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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000216554 Accession number: S74678 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP;
 
 

Transcript original information
Accession number S74678.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 2302[bp] (No. of exon:15)[A:646 T:651 G:556 C:449]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0008131
Genomic location  G-integra Help Chromosome 9
Location 9q21.32
Position 86583461- 86593367
Strand -
Possible duplicated location(s) NA
Gene structure 15 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3190
KEGG GENES KEGG GENES(3190)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000051002
Predicted CDS 108..1499;  463[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.74
Database links RefSeq NP_112552
UniProt P61978P61979P61980
CCDS CCDS6667

Motif information
ORF

length(463),orf(108:1499)
METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQ
SKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEI
LKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLL
IHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPD
RVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRP
VGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRG
GSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAID
TWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAG
SIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYL
LQNSVKQYSGKFF*
a.a.
length
InterPro Name
length(43), motif(1:43) 43 IPR012987 ROK, N-terminal [Domain]
length(73), motif(38:110) 73 IPR004088 K Homology domain, type 1 [Domain]
length(69), motif(41:109) 69 IPR004087 K Homology domain [Domain]
length(63), motif(42:104) 63 IPR004088 K Homology domain, type 1 [Domain]
length(59), motif(45:103) 59 IPR004088 K Homology domain, type 1 [Domain]
length(80), motif(141:220) 80 IPR004088 K Homology domain, type 1 [Domain]
length(80), motif(142:221) 80 IPR004088 K Homology domain, type 1 [Domain]
length(72), motif(143:214) 72 IPR004087 K Homology domain [Domain]
length(66), motif(144:209) 66 IPR004088 K Homology domain, type 1 [Domain]
length(63), motif(147:209) 63 IPR004088 K Homology domain, type 1 [Domain]
length(79), motif(379:457) 79 IPR004088 K Homology domain, type 1 [Domain]
length(75), motif(385:459) 75 IPR004088 K Homology domain, type 1 [Domain]
length(71), motif(386:456) 71 IPR004087 K Homology domain [Domain]
length(65), motif(387:451) 65 IPR004088 K Homology domain, type 1 [Domain]
length(62), motif(389:450) 62 IPR004088 K Homology domain, type 1 [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000216554
H-Inv cluster ID Locus viewHIX0008131
Accession number S74678.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P61978)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 17295968107114965136110369774118405671199163812093748121834651516405315489334163600361656467716964243170819831792467918669648186919761877570219690332200682312067399021269460214066922282585022967762ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt HNRNPK
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000051002
No. of interaction 18
Interaction partner(s) HIP000022035HIP000022049HIP000022971HIP000022971HIP000023960HIP000025001HIP000030471HIP000039590HIP000039653HIP000040680HIP000057536HIP000058310HIP000064456HIP000076215HIP000076215HIP000079240HIP000091500HIP000095024
BIND 145824;  177285;  177286;  19219;  24463;  24472;  263126;  50116;  50117;  50266;  54906;  57935;  57936;  57937;  57938; 
DIP 102592E;  111677E;  111706E;  112072E;  144758E;  151748E;  151750E;  151752E;  175753E;  179997E;  185077E;  185374E; 
MINT MINT-2855592;  MINT-2859739;  MINT-2859758;  MINT-2859777;  MINT-3296872;  MINT-5205854;  MINT-6803834;  MINT-6803853;  MINT-6803869;  MINT-6803896;  MINT-6803939;  MINT-6823857;  MINT-6823877;  MINT-7035260;  MINT-7035286;  MINT-7035298;  MINT-7035309;  MINT-7035323;  MINT-7035338;  MINT-7945693;  MINT-7947479;  MINT-8200625;  MINT-8200636;  MINT-8200651;  MINT-8201404;  MINT-8201427;  MINT-8201449; 
HPRD 00146;  00298;  00496;  00535;  00579;  00589;  00655;  00796;  01095;  01228;  01284;  01301;  01501;  01726;  01746;  01801;  01818;  01819;  02186;  02511;  02877;  03128;  03129;  03144;  03158;  03183;  03926;  04066;  04184;  04205;  04207;  04257;  04340;  04360;  04530;  05059;  05088;  05156;  05270;  05378;  05496;  06515;  06691;  07601;  09045;  09060;  09113;  09273;  10007;  11303;  11488;  11535;  12048;  12752;  13775;  14358;  15334;  15998;  16246;  17835;  18043; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3190
KEGG GENES KEGG GENES(3190)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function nucleic acid binding (GO:0003676);  RNA binding (GO:0003723); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
40 110 2axyA1 3e-10 29.6 71/71 d.51.1.1
144 251 2dp9A1 2e-17 11.0 100/120 b.122.1.5
384 457 1we8A 2e-04 17.1 74/104 d.51.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus 200097_s_at; 
HG-U133 200097_s_at;  200775_s_at; 
HG-U133A 200097_s_at;  200775_s_at; 
HG-U133A_2 200097_s_at;  200775_s_at; 
HG-U133B 200097_s_at; 
HG-U133_Plus_2 200097_s_at;  200775_s_at; 
HG-U95 39415_at; 
HG-U95A 39415_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2578076;  2578092;  2578094;  2578096;  2632703;  2632704;  2632705;  2632706;  2632707;  2632708;  2632709;  2802833;  2802834;  2874170;  3170334;  3176991;  3176994;  3212296;  3212297;  3212298;  3212299;  3212300;  3212313;  3212314;  3212315;  3212316;  3212319;  3212321;  3212324;  3212330;  3212331;  3212332;  3212334;  3212335;  3370699; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
5 .. 5 C/A rs201348285 - 5'UTR
54 .. 54 G/C rs167203 + 5'UTR
58 .. 58 T/C rs150285449 - 5'UTR
92 .. 92 C/T rs111648912 - 5'UTR
100 .. 100 A/G rs11548842 + 5'UTR
107 .. 107 T/A rs138667733 - 5'UTR
113 .. 113 A/G rs202064506 - CDS Synonymous[Glu2Glu]
123 .. 123 C/T rs150076109 - CDS Nonsynonymous[Pro6Ser]
152 .. 152 C/T rs199952772 - CDS Synonymous[Thr15Thr]
179 .. 179 A/C rs114536498 - CDS Synonymous[Ala24Ala]
182 .. 182 A/G rs11548845 + CDS Synonymous[Glu25Glu]
350 .. 350 C/T rs201251896 - CDS Synonymous[Ser81Ser]
428 .. 428 C/T rs11548846 + CDS Synonymous[Thr107Thr]
493 .. 493 C/G rs140707980 - CDS Nonsynonymous[Ala129Gly]
542 .. 542 C/T rs116557087 - CDS Synonymous[Cys145Cys]
626 .. 626 C/T rs143811423 - CDS Synonymous[Asn173Asn]
635 .. 635 C/G rs201881795 - CDS Synonymous[Thr176Thr]
700 .. 700 A/G rs111725016 - CDS Nonsynonymous[Lys198Arg]
797 .. 797 C/T rs200783060 - CDS Synonymous[Tyr230Tyr]
1091 .. 1091 A/G rs140679593 - CDS Synonymous[Arg328Arg]
1169 .. 1169 A/T rs114279043 - CDS Synonymous[Pro354Pro]
1209 .. 1209 G/C rs182293768 - CDS Nonsynonymous[Gly368Arg]
1226 .. 1226 T/C rs143712714 - CDS Synonymous[Tyr373Tyr]
1247 .. 1247 T/C rs181141777 - CDS Synonymous[Tyr380Tyr]
1313 .. 1313 T/C rs115527397 - CDS Synonymous[Ile402Ile]
1343 .. 1343 A/G rs61755088 - CDS Synonymous[Gln412Gln]
1397 .. 1397 C/T rs115346013 - CDS Synonymous[Ser430Ser]
1603 .. 1603 A/G rs11548848 + 3'UTR
1606 .. 1606 G/C rs11548841 + 3'UTR
1732 .. 1732 C/T rs14961 + 3'UTR
1737 .. 1737 T/C rs7033844 - 3'UTR
1740 .. 1740 T/G rs149773802 - 3'UTR
1756 .. 1756 T/C rs140560283 - 3'UTR
1781 .. 1781 A/C rs1055950 + 3'UTR
1797 .. 1797 A/C rs3196513 + 3'UTR
1879 .. 1879 G/A rs187791877 - 3'UTR
2070 ^ 2071 -/G rs35668472 - 3'UTR
2132 .. 2132 A/G rs182623942 - 3'UTR
2195 .. 2195 G/T rs11548852 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer