H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000099129 Accession number: BC050279 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Dynamin-1; EC=3.6.5.5;
 
 

Transcript original information
Accession number BC050279.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:33790 IMAGE:5284480
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (DNM1) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (DNM1);
Sequence data provider NA
Annotation project NA
Length of cDNA 3261[bp] (No. of exon:21)[A:736 T:600 G:925 C:1000]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Brain, hippocampus
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3247(+) Signal: 3226-3230(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  GAGCAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0008422
Genomic location  G-integra Help Chromosome 9
Location 9q34.11
Position 130965658- 131017516
Strand +
Possible duplicated location(s) NA
Gene structure 21 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:1759
KEGG GENES KEGG GENES(1759)
GeneCard GeneCardDNM1*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000138653
Predicted CDS 93..2648;  851[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.834

Motif information
ORF

length(851),orf(93:2648)
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLEN
FVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLE
IEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPP
DIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALEVAKEVDPQGQRT
IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITA
ALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTDHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQ
IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRT
GLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYP
RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQ
QRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENL
SWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHS
MDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSE
LLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTV
STPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAP
GPPPAGSAMGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPRITISD
P*
a.a.
length
InterPro Name
length(763), motif(1:763) 763 IPR027741 Dynamin-1 [Family]
length(763), motif(1:763) 763 IPR022812 Dynamin superfamily [Family]
length(301), motif(3:303) 301 IPR027417 P-loop containing nucleoside triphosphate hydrolase [Domain]
length(240), motif(6:245) 240 IPR001401 Dynamin, GTPase domain [Domain]
length(19), motif(31:49) 19 IPR022812 Dynamin superfamily [Family]
length(174), motif(34:207) 174 IPR001401 Dynamin, GTPase domain [Domain]
length(18), motif(56:73) 18 IPR022812 Dynamin superfamily [Family]
length(10), motif(57:66) 10 IPR019762 Dynamin, GTPase region, conserved site [Conserved_site]
length(18), motif(126:143) 18 IPR022812 Dynamin superfamily [Family]
length(19), motif(176:194) 19 IPR022812 Dynamin superfamily [Family]
length(17), motif(195:211) 17 IPR022812 Dynamin superfamily [Family]
length(292), motif(216:507) 292 IPR000375 Dynamin central domain [Domain]
length(20), motif(218:237) 20 IPR022812 Dynamin superfamily [Family]
length(125), motif(509:633) 125 IPR011993 Pleckstrin homology-like domain [Domain]
length(107), motif(519:625) 107 IPR001849 Pleckstrin homology domain [Domain]
length(99), motif(520:618) 99 IPR001849 Pleckstrin homology domain [Domain]
length(108), motif(520:627) 108 IPR001849 Pleckstrin homology domain [Domain]
length(92), motif(654:745) 92 IPR003130 Dynamin GTPase effector [Domain]
length(90), motif(655:744) 90 IPR003130 Dynamin GTPase effector [Domain]
length(92), motif(659:750) 92 IPR020850 GTPase effector domain, GED [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000099129
H-Inv cluster ID Locus viewHIX0008422
Accession number BC050279.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Dynamin-1; EC=3.6.5.5;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q05193)  [Identity/coverage = 99.653%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 763408878504217954789810152515164053154893341570320917081983172575981808808721269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol DNM1
HGNC aliases NA
HGNC name dynamin 1
DDBJ DNM1
UniProt DNM1
EC number EC 3.6.5.5dynamin GTPase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000138653
No. of interaction 13
Interaction partner(s) HIP000022280HIP000023025HIP000027204HIP000027204HIP000076124HIP000079588HIP000100433HIP000102217HIP000114524HIP000207752HIP000253715HIP000253715HIP000349364
BIND NA
DIP 132061E;  133924E;  65471E; 
MINT MINT-18828;  MINT-18829;  MINT-61330;  MINT-61333;  MINT-62868;  MINT-64668;  MINT-64669;  MINT-64670;  MINT-64671;  MINT-65945;  MINT-65947;  MINT-65948;  MINT-65950;  MINT-65951;  MINT-65952;  MINT-65953;  MINT-7102122;  MINT-7213627;  MINT-7302450;  MINT-8096278;  MINT-8096329;  MINT-8096359;  MINT-8096384;  MINT-8096409;  MINT-8110299; 
HPRD 00146;  00150;  00449;  01132;  01268;  01381;  01398;  01453;  01498;  01503;  01809;  01819;  02219;  02637;  02687;  02740;  03028;  03150;  03281;  03462;  03898;  04095;  04528;  05125;  05378;  05936;  05937;  05941;  05943;  06256;  08968;  10165;  10369;  10446;  10667;  10918;  12072;  12118;  14382;  15926;  16029;  17212; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:1759
KEGG GENES KEGG GENES(1759)
GeneCard GeneCardDNM1*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR198372
Accession
Description
Location
PMID
FR ID FR301597
Accession
Description
Location
PMID

Gene ontology information
Molecular function GTP binding (GO:0005525);  GTPase activity (GO:0003924); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT cytosol;  cytoskeleton;  peroxisome; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
7 304 1jwyB e-113 61.8 272/281 c.37.1.8
518 630 1dynA 4e-12 92.0 113/113 b.55.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL neural; 
Probe
information DNAProbeLocator
AceGene AGhsB220901; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 217341_at; 
HG-U133A 217341_at; 
HG-U133A_2 217341_at; 
HG-U133B NA
HG-U133_Plus_2 217341_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3190243;  3190244;  3190247;  3190249;  3190250;  3190251;  3190252;  3190253;  3190254;  3190255;  3190256;  3190260;  3190272;  3190273;  3190274;  3190276;  3190279;  3190281;  3190282;  3190283;  3190284;  3190286;  3190287;  3226421; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
138 .. 138 C/A rs61757224 + CDS Nonsynonymous[Leu16Met]
209 .. 209 C/T rs142432944 + CDS Synonymous[Gly39Gly]
291 .. 291 C/T rs199575353 + CDS Nonsynonymous[Arg67Cys]
355 .. 355 G/C rs200251552 + CDS Nonsynonymous[Gly88Ala]
356 .. 356 A/T rs199738085 + CDS Synonymous[Gly88Gly]
404 .. 404 G/A rs2229917 + CDS Synonymous[Glu104Glu]
424 .. 424 C/G rs192913494 + CDS Nonsynonymous[Thr111Ser]
449 .. 449 T/C rs77325628 + CDS Synonymous[Pro119Pro]
480 .. 480 C/T rs36009729 + CDS Synonymous[Leu130Leu]
482 .. 482 G/T rs183885342 + CDS Synonymous[Leu130Leu]
506 .. 506 C/T rs141748215 + CDS Synonymous[Pro138Pro]
542 .. 542 C/G rs143834670 + CDS Synonymous[Pro150Pro]
620 .. 620 C/T rs146242842 + CDS Synonymous[Pro176Pro]
654 .. 654 G/A rs141079649 + CDS Nonsynonymous[Glu188Lys]
770 .. 770 C/G rs150094408 + CDS Synonymous[Pro226Pro]
817 .. 817 T/C rs138357499 + CDS Nonsynonymous[Ile242Thr]
839 .. 839 C/T rs141651183 + CDS Synonymous[Thr249Thr]
866 .. 866 C/G rs146211149 + CDS Nonsynonymous[Phe258Leu]
888 .. 888 C/T rs138053929 + CDS Nonsynonymous[Arg266Cys]
889 .. 889 G/A rs200136679 + CDS Nonsynonymous[Arg266His]
904 .. 904 G/A rs201656136 + CDS Nonsynonymous[Arg271His]
1100 .. 1100 C/T rs3003609 + CDS Synonymous[Phe336Phe]
1145 .. 1145 C/T rs143999521 + CDS Synonymous[Ile351Ile]
1146 .. 1146 G/A rs148695604 + CDS Nonsynonymous[Asp352Asn]
1154 .. 1154 C/T rs35048348 + CDS Synonymous[Tyr354Tyr]
1238 .. 1238 G/A rs150617335 + CDS Synonymous[Lys382Lys]
1247 .. 1247 A/C rs140703430 + CDS Synonymous[Arg385Arg]
1264 .. 1264 C/T rs144768415 + CDS Nonsynonymous[Ala391Val]
1353 .. 1353 C/T rs200535620 + CDS AA-STOP[Arg421*]
1442 .. 1442 G/T rs147897973 + CDS Synonymous[Pro450Pro]
1529 .. 1529 C/T rs141788807 + CDS Synonymous[Ile479Ile]
1678 .. 1678 A/G rs150040014 + CDS Nonsynonymous[Asn529Ser]
1799 .. 1799 C/T rs145318071 + CDS Synonymous[Asn569Asn]
1856 .. 1856 C/T rs111534551 + CDS Synonymous[Leu588Leu]
1899 .. 1899 C/G rs201231277 + CDS Nonsynonymous[Leu603Val]
2010 .. 2010 G/A rs143374099 + CDS Nonsynonymous[Glu640Lys]
2038 .. 2038 A/G rs200057370 + CDS Nonsynonymous[His649Arg]
2043 .. 2043 A/C rs202117494 + CDS Nonsynonymous[Met651Leu]
2255 .. 2255 G/A rs146678077 + CDS Synonymous[Gln721Gln]
2273 .. 2273 G/C rs140234146 + CDS Nonsynonymous[Glu727Asp]
2280 .. 2280 C/A rs10987947 + CDS Nonsynonymous[Arg730Ser]
2310 .. 2310 A/G rs145381151 + CDS Nonsynonymous[Ser740Gly]
2322 .. 2322 G/A rs1042007 + CDS Nonsynonymous[Asp744Asn]
2501 .. 2501 G/C rs112104987 + CDS Synonymous[Pro803Pro]
2669 .. 2669 C/T rs199498658 + 3'UTR
2711 .. 2711 C/A rs187315526 + 3'UTR
2774 .. 2774 G/A rs150365327 + 3'UTR
2975 .. 2975 C/T rs191764646 + 3'UTR
3005 .. 3005 C/G rs113109726 + 3'UTR
3110 .. 3110 G/A rs183885743 + 3'UTR
3171 .. 3171 G/A rs138036588 + 3'UTR
3179 ^ 3180 -/C rs34900754 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer