H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000259193 Accession number: BC051670 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Nuclear receptor subfamily 2 group C member 2.
 
 

Transcript original information
Accession number BC051670.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:48324 IMAGE:5272493
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (NR2C2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (NR2C2);
Sequence data provider NA
Annotation project NA
Length of cDNA 3319[bp] (No. of exon:14)[A:952 T:812 G:749 C:806]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Testis
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3304(+) Signal: 3280-3284(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NMD predicted; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0018362
Genomic location  G-integra Help Chromosome 3
Location 3p25.1
Position 14990139- 15084851
Strand +
Possible duplicated location(s) NA
Gene structure 14 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:7182
KEGG GENES KEGG GENES(7182)
GeneCard GeneCardNR2C2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000108788
Predicted CDS 136..1728;  530[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.768

Motif information
ORF

length(530),orf(136:1728)
MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQT
GQKIQIVTAVDASGSPKQQFTLTSPDGAGTGKVILASPETSSAKQLIFTT
SDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGA
VSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMG
MKMESVQSKRKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADK
DGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVV
TSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSL
ADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYL
NVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGL
AQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNS
MAKLDIDGYEYAYLKAIVLFSPGKICGGDA*
a.a.
length
InterPro Name
length(65), motif(133:197) 65 IPR013088 Zinc finger, NHR/GATA-type [Domain]
length(76), motif(133:208) 76 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(72), motif(133:204) 72 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(68), motif(135:202) 68 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(17), motif(136:152) 17 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(27), motif(136:162) 27 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(16), motif(152:167) 16 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(28), motif(185:212) 28 IPR008946 Nuclear hormone receptor, ligand-binding [Domain]
length(9), motif(185:193) 9 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(9), motif(193:201) 9 IPR001628 Zinc finger, nuclear hormone receptor-type [Domain]
length(11), motif(197:207) 11 IPR001723 Steroid hormone receptor [Family]
length(20), motif(198:217) 20 IPR008946 Nuclear hormone receptor, ligand-binding [Domain]
length(2), motif(334:335) 2 IPR008946 Nuclear hormone receptor, ligand-binding [Domain]
length(167), motif(357:523) 167 IPR008946 Nuclear hormone receptor, ligand-binding [Domain]
length(142), motif(381:522) 142 IPR008946 Nuclear hormone receptor, ligand-binding [Domain]
length(131), motif(393:523) 131 IPR000536 Nuclear hormone receptor, ligand-binding, core [Domain]
length(120), motif(407:526) 120 IPR000536 Nuclear hormone receptor, ligand-binding, core [Domain]
length(22), motif(408:429) 22 IPR001723 Steroid hormone receptor [Family]
length(17), motif(429:445) 17 IPR001723 Steroid hormone receptor [Family]
length(16), motif(504:519) 16 IPR001723 Steroid hormone receptor [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000259193
H-Inv cluster ID Locus viewHIX0018362
Accession number BC051670.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Nuclear receptor subfamily 2 group C member 2.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_003289)  [Identity/coverage = 100.0%/15.12%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NR2C2
HGNC aliases NA
HGNC name nuclear receptor subfamily 2, group C, member 2
DDBJ NR2C2
UniProt NA
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000108788
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:7182
KEGG GENES KEGG GENES(7182)
GeneCard GeneCardNR2C2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR023405
Accession
Description
Location
PMID
FR ID FR042845
Accession
Description
Location
PMID

Gene ontology information
Molecular function DNA binding (GO:0003677);  zinc ion binding (GO:0008270);  steroid hormone receptor activity (GO:0003707);  sequence-specific DNA binding (GO:0043565);  transcription factor activity (GO:0003700); 
Biological process steroid hormone mediated signaling (GO:0043401);  regulation of transcription, DNA-dependent (GO:0006355); 
Cellular component nucleus (GO:0005634); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
136 210 1a6yA 2e-20 53.3 75/78 g.39.1.2
378 524 1oshA 2e-32 24.3 136/216 a.123.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus 206038_s_at; 
HG-U133 206038_s_at; 
HG-U133A 206038_s_at; 
HG-U133A_2 206038_s_at; 
HG-U133B NA
HG-U133_Plus_2 206038_s_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2612178;  2612203;  2612204;  2612206;  2612207;  2612208;  2612211;  2612212;  2612214;  2612215;  2612217;  2612219;  2612220;  2612223;  2612224;  2612225;  2612226;  2612227;  2664093;  2664097; 
HuGeneFL L27586_at; 
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
65 .. 65 C/T rs192578898 + 5'UTR
123 .. 123 G/A rs200130466 + 5'UTR
155 .. 155 G/A rs146761800 + CDS Nonsynonymous[Arg7His]
184 .. 184 G/A rs144140973 + CDS Nonsynonymous[Val17Ile]
192 .. 192 A/T rs35542411 + CDS Synonymous[Ser19Ser]
200 .. 200 G/A rs199933863 + CDS Nonsynonymous[Arg22His]
232 .. 232 T/C rs77813966 + CDS Synonymous[Leu33Leu]
243 .. 243 C/G rs7617704 + CDS Nonsynonymous[Phe36Leu]
252 .. 252 G/T rs143346122 + CDS Nonsynonymous[Leu39Phe]
253 .. 253 A/T rs147114098 + CDS Nonsynonymous[Asn40Tyr]
309 .. 309 C/T rs143952286 + CDS Synonymous[Thr58Thr]
325 .. 325 G/A rs145012695 + CDS Nonsynonymous[Gly64Arg]
368 .. 368 C/G rs201268512 + CDS Nonsynonymous[Ala78Gly]
414 .. 414 C/T rs199953589 + CDS Synonymous[Ala93Ala]
473 .. 473 C/T rs141157692 + CDS Nonsynonymous[Thr113Met]
485 .. 485 C/T rs139070917 + CDS Nonsynonymous[Ser117Phe]
494 .. 494 G/A rs146514188 + CDS Nonsynonymous[Arg120His]
512 .. 512 A/T rs149712183 + CDS Nonsynonymous[Asp126Val]
519 .. 519 G/T rs149174256 + CDS Nonsynonymous[Gln128His]
600 .. 600 T/C rs144701498 + CDS Synonymous[Gly155Gly]
705 .. 705 T/C rs147117197 + CDS Synonymous[Phe190Phe]
729 .. 729 G/T rs141054676 + CDS Nonsynonymous[Glu198Asp]
747 .. 747 A/G rs150753845 + CDS Synonymous[Glu204Glu]
762 .. 762 A/G rs150235701 + CDS Synonymous[Lys209Lys]
775 .. 775 G/A rs113551154 + CDS Nonsynonymous[Asp214Asn]
831 .. 831 C/A rs147052449 + CDS Synonymous[Ile232Ile]
852 .. 852 C/T rs137903993 + CDS Synonymous[Pro239Pro]
864 .. 864 T/A rs2230441 + CDS Synonymous[Thr243Thr]
873 .. 873 T/C rs2230442 + CDS Synonymous[Phe246Phe]
880 .. 880 G/A rs139146701 + CDS Nonsynonymous[Asp249Asn]
890 .. 890 G/A rs141549777 + CDS Nonsynonymous[Gly252Glu]
897 .. 897 A/G rs200291251 + CDS Synonymous[Arg254Arg]
915 .. 915 T/G rs145414944 + CDS Nonsynonymous[Asp260Glu]
942 .. 942 G/T rs149255046 + CDS Nonsynonymous[Gln269His]
955 ^ 956 -/G rs34660472 + CDS
973 .. 973 C/T rs140658786 + CDS Synonymous[Leu280Leu]
980 .. 980 C/T rs145356913 + CDS Nonsynonymous[Thr282Met]
1067 .. 1067 A/G rs142370279 + CDS Nonsynonymous[Asn311Ser]
1157 .. 1157 C/A rs138369729 + CDS Nonsynonymous[Thr341Asn]
1175 .. 1175 C/T rs144602409 + CDS Nonsynonymous[Ser347Phe]
1202 .. 1202 C/A rs201585610 + CDS Nonsynonymous[Thr356Asn]
1245 .. 1245 G/A rs145188667 + CDS Synonymous[Ser370Ser]
1290 .. 1290 C/T rs200745977 + CDS Synonymous[His385His]
1291 .. 1291 G/A rs145430192 + CDS Nonsynonymous[Val386Ile]
1371 .. 1371 G/T rs139690648 + CDS Synonymous[Leu412Leu]
1479 .. 1479 C/T rs145844147 + CDS Synonymous[Leu448Leu]
1513 .. 1513 T/C rs76148824 + CDS Nonsynonymous[Ser460Pro]
1615 .. 1615 C/T rs145762160 + CDS Synonymous[Leu494Leu]
1641 .. 1641 G/A rs2230443 + CDS Synonymous[Ala502Ala]
1701 .. 1701 C/T rs148205226 + CDS Synonymous[Pro522Pro]
1757 .. 1757 T/C rs151217039 + 3'UTR
1982 .. 1982 A/G rs184185192 + 3'UTR
2002 .. 2002 G/A rs190431387 + 3'UTR
2057 .. 2057 T/C rs113857408 + 3'UTR
2108 .. 2108 A/G rs139059892 + 3'UTR
2112 .. 2112 C/T rs149876237 + 3'UTR
2139 .. 2139 G/T rs144973907 + 3'UTR
2145 .. 2145 G/A rs192647003 + 3'UTR
2202 .. 2202 C/G rs17040683 + 3'UTR
2215 ^ 2216 -/G rs34654209 + 3'UTR
2258 .. 2258 T/C rs17040686 + 3'UTR
2419 ^ 2420 -/G rs147454325 + 3'UTR
2424 .. 2424 G/T rs113553343 + 3'UTR
2652 .. 2652 G/A rs202011915 + 3'UTR
2660 ^ 2661 -/G/GG rs10663366 + 3'UTR
2661 ^ 2662 -/GG rs66552553 + 3'UTR
2663 .. 2663 G/T rs41284021 + 3'UTR
2669 .. 2669 G/T rs199792577 + 3'UTR
2674 .. 2674 T/C rs142064828 + 3'UTR
2684 .. 2684 C/T rs145826673 + 3'UTR
2744 .. 2744 T/C rs150377665 + 3'UTR
2754 .. 2754 G/A/C rs2230444 + 3'UTR
2766 .. 2766 G/A rs140480023 + 3'UTR
2856 .. 2856 A/G rs199626604 + 3'UTR
2874 .. 2874 C/A rs143937107 + 3'UTR
2882 .. 2882 A/G rs148719288 + 3'UTR
2954 .. 2954 G/A rs112640832 + 3'UTR
2957 .. 2957 C/T rs1042123 + 3'UTR
2969 .. 2969 G/A rs139778021 + 3'UTR
2979 .. 2979 C/T rs200379124 + 3'UTR
2996 .. 2996 C/T rs193049177 + 3'UTR
3020 .. 3020 A/G rs185225667 + 3'UTR
3038 .. 3038 G/A rs189683000 + 3'UTR
3064 .. 3064 A/G rs191787665 + 3'UTR
3067 .. 3067 T/C rs183766871 + 3'UTR
3093 .. 3093 C/T rs149009663 + 3'UTR
3128 .. 3128 G/T rs143800576 + 3'UTR
3273 .. 3273 G/A rs138237462 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer