H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000218572 Accession number: U20770 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; AltName: CD_antigen=CD82;
 
 

Transcript original information
Accession number U20770.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 1607[bp] (No. of exon:10)[A:311 T:333 G:496 C:467]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0017389
Genomic location  G-integra Help Chromosome 11
Location 11p11.2
Position 44587224- 44641315
Strand +
Possible duplicated location(s) NA
Gene structure 10 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3732
KEGG GENES KEGG GENES(3732)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000060319
Predicted CDS 166..969;  267[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.863
Database links RefSeq NP_002222
UniProt P27701
CCDS CCDS7909

Motif information
ORF

length(267),orf(166:969)
MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISVLQTSSS
SLRMGAYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQV
TAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCC
GWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRT
QSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSI
CLCRHVHSEDYSKVPKY*
a.a.
length
InterPro Name
length(247), motif(9:255) 247 IPR018499 Tetraspanin/Peripherin [Family]
length(24), motif(11:34) 24 IPR000301 Tetraspanin [Family]
length(27), motif(52:78) 27 IPR000301 Tetraspanin [Family]
length(23), motif(63:85) 23 IPR018503 Tetraspanin, conserved site [Conserved_site]
length(29), motif(79:107) 29 IPR000301 Tetraspanin [Family]
length(122), motif(107:228) 122 IPR008952 Tetraspanin, EC2 domain [Domain]
length(27), motif(230:256) 27 IPR000301 Tetraspanin [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000218572
H-Inv cluster ID Locus viewHIX0017389
Accession number U20770.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; AltName: CD_antigen=CD82;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P27701)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 14019191842498775437491264781275029515489334165548111915921819349973ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ KAI1
UniProt CD82
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000060319
No. of interaction 5
Interaction partner(s) HIP000042958HIP000047114HIP000060603HIP000103357HIP000103357
BIND NA
DIP NA
MINT NA
HPRD 18279; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3732
KEGG GENES KEGG GENES(3732)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Cellular component integral to membrane (GO:0016021); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT plasma membrane; 
Target P signal peptide
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA100203; 
Affymetrix
GeneChip
HG-Focus 203904_x_at; 
HG-U133 203904_x_at; 
HG-U133A 203904_x_at; 
HG-U133A_2 203904_x_at; 
HG-U133B NA
HG-U133_Plus_2 203904_x_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3328521;  3328533;  3328536;  3328539;  3328543;  3328545;  3328553;  3328555;  3328556;  3328558;  3328559;  3328560;  3370965; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P1782; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P1782; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: {Prostate cancer, susceptibility to} (176807); 
Related information in OMIM OMIM ID:  600623;  Title: CD82 ANTIGEN
Co-localized orphan diseases NA
Disease related mutation MutationView:  600623
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(3732)
Disease Entrez Gene ID:(3732)
Substance Entrez Gene ID:(3732)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
142 .. 142 G/T rs11541050 + 5'UTR
162 .. 162 C/T rs200238062 + 5'UTR
169 .. 169 G/A rs111718702 + CDS Nonsynonymous[Gly2Ser]
260 .. 260 T/C rs148396643 + CDS Nonsynonymous[Val32Ala]
273 .. 273 C/T rs138833231 + CDS Synonymous[Ala36Ala]
301 .. 301 C/T rs150533529 + CDS AA-STOP[Gln46*]
317 .. 317 C/A rs139889503 + CDS AA-STOP[Ser51*]
324 .. 324 G/T rs201294710 + CDS Nonsynonymous[Arg53Ser]
336 .. 336 T/C rs143270517 + CDS Synonymous[Tyr57Tyr]
345 .. 345 C/T rs146594387 + CDS Synonymous[Ile60Ile]
351 .. 351 G/A rs34170190 - CDS Synonymous[Val62Val]
378 .. 378 C/T rs149844780 + CDS Synonymous[Phe71Phe]
403 .. 403 G/A rs145881169 + CDS Nonsynonymous[Glu80Lys]
410 .. 410 G/A rs148925723 + CDS Nonsynonymous[Arg82His]
423 .. 423 G/T rs35348953 - CDS Synonymous[Gly86Gly]
513 .. 513 G/A rs2303865 - CDS Synonymous[Glu116Glu]
519 .. 519 C/T rs883752 + CDS Synonymous[Gly118Gly]
528 .. 528 G/A rs2303864 - CDS Synonymous[Val121Val]
535 .. 535 C/T rs138793220 + CDS Nonsynonymous[Leu124Phe]
559 .. 559 C/T rs142819851 + CDS Nonsynonymous[Arg132Cys]
560 .. 560 G/T rs117157354 + CDS Nonsynonymous[Arg132Leu]
564 .. 564 G/T rs11541051 + CDS Nonsynonymous[Glu133Asp]
592 .. 592 G/A rs200277144 + CDS Nonsynonymous[Val143Met]
615 .. 615 C/T rs150371864 + CDS Synonymous[Cys150Cys]
622 .. 622 G/A rs138109186 + CDS Nonsynonymous[Val153Ile]
648 .. 648 C/T rs200149429 + CDS Synonymous[Asn161Asn]
664 .. 664 C/T rs149456679 + CDS Nonsynonymous[Arg167Cys]
665 .. 665 G/A rs143845294 + CDS Nonsynonymous[Arg167His]
693 .. 693 C/T rs139816598 + CDS Synonymous[Cys176Cys]
744 .. 744 C/T rs141597594 + CDS Synonymous[Cys193Cys]
745 .. 745 G/A rs200920132 + CDS Nonsynonymous[Glu194Lys]
773 .. 773 G/T rs200514878 + CDS Nonsynonymous[Gly203Val]
818 .. 818 A/G rs146220817 + CDS Nonsynonymous[Glu218Gly]
830 .. 830 C/T rs201290700 + CDS Nonsynonymous[Ala222Val]
843 .. 843 G/A rs74375347 + CDS Synonymous[Glu226Glu]
861 .. 861 C/T rs142423874 + CDS Synonymous[Leu232Leu]
864 .. 864 C/T rs79095986 + CDS Synonymous[Gly233Gly]
870 .. 870 C/T rs190517526 + CDS Synonymous[Gly235Gly]
885 .. 885 C/T rs199858417 + CDS Synonymous[Ile240Ile]
886 .. 886 A/G rs1139971 + CDS Nonsynonymous[Ile241Val]
888 .. 888 C/T rs150062713 + CDS Synonymous[Ile241Ile]
909 .. 909 G/C rs74885383 + CDS Synonymous[Leu248Leu]
925 .. 925 C/T rs201405906 + CDS Nonsynonymous[Arg254Trp]
931 .. 931 G/A rs142351354 + CDS Nonsynonymous[Val256Ile]
933 .. 933 C/G rs7107335 + CDS Synonymous[Val256Val]
939 .. 939 C/T rs201650491 + CDS Synonymous[Ser258Ser]
958 .. 958 C/T rs147912305 + CDS Nonsynonymous[Pro265Ser]
959 .. 959 C/T rs201671713 + CDS Nonsynonymous[Pro265Leu]
960 .. 960 C/G rs148874083 + CDS Synonymous[Pro265Pro]
1085 .. 1085 C/T rs4755266 + 3'UTR
1086 .. 1086 C/G rs77781241 + 3'UTR
1201 .. 1201 C/T rs71490073 + 3'UTR
1216 .. 1216 A/C rs116250454 + 3'UTR
1253 .. 1253 T/C rs193127050 + 3'UTR
1318 .. 1318 G/A rs1063031 + 3'UTR
1325 .. 1325 G/C rs12225877 + 3'UTR
1371 .. 1371 G/A rs113805595 + 3'UTR
1382 .. 1382 A/G rs112667982 + 3'UTR
1404 .. 1404 A/C rs6485552 + 3'UTR
1432 .. 1432 G/A rs145762348 + 3'UTR
1464 .. 1464 G/A rs111384781 + 3'UTR
1468 .. 1468 G/A rs143013555 + 3'UTR
1537 .. 1537 C/T rs190156561 + 3'UTR
1606 .. 1606 A/-/AA rs10540347 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
AluY 1324 1607 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer