H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000192533 Accession number: L23208 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Cyclin-dependent kinase 8; EC=2.7.11.22; EC=2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35;
 
 

Transcript original information
Accession number L23208.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 846[bp] (No. of exon:5)[A:250 T:200 G:178 C:218]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type whole brain
Develpmental stage 3 month post natal
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) GAGAAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0037326
Genomic location  G-integra Help Chromosome 13
Location 13q12.13
Position 26971294- 26978533
Strand +
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:1024
KEGG GENES KEGG GENES(1024)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000130245
Predicted CDS 1..531;  176[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.767

Motif information
ORF

length(176),orf(1:531)
TNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLED
PLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHP
GNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPST
SQPQSSMGYSATSQQPPQYSHQTHRY*
a.a.
length
InterPro Name
length(45), motif(9:53) 45 IPR011009 Protein kinase-like domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000192533
H-Inv cluster ID Locus viewHIX0037326
Accession number L23208.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Cyclin-dependent kinase 8; EC=2.7.11.22; EC=2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P49336)  [Identity/coverage = 100.0%/37.93%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 756803497343581002488310993082150578231517516315489334155466121598996717000779173448461936919521806996ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt CDK8
EC number EC 2.7.11.22cyclin-dependent kinase;  EC 2.7.11.23[RNA-polymerase]-subunit kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000130245
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:1024
KEGG GENES KEGG GENES(1024)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
7 41 1ia8A 5e-07 34.3 35/272 d.144.1.7
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA170423; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 1553112_s_at; 
HG-U95 1189_at; 
HG-U95A 1189_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2501099;  3482544;  3482546;  3482548;  3482550;  3482553;  3482554;  3506526;  3506528;  3506529; 
HuGeneFL X85753_at; 
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_23_P139958; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
119 .. 119 A/G rs202027259 + CDS Nonsynonymous[Gln40Arg]
209 .. 209 T/C rs202007506 + CDS Nonsynonymous[Phe70Ser]
216 .. 216 G/A rs140567276 + CDS Synonymous[Thr72Thr]
228 .. 228 T/C rs200968385 + CDS Synonymous[Pro76Pro]
297 .. 297 C/T rs145770778 + CDS Synonymous[His99His]
336 .. 336 G/A rs138501276 + CDS Synonymous[Pro112Pro]
356 .. 356 T/C rs141416704 + CDS Nonsynonymous[Val119Ala]
451 .. 451 T/C rs77965388 + CDS Nonsynonymous[Ser151Pro]
559 .. 559 G/A rs182536040 + 3'UTR
566 .. 566 A/T rs200275587 + 3'UTR
708 .. 708 C/T rs139519579 + 3'UTR
770 ^ 771 -/C rs36088650 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer