEGG GENES(23512)
GeneCard GeneCardSUZ12*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
522 644 1fvpA 3e-21 17.0 106/100 c.1.16.2
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB210513; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 212287_at; 
HG-U133A 212287_at; 
HG-U133A_2 212287_at; 
HG-U133B NA
HG-U133_Plus_2 212287_at; 
HG-U95 40957_at; 
HG-U95A 40957_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3717413;  3717420;  3717422;  3717424;  3717425;  3717426;  3717428;  3717430;  3717431;  3717432;  3752513;  3752515;  3752516;  3752517; 
HuGeneFL D63881_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P100883; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P100883;  A_32_P24223; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name:NA
Related information in OMIM OMIM ID:  606245;  Title: SUPPRESSOR OF ZESTE 12, DROSOPHILA, HOMOLOG OF
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(23512)
Disease Entrez Gene ID:(23512)
Substance Entrez Gene ID:(23512)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
101 .. 101 G/A rs182208921 + 5'UTR
376 .. 376 G/A rs199728576 + CDS Nonsynonymous[Ala66Thr]
391 .. 391 G/A rs149833913 + CDS Nonsynonymous[Val71Met]
472 .. 472 A/G rs79452603 + CDS Nonsynonymous[Arg98Gly]
481 .. 481 C/T rs2627175 - CDS AA-STOP[Arg101*]
563 .. 563 A/G rs79415083 + CDS Nonsynonymous[Lys128Arg]
758 .. 758 A/T rs17339444 + CDS Nonsynonymous[Asn193Ile]
858 .. 858 G/A rs145801482 + CDS Synonymous[Ser226Ser]
973 .. 973 C/T rs199547628 + CDS Nonsynonymous[Arg265Cys]
980 .. 980 A/G rs183650826 + CDS Nonsynonymous[Asp267Gly]
985 .. 985 G/A rs148546138 + CDS Nonsynonymous[Glu269Lys]
1053 .. 1053 A/G rs145438545 + CDS Synonymous[Glu291Glu]
1086 .. 1086 T/C rs147681445 + CDS Synonymous[Cys302Cys]
1183 .. 1183 A/G rs142354346 + CDS Nonsynonymous[Thr335Ala]
1189 .. 1189 C/T rs146306622 + CDS Nonsynonymous[Arg337Cys]
1208 .. 1208 A/G rs151019506 + CDS Nonsynonymous[Asn343Ser]
1344 .. 1344 A/C rs140872258 + CDS Nonsynonymous[Gln388His]
1377 .. 1377 C/T rs77143645 + CDS Synonymous[Asn399Asn]
1437 .. 1437 T/G rs138584567 + CDS Synonymous[Thr419Thr]
1521 .. 1521 C/T rs148296125 + CDS Synonymous[Cys447Cys]
1596 .. 1596 T/C rs113231885 + CDS Synonymous[Tyr472Tyr]
1658 .. 1658 G/T rs137920170 + CDS Nonsynonymous[Arg493Leu]
1661 .. 1661 A/G rs142366304 + CDS Nonsynonymous[Asn494Ser]
1662 .. 1662 C/T rs143863610 + CDS Synonymous[Asn494Asn]
1692 .. 1692 T/C rs148804361 + CDS Synonymous[His504His]
1782 .. 1782 T/C rs55832508 + CDS Synonymous[Tyr534Tyr]
1809 .. 1809 C/A rs11551268 + CDS Nonsynonymous[Phe543Leu]
1818 .. 1818 T/C rs201407775 + CDS Synonymous[Asp546Asp]
1995 .. 1995 T/A rs150888728 + CDS Synonymous[Ala605Ala]
2043 .. 2043 A/G rs138328609 + CDS Synonymous[Gly621Gly]
2064 .. 2064 T/C rs200797131 + CDS Synonymous[Asn628Asn]
2135 .. 2135 A/G rs112915103 + CDS Nonsynonymous[Asp652Gly]
2147 .. 2147 C/T rs139363631 + CDS Nonsynonymous[Thr656Ile]
2204 .. 2204 A/G rs145524414 + CDS Nonsynonymous[Asn675Ser]
2235 .. 2235 A/G rs147697832 + CDS Synonymous[Thr685Thr]
2258 .. 2258 A/G rs115100527 + CDS Nonsynonymous[Asn693Ser]
2288 .. 2288 G/A rs140801412 + CDS Nonsynonymous[Ser703Asn]
2440 .. 2440 T/G rs143901922 + 3'UTR
2554 .. 2554 T/C rs115308907 + 3'UTR
2596 .. 2596 A/T rs1061194 + 3'UTR
2664 .. 2664 T/G rs113398624 + 3'UTR
2669 .. 2669 A/C rs15654 - 3'UTR
2681 .. 2681 C/T rs201628524 - 3'UTR
2736 .. 2736 T/G rs16967070 + 3'UTR
2900 .. 2900 T/C rs116124238 + 3'UTR
2958 .. 2958 T/C rs79896497 + 3'UTR
3003 .. 3003 T/C rs148348149 + 3'UTR
3025 .. 3025 C/A rs186993715 + 3'UTR
3064 .. 3064 C/T rs141497489 + 3'UTR
3136 .. 3136 C/T rs537166 - 3'UTR
3322 .. 3322 G/C rs550923 + 3'UTR
3424 .. 3424 C/T rs191480323 + 3'UTR
3628 .. 3628 G/A rs10627 + 3'UTR
3642 .. 3642 T/C rs150884111 + 3'UTR
3667 .. 3667 C/T rs185207156 + 3'UTR
3947 .. 3947 C/T rs190103141 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer