H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000259193 Accession number: BC051670 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Nuclear receptor subfamily 2 group C member 2.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC051670.1 CAGE tag ID NA EST ID NA Clone Number MGC:48324 IMAGE:5272493 Experimental resources   NBRC ; HGPD ; Antibody (NR2C2) ; Catalog (NR2C2); Sequence data provider NA Annotation project NA Length of cDNA 3319[bp] (No. of exon:14)[A:952 T:812 G:749 C:806] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Testis Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 3304(+) Signal: 3280-3284(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NMD predicted;  Notes NA

GGAGAGGCCGGCGCCTGGTCTTGGGTCAGCAGGTGGGCTGCTTCCCTCCG CCTGGAACGCGTCTCGAATGAGTACTGAGGAACAATAGTAATAAAGGTAA CACGTACACAGACCTCTCGGCCGGAATCTCCAGGGATGACCAGCCCCTCC CCACGCATCCAGATAATCTCCACCGACTCTGCTGTAGCCTCACCTCAGCG CATTCAGGGCTCTGAACCTGCCTCTGGCCCATTGAGTGTTTTCACATCTT TGAACAAAGAGAAGATTGTCACAGACCAGCAGACAGGACAGAAAATCCAG ATAGTCACCGCAGTGGACGCCTCCGGATCCCCCAAACAGCAGTTCACCCT GACCAGCCCAGATGGAGCTGGAACTGGGAAGGTGATCCTGGCTTCCCCAG AGACATCCAGCGCCAAGCAACTCATATTCACCACCTCAGACAACCTCGTC CCTGGCAGGATCCAGATTGTCACGGATTCTGCCTCTGTGGAGCGTTTACT GGGGAAGACGGACGTCCAGCGGCCCCAGGTGGTAGAGTACTGTGTGGTCT GTGGCGACAAAGCCTCCGGCCGTCACTATGGGGCTGTCAGTTGTGAAGGT TGCAAAGGTTTCTTCAAAAGGAGTGTGAGGAAAAATTTGACCTACAGCTG CCGGAGCAACCAAGACTGCATCATCAATAAACATCACCGGAACCGCTGTC AGTTTTGCCGGCTGAAAAAATGCTTAGAGATGGGCATGAAAATGGAATCT GTGCAGAGTAAACGGAAGCCCTTCGATGTGCAACGGGAGAAACCAAGCAA TTGTGCTGCTTCAACTGAGAAAATCTATATCCGGAAAGACCTGAGAAGTC CCCTGATAGCTACTCCCACGTTTGTGGCAGACAAAGATGGAGCAAGACAA ACAGGTCTTCTTGATCCAGGGATGCTTGTGAACATCCAGCAGCCTTTGAT ACGTGAGGATGGTACAGTTCTCCTGGCCACGGATTCTAAGGCTGAAACAA GCCAGGGAGCTCTGGGCACACTGGCAAATGTAGTGACCTCCCTTGCCAAC CTAAGTGAATCTTTGAACAACGGTGACACTTCAGAAATCCAGCCAGAGGA CCAGTCTGCAAGTGAGATAACTCGGGCATTTGATACCTTAGCTAAAGCAC TTAATACCACAGACAGCTCCTCTTCTCCAAGCTTGGCAGATGGGATAGAC ACCAGTGGAGGAGGGAGCATCCACGTCATCAGCAGAGACCAGTCGACACC CATCATTGAGGTTGAAGGCCCCCTCCTTTCAGACACACACGTCACATTTA AGCTAACAATGCCCAGTCCAATGCCAGAGTACCTCAACGTGCACTACATC TGTGAGTCTGCATCCCGTCTGCTTTTCCTCTCAATGCACTGGGCTCGGTC AATCCCAGCCTTTCAGGCACTTGGGCAGGACTGCAACACCAGCCTTGTGC GGGCCTGCTGGAATGAGCTCTTCACCCTCGGCCTGGCCCAGTGTGCCCAG GTCATGAGTCTCTCCACCATCCTGGCTGCCATTGTCAACCACCTGCAGAA CAGCATCCAGGAAGATAAACTTTCTGGTGACCGGATAAAGCAAGTCATGG AGCACATCTGGAAGCTGCAGGAGTTCTGTAACAGCATGGCGAAGCTGGAT ATAGATGGCTATGAGTATGCATACCTTAAAGCTATAGTTCTCTTTAGCCC CGGTAAGATATGCGGTGGGGATGCATGACCCCTTTCCACCTGTATCTACT GATGTTTCTGAACGTGAACATGTTGTCATCATTGGTGTAGAAAGAGCCCT GCAGATTGTATGTGACCTAGTGTTCTTATGATAGGTGTTTTGCTAGATAA ATACATAAACGCTTTTAAATTCTTGCCTTTACAGCCCCAAAGAAATATGC TGCAGTGCCTGATGATGTCACGCACTGAATAGATTTAATCTGTGTCCTAA TTAAACCATTGGCCAAACAAGACTACACCATACAAAAGTGTGCTGCCACC CGATGTCCTTTCTTTTTTTTCCGGCCCTTTGCCAGTTTCCAAGTTTTGTT AGCGCATATAATCCAGTACACATTGAAGTTCCACTTGTTTGCCCACAGAC TGTGTATAGCACTGCAGAGCATGCTAAAAGGTATGTTCGCAGGAGATGAA GAGGCAGCAATCACGATGCCTGGGCTGGCCTCACTCCCCTTATTAACTGT TCTCTCAAGTCCTCTGGAAAAGTCACTTAGGCTAATTGTTCACCTCACAG TAAGGGGTTGGACACAGCTTAACCTTTTTGTCTTCCTTCCCAGCCCTTCA CTCACAAACAACAAAATAGCTAATAAAATTGGGACAAATTATATAATTAT TTAGAAAGTAAATGACAATTTGTAATTTTATGTGATAGTTTTTAAAACTA TGTGTTTTCTAGGGTAGTAGGAAGCCAGATGTCCAGAACCAATCATGTGG GGCTGTTCAGACTGGGATCCACTCAGGGTCCCCGACCCGCTCCCAGGAAC TTCAGGCCTGGGCAGAAAACAGAGGAAAAGCCAGTGTTCTAATAATACCC AAACTAGATCAGTCTTTGAGTTCAATTTGTTGTACTTAAGAAGTTTGCAG AAGTTTGACTAAAAGTACTAAGAAGTCTACAAGTGAGACTTTTCAAATAC AGAGGGAACTGGGGGGGGGTACTTTTCTGTTTTCAGATCATCCAGGTTTG ACCAGCACAAGCCAGATTGAAAAATTCCAAGAAAAGGCACAGATGGAGTT GCAGGACTATGTTCAGAAAACCTACTCAGAAGACACCTACCGATTGGCCC GGATCCTCGTTCGCCTGCCGGCACTCAGGCTGATGAGCTCCAACATAACA GAAGAACTTTTTTTTACTGGTCTCATTGGCAATGTTTCGATAGACAGCAT AATCCCCTACATCCTCAAGATGGAGACAGCAGAGTATAATGGCCAGATCA CCGGAGCCAGTCTATAGCGCAAACCACACACCTGCCAAGGAGCAACAGAA TCCTTCCAGGACCGTTCACATACAAAGAAAAGTAGTGGTATTTTGGTATG TGCAAATATTTCCATATGTTAGCCATTTCCTGTCTGGTTTCTCCTTATCT GTTAATCCCAGACAATAGCAATTAAAAGACTAGTAGGATCCTTTCCTGAC ATAAGAAATGTTTTAATGCCTTTTGATGAAGCAGCAGATTTTGGAACAAT CTTTTAACTCAATTTGTATTTAGAAATTCTCAAAGGGCAAAAAAACAAAA AAAAAGGTTTTATAATGTCAGAGACTAGTATTAAAGAAAACTGAAAGAAC CCGAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0018362
Genomic location	Chromosome	3
	Location	3p25.1
	Position	14990139- 15084851
	Strand	+
Possible duplicated location(s)		NA
Gene structure		14 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:7182;
	KEGG GENES	KEGG GENES(7182);
	GeneCard	NR2C2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000108788 Predicted CDS 136..1728;  530[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.768

MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQT GQKIQIVTAVDASGSPKQQFTLTSPDGAGTGKVILASPETSSAKQLIFTT SDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGA VSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMG MKMESVQSKRKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADK DGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVV TSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSL ADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYL NVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGL AQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNS MAKLDIDGYEYAYLKAIVLFSPGKICGGDA*

Motif information

	a.a. length	InterPro	Name
	65	IPR013088	Zinc finger, NHR/GATA-type [Domain]
	76	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	72	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	68	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	17	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	27	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	16	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	28	IPR008946	Nuclear hormone receptor, ligand-binding [Domain]
	9	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	9	IPR001628	Zinc finger, nuclear hormone receptor-type [Domain]
	11	IPR001723	Steroid hormone receptor [Family]
	20	IPR008946	Nuclear hormone receptor, ligand-binding [Domain]
	2	IPR008946	Nuclear hormone receptor, ligand-binding [Domain]
	167	IPR008946	Nuclear hormone receptor, ligand-binding [Domain]
	142	IPR008946	Nuclear hormone receptor, ligand-binding [Domain]
	131	IPR000536	Nuclear hormone receptor, ligand-binding, core [Domain]
	120	IPR000536	Nuclear hormone receptor, ligand-binding, core [Domain]
	22	IPR001723	Steroid hormone receptor [Family]
	17	IPR001723	Steroid hormone receptor [Family]
	16	IPR001723	Steroid hormone receptor [Family]

Gene function information

H-Inv ID		HIT000259193
H-Inv cluster ID		HIX0018362
Accession number		BC051670.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Nuclear receptor subfamily 2 group C member 2.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_003289)  [Identity/coverage = 100.0%/15.12%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NR2C2
	HGNC aliases	NA
	HGNC name	nuclear receptor subfamily 2, group C, member 2
	DDBJ	NR2C2
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000108788
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:7182;
	KEGG GENES	KEGG GENES(7182);
	GeneCard	NR2C2;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

FR ID	FR023405
Accession
Description
Location
PMID

FR ID	FR042845
Accession
Description
Location
PMID

Gene ontology information

Molecular function	DNA binding (GO:0003677);  zinc ion binding (GO:0008270);  steroid hormone receptor activity (GO:0003707);  sequence-specific DNA binding (GO:0043565);  transcription factor activity (GO:0003700);
Biological process	steroid hormone mediated signaling (GO:0043401);  regulation of transcription, DNA-dependent (GO:0006355);
Cellular component	nucleus (GO:0005634);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;
Target P	Not predicted
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 136 210 1a6yA 2e-20 53.3 75/78 g.39.1.2 378 524 1oshA 2e-32 24.3 136/216 a.123.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	206038_s_at;
		HG-U133	206038_s_at;
		HG-U133A	206038_s_at;
		HG-U133A_2	206038_s_at;
		HG-U133B	NA
		HG-U133_Plus_2	206038_s_at;
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2612178;  2612203;  2612204;  2612206;  2612207;  2612208;  2612211;  2612212;  2612214;  2612215;  2612217;  2612219;  2612220;  2612223;  2612224;  2612225;  2612226;  2612227;  2664093;  2664097;
		HuGeneFL	L27586_at;
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 65 .. 65 C/T rs192578898 + 5'UTR 123 .. 123 G/A rs200130466 + 5'UTR 155 .. 155 G/A rs146761800 + CDS Nonsynonymous[Arg7His] 184 .. 184 G/A rs144140973 + CDS Nonsynonymous[Val17Ile] 192 .. 192 A/T rs35542411 + CDS Synonymous[Ser19Ser] 200 .. 200 G/A rs199933863 + CDS Nonsynonymous[Arg22His] 232 .. 232 T/C rs77813966 + CDS Synonymous[Leu33Leu] 243 .. 243 C/G rs7617704 + CDS Nonsynonymous[Phe36Leu] 252 .. 252 G/T rs143346122 + CDS Nonsynonymous[Leu39Phe] 253 .. 253 A/T rs147114098 + CDS Nonsynonymous[Asn40Tyr] 309 .. 309 C/T rs143952286 + CDS Synonymous[Thr58Thr] 325 .. 325 G/A rs145012695 + CDS Nonsynonymous[Gly64Arg] 368 .. 368 C/G rs201268512 + CDS Nonsynonymous[Ala78Gly] 414 .. 414 C/T rs199953589 + CDS Synonymous[Ala93Ala] 473 .. 473 C/T rs141157692 + CDS Nonsynonymous[Thr113Met] 485 .. 485 C/T rs139070917 + CDS Nonsynonymous[Ser117Phe] 494 .. 494 G/A rs146514188 + CDS Nonsynonymous[Arg120His] 512 .. 512 A/T rs149712183 + CDS Nonsynonymous[Asp126Val] 519 .. 519 G/T rs149174256 + CDS Nonsynonymous[Gln128His] 600 .. 600 T/C rs144701498 + CDS Synonymous[Gly155Gly] 705 .. 705 T/C rs147117197 + CDS Synonymous[Phe190Phe] 729 .. 729 G/T rs141054676 + CDS Nonsynonymous[Glu198Asp] 747 .. 747 A/G rs150753845 + CDS Synonymous[Glu204Glu] 762 .. 762 A/G rs150235701 + CDS Synonymous[Lys209Lys] 775 .. 775 G/A rs113551154 + CDS Nonsynonymous[Asp214Asn] 831 .. 831 C/A rs147052449 + CDS Synonymous[Ile232Ile] 852 .. 852 C/T rs137903993 + CDS Synonymous[Pro239Pro] 864 .. 864 T/A rs2230441 + CDS Synonymous[Thr243Thr] 873 .. 873 T/C rs2230442 + CDS Synonymous[Phe246Phe] 880 .. 880 G/A rs139146701 + CDS Nonsynonymous[Asp249Asn] 890 .. 890 G/A rs141549777 + CDS Nonsynonymous[Gly252Glu] 897 .. 897 A/G rs200291251 + CDS Synonymous[Arg254Arg] 915 .. 915 T/G rs145414944 + CDS Nonsynonymous[Asp260Glu] 942 .. 942 G/T rs149255046 + CDS Nonsynonymous[Gln269His] 955 ^ 956 -/G rs34660472 + CDS 973 .. 973 C/T rs140658786 + CDS Synonymous[Leu280Leu] 980 .. 980 C/T rs145356913 + CDS Nonsynonymous[Thr282Met] 1067 .. 1067 A/G rs142370279 + CDS Nonsynonymous[Asn311Ser] 1157 .. 1157 C/A rs138369729 + CDS Nonsynonymous[Thr341Asn] 1175 .. 1175 C/T rs144602409 + CDS Nonsynonymous[Ser347Phe] 1202 .. 1202 C/A rs201585610 + CDS Nonsynonymous[Thr356Asn] 1245 .. 1245 G/A rs145188667 + CDS Synonymous[Ser370Ser] 1290 .. 1290 C/T rs200745977 + CDS Synonymous[His385His] 1291 .. 1291 G/A rs145430192 + CDS Nonsynonymous[Val386Ile] 1371 .. 1371 G/T rs139690648 + CDS Synonymous[Leu412Leu] 1479 .. 1479 C/T rs145844147 + CDS Synonymous[Leu448Leu] 1513 .. 1513 T/C rs76148824 + CDS Nonsynonymous[Ser460Pro] 1615 .. 1615 C/T rs145762160 + CDS Synonymous[Leu494Leu] 1641 .. 1641 G/A rs2230443 + CDS Synonymous[Ala502Ala] 1701 .. 1701 C/T rs148205226 + CDS Synonymous[Pro522Pro] 1757 .. 1757 T/C rs151217039 + 3'UTR 1982 .. 1982 A/G rs184185192 + 3'UTR 2002 .. 2002 G/A rs190431387 + 3'UTR 2057 .. 2057 T/C rs113857408 + 3'UTR 2108 .. 2108 A/G rs139059892 + 3'UTR 2112 .. 2112 C/T rs149876237 + 3'UTR 2139 .. 2139 G/T rs144973907 + 3'UTR 2145 .. 2145 G/A rs192647003 + 3'UTR 2202 .. 2202 C/G rs17040683 + 3'UTR 2215 ^ 2216 -/G rs34654209 + 3'UTR 2258 .. 2258 T/C rs17040686 + 3'UTR 2419 ^ 2420 -/G rs147454325 + 3'UTR 2424 .. 2424 G/T rs113553343 + 3'UTR 2652 .. 2652 G/A rs202011915 + 3'UTR 2660 ^ 2661 -/G/GG rs10663366 + 3'UTR 2661 ^ 2662 -/GG rs66552553 + 3'UTR 2663 .. 2663 G/T rs41284021 + 3'UTR 2669 .. 2669 G/T rs199792577 + 3'UTR 2674 .. 2674 T/C rs142064828 + 3'UTR 2684 .. 2684 C/T rs145826673 + 3'UTR 2744 .. 2744 T/C rs150377665 + 3'UTR 2754 .. 2754 G/A/C rs2230444 + 3'UTR 2766 .. 2766 G/A rs140480023 + 3'UTR 2856 .. 2856 A/G rs199626604 + 3'UTR 2874 .. 2874 C/A rs143937107 + 3'UTR 2882 .. 2882 A/G rs148719288 + 3'UTR 2954 .. 2954 G/A rs112640832 + 3'UTR 2957 .. 2957 C/T rs1042123 + 3'UTR 2969 .. 2969 G/A rs139778021 + 3'UTR 2979 .. 2979 C/T rs200379124 + 3'UTR 2996 .. 2996 C/T rs193049177 + 3'UTR 3020 .. 3020 A/G rs185225667 + 3'UTR 3038 .. 3038 G/A rs189683000 + 3'UTR 3064 .. 3064 A/G rs191787665 + 3'UTR 3067 .. 3067 T/C rs183766871 + 3'UTR 3093 .. 3093 C/T rs149009663 + 3'UTR 3128 .. 3128 G/T rs143800576 + 3'UTR 3273 .. 3273 G/A rs138237462 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;