H-InvDB x AHG DB
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H-Invitational ID: HIT000249504 Accession number: AK131216 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Mitogen-activated protein kinase kinase kinase 19; EC=2.7.11.1; Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4;
 
 

Transcript original information
Accession number AK131216.1
CAGE tag ID NA
EST ID NA
Clone Number TESTI2025879
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 2195[bp] (No. of exon:3)[A:735 T:571 G:466 C:423]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type testis
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0214543
Genomic location  G-integra Help Chromosome 2
Location 2q21.3
Position 135738286- 135744611
Strand -
Possible duplicated location(s) NA
Gene structure 3 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:80122
KEGG GENES KEGG GENES(80122)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000346551
Predicted CDS 1..2094;  697[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.708

Motif information
ORF

length(697),orf(1:2094)
KQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGP
GIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKS
NIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGD
GISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIV
EEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPS
EKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQA
KQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSV
NNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGST
PKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPIL
WTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYWKLQE
EVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPE
MVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARR
LAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM
ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTR*
a.a.
length
InterPro Name
length(246), motif(451:696) 246 IPR011009 Protein kinase-like domain [Domain]
length(247), motif(451:697) 247 IPR000719 Protein kinase domain [Domain]
length(246), motif(451:696) 246 IPR000719 Protein kinase domain [Domain]
length(23), motif(457:479) 23 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(13), motif(572:584) 13 IPR008271 Serine/threonine-protein kinase, active site [Active_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000249504
H-Inv cluster ID Locus viewHIX0214543
Accession number AK131216.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Mitogen-activated protein kinase kinase kinase 19; EC=2.7.11.1; Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q56UN5)  [Identity/coverage = 99.287%/52.79%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 14702039154893341581562117344846ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt MAP3K19
EC number EC 2.7.11.1non-specific serine/threonine protein kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04150 :mTOR signaling pathway;  04210 :Apoptosis;  04310 :Wnt signaling pathway;  04320 :Dorso-ventral axis formation;  04340 :Hedgehog signaling pathway;  04350 :TGF-beta signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04620 :Toll-like receptor signaling pathway;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04720 :Long-term potentiation;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04910 :Insulin signaling pathway;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05010 :Alzheimer's disease;  05210 :Colorectal cancer; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000346551
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:80122
KEGG GENES KEGG GENES(80122)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT cytosol;  nuclear; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
413 659 1nw1A 3e-39 7.9 240/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA061001; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 1555804_a_at; 
HG-U95 55473_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 55473_at; 
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2577651;  2577652;  2577653;  2577657;  2577658;  2577660;  2577661; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_24_P63078; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
49 .. 49 T/C rs150014704 - CDS Nonsynonymous[Cys17Arg]
60 .. 60 C/G rs200673780 - CDS Synonymous[Leu20Leu]
71 .. 71 C/G rs200710231 - CDS Nonsynonymous[Pro24Arg]
99 .. 99 T/C rs201468138 - CDS Synonymous[Asp33Asp]
120 .. 120 C/A rs190010427 - CDS Nonsynonymous[Phe40Leu]
143 .. 143 A/G rs55999472 - CDS Nonsynonymous[Asn48Ser]
151 .. 151 G/A rs146312185 - CDS Nonsynonymous[Gly51Arg]
193 .. 193 C/T rs143563019 - CDS AA-STOP[Arg65*]
194 .. 194 G/A rs141304858 - CDS Nonsynonymous[Arg65Gln]
196 .. 196 G/C rs1112542 + CDS Nonsynonymous[Glu66Gln]
218 .. 218 C/T rs200164509 - CDS Nonsynonymous[Thr73Met]
226 .. 226 C/T rs148647253 - CDS Nonsynonymous[Arg76Cys]
239 .. 239 C/T rs55867035 - CDS Nonsynonymous[Ser80Leu]
243 .. 243 T/C rs7591604 - CDS Synonymous[Ala81Ala]
256 .. 256 C/T rs56211316 - CDS Nonsynonymous[Arg86Cys]
272 .. 272 G/A rs137859461 - CDS Nonsynonymous[Cys91Tyr]
341 .. 341 A/C rs147328989 - CDS Nonsynonymous[Lys114Thr]
351 .. 351 G/T rs148962037 - CDS Nonsynonymous[Lys117Asn]
365 .. 365 T/C rs116193430 - CDS Nonsynonymous[Ile122Thr]
411 .. 411 G/A rs140029373 - CDS Synonymous[Lys137Lys]
429 .. 429 A/G rs146051594 - CDS Synonymous[Leu143Leu]
459 .. 459 A/G rs56015131 - CDS Synonymous[Ser153Ser]
473 .. 473 A/G rs139614326 - CDS Nonsynonymous[Gln158Arg]
523 .. 523 C/T rs144059874 - CDS Nonsynonymous[Pro175Ser]
593 .. 593 C/G rs142728110 - CDS Nonsynonymous[Ser198Cys]
605 .. 605 A/G rs3905317 + CDS Nonsynonymous[Glu202Gly]
649 .. 649 A/C rs201238211 - CDS Nonsynonymous[Asn217His]
807 .. 807 T/A rs150468326 - CDS Nonsynonymous[Ser269Arg]
824 .. 824 G/A rs140658941 - CDS Nonsynonymous[Arg275Gln]
837 .. 837 T/C rs55950034 - CDS Synonymous[Asn279Asn]
993 .. 993 G/A rs200722685 - CDS Nonsynonymous[Met331Ile]
1018 .. 1018 A/G rs138526441 - CDS Nonsynonymous[Asn340Asp]
1019 .. 1019 A/G rs79528341 - CDS Nonsynonymous[Asn340Ser]
1038 .. 1038 T/G rs6738788 - CDS Nonsynonymous[Ile346Met]
1104 .. 1104 A/G rs56319025 - CDS Synonymous[Leu368Leu]
1108 .. 1108 C/T rs140544677 - CDS Nonsynonymous[Leu370Phe]
1155 .. 1155 A/C rs142759038 - CDS Synonymous[Thr385Thr]
1201 .. 1201 C/T rs148336430 - CDS Nonsynonymous[Pro401Ser]
1223 .. 1223 C/A rs202227881 - CDS Nonsynonymous[Thr408Lys]
1257 .. 1257 G/A rs201510810 - CDS Synonymous[Gly419Gly]
1268 .. 1268 A/G rs201999699 - CDS Nonsynonymous[Tyr423Cys]
1271 .. 1271 A/G rs55832179 - CDS Nonsynonymous[Asp424Gly]
1297 .. 1297 A/G rs79961158 - CDS Nonsynonymous[Asn433Asp]
1349 .. 1349 T/C rs199829558 - CDS Nonsynonymous[Leu450Pro]
1369 .. 1369 C/G rs143823503 - CDS Nonsynonymous[Leu457Val]
1390 .. 1390 A/G rs62168905 - CDS Nonsynonymous[Thr464Ala]
1486 .. 1486 T/C rs192434665 - CDS Nonsynonymous[Trp496Arg]
1631 .. 1631 G/A rs56349597 - CDS Nonsynonymous[Arg544His]
1671 .. 1671 G/A rs200267339 - CDS Synonymous[Thr557Thr]
1719 .. 1719 A/C rs201993219 - CDS Synonymous[Val573Val]
1723 .. 1723 C/T rs142199742 - CDS Nonsynonymous[Arg575Cys]
1724 .. 1724 G/A rs145092752 - CDS Nonsynonymous[Arg575His]
1763 .. 1763 G/A rs145246801 - CDS Nonsynonymous[Gly588Glu]
1766 .. 1766 T/C rs56284052 - CDS Nonsynonymous[Ile589Thr]
1792 .. 1792 G/T rs200326947 - CDS Nonsynonymous[Ala598Ser]
1906 .. 1906 C/T rs139473560 - CDS Nonsynonymous[Arg636Trp]
1976 .. 1976 C/T rs147832465 - CDS Nonsynonymous[Ser659Phe]
1984 .. 1984 A/G rs140447534 - CDS Nonsynonymous[Arg662Gly]
2007 .. 2007 C/T rs149473090 - CDS Synonymous[Ile669Ile]
2015 .. 2015 A/G rs186711668 - CDS Nonsynonymous[His672Arg]
2131 .. 2131 A/T rs147345543 - 3'UTR
2144 .. 2144 C/T rs182185399 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer