H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000260125 Accession number: BC060823 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Histone acetyltransferase KAT2B; EC=2.3.1.48; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF;
 
 

Transcript original information
Accession number BC060823.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:71679 IMAGE:30336561
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (KAT2B) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (KAT2B);
Sequence data provider NA
Annotation project NA
Length of cDNA 4443[bp] (No. of exon:18)[A:1381 T:1231 G:928 C:903]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Placenta, pre-eclamptic
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 4428(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) TAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0003121
Genomic location  G-integra Help Chromosome 3
Location 3p24.3
Position 20081919- 20195895
Strand +
Possible duplicated location(s) NA
Gene structure 18 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8850; 
KEGG GENES KEGG GENES(8850); 
GeneCard GeneCardKAT2B;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000096938
Predicted CDS 52..2550;  832[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.737
Database links RefSeq NP_003875; 
UniProt Q92831; 
CCDS CCDS2634; 

Motif information
ORF

length(832),orf(52:2550) MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSG ACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSAC KAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHL ENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQ RGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKM FLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFL SMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTS SSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIP MELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVG NSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIK DGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCEL NPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPI ESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFME PVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCK EYNPPESEYYKCANILEKFFFSKIKEAGLIDK* 		a.a.
length		 InterPro Name
length(253), motif(74:326) 253 IPR009464 PCAF, N-terminal [Domain]
length(149), motif(503:651) 149 IPR000182 GNAT domain [Domain]
length(145), motif(509:653) 145 IPR016181 Acyl-CoA N-acyltransferase [Domain]
length(145), motif(512:656) 145 IPR016181 Acyl-CoA N-acyltransferase [Domain]
length(82), motif(542:623) 82 IPR000182 GNAT domain [Domain]
length(115), motif(712:826) 115 IPR001487 Bromodomain [Domain]
length(114), motif(713:826) 114 IPR001487 Bromodomain [Domain]
length(109), motif(721:829) 109 IPR001487 Bromodomain [Domain]
length(82), motif(733:814) 82 IPR001487 Bromodomain [Domain]
length(71), motif(740:810) 71 IPR001487 Bromodomain [Domain]
length(14), motif(743:756) 14 IPR001487 Bromodomain [Domain]
length(58), motif(745:802) 58 IPR018359 Bromodomain, conserved site [Conserved_site]
length(17), motif(757:773) 17 IPR001487 Bromodomain [Domain]
length(19), motif(773:791) 19 IPR001487 Bromodomain [Domain]
length(20), motif(791:810) 20 IPR001487 Bromodomain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000260125
H-Inv cluster ID Locus viewHIX0003121
Accession number BC060823.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Histone acetyltransferase KAT2B; EC=2.3.1.48; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q92831)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 8684459;  8945521;  9296499;  9346901;  9707565;  10365964;  10675335;  10766811;  11568182;  11931765;  12486002;  14767476;  15273251;  15489334;  16887930;  17226766;  17707232;  22464331;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol KAT2B
HGNC aliases "p300/CBP-associated factor"
HGNC name K(lysine) acetyltransferase 2B
DDBJ KAT2B
UniProt KAT2B
EC number EC 2.3.1.48histone acetyltransferase; 
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 01510 :Neurodegenerative Disorders;  04310 :Wnt signaling pathway;  04330 :Notch signaling pathway;  04350 :TGF-beta signaling pathway;  04520 :Adherens junction;  04630 :Jak-STAT signaling pathway;  04720 :Long-term potentiation;  05040 :Huntington's disease; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000096938
No. of interaction 31
Interaction partner(s) HIP000027257;  HIP000027883;  HIP000028128;  HIP000028128;  HIP000036688;  HIP000037809;  HIP000039705;  HIP000039705;  HIP000046703;  HIP000046967;  HIP000054970;  HIP000064276;  HIP000065748;  HIP000068668;  HIP000070701;  HIP000072201;  HIP000072201;  HIP000080779;  HIP000084077;  HIP000086021;  HIP000092109;  HIP000100766;  HIP000101027;  HIP000101027;  HIP000104448;  HIP000106438;  HIP000106966;  HIP000131477;  HIP000161736;  HIP000204458;  HIP000213905; 
BIND 145156;  151432;  151708;  196942;  199986;  295233; 
DIP 136394E; 
MINT MINT-2632018;  MINT-50175;  MINT-7299740;  MINT-7299749;  MINT-7299763;  MINT-7299777;  MINT-7299797;  MINT-7299990;  MINT-7300008;  MINT-7300181;  MINT-7300201;  MINT-7300223;  MINT-7300243;  MINT-7300263;  MINT-7300283;  MINT-7914936; 
HPRD 00019;  00020;  00295;  00307;  00532;  00744;  00800;  00918;  00920;  00961;  00962;  01166;  01230;  01241;  01261;  01310;  01346;  01574;  01753;  01806;  01827;  01859;  02437;  02475;  02534;  02554;  02607;  02765;  02866;  03036;  03082;  03337;  03356;  03374;  03465;  03570;  03584;  03587;  03647;  03807;  03927;  04015;  04061;  04070;  04078;  04155;  04157;  04176;  04253;  05002;  05600;  05620;  06039;  06481;  06769;  07077;  09137;  10377;  11821;  11822;  11906;  11907;  11909;  11912;  11915;  11921;  13626;  13662;  15094;  15972;  15981;  16360; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8850; 
KEGG GENES KEGG GENES(8850); 
GeneCard GeneCardKAT2B;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function histone acetyltransferase activity (GO:0004402);  protein binding (GO:0005515);  N-acetyltransferase activity (GO:0008080); 
Biological process regulation of transcription, DNA-dependent (GO:0006355); 
Cellular component nucleus (GO:0005634); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  cytoskeleton;  golgi apparatus; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
493 653 1cm0A 1e-36 100.0 161/162 d.108.1.1
712 826 1eqfA1 6e-29 27.0 115/139 a.29.2.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA110803; 
Affymetrix
GeneChip		 HG-Focus 203845_at; 
HG-U133 203845_at; 
HG-U133A 203845_at; 
HG-U133A_2 203845_at; 
HG-U133B NA
HG-U133_Plus_2 203845_at; 
HG-U95 1012_at;  63536_at;  63537_g_at;  63868_at;  69300_at;  75936_at; 
HG-U95A 1012_at; 
HG-U95B NA
HG-U95C 63536_at;  63537_g_at;  63868_at; 
HG-U95D NA
HG-U95E 69300_at;  75936_at; 
HG-U95Av2 NA
HuEx-1_0 2613443;  2613453;  2613464;  2613465;  2613466;  2613468;  2613469;  2613471;  2613473;  2613474;  2613476;  2613480;  2613481;  2613485;  2613487;  2613488;  2613490;  2613491;  2613492;  2613495;  2613496;  2665565;  2665567;  2665569; 
HuGeneFL U57317_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P41127; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P41128;  A_32_P159651; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
21 .. 21 C/A rs111595165 + 5'UTR
203 .. 203 C/G rs200723262 + CDS Nonsynonymous[Ala51Gly]
209 .. 209 G/C rs113149969 + CDS Nonsynonymous[Gly53Ala]
210 .. 210 T/A rs113171361 + CDS Synonymous[Gly53Gly]
236 .. 236 G/A rs201810024 + CDS Nonsynonymous[Gly62Asp]
360 .. 360 G/A rs3021408 - CDS Synonymous[Glu103Glu]
385 .. 385 A/G rs199589780 + CDS Nonsynonymous[Lys112Glu]
413 .. 413 C/A/G rs200560854 + CDS
420 .. 420 C/T rs201922668 + CDS Synonymous[Ala123Ala]
617 .. 617 A/G rs192747064 + CDS Nonsynonymous[Tyr189Cys]
621 .. 621 A/C rs2293143 + CDS Synonymous[Leu190Leu]
630 .. 630 C/T rs35424474 + CDS Synonymous[Leu193Leu]
639 .. 639 G/A rs200387198 + CDS Synonymous[Lys196Lys]
643 .. 643 A/G rs182486173 + CDS Nonsynonymous[Ile198Val]
757 .. 757 C/G rs201795949 + CDS Nonsynonymous[Leu236Val]
792 .. 792 G/A rs148725281 + CDS Synonymous[Leu247Leu]
814 .. 814 A/C rs151336172 + CDS Nonsynonymous[Ile255Leu]
818 .. 818 A/G rs147708206 + CDS Nonsynonymous[Asn256Ser]
864 .. 864 C/A rs201397595 + CDS Synonymous[Pro271Pro]
866 .. 866 A/G rs142082974 + CDS Nonsynonymous[Asn272Ser]
873 .. 873 T/C rs145500471 + CDS Synonymous[Asp274Asp]
921 .. 921 C/T rs9859493 + CDS Synonymous[Asn290Asn]
1067 .. 1067 G/A rs202132144 + CDS Nonsynonymous[Arg339Gln]
1079 .. 1079 T/C rs138650015 + CDS Nonsynonymous[Leu343Pro]
1147 .. 1147 G/C rs199916721 + CDS Nonsynonymous[Asp366His]
1204 .. 1204 A/G rs150650600 + CDS Nonsynonymous[Ile385Val]
1208 .. 1208 A/G rs17006625 + CDS Nonsynonymous[Asn386Ser]
1231 .. 1231 A/G rs145622725 + CDS Nonsynonymous[Ile394Val]
1240 .. 1240 A/G rs147304960 + CDS Nonsynonymous[Asn397Asp]
1299 .. 1299 A/C rs137884855 + CDS Nonsynonymous[Lys416Asn]
1343 .. 1343 T/C rs144806388 + CDS Nonsynonymous[Met431Thr]
1352 .. 1352 C/G rs146721823 + CDS Nonsynonymous[Ser434Cys]
1416 .. 1416 C/T rs149881135 + CDS Synonymous[Asn455Asn]
1417 .. 1417 G/A rs201839892 + CDS Nonsynonymous[Glu456Lys]
1436 .. 1436 C/T rs144875299 + CDS Nonsynonymous[Thr462Met]
1450 .. 1450 A/G rs41285059 + CDS Nonsynonymous[Met467Val]
1488 .. 1488 G/A rs143548388 + CDS Synonymous[Ser479Ser]
1556 .. 1556 C/T rs141445570 + CDS Nonsynonymous[Ser502Phe]
1594 .. 1594 C/T rs201537605 + CDS Synonymous[Leu515Leu]
1673 .. 1673 C/T rs200471371 + CDS Nonsynonymous[Pro541Leu]
1733 .. 1733 G/A rs200572606 + CDS Nonsynonymous[Arg561His]
1774 .. 1774 G/A rs138266237 + CDS Nonsynonymous[Ala575Thr]
1848 .. 1848 G/A rs141010149 + CDS Synonymous[Lys599Lys]
2008 .. 2008 C/T rs116196143 + CDS Nonsynonymous[Arg653Trp]
2016 .. 2016 G/A rs142548774 + CDS Synonymous[Pro655Pro]
2075 .. 2075 A/G rs150952531 + CDS Nonsynonymous[Glu675Gly]
2096 .. 2096 G/A rs200681006 + CDS Nonsynonymous[Arg682Gln]
2116 .. 2116 T/A rs143156951 + CDS Nonsynonymous[Ser689Thr]
2133 .. 2133 A/C rs150351875 + CDS Synonymous[Gly694Gly]
2188 .. 2188 C/A rs148960024 + CDS Nonsynonymous[Pro713Thr]
2226 .. 2226 T/C rs202116411 + CDS Synonymous[Pro725Pro]
2243 .. 2243 C/T rs138379232 + CDS Nonsynonymous[Thr731Met]
2330 .. 2330 A/G rs199925890 + CDS Nonsynonymous[Tyr760Cys]
2331 .. 2331 T/A rs201066836 + CDS AA-STOP[Tyr760*]
2345 .. 2345 G/T rs1138421 + CDS Nonsynonymous[Arg765Met]
2382 .. 2382 C/G rs143874407 + CDS Synonymous[Leu777Leu]
2460 .. 2460 C/G/T rs139361011 + CDS
2481 .. 2481 C/T rs150884035 + CDS Synonymous[Tyr810Tyr]
2516 .. 2516 G/A rs149611433 + CDS Nonsynonymous[Ser822Asn]
2567 .. 2567 C/T rs200915849 + 3'UTR
2592 .. 2592 T/C rs191880040 + 3'UTR
2740 .. 2740 T/C rs111392228 + 3'UTR
2788 .. 2788 A/G rs41276509 + 3'UTR
2828 .. 2828 G/A rs140972380 + 3'UTR
2956 .. 2956 C/T rs4858770 + 3'UTR
3041 .. 3041 T/A rs144654473 + 3'UTR
3323 .. 3323 A/T rs184263350 + 3'UTR
3378 .. 3378 A/T rs17006672 + 3'UTR
3434 .. 3434 G/A rs187406655 + 3'UTR
3583 .. 3583 A/G rs10510499 + 3'UTR
3699 .. 3699 T/A rs147870914 + 3'UTR
3713 .. 3713 A/G rs3749184 + 3'UTR
3756 .. 3756 A/G rs3749185 + 3'UTR
3869 .. 3869 A/G rs193162300 + 3'UTR
3928 .. 3928 T/C rs68050031 + 3'UTR
3962 .. 3962 A/C rs199548798 + 3'UTR
4063 .. 4063 A/G rs75780220 + 3'UTR
4243 .. 4243 T/A rs200290890 + 3'UTR
4284 .. 4284 T/A rs1046039 + 3'UTR
4287 .. 4287 T/A rs1062974 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;